An everlasting role of genetics and genomics in public health: a meeting report of ACGA-HKSMG International Conference on Genetic and Genomic Medicine 2008

The Association of Chinese Geneticists in America （ACGA） and the Hong Kong Society of Medical Genetics （HKSMG） held their first joint Conference on Genetic and Genomic Medicine in Hong Kong from June 9-11 in 2008 at the Cheung Kung Hai Conference Center, William MW Mong Block, Li Ka Shing Faculty of Medicine, the University of Hong Kong. Other co-organizers included the University of Hong Kong and Chinese Society of Medical Genetics. A satellite conference ＂ACGA-WZMC International Symposium of Genetics and Translational Medicine＂, co-organized with Wenzhou Medical College and Chinese Society of Medical Genetics, was held from June 12-14, 2008 at Wenzhou, Zhejiang Province of China.     

Instructions for authors

Journal of Genetics and Genomics （JGG, formerly known as Acta Genetica Sinica） is one of the China＇s leading journals in the life science. JGG is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology, the Chinese Academy of Sciences and jointly published by Elsevier Ltd. and Science Press, Beijing, E R. China. Currently, JGG is indexed by Science Citation Index Expanded （SCI-E）, Abstracts Journal, VINTI （A J）, BIOSIS Previews （BA）,     

Instructions for authors

Journal of Genetics and Genomics （JGG, formerly known as Acta Genetica Sinica） is one of the China＇s leading journals in the life science. JGG is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology, the Chinese Academy of Sciences and jointly published by Elsevier Ltd. and Science Press, Beijing, P. R. China. Currently,     

Instructions for authors

Journal of Genetics and Genomics （JGG, formerly known as Acta Genetica Sinica） is one of the China＇s leading journals in the life science. JGG is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology, the Chinese Academy of Sciences and jointly published by Elsevier Ltd. and Sci- ence Press, Beijing, P. R. China. Currently, JGG is indexed by Science Citation Index Expanded （SCI-E）, Abstracts Journal, VINTI （AJ）, BIOSIS Previews （BA）, Chemical Abstracts （CA）, Excepta Media （EM）, MEDLINE, Scopus, and Zoological Record （ZR）. JGG publishes papers in English only and distributed internationally.     

Instructions for authors

Journal of Genetics and Genomics (JGG, formerly known as Acta Genetica Sinica) is one of the China's leading journals in the life science. JGG is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology, the Chinese Academy of Sciences and jointly published by Elsevier Ltd.     

Journal of Molecular Cell Biology calls for contributions in English

Journal of Molecular Cell Biology （JMCB, ISSN 1673-520X, CN 31-1976/Q）, originally launched in 1936 under the title of the Chinese Journal of Experimental Biology, is sponsored by Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and the Chinese Society of Cell Biology.     

Instructions for Authors

Acta Genetica Sinica is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology,Chinese Academy of Sciences and jointly published by Elsevier Press of the Netherlands and Science Press,Beijing,P.R.China.Acta Genetica Sinica is one of the leading national academic periodicals of natural sciences. Currently,Acta Genetica Sinica are indexed by several well-known domestic and international indexing systems, such as the American Chemical Digest (CA),BIOSIS database,Biological Digest (BA),Medical Index (MED), and Russian Digest (AJ).From 2006,the journal will publish all papers in English and distributed internationally.     

Up-regulation of hypoxia-inducible factor-1α enhanced the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats

Hyperlipidemia is an independent risk factor in the devel- opment of ischemic heart disease, which can increase myo- cardial susceptibility to ischemia/reperfusion （I/R） injury. Ischemic postconditioning （PostC） has now been demon- strated as a novel strategy to harness nature＇s protection against myocardial I/R injury in normal conditions. However, the effect of PostC on hyperlipidemic animals remains elusive. It has been shown in our previous study that PostC reduces the myocardial I/R injury, and hypoxia- inducible factor-1α （HIF-1α） may play an important role in the cardioprotective mechanisms of PostC on normal rats. Here, we tested the hypothesis that the cardioprotec- tion of PostC on hyperlipidemic rats is associated with the up-regulated HIF-1α expression. Male Wistar rats were fed with a high-fat diet for 8 weeks, and then randomly div- ided into five groups： sham, I/R, dimethyloxalylglycine （DMOG） ＋ I/R, PostC, and DMOG ＋ PostC group. The detrimental indices induced by I/R injury included infarct size, plasma creatine kinase （CK） activity and caspase-3 ac- tivity. The results showed that PostC could reduce the infarct size, when compared with the I/R group, which was consistent with the significant lower levels of plasma CK activity and caspase-3 activity, and that it increased the ex- pression of HIF-1α in hyperlipidemic rats. When DMOG was given before PostC to up-regulate HIF-1α protein level, the degree of I/R injury was attenuated. In conclu- sion, these data suggested that the up-regulation of HIF-1α may be one of the cardioprotective mechanisms of PostC against I/R injury in hyperlipidemic rats.     

作者须知

Acta Genetica Sinica is sponsored by the Genetics Society of China and the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences and jointly published by Elsevier Press of the Netherlands and Science Press, Beijing, P. R. China. Acta Genetica Sinica is one of the leading national academic periodicals of natural sciences. Currently, Acta Genetica Sinica are indexed by several well-known domestic and international indexing systems, such as the American Chemical Digest (CA), BIOSIS database, Biological Digest (BA), Medical Index (MED),and Russian Digest (AJ). From 2006, the journal will publish all papers in English and distributed internationally.     

Copy number variations of HLA-DRB5 is associated with systemic lupus erythematosus risk in Chinese Han population

Systemic lupus erythematosus （SLE） is a polygenic, systemic, autoimmune disease. Copy number variants （CNVS） have been discovered to be associated with a number of complex disorders. We undertook the current study to explore the potential associations between genomic CNVS and SLE in Chinese Han population. In the discovery stage, seven SLE patients were examined with the high-density comparative genomic hybridization microarrays in the screening test for SLE associated CNVS. Then, in the validation stage, 135 SLE patients and 219 matched healthy subjects were investigated for the CNVS of gene HLA-DRB5 by AccuCopyTM technol- ogy. Quantitative polymerase chain reaction was carried out to determine the copy number （CN） and mRNA level of HLA- DRB5 in SLE patients. Although the mRNA level of HLA- DRB5 between the CN deletion group and the CN normal group in SLE patients was not statistically positive （P = 0.46）, our results still showed more CN of HLA-DRB5 in SLE patients than in healthy controls （P = 3.98×10^-6）. Odds ratio for CN deletion was 0.38 （95% confidence interval （C1）, 0.23-0.61, P = 7.79×10^-5） and for CN duplication was 1.89 （95% CI, 0.56-7.66, P = 0.37）, respectively. These findings indicated that CNVS of HLA-DRB5 was associated with the risk of SLE, and CN deletion appeared to be protective for SLE.     

Introduction to Asian Herpetological Research

Asian Herpetological Research （AHR）, an international English language journal, is published quarterly by the Chengdu Institute of Biology （CIB）, Chinese Academy of Sciences and the Science Press of China, cooperated with the Asiatic Herpetological Research Society （AHRS）, with its registered numbers： CN 51-1735/Q and ISSN 2095-0357, and post distribution code： 62-218. AHR has an international Editorial Board consisting of many top herpetologists from different countries in the world. The journal＇s website can be found at： http：//www.ahr-journal.com.     

Mutation of Residue Arginine^18 of Cytochrome b559 α-Subunit and its Effects on Photosystem Ⅱ Activities in Chlamydomonas reinhardtii

It has been known that arginine is used as the basic amino acid in the α-subunit of cytochrome bsss （Cyt bsss） except histidine. However, previous studies have focused on the function of histidine in the activities of photosystem （PS） Ⅱ and there are no reports regarding the structural and/or functional roles of arginine in PSll complexes. In the present study, two arginine18 （R18） mutants of Chlamydomonas reinhardtii were constructed using site-directed mutagenesis, in which R18 was replaced by glutamic acid （E） and glycine （G）. The results show that the oxygen evolution of the PSII complex in the R18G and R18E mutants was approximately 60% of wild-type （WT） levels and that, after irradiation at high light intensity, oxygen evolution for the PSll of mutants was reduced to zero compared with 40% in WT cells. The efficiency of light capture by PSll （Fv/Fm） of R18G and R18E mutants was approximately 42%-46% that of WT cells. Furthermore, levels of the α-subunit of Cyt bsss and PsbO proteins were reduced in thylakoid membranes compared with WT. Overall, these data suggest that R18 plays a significant role in helping Cyt bss9 maintain the structure of the PSll complex and its activity, although it is not directly bound to the heme group.     

Introduction to Asian Herpetological Research

Asian Herpetological Research （AHR）, an international English language journal, is published quarterly by the Chengdu Institute of Biology （CIB）, Chinese Academy of Sciences and the Science Press of China, cooperated with the Asiatic Herpetological Research Society （AHRS）, with its registered numbers： CN 51-1735/Q and ISSN 2095-0357, and post distribution code： 62-218. AHR has an international Editorial Board consisting of many top herpetologists from different countries in the world. The journal＇s website can be found at： http：//www.ahr-journal.com.     

Journal of Genetics and Genomics in Transition

正Journal of Genetics and Genomics(JGG),sponsored by the Genetics Society of China and Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,has become a high-quality societal journal in the fields of genetics and genomics by a joint effort of our authors,editorial board     

Instructions for Authors

Journal of Genetics and Genomics (JGG,for-merly known as Acta Genetica Sinica) is one of China’s leading journals in life sciences.JGG is spon-sored by the Genetics Society of China and the Insti-tute of Genetics and Developmental Biology,Chinese     

Journal of Genetics and Genomics （Formerly Acta Genetica）

In order to further promote the international scientific communication of genetics and genomics research, the joumal name of Acra Genetica Sinica will be changed to Journal of Genetics and Genomics （JGG） from the year 2007. The aim and scope of the Journal are continuously interested in publishing primarily research papers and topic reviews in the fields of genetics, genomics, molecular biology,developmental biology, bioinformatics, and evolution.     

Journal of Genetics and Genomics （Formerly Acta Genetica Sinica）

In order to further promote the international scientific communication of genetics and genomics research, the journal name of Acta Genetica Sinica will be changed to Journal of Genetics and Genomics （JGG） from the year 2007. The aim and scope of the Journal are continuously interested in publishing primarily research papers and topic reviews in the fields of genetics, genomics, molecular biology, developmental biology, bioinformatics, and evolution.     

Journal of Genetics and Genomics

Aims and Scope
Journal of Genetics and Genomics （JGG） publishes original research of special significance in all areas of genetics and genomics.     

Journal of Genetics and Genomics （Formerly Acta Genetica Sinica）

In order to further promote the international scientific communication of genetics and genomics research, the journal name of Acta Genetica Sinica will be changed to Journal of Genetics and Genomics （JGG） from the year 2007. The aim and scope of the Journal are continuously interested in publishing primarily research papers and topic reviews in the fields of genetics, genomics, molecular biology, developmental biology, bioinformatics, and evolution.