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Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo 总被引:7,自引:0,他引:7
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Martinez E Palhan VB Tjernberg A Lymar ES Gamper AM Kundu TK Chait BT Roeder RG 《Molecular and cellular biology》2001,21(20):6782-6795
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Borggrefe T Davis R Erdjument-Bromage H Tempst P Kornberg RD 《The Journal of biological chemistry》2002,277(46):44202-44207
The Srb8, -9, -10, and -11 proteins of yeast have been isolated as a discrete, stoichiometric complex. The isolated complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II at serines 2 and 5. In addition to the previously reported human homologs of Srb10 and 11, we have identified TRAP230/ARC240 and TRAP240/ARC250 as the human homologs of Srb8 and Srb9, showing the entire Srb8/9/10/11 complex is conserved from yeast to humans. 相似文献
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