共查询到20条相似文献,搜索用时 15 毫秒
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Roudier F Ahmed I Bérard C Sarazin A Mary-Huard T Cortijo S Bouyer D Caillieux E Duvernois-Berthet E Al-Shikhley L Giraut L Després B Drevensek S Barneche F Dèrozier S Brunaud V Aubourg S Schnittger A Bowler C Martin-Magniette ML Robin S Caboche M Colot V 《The EMBO journal》2011,30(10):1928-1938
Post-translational modification of histones and DNA methylation are important components of chromatin-level control of genome activity in eukaryotes. However, principles governing the combinatorial association of chromatin marks along the genome remain poorly understood. Here, we have generated epigenomic maps for eight histone modifications (H3K4me2 and 3, H3K27me1 and 2, H3K36me3, H3K56ac, H4K20me1 and H2Bub) in the model plant Arabidopsis and we have combined these maps with others, produced under identical conditions, for H3K9me2, H3K9me3, H3K27me3 and DNA methylation. Integrative analysis indicates that these 12 chromatin marks, which collectively cover ~90% of the genome, are present at any given position in a very limited number of combinations. Moreover, we show that the distribution of the 12 marks along the genomic sequence defines four main chromatin states, which preferentially index active genes, repressed genes, silent repeat elements and intergenic regions. Given the compact nature of the Arabidopsis genome, these four indexing states typically translate into short chromatin domains interspersed with each other. This first combinatorial view of the Arabidopsis epigenome points to simple principles of organization as in metazoans and provides a framework for further studies of chromatin-based regulatory mechanisms in plants. 相似文献
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Rafael Guerrero-Preston Christina Michailidi Luigi Marchionni Curtis R Pickering Mitchell J Frederick Jeffrey N Myers Srinivasan Yegnasubramanian Tal Hadar Maartje G Noordhuis Veronika Zizkova Elana Fertig Nishant Agrawal William Westra Wayne Koch Joseph Califano Victor E Velculescu David Sidransky 《Epigenetics》2014,9(7):1031-1046
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Ting Gong Xin Gu Yu-Ting Liu Zhen Zhou Ling-Li Zhang Yang Wen Wei-Li Zhong Guo-Liang Xu Jin-Qiu Zhou 《遗传学报》2020,47(2):105-114
A nucleosome contains two copies of each histone H2A,H2B,H3 and H4.Histone H3 K4me0 and K36me3are two key chromatin marks for de novo DNA methylation catalyzed by DNA methyltransferases in mammals.However,it remains unclear whether K4me0 and K36me3 marks on both sister histone H3s regulate de novo DNA methylation independently or cooperatively.Here,taking advantage of the bivalent histone H3 system in yeast,we examined the contributions of K4 and K36 on sister histone H3s to genomic DNA methylation catalyzed by ectopically co-expressed murine Dnmt3a and Dnmt3L.The results show that lack of both K4me0 and K36me3 on one sister H3 tail,or lack of K4me0 and K36me3 on respective sister H3s results in a dramatic reduction of 5mC,revealing a synergy of two sister H3s in DNA methylation regulation.Accordingly,the Dnmt3a or Dnmt3L mutation that disrupts the interaction of Dnmt3aADD domain-H3K4me0,Dnmt3LADD domain-H3K4me0,orDnmt3aPWWP domain-H3K36me3 causes a significant reduction of DNA methylation.These results support the model that each heterodimeric Dnmt3a-Dnmt3L reads both K4me0 and K36me3 marks on one tail of sister H3s,and the dimer of heterodimeric Dnmt3a-Dnmt3L recognizes two tails of sister histone H3s to efficiently execute de novo DNA methylation. 相似文献
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