共查询到20条相似文献,搜索用时 15 毫秒
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N M Johnson 《BMJ (Clinical research ed.)》1985,290(6478):1299-1301
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Xiaoping Tang Yongjian Zhou Haoming Xu Xianfei Wang Kang Li Jie He Yanlei Du Hong Wang Ye Chen Yuqiang Nie 《Journal of cellular and molecular medicine》2018,22(4):2263-2271
Acquired immune deficiency syndrome (AIDS), caused by infection with human immunodeficiency virus (HIV), is associated with gastrointestinal disease, systemic immune activation and changes in the gut microbiota. Here, we aim to investigate the gut microbiota patterns of HIV‐infected individuals and HIV‐uninfected individuals in populations from South China. We enrolled 33 patients with HIV (14 participants treated with highly active antiretroviral therapy [HAART] for more than 3 months; the remaining 19 individuals had not received treatment) and 35 healthy controls (HC) for a cross‐sectional comparison of gut microbiota using stool samples. Gut microbial communities were profiled by sequencing the bacterial 16S rRNA genes. Dysbiosis was more common among patients with AIDS compared with healthy individuals. Dysbiosis was characterized by decreased α‐diversity, low mean counts of Bacteroidetes, Faecalibacterium, Prevotella, Bacteroides vulgatus, Dialister and Roseburia inulnivorans, and high mean counts of Proteobacteria, Enterococcus, Streptococcus, Lactobacillus, Lachnociostridium, Ruminococcus gnavus and Streptococcus vestibularis. Increased abundance of Bacilli was observed in homosexual patients. Proteobacteria were higher among heterosexual patients with HIV infections. Tenericutes were higher among patients with history of intravenous drug abuse. Restoration of gut microbiota diversity and a significant increase in abundance of Faecalibacterium, Blautia and Bacteroides were found in patients receiving HAART compared to those who did not receive. HIV infection‐associated dysbiosis is characterized by decreased levels of α‐diversity and Bacteroidetes, increased levels of Proteobacteria and the alterations of gut microbiota correlate with the route of HIV transmission. The imbalanced faecal microbiota of HIV infection is partially restored after therapy. 相似文献
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A case of pulmonary infection with Mycobacterium tuberculosis in a patient with the acquired immune deficiency syndrome (AIDS) was studied. Diagnosis of AIDS was confirmed by the finding of pulmonary M tuberculosis with oral and oesophageal candidiasis accompanied by characteristic immunological changes with evidence of infection with human T cell lymphotropic virus III. Treatment of this patient was complicated by an unusual drug interaction between rifampicin and ketoconazole, leading to subtherapeutic serum concentrations and poor clinical response to treatment. Intravenous treatment was more effective than oral treatment. This drug interaction should be studied in greater detail as ketoconazole and rifampicin may be used together to treat patients with candidiasis and infection with M tuberculosis. 相似文献
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E. S. Odintsova M. A. Kharitonova A. G. Baranovskii L. P. Sizyakina V. N. Buneva G. A. Nevinsky 《Molecular Biology》2006,40(5):770-777
DNase activity was analyzed in 110 IgG preparations from the blood of AIDS patients. The relative activity of the preparations varied markedly among patients, being reliably detectable in 96% of the preparations. It was shown with several rigid criteria that DNAase activity is an intrinsic property of antibodies (Abs) from AIDS patients. Not only intact IgG, but also isolated light chains of polyclonal Abs were shown to possess catalytic activity. The abzymes efficiently catalyzed DNA hydrolysis in a wide range of pH (5.0–9.5). The K M and V max values were evaluated for Ab-dependent hydrolysis of DNA. 相似文献
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Odintsova ES Kharitonova MA Baranovskiĭ AG Siziakina LP Buneva VN Nevinskiĭ GA 《Molekuliarnaia biologiia》2006,40(5):857-864
DNAase activity of 110 samples of IgG from the blood of AIDS patients was analyzed. It was shown that the relative activity of preparations varies very much from patient to patient, but 96% preparations show detectable level of DNAase activity. Several rigid criteria were applied and it was shown that DNAase activity is an intrinsic property of antibodies from AIDS patients. It was shown that catalytic activity could posses not only intact IgG, but also separated light chains of polyclonal antibodies. The abzymes catalyze DNA hydrolysis effectively in a wild range of pH (5.0-9.5). K(M) and V(MaKC) values of antibody-dependent hydrolysis of DNA was estimated. 相似文献
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Tuberculosis and the acquired immune deficiency syndrome 总被引:3,自引:0,他引:3
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M E Bégin M S Manku D F Horrobin 《Prostaglandins, leukotrienes, and essential fatty acids》1989,37(2):135-137
Polyunsaturated fatty acids (PUFAs) are known to modulate the immune system in vivo and to inactivate envelope viruses in vitro. Patients with AIDS had low total plasma lipid levels and low levels of a number of individual fatty acids. However, the C20 and C22 essential fatty acids of the n-3 series were selectively and highly significantly reduced. Normalization of these fatty acid levels in AIDS patients may be a worthwhile therapeutic aim. 相似文献
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《CMAJ》1988,139(10):939-941
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Murine models for acquired immune deficiency syndrome 总被引:1,自引:0,他引:1
R R Watson 《Life sciences》1989,44(3):iii-ixv
The mouse has been suggested as a host for comparative studies of several aspects of Human Acquired Immune Deficiency Syndrome (AIDS). Models include studies where part or all of the genome of Human Immunodeficiency Virus (HIV) has been incorporated into murine DNA in living mice. However, the most promising opportunities for study of immunological changes, vaccine development, cofactor involvement in disease, and anti-retroviral and immunostimulatory drug testing involve infection with murine retroviruses which cause many functional changes similar to AIDS. The viruses' effects on immune systems are reviewed with special emphasis. LP-BM5 murine leukemia virus which infects T and B cells, and macrophages. LP-BM5 infection suppresses cell functions while causing polyclonal lymphocyte activation. Murine immunological characterization, availability of inbred mouse strains, economy of using mice versus primates or humans models, and similarity of immune change caused by murine retroviruses compared to those seen in AIDS caused by HIV encourage rapid development of the LP-BM5 murine leukemia model. 相似文献
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《CMAJ》1987,137(11):1025-1029
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The distribution of selenium and mortality owing to acquired immune deficiency syndrome in the continental United States 总被引:3,自引:0,他引:3
U. M. Cowgill 《Biological trace element research》1997,56(1):43-61
A hypothesis has been proposed that Selenium (Se) concentration in the environment as measured by its uptake by alfalfa, which
sorbs Se from the soil in proportion to what is present, exerted an apparent effect on incidence of (acquired immune deficiency
syndrome) AIDS such that AIDS’ mortality within the conterminous United States was lower where the Se quantity in the soil
was high than where the amount was low. The object of this study was to test this hypothesis for statistical significance
and to discover whether the apparent pattern of AIDS mortality in relation to Se distribution holds true with respect to all
ages, both races (Black and White), and both genders. The statistical analysis employed was analysis of variance. Age-specific
data as well as age-adjusted data were subject to statistical analysis. Ages where AIDS mortality rates per 100,000 were greatest
were in the range from 25–54 yr for low-, medium-, and high-Se areas of the US. Black mortality owing to AIDS showed highly
statistically significant results for the three Se regions, both genders, and six age groups, whereas white mortality was
not as significantly affected by Se. A hypothesis is proposed that the Black population during the last decade or so has been
less migratory than the White population. Thus, their food supply and hence its Se content have been more stable than that
of the White population, which is more prone to consume imported foods of unknown Se content and be more migratory. A second
hypothesis is advanced that suggests that medical care is not equally available to the poor and especially poor Blacks. Black
men and women die at a greater death rate than do Whites. This implies that a lack of medical care is the true cause. This
article suggests that a pattern exists between the geographical distribution of Se using alfalfa as a dietary guide and AIDS’
mortality such that an inverse relationship persists between Se quantity in an area and AIDS’ mortality in the same area. 相似文献
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M A Sanchez E D Ames K Erhardt G U Auer 《Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology》1988,10(1):16-20
While Kaposi's sarcoma in patients with the acquired immune deficiency syndrome (AIDS) may present as a multicentric disease with progressive organ involvement, the classic form of Kaposi's sarcoma is an indolent tumor seldom affecting extracutaneous areas and almost never responsible for the patient's demise. An attempt was made to correlate these clinical differences with the nuclear DNA content of tumor cells in histologic sections from 15 patients (9 with AIDS and 6 without AIDS). All tumors showed a similar DNA distribution pattern, with most cells appearing diploid, indicative of a low malignant potential. These findings indicate that Kaposi's sarcoma of both AIDS and non-AIDS patients is a tumor of intrinsically low malignancy and that lack of immune surveillance is most probably responsible for its aggressive biologic behavior in many AIDS patients. 相似文献