共查询到20条相似文献,搜索用时 15 毫秒
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The mouse Hox2.3 homeobox-containing gene: regulation in differentiating pluripotent stem cells and expression pattern in embryos 总被引:1,自引:0,他引:1
Jacqueline Deschamps Rozalia de Laaf Peter Verrijzer Miebet de Gouw Olivier Destrée Frits Meijlink 《Differentiation; research in biological diversity》1987,35(1):21-30
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Coding sequence and expression of the homeobox gene Hox 1.3 总被引:15,自引:0,他引:15
M Fibi B Zink M Kessel A M Colberg-Poley S Labeit H Lehrach P Gruss 《Development (Cambridge, England)》1988,102(2):349-359
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Induction of c-fos and AFP expression in a differentiating teratocarcinoma cell line 总被引:2,自引:0,他引:2
The introduction of a c-fos expression vector has been shown to potentiate spontaneous differentiation in teratocarcinoma cells. We have studied a teratocarcinoma stem cell line which can be induced to differentiate with dimethylsulfoxide (DMSO) to determine endogenous c-fos expression during the process of differentiation. c-Fos expression increases dramatically as P19S1801A1 embryonal carcinoma cells are induced to differentiate into a variety of cell types. Expression peaks 12 days after the start of aggregate culture about the same time as alphafetoprotein (AFP), a characteristic of visceral endoderm differentiation, as demonstrated by RNA hybridization to specific probes, ELISA, and immunofluorescent staining with specific antibodies. However, most differentiated cells expressed c-fos, while AFP was expressed in a minor fraction (less than 5%). The data suggest that c-fos is correlated with differentiation of teratocarcinoma cells but not specifically to visceral endoderm formation. 相似文献
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观察自发性高血压大鼠(SHR)血管平滑肌细胞(VSMCs)的生长曲线、c-fos原癌基因表达和c-fos基因酶切图谱的情况,与对照组京都维斯特大鼠(WKY)进行对比.结果显示,在小牛血清作用下SHR的VSMCs生长速率和c-fos原癌基因表达明显大于WKY;c-fos原癌基因限制性内切酶片段长度多态性(RFLP)分析表明,经BamHⅠ或EcoRⅠ酶切后的SHR和WKY的酶切图谱一致,同时也未发现SHR的fos基因扩增现象.提示,VSMCs的异常增殖和c-fos原癌基因的表达异常与高血压的形成有关,而c-fos原癌基因的过度表达可能是由于某些与基因转录调控有关的因素异常所致. 相似文献
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