共查询到20条相似文献,搜索用时 31 毫秒
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Polymorphisms of alpha-1-acid (orosomucoid), alpha-2-HS-glycoproteins and alpha-1-B among the Parsis of India. 总被引:1,自引:0,他引:1
Genetic polymorphisms of plasma alpha 1-acid glycoprotein (oro-somucoid, ORM), alpha 2-HS-glycoprotein (A2HS) and alpha 1-B-glycoprotein (alpha 1B) were studied in a group of Parsis in Bombay, India. The frequencies of ORM1*1, ORM1*2 and ORM1*3 were found to be 0.636, 0.356 and 0.008, respectively. A2HS*1, A2HS*2 and A2HS*3 frequencies were 0.855, 0.135 and 0.010, while the frequencies of A1B*1 and A1B*2 were 0.881 and 0.119, respectively. The phenotype distribution at all three loci was at Hardy-Weinberg equilibrium. The ORM2 locus was monomorphic in the Parsis. 相似文献
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C Betterle F Fabris A Burul T Bersani A Girolami 《Folia haematologica (Leipzig, Germany : 1928)》1978,105(4):539-543
Rabbit raised anti-alpha-1-antitrypsin or anti alpha-2-macroglobulin antisera at dilution of less than 1:80 yielded non-specific staining on human platelets by indirect immunofluorescent technique. A similar pattern was in fact obtained by using normal rabbit sera at the same dilution and was due to the presence of smooth muscle autoantibodies. This indicates that human platelets do not contain significant quantities of these antigens. In agreement with the above, only microamounts of alpha-1-antitrypsin and alpha-2-macroglobulin were found to be present in human platelets by means of the electroimmunoassay. 相似文献
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An inherited alpha-1-antitrypsin variant 总被引:1,自引:0,他引:1
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M Dabrowska J Prokopowicz H Kemona J Kretowska S Kiluk M Gluszczak 《Folia haematologica (Leipzig, Germany : 1928)》1988,115(6):817-823
Serum concentration of alpha-2-macroglobulin, alpha-1-antitrypsin and alpha-2-antichymotrypsin was evaluated in 26 patients with lung carcinoma. We observed an evident decrease in alpha-2-M and alpha-1-antitrypsin level and no differences between tested and control groups in alpha-1-antichymotrypsin concentration. The deficiency of protease inhibitors may be due to the increased level of protease activity in malignant cells. Infiltration of granulocytes near tumor and released enzymes from them may exhaust proteolytic inhibitory capacity, too. Increased protease activity is associated with transformation and uncontrolled proliferation, therefore antiproteases may be accepted as anticancerogenic factors. Further investigations are needed to bring us closer to understanding this question. 相似文献
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Mechanism of action of alpha-1-antitrypsin 总被引:4,自引:0,他引:4
A B Cohen 《The Journal of biological chemistry》1973,248(20):7055-7059
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Elizondo-Riojas MA Chamow SM Tuthill CW Gorenstein DG Volk DE 《Biochemical and biophysical research communications》2011,416(3-4):356-361
800 MHz NMR structure of the 28-residue peptide thymosin alpha-1 in 40% TFE/60% water (v/v) has been determined. Restrained molecular dynamic simulations with an explicit solvent box containing 40% TFE/60% TIP3P water (v/v) were used, in order to get the 3D model of the NMR structure. We found that the peptide adopts a structured conformation having two stable regions: an alpha-helix region from residues 14 to 26 and two double β-turns in the N-terminal twelve residues which form a distorted helical structure. 相似文献
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《Comparative biochemistry and physiology. B, Comparative biochemistry》1993,104(3):531-533
- 1.1. A genetically determined polymorphism of alpha-1 antitrypsin is demonstrated in dog serum by isoelectric focusing in a pH range of 3.5–5.0, followed by direct immunoblotting using a specific antiserum.
- 2.2. Alpha 1 antitrypsin focuses as two major bands at isoelectric points of 4.60 and 4.64 or 4.67 and 4.7 in presumed homozygous animals. Heterozygotes show both sets of bands.
- 3.3. The results of seven crosses with 33 offspring are best explained by two codominant alleles, PiM and PiS at a single locus designated as Pi for proteinase inhibitor.
- 4.4. The concentration of alpha-1 antitrypsin in serum of healthy dogs was 2.65 ± 0.42 mg/ml and 2.19 ± 0.38 mg/ml in females andv males respectively.
- 5.5. The higher concentration in female dogs suggests that estrogens may influence the serum level of alpha-1 antitrypsin.
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Distribution of alpha-1-antitrypsin phenotypes in Sweden 总被引:1,自引:0,他引:1
K Hjalmarsson 《Human heredity》1988,38(1):27-30
The distribution of phenotypes of alpha-1-antitrypsin (Pi) in 1,062 unrelated Swedes was determined by isoelectric focusing with carrier ampholytes. The frequencies calculated were: PiM1 = 0.6940, PiM2 = 0.1384, PiM3 = 0.1139, PiZ = 0.0231, PiS = 0.0245, PiF = 0.0038, Pivar = 0.0024. A mother-child material consisting of 194 pairs is also presented. 相似文献
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Bovine collagen alpha-1 is a naturally occurring extracellular matrix protein found in tendons and other connective tissues. It plays
a vital role in cell growth, differentiation, attachment, and migration. Recent findings have established that collagen alpha-1 is
involved in osteogenesis imperfecta phenotype in cattle but deep information about other members of this large family is not
available so far. So with a view to finding a new edge and attempt to figure out a correlation among the well attributed Bovine
alpha-1 collagen sequences are executed and analyzed. To do so, comparative analysis among the 28 members of collagen family
has been carried out using Computational tools. Consequently, based on the physico-chemical, secondary structural, functional
and phylogenetic classifications, we have selected collagen 12, 14 and 20 as targets for pathological conditions. These proteins
belong to the FACIT family and significantly showed low glycine and proline content, high instability and aliphatic index.
Moreover, FACIT family collagens contain multiple triple helical domains and being members of the FACIT family, bovine
collagen 12, 14, 20 do not form fibrils by themselves but they are associated to collagen 1 associated fibrils. These collagen
molecules might be crucial candidates to detect and understand the process of matrix remodeling in diseases especially in the arena
of cellular compartments. 相似文献
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The amino-terminal peptide of alpha-1-acid glycoprotein 总被引:5,自引:0,他引:5
T Ikenaka H Bammerlin H Kaufmann K Schmid 《The Journal of biological chemistry》1966,241(23):5560-5563
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Shasany AK Shukla AK Darokar MP Saraiya M Chaturvedi N Tewari L Khanuja SP 《Indian journal of biochemistry & biophysics》2007,44(3):176-178
The highly polymorphic human alpha-1 antitrypsin (AAT) gene codes for the most abundant circulating plasma serine protease inhibitor. Previously, genetic variants of the AAT gene were reported from different regions of the world. In the present study, the AAT gene was characterized in an Indian sample. The AAT gene was isolated and cloned from a liver biopsy sample through RT-PCR and the full-length gene was sequenced. Nucleotide sequence comparison with the human genome and the AAT sequences available in the GenBank (NCBI) demonstrated four unique variations--(i) an A to G variation at position 286 (Thr96Ala), (ii) an A to G variation at position 839 (Asp280Gly), (iii) a T to C variation at position 1182 that did not result in any change in the protein sequence (TTT to TTC both code for Phe) and (iv) an A to C variation at position 1200 (Glu400Asp) that resulted in replacement by an amino acid of similar nature. Other variations found were T to C at position 710 (Val273Ala) and T to C position 863 (Val288Glu), which were also reported earlier. In conclusion, this study reports the entire 1257 bp nucleotide sequence of protein coding region of the human AAT gene from an Indian sample. This preliminary finding is significant, as it reports for the first time the AAT gene sequence in the Indian sample. 相似文献
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Alpha-1-antitrypsin (AAT) or serine protease inhibitor A1 (SERPINA1) is an important serine protease inhibitor in humans. The main physiological role of AAT is to inhibit neutrophil elastase (NE) released from triggered neutrophils, with an additional lesser role in the defense against damage inflicted by other serine proteases, such as cathepsin G and proteinase 3. Although there is a reported association between AAT polymorphism and different types of cancer, this association with hematological malignancies (HM) is, as yet, unknown. We identified AAT phenotypes by isoelectric focusing (in the pH 4.2-4.9 range) in 151 serum samples from patients with HM (Hodgkins lymphomas, non-Hodgkins lymphomas and malignant monoclonal gammopathies). Healthy blood-donors constituted the control group (n = 272). The evaluated population of patients as well as the control group, were at Hardy-Weinberg equilibrium for the AAT gene (χ(2) = 4.42, d.f.11, p = 0.96 and χ(2) = 4.71, d.f.11, p = 0.97, respectively). There was no difference in the frequency of deficient AAT alleles (Pi Z and Pi S) between patients and control. However, we found a significantly higher frequency of PiM1M1 homozygote and PiM1 allele in HM patients than in control (for phenotype: f = 0.5166 and 0.4118 respectively, p = 0.037; for allele: f = 0.7020 and 0.6360 respectively, p = 0.05). In addition, PiM homozygotes in HM-patients were more numerous than in controls (59% and 48%, respectively, p = 0.044). PiM1 alleles and PiM1 homozygotes are both associated with hematological malignancies, although this is considered a functionally normal AAT variant. 相似文献
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Elena Karnaukhova Sonia Silinsky KrupnikovaMohsen Rajabi Abdu I. Alayash 《Biochimica et Biophysica Acta (BBA)/General Subjects》2012