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1.
M Ravazzola D Baetens R Engerman N Kovacevic M Vranic L Orci 《Hormones et métabolisme》1977,9(6):480-483
Immunofluorescence shows that the oxyntic mucosa of a dog depancreatized for 5 years and having a poorly-controlled diabetes has more glucagon- and somatostatin-containing cells than the mucosa of a control dog. At the ultrastructural level, 4 endocrine cell types are identified: A-, A-like, D- and enterochromaffin-like (ECL) cells, with increased numbers of A-, A-like and D-cells in gastric glands of the depancreatized dog, together with a higher concentration of immunoreactive glucagon in the gastric mucosa. The increase in A-, A-like and D-cells is compatible with: a) a change induced by the diabetic state itself; b) a hyperplasia secondary to the loss of corresponding pancreatic cells. At any rate, the fact that A-, A-like and D-cells increase parallely may indicate that these three cell types are functionally related one with another. 相似文献
2.
Summary In the gastric mucosa of two teleost species, the perch (Perca fluviatilis) and the catfish (Ameiurus nebulosus) three endocrine cell types were found, located predominantly between the mucoid cells of the gastric mucosa. A fourth cell type is present in the gastric glands of catfish. Each cell type was defined by its characteristic secretory granules. Type-I cells were predominant in both fish. These cells contained round or oval granules with a pleomorphic core. The average diameter of granules was 400 nm for the perch and 270 nm for the catfish. Type-II cells of both species displayed small, highly osmiophilic granules about 100 nm in diameter. The secretory granules of type-III cells (260 nm in the perch and 190 nm in the catfish) were round or slightly oval in shape and were filled with a finely particulate electron-dense material. Type-IV cells of the catfish were found in the gastric glands only. Their cytoplasm was filled with homogeneous, moderately electron-dense granules averaging 340 nm in diameter. The physiological significance of these different morphological types of gastric endocrine cells requires further investigation. 相似文献
3.
The stomach of the hedgehog is a simple sac-like structure, and is divisible into three main regions based upon the histological structure of the gastric glands.
Peptic cells containing prominent Bowie positive granules are present at the bases of the rudimentary gastric glands at birth. A mucinogen component persists in these cells until about three weeks after birth.
Oxyntic cells differentiate from a non-mucoid cell type, they are far less numerous than petic cells throughout the suckling period.
Pepsin assays on the fundic mucosa reveal that pepsin is present in considerable amounts at nine days of age, and that near-adult levels are attained by about the end of the fourth week. Gastric pH declines during the suckling period, from near neutrality at birth to generally between 3.0 and 4.0 during the fourth and fifth weeks. Proteolytic digestion of antibody is delayed not through lack of enzyme but because the hydrogen ion concentration is generally inadequate for its action.
Evidence is presented to support the suggestion that the cessation of antibody absorption in the hedgehog and the rat is brought about, initially at least, by changes in the secretory activity of the gut, rather than by changes in the absorptive intestinal epithelium. 相似文献
Peptic cells containing prominent Bowie positive granules are present at the bases of the rudimentary gastric glands at birth. A mucinogen component persists in these cells until about three weeks after birth.
Oxyntic cells differentiate from a non-mucoid cell type, they are far less numerous than petic cells throughout the suckling period.
Pepsin assays on the fundic mucosa reveal that pepsin is present in considerable amounts at nine days of age, and that near-adult levels are attained by about the end of the fourth week. Gastric pH declines during the suckling period, from near neutrality at birth to generally between 3.0 and 4.0 during the fourth and fifth weeks. Proteolytic digestion of antibody is delayed not through lack of enzyme but because the hydrogen ion concentration is generally inadequate for its action.
Evidence is presented to support the suggestion that the cessation of antibody absorption in the hedgehog and the rat is brought about, initially at least, by changes in the secretory activity of the gut, rather than by changes in the absorptive intestinal epithelium. 相似文献
4.
Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues 总被引:6,自引:1,他引:5
Rindi G Necchi V Savio A Torsello A Zoli M Locatelli V Raimondo F Cocchi D Solcia E 《Histochemistry and cell biology》2002,117(6):511-519
Ghrelin is a new gastric peptide involved in food intake control and growth hormone release. We aimed to assess its cell localisation in man during adult and fetal life and to clarify present interspecies inconsistencies of gastric endocrine cell types. A specific serum generated against amino acids 13-28 of ghrelin was tested on fetal and adult gastric mucosa and compared with ghrelin in situ hybridisation. Immunogold electron microscopy was performed on normal human, rat and dog adult stomach. Ghrelin cells were detected in developing gut, pancreas and lung from gestational week 10 and in adult human, rat and dog gastric mucosa. By immunogold electron microscopy, gastric ghrelin cells showed distinctive morphology and hormone reactivity in respect to histamine enterochromaffin-like, somatostatin D, glucagon A or serotonin enterochromaffin cells. Ghrelin cells were characterised by round, compact, electron-dense secretory granules of P/D(1) type in man (mean diameter 147+/-30 nm), A-like type in the rat (183+/-37 nm) and X type in the dog (273+/-49 nm). It is concluded that, ghrelin is produced by well-defined cell types, which in the past had been labelled differently in various mammals mostly because of the different size of their secretory granule. In man ghrelin cells develop during early fetal life. 相似文献
5.
Y Oomori 《Zeitschrift für mikroskopisch-anatomische Forschung》1983,97(3):369-385
In the ovine abomasum, 8 types of endocrine cells were classified at ultrastructural level. The gastric-type EC cells contained oval and pleomorphic granules with high electron density. The intestinal-type EC cells were filled with oval, irregular and highly dense granules. ECL cells contained irregular granules with high density and wide clear spaces. D cells were filled with round granules showing low to moderate density and finely granular matrix D1 cells contained round or oval granules with variable, low to moderate density and finely granular content. G cells showed round and oval granules with moderate density, densely packed or flocculent content. F cells were filled with oval or elliptic granules showing low density with a finely granular and flocculent matrix. X cells contained round granules with high density and homogeneous material. Gastric-type EC cells, intestinal-type EC cells, D cells, and D1 cells were represented in the cardiac, fundic and pyloric gland areas of the ovine abomasum. ECL cells and F cells were confined to the fundic glands, G cells and X cells to the pyloric glands. 相似文献
6.
P Norlén W J Curry M Bj?rkqvist A Maule R T Cunningham R B Hogg P Harriott C F Johnston J C Hutton R H?kanson 《The journal of histochemistry and cytochemistry》2001,49(1):9-18
The rat stomach is rich in endocrine cells. The acid-producing (oxyntic) mucosa contains ECL cells, A-like cells, and somatostatin (D) cells, and the antrum harbours gastrin (G) cells, enterochromaffin (EC) cells and D cells. Although chromogranin A (CgA) occurs in all these cells, its processing appears to differ from one cell type to another. Eleven antisera generated to different regions of rat CgA, two antisera generated to a human (h) CgA sequences, and one to a bovine (b) CgA sequence, respectively, were employed together with antisera directed towards cell-specific markers such as gastrin (G cells), serotonin (EC cells), histidine decarboxylase (ECL cells) and somatostatin (D cells) to characterize the expression of CgA and CgA-derived peptides in the various endocrine cell populations of the rat stomach. In the oxyntic mucosa, antisera raised against CgA(291-319) and CGA(316-321) immunostained D cells exclusively, whereas antisera raised against bCgA(82-91) and CgA(121-128) immunostained A-like cells and D cells. Antisera raised against CgA(318-349) and CgA(437-448) immunostained ECL cells and A-like cells, but not D cells. In the antrum, antisera against CgA(291-319) immunostained D cells, and antisera against CgA(351-356) immunostained G cells. Our observations suggest that each individual endocrine cell type in the rat stomach generates a unique mixture of CgA-derived peptides, probably reflecting cell-specific differences in the post-translational processing of CgA and its peptide products. A panel of antisera that recognize specific domains of CgA may help to identify individual endocrine cell populations. 相似文献
7.
Summary The gastric mucosa of a reptile, the lizard Tiliqua scincoides, has been examined by light and electron microscopy. The gastric pits lead into glands that are extensively coiled in the proximal stomach but become progressively shorter and straighter in the distal stomach. The following epithelial cell types have been identified: (i) Surface mucous cells (SMC) line the entire lumenal surface as well as the pits. They contain mucus granules that stain with periodic acid-Schiff and, like the granules of mammalian SMC, commonly contain an electron dense core that appears not to be mucus (periodic acid-chromic acid-silver methenamine nonreactive). (ii) Glandular mucous cells are present in glands throughout the mucosa. They are probably homologous with the mucous neck and antral gland cells of mammals; like SMC their mucus granules contain nonglycoprotein cores. (iii) Oxynticopeptic cells (OPC) are the predominant cell type in the proximal glands but become infrequent distally. Their fine structure resembles that of OPC in other nonmammalian vertebrates, with features like those of both parietal cells and zymogen cells of mammals, (iv) Endocrine cells of three different types have been identified. Two of these show close similarities to the EC and ECL cells of mammals.The authors thank Mrs. D. Flavell for technical assistance. This study was supported by a grant from the Clive and Vera Ramaciotti Foundations 相似文献
8.
9.
Summary The epithelium of the fundic region mucosa of the hind stomach in the Llama guanacoe has been studied using morphological and histochemical methods. Morphology suggests that solute and water absorption may occur in the epithelium of the surface and of the foveolae, although this absorption can not be estimated because of the extensive secretion of the gastric glands. The same cells of the surface and foveolar epithelium show numerous secretory granules. The glands reveal neck cells, chief cells, a large number of oxyntic cells, four types of endocrine cells (A-like, ECL, D and EC), brush cells and wandering cells. PAS and Alcian blue reactions for light microscopy suggest a secretion of neutral and acidic mucosubstances in the surface and foveolar epithelium, of neutral mucosubstances only in the neck cells. Periodic acid-thiocarbohydrazide silver proteinate (PA-TCH-SP) reaction for electron microscopy confirms the presence of neutral mucosubstances within the secretory granules of the surface, foveolar and neck epithelial cells. In all these cells, the reaction product is also evident within sacculi and vesicles of the maturing surface of the Golgi apparatus. A positive PA-TCH-SP reaction also occurs on the membrane (and not on the contents) of the Golgi apparatus (maturing surface) and of the secretory granules of the chief cells as well as on the membrane of the Golgi apparatus and of apical vesicles and tubules of the oxyntic cells. In addition, silver granules slightly enhance the electron density of the contents of the secretory granules in the endocrine cells. Morphological and histochemical findings are discussed and compared with results described by others for monogastric mammals. 相似文献
10.
J. Alumets M. Ekelund H. A. El Munshid Dr. R. Håkanson I. Lorén F. Sundler 《Cell and tissue research》1979,202(2):177-188
Summary Somatostatin cells in the stomach of the rat have a characteristic shape and distribution. In the antral mucosa they occur together with gastrin cells and enterochromaffin cells at the base of the glands. In the oxyntic mucosa they are scattered along the entire glands with some predominance in the zone of parietal cells. Throughout the gastric mucosa the somatostatin cells possess long and slender processes that emerge from the base of the cell and end in clublike swellings. Such processes appear to contact a certain proportion of neighbouring gastrin cells in the antral mucosa and parietal cells in the oxyntic mucosa.Exogenous somatostatin given by intravenous infusion to conscious rats counteracted the release of gastrin stimulated by feeding, elevated antral pH or vagal excitation. Gastrin causes parietal cells to secrete HCl and endocrine cells in the oxyntic mucosa to mobilise and synthesise histamine. Somatostatin is known to block the response of the parietal cells to gastrin. In contrast, somatostatin did not block the response of the histamine-storing endocrine cells to gastrin, perhaps because these endocrine cells lack receptors to somatostatin. Conceivably, somatostatin in the gastric mucosa has a paracrine mode of action. The observations of the present study suggest that somatostatin may affect some, but not all of the various cell types in the stomach. Under physiological conditions this selectivity may be achieved in the following ways: 1) Communication may be based on direct cell-to-cell contact. 2) Only certain cell types are supplied with somatostatin receptors. 相似文献
11.
The endocrine cells of the pyloric glands of adult ox 总被引:1,自引:0,他引:1
As part of a project to identify the endocrine cells ("EC" and "APUD" series) of the gastroenteric apparatus of ruminants, the ultrastructure of the mucosa of the pyloric glands of adult ox was studied morphologically and cytochemically, in parallel with a light microscope histochemical analysis. The results show that: the "EC" cells (producing 5-HT) are recognizable by their secretory granules which are heavily osmiophilic, argentaffin ("Masson") and argyrophilic ("Grimelius"). A further distinction is possible on the basis of their morphological features: the "EC" cells of the gastric type (which belong to the "ECn" group) contain granules fairly homogeneous in shape and size, while the "EC" cells of the intestinal type (or "EC1") show granules which are more pleiomorphic and variable in size. Of particular interest is the presence in some cells of granules typical of the "EC" cells of the intestinal type, in the vicinity of a few others, which appear quite similar to those of the adjoining exocrine cells; the "G" cells (gastrin producing) contain medium sized granules, which are unreactive to "Masson" and poorly argyrophilic. Their morphology is rather diverse; some of them (these are the "typical" cells) have a granular and weakly electron dense content, others (which we consider "atypical") show a homogeneous and heavily osmiophilic core, with an eccentrical empty area. Also present are granules whose appearance is intermediate and empty vesicles; the "D cells" (somatostatin producting) show round, medium sized granules which have a granular, moderately osmiophilic core, tightly encircled by the membrane. These granules are unreactive to "Masson" and to "Grimelius"; the "D1" cells (whose function is yet unclear) contain small, round granules whose core is variously but discretely electron dense and not always homogeneous; they are unreactive to "Masson" and fairly argyrophilic. These granules may be numerous and packed, or scarce; in this latter instance the few granules are intermingled with variously running tufts of parallel filaments, thus resembling the "P" cells, whose function is still undefined. These data show therefore that the types of endocrine cells we have identified in the pyloric glands of adult ox correspond to those described in other mammals; "X" and "F" or "PP" cell appear to be lacking. 相似文献
12.
The epitracheal glands in pharate and young pupae of Lymantria dispar are located at the base of ventrolateral tracheal trunks in the prothoracic and first through eighth abdominal segments. Each gland is composed of four cells the ultrastructure of which is described in this paper. One large cell and one smaller cell have an endocrine function, while a third cell is exocrine. A fourth cell forms a canal running from the exocrine cell into the trachea. The large endocrine cell, but not the smaller endocrine cell has released its secretions in freshly moulted pupae. The exocrine cell is assumed to be involved in the pupal moult events as well. The physiological role of the different cell types is discussed: The large endocrine cell (type I endocrine cell) is supposedly homologous with the 'Inka cell', which produces ecdysis triggering hormone (ETH) and was previously described in Manduca sexta; the functions of the smaller endocrine cell (type II endocrine cell) and the exocrine cell remain unknown. 相似文献
13.
The cardiac and pyloric glands in the gastric mucosa of the South African hedgehog, Atelerix frontalis, are described. The cardiac area of the stomach contains proper cardiac glands and lacks undifferentiated fundic glands. The cardiac glands are simple tubular, coiled, and lined with columnar cells ultrastructurally similar to those of the gastric surface epithelium. Secretory granules with varying electron densities fill the apical cytoplasm of these cells. In contrast to other mammals, these glands lack mucous neck cells. The neck of the pyloric glands contains only a single cell type, whereas the basal regions of these glands contain “light” and “dark” cells. The secretory granules in the “dark” cells and the pyloric neck cells have a moderate electron density and often contain an electron dense core. An electron-lucent cytoplasm with numerous polysomes is characteristic of the “light” cells. Some “light” cells contain electron-dense granules in the apical cytoplasm. The presence of only neutral mucins in the cardiac gland cells denotes the absence of mucous neck cells. The acidic mucins within the pyloric neck cells seem to indicate that these cells are mucous neck cells, whereas the neutral mucins within the basally located pyloric gland cells show at least a partial functional difference from the pyloric neck cells. © 1993 Wiley-Liss, Inc. 相似文献
14.
Summary Four immunoreactive endocrine cell types can be distinguished in the pancreatic islets of B. conchonius: insulin-producing B cells, somatostatin-producing A1 (= D) cells, glucagon-producing A2 cells and pancreatic poly-peptide-producing PP cells. The principal islet of this species contains only a few PP cells, while many PP cells are present in the smaller islets. Except for the B cell all pancreatic endocrine cell types are also present in the pancreatic duct.At least six enteroendocrine cell types are present in the gut of B. conchonius: 1. a cell type (I) with small secretory granules, present throughout the intestine, and possibly involved in the regulation of gut motility; 2. a C-terminal gastrin immunoreactive cell, probably producing a caerulein-like peptide; these cells are located at the upper parts of the folds, especially in the proximal part of the intestinal bulb; 3. a met-enkephalin-immunoreactive cell, present throughout the first segment; 4. a glucagon-immunoreactive cell, which is rare in the first segment; 5. a PP-immunoreactive cell, mainly present in the first half of the first segment; 6. an immunoreactive cell, which cannot at present be specified, located in the intestinal bulb. The latter four cell types are mostly located in the basal parts of the folds, although some PP-immunoreactive cells can also be found in the upper parts.Most if not all enteroendocrine cells are of the open type. The possible functions of all enteroendocrine cell types are discussed.Abbreviations BPP
bovine pancreatic polypeptide
- CCK
cholecystokinin
- GEP
gastro-entero-pancreatic
- GIP
gastric inhibitory peptide or glucose-dependent insulin releasing peptide
- PPP
pig pancreatic polypeptide
- VIP
vasoactive intestinal polypeptide 相似文献
15.
Whole pancreases from fetal rats of 13 days and 18 days gestation were explanted onto rayon grids and grown in organ culture. Cultures were fixed in Bouin's fluid, sectioned and stained with the fluorescent antibody techniques for glucagon and insulin, aldehyde fuchsin for B cells, pseudoisocyanin for D cells and a silver technique for the fourth cell type. The 13-day explants were fixed after 10 days in culture. A, B and D and the fourth cell type were seen, indicating that precursors of all four endocrine cell types must be present in the fetal pancreas shortly after the formation of the pancreatic bud (11 days). Further, the presence of these four cell types in the walls of tubules in these cultures indicates the tubules as the site of origin of all the endocrine tissue. The 18-day explants were collected every other day of culture from 2 to 30 days in a long-term experiment. A number of large islets with well granulated B cells was still present after 30 days of culture. The relative abundance of cell types at different stages was estimated as follows: 18-day fetal controls, A greater than B=4 greater than D; after 2 to 10 days in culture, B greater than A greater than or equal to D; after 18 to 30 days in culture, B greater than D greater than A greater than 4. 相似文献
16.
Michael R. Schweisthal Cecil C. Frost 《In vitro cellular & developmental biology. Plant》1976,12(12):814-820
Summary Whole pancreases from fetal rats of 13 days and 18 days gestation were explanted onto rayon grids and grown in organ culture.
Cultures were fixed in Bouin’s fluid, sectioned and stained with the fluorescent antibody techniques for glucagon and insulin,
aldehyde fuchsin for B cells, pseudoisocyanin for D cells and a silver technique for the fourth cell type.
The 13-day explants were fixed after 10 days in culture. A, B and D and the fourth cell type were seen, indicating that precursors
of all four endocrine cell types must be present in the fetal pancreas shortly after the formation of the pancreatic bud (11
days). Further, the presence of these four cell types in the walls of tubules in these cultures indicates the tubules as the
site of origin of all the endocrine tissue.
The 18-day explants were collected every other day of culture from 2 to 30 days in a long-term experiment. A number of large
islets with well granulated B cells was still present after 30 days of culture. The relative abundance of cell types at different
stages was estimated as follows: 18-day fetal controls, A>B=4>D; after 2 to 10 days in culture, B>A⩾4>D; after 18 to 30 days
in culture, B>D>A>4. 相似文献
17.
Kjell Andersson Chun-Mei Zhao Duan Chen Frank Sundler Rolf Håkanson 《Cell and tissue research》1996,286(3):375-384
The oxyntic mucosa of the mammalian stomach is rich in endocrine cells, such as ECL cells, A-like cells, somatostatin cells,
D1/P cells and, in some species, enterochromaffin cells. The various endocrine cell types can be distinguished on the basis
of their characteristic cytoplasmic granules and vesicles. The ECL cells contain numerous large secretory vesicles and relatively
few, small electron-dense granules and small clear microvesicles. We have suggested that in the rat the ECL cells contain
most of the gastric histamine with the secretory vesicles as the major histamine storage site in these cells. α-Fluoromethylhistidine
is an irreversible inhibitor of histidine decarboxylase, the histamine-forming enzyme. We have previously shown that this
enzyme inhibitor depletes histamine from the ECL cells in the rat and reduces the number of secretory vesicles in the cytoplasm.
In the present study, we have examined whether α-fluoromethylhistidine affects the ECL cells in other species and whether
it affects other types of endocrine cells in the oxyntic mucosa of the rat. Mice, rats and hamsters were treated with the
inhibitor (3 mg/kg per h) via minipumps subcutaneously for 24 h. This treatment lowered the oxyntic mucosal histamine concentration
by 65–90% and the number and volume density of the secretory vesicles by 85–95% in the ECL cells of the three species examined.
In contrast, the number and volume density of granules and microvesicles were not greatly affected. No evidence was found
for an effect of α-fluoromethylhistidine on A-like cells, somatostatin cells or D1/P cells of the rat stomach, suggesting that, unlike the ECL cells, they do not contain histamine.
Received: 18 January 1996 / Accepted: 23 May 1996 相似文献
18.
J Yamada B R Li Z P Deng N Kitamura T Yamashita C J Phillips 《Gegenbaurs morphologisches Jahrbuch》1988,134(1):79-91
11 endocrine cell types immunoreactive for either 5-hydroxytryptamine (5-HT), somatostatin, gastrin, cholecystokinin (CCK), gastric inhibitory peptide (GIP), motilin, secretin, neurotensin, pancreatic glucagon, enteroglucagon or bovine pancreatic polypeptide (BPP) were found in gastrointestinal tract of 2 species of insectivorous bats. 5 of these 11 types of endocrine cells were located in the stomach and all 11 types of endocrine cells were found in the intestine. However, the distribution and relative frequency of each immunoreactive endocrine cell varied among the cell types and between the 2 species of bats examined. In Brunner's glands, gastrin- and 5-HT-immunoreactive cells were detected very rarely in Pipistrellus and only occasionally in Plecotus. The present results obtained from the insectivorous bats were compared with those of the sanguivorous vampire bats. 相似文献
19.
A-like cells in the rat stomach contain ghrelin and do not operate under gastrin control 总被引:19,自引:0,他引:19
Dornonville de la Cour C Björkqvist M Sandvik AK Bakke I Zhao CM Chen D Håkanson R 《Regulatory peptides》2001,99(2-3):141-150
Ghrelin is a 28 a.a. gastric peptide, recently identified as a natural ligand of the growth hormone secretagogue receptor (orphan receptor distinct from the receptor for growth hormone releasing hormone). In the present study, radioimmunoassay demonstrated ghrelin-like material in the rat oxyntic mucosa with moderate amounts also in antrum and duodenum. Small amounts were found in the distal intestines and pancreas. Northern blot analysis revealed abundant ghrelin mRNA in the oxyntic mucosa. Immunocytochemistry demonstrated ghrelin-immunoreactivity in endocrine-like cells in the oxyntic mucosa. Such cells occurred in low numbers also in the antrum and duodenum. The rat oxyntic mucosa is rich in endocrine (chromogranin A/pancreastatin-immunoreactive) cells, such as the histamine-rich ECL cells (65-75% of the endocrine cells), the A-like cells (20-25%) and the D cells (somatostatin cells) (10%). The ghrelin-immunoreactive (IR) cells contained pancreastatin but differed from ECL cells and D cells by being devoid of histamine-forming enzyme (ECL cell constituent) and somatostatin (D cell constituent). Hence, ghrelin seems to occur in the A-like cells. The ghrelin-IR cells in the antrum were distinct from the gastrin cells, the serotonin-containing enterochromaffin cells and the D cells. Conceivably, ghrelin cells in the antrum and distally in the intestines also belong to the A-like cell population. The concentration of ghrelin in the circulation was lowered by about 80% following the surgical removal of the acid-producing part of the stomach in line with the view that the oxyntic mucosa is the major source of ghrelin. The serum ghrelin concentration was higher in fasted rats than in fed rats; it was reduced upon re-feeding and seemed unaffected by 1-week treatment with the proton pump inhibitor omeprazole, resulting in elevated serum gastrin concentration. Infusion of gastrin-17 for 2 days failed to raise the serum ghrelin concentration. Omeprazole treatment for 10 weeks raised the level of HDC mRNA but not that of ghrelin mRNA or somatostatin mRNA in the oxyntic mucosa. Hence, unlike the ECL cells, ghrelin-containing A-like cells do not seem to operate under gastrin control. 相似文献
20.
Summary The ultrastructure of the mucous and endocrine cells of the gastric mucosa of the cane toad (Bufo marinus) has been examined. Surface mucous cells line the entire gastric mucosa and pits. Many of their secretory granules contain an electron-dense core that remains unreactive after cytochemical testing for glycoproteins. A second spatially and structurally discrete population of mucous cells is present in the gastric glands. These glandular mucous cells are probably homologous with the antral gland and mucous neck cells of mammals; their secretory granules also contain non-glycoprotein cores. Three distinct populations of endocrine cells show structural homologies with gastric hormone-storing cells of higher vertebrates.This study was supported by grants from N.H. & M.R.C. (Australia) and the Clive and Vera Ramaeiotti Foundations 相似文献