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GATA-dependent recruitment of MEF2 proteins to target promoters 总被引:38,自引:0,他引:38
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Identification of a new hybrid serum response factor and myocyte enhancer factor 2-binding element in MyoD enhancer required for MyoD expression during myogenesis 总被引:1,自引:0,他引:1 下载免费PDF全文
L'honore A Rana V Arsic N Franckhauser C Lamb NJ Fernandez A 《Molecular biology of the cell》2007,18(6):1992-2001
MyoD is a critical myogenic factor induced rapidly upon activation of quiescent satellite cells, and required for their differentiation during muscle regeneration. One of the two enhancers of MyoD, the distal regulatory region, is essential for MyoD expression in postnatal muscle. This enhancer contains a functional divergent serum response factor (SRF)-binding CArG element required for MyoD expression during myoblast growth and muscle regeneration in vivo. Electrophoretic mobility shift assay, chromatin immunoprecipitation, and microinjection analyses show this element is a hybrid SRF- and MEF2 Binding (SMB) sequence where myocyte enhancer factor 2 (MEF2) complexes can compete out binding of SRF at the onset of differentiation. As cells differentiate into postmitotic myotubes, MyoD expression no longer requires SRF but instead MEF2 binding to this dual-specificity element. As such, the MyoD enhancer SMB element is the site for a molecular relay where MyoD expression is first initiated in activated satellite cells in an SRF-dependent manner and then increased and maintained by MEF2 binding in differentiated myotubes. Therefore, SMB is a DNA element with dual and stage-specific binding activity, which modulates the effects of regulatory proteins critical in controlling the balance between proliferation and differentiation. 相似文献
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Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D 总被引:1,自引:0,他引:1
Slepak TI Webster KA Zang J Prentice H O'Dowd A Hicks MN Bishopric NH 《The Journal of biological chemistry》2001,276(10):7575-7585
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