Can Eph Receptors Stimulate the Mind?

The Eph receptors are multitalented tyrosine kinases capable of performing many tasks. The receptors together with their ligands--the ephrins--are well known to play a critical role in the initial assembly of neuronal circuits in the embryo. However, the recently discovered function of these receptors in the adult brain is now receiving significant acclaim. Three new articles show that the Eph receptors continue to be important in modifying the strength of existing neuronal connections (synapses). They do so in close association with at least one family of ion channels, the NMDA receptors.     

Behavioral Priming: It's All in the Mind,but Whose Mind?

The perspective that behavior is often driven by unconscious determinants has become widespread in social psychology. Bargh, Chen, and Burrows' (1996) famous study, in which participants unwittingly exposed to the stereotype of age walked slower when exiting the laboratory, was instrumental in defining this perspective. Here, we present two experiments aimed at replicating the original study. Despite the use of automated timing methods and a larger sample, our first experiment failed to show priming. Our second experiment was aimed at manipulating the beliefs of the experimenters: Half were led to think that participants would walk slower when primed congruently, and the other half was led to expect the opposite. Strikingly, we obtained a walking speed effect, but only when experimenters believed participants would indeed walk slower. This suggests that both priming and experimenters' expectations are instrumental in explaining the walking speed effect. Further, debriefing was suggestive of awareness of the primes. We conclude that unconscious behavioral priming is real, while real, involves mechanisms different from those typically assumed to cause the effect.     

The “Reading the Mind in the Eyes” Test: Complete Absence of Typical Sex Difference in ~400 Men and Women with Autism

The “Reading the Mind in the Eyes” test (Eyes test) is an advanced test of theory of mind. Typical sex difference has been reported (i.e., female advantage). Individuals with autism show more difficulty than do typically developing individuals, yet it remains unclear how this is modulated by sex, as females with autism have been under-represented. Here in a large, non-male-biased sample we test for the effects of sex, diagnosis, and their interaction. The Eyes test (revised version) was administered online to 395 adults with autism (178 males, 217 females) and 320 control adults (152 males, 168 females). Two-way ANOVA showed a significant sex-by-diagnosis interaction in total correct score (F(1,711) = 5.090, p = 0.024, η_p ² = 0.007) arising from a significant sex difference between control males and females (p < 0.001, Cohen’s d = 0.47), and an absence of a sex difference between males and females with autism (p = 0.907, d = 0.01); significant case-control differences were observed across sexes, with effect sizes of d = 0.35 in males and d = 0.69 in females. Group-difference patterns fit with the extreme-male-brain (EMB) theory predictions. Eyes test-Empathy Quotient and Eyes test-Autism Spectrum Quotient correlations were significant only in females with autism (r = 0.35, r = -0.32, respectively), but not in the other 3 groups. Support vector machine (SVM) classification based on response pattern across all 36 items classified autism diagnosis with a relatively higher accuracy for females (72.2%) than males (65.8%). Nevertheless, an SVM model trained within one sex generalized equally well when applied to the other sex. Performance on the Eyes test is a sex-independent phenotypic characteristic of adults with autism, reflecting sex-common social difficulties, and provides support for the EMB theory predictions for both males and females. Performance of females with autism differed from same-sex controls more than did that of males with autism. Females with autism also showed stronger coherence between self-reported dispositional traits and Eyes test performance than all other groups.     

Mind the gap: how open were European primeval forests?

There are two competing hypotheses about the structure and dynamics of primeval forests in lowland Europe: the high-forest and the wood-pasture hypotheses, both of which influence current European forest conservation policies. In a recent study using pollen-analytical data from across lowland Europe, Mitchell provides support for rejecting the wood-pasture hypothesis. His study is important for future forest management planning and for showing how hypotheses about large herbivores as biotic factors can be tested using palaeoecological data.     

From the Chef’s Mind to the Dish: How Scientific Approaches Facilitate the Creative Process

This work describes a practical way to optimize the high level of the chef creativity to produce rational approaches to food design. It is particularly focused on the preparation of two dishes: bubbly juice and false skin. For the first dish, three samples were prepared with egg white protein (EWP) and xanthan gum at pH 4.6 and pH 7.0. At pH 4.6 (isoelectric point), there were substantial differences of the interfacial dilational modulus of EWP when xanthan gum was added. At 1 mg/ml xanthan, the system showed a very strong interface (high viscoelasticity) compared to the other samples. Measuring half drainage time revealed which samples were the most stable. The properties discussed were related to stability. For the false skin dish, edible films were made by gelatin extracted from cod skins (A solution) and a mixture of cod skin gelatin and commercial gelatin (AG solution). The results showed that tensile strength (TS) of gelatin films increases almost by 25%, elongation at break (EAB) by 14%, and the Young modulus (E) by almost 100% when increasing protein concentration. To confirm water plasticizer effect, the results were compared to a gelatin film made with 30% glycerol (plasticizer). Water content affects to a great extent the mechanical properties of the films. Finally, images of the dishes are presented in order to have a full view of the purpose and the results obtained. This research has been supported by the Department of Agriculture and Fisheries from the Basque Government. This work was presented at the conference Delivery of Functionality in Complex Food Systems, Amherst, USA, October, 2007.     

What Bateson had in Mind About ‘Mind’?

G. Bateson believed that the scientific school of the future would be ‘ecology of mind’. The first aim of this paper is to understand what he meant by ‘mind’, and the other is to understand how this concept emerged in his thought, i.e., how its meaning would become more flexible throughout his life and work. Furthermore, we will approach the epistemological implications of ecology of mind for scientific education in the West. Bateson’s concept of mind emerged when he became aware (in 1926) of his own way of thinking, i.e., of his immense abductive capacity. This led him to search for patterns of similarity and difference between organisms (like in homology). Later, he identified this thought process as being abstract and formal, relating not just facts but also ideas. Afterwards, Bateson developed criteria for us to consider a system as being mental, with special emphasis on living and cybernetic systems.     

Is the Medial Prefrontal Cortex Necessary for Theory of Mind?

Background

Successful social interaction relies on the ability to attribute mental states to other people. Previous functional neuroimaging studies have shown that this process, described as Theory of Mind (ToM) or mentalization, is reliably associated with activation of the medial prefrontal cortex (mPFC). However, this study presents a novel and surprising finding that provides new insight into the role of the mPFC in mentalization tasks.

Methodology/Principal Findings

Twenty healthy individuals were recruited from a wide range of ages and social backgrounds. Participants underwent functional magnetic resonance imaging (fMRI) while viewing a well-established ToM visual paradigm involving moving triangles. Functional MRI data were analyzed using a classical general linear model. No activation was detected in the medial prefrontal cortex (mPFC) during movement patterns that typically elicit ToM. However, increased activity was observed in the right middle occipital gyrus, right temporoparietal junction (TPJ), left middle occipital gyrus and right inferior frontal gyrus. No correlation was found between participants’ age and BOLD response.

Conclusions/Significance

In contrast with previous neuroimaging research, our findings support the notion that mPFC function is not critical for reasoning about the mental states of others; furthermore, our data indicate that the right TPJ and right inferior frontal gyrus are able to perform mentalization without any contributions from the mPFC.     

Reading the glyco-code: New approaches to studying protein–carbohydrate interactions

The surface of all living cells is decorated with carbohydrate molecules. Hundreds of functional proteins bind to these glycosylated ligands; such binding events subsequently modulate many aspects of protein and cell function. Identifying ligands for glycan-binding proteins (GBPs) is a defining challenge of glycoscience research. Here, we review recent advances that are allowing protein-carbohydrate interactions to be dissected with an unprecedented level of precision. We specifically highlight how cell-based glycan arrays and glyco-genomic profiling are being used to define the structural determinants of glycan-protein interactions in living cells. Going forward, these methods create exciting new opportunities for the study of glycans in physiology and disease.     

Reading vascular changes in brain imaging: is dendritic calcium the key?

A key goal in functional neuroimaging is to use signals that are related to local changes in metabolism and blood flow to track the neuronal correlates of mental activity. Recent findings indicate that the dendritic processing of excitatory synaptic inputs correlates more closely than the generation of spikes with brain imaging signals. The correlation is often nonlinear and context-sensitive, and cannot be generalized for every condition or brain region. The vascular signals are mainly produced by increases in intracellular calcium in neurons and possibly astrocytes, which activate important enzymes that produce vasodilators to generate increments in flow and the positive blood oxygen level dependent signal. Our understanding of the cellular mechanisms of functional imaging signals places constraints on the interpretation of the data.     

Do Chinese Readers Follow the National Standard Rules for Word Segmentation during Reading?

We conducted a preliminary study to examine whether Chinese readers’ spontaneous word segmentation processing is consistent with the national standard rules of word segmentation based on the Contemporary Chinese language word segmentation specification for information processing (CCLWSSIP). Participants were asked to segment Chinese sentences into individual words according to their prior knowledge of words. The results showed that Chinese readers did not follow the segmentation rules of the CCLWSSIP, and their word segmentation processing was influenced by the syntactic categories of consecutive words. In many cases, the participants did not consider the auxiliary words, adverbs, adjectives, nouns, verbs, numerals and quantifiers as single word units. Generally, Chinese readers tended to combine function words with content words to form single word units, indicating they were inclined to chunk single words into large information units during word segmentation. Additionally, the “overextension of monosyllable words” hypothesis was tested and it might need to be corrected to some degree, implying that word length have an implicit influence on Chinese readers’ segmentation processing. Implications of these results for models of word recognition and eye movement control are discussed.     

Actively Negotiating the Mind–Body Divide: How Clozapine-Treated Schizophrenia Patients Make Health for Themselves

It is well recognised that antipsychotic treatments impact the whole body, not just the target area of the brain. For people with refractory schizophrenia on clozapine, the gold standard antipsychotic treatment in England and Australia, the separation of mental and physical regimes of health is particularly pronounced, resulting in multiple, compartmentalised treatment registers. Clinicians often focus on the mental health aspects of clozapine use, using physical indicators to determine whether treatment can continue. Our observations of 59 participants in England and Australia over 18 months revealed that patients did not observe this hierarchisation of mental treatments and physical outcomes. Patients often actively engaged in the management of their bodily symptoms, leading us to advance the figure of the active, rather than passive, patient. In our paper, we do not take the position that the facility for active management is a special one utilised only by these patients. We seek instead to draw attention to what is currently overlooked as an ordinary capacity to enact some sort of control over life, even under ostensibly confined and confining circumstances. We argue that clozapine-treated schizophrenia patients utilise the clinical dichotomy between mental and physical domains of health to rework what health means to them. This permits patients to actively manage their own phenomenological ‘life projects’ (Rapport, I am Dynamite: an Alternative Anthropology of Power, Routledge, London 2003), and forces us to reconsider the notion of clinical giveness of what health means. This making of one’s own meanings of health may be critical to the maintenance of a sense of self.     

Mind the gap: how do climate and agricultural management explain the ‘yield gap’ of croplands around the world?

Aim As the demands for food, feed and fuel increase in coming decades, society will be pressed to increase agricultural production – whether by increasing yields on already cultivated lands or by cultivating currently natural areas – or to change current crop consumption patterns. In this analysis, we consider where yields might be increased on existing croplands, and how crop yields are constrained by biophysical (e.g. climate) versus management factors. Location This study was conducted at the global scale. Methods Using spatial datasets, we compare yield patterns for the 18 most dominant crops within regions of similar climate. We use this comparison to evaluate the potential yield obtainable for each crop in different climates around the world. We then compare the actual yields currently being achieved for each crop with their ‘climatic potential yield’ to estimate the ‘yield gap’. Results We present spatial datasets of both the climatic potential yields and yield gap patterns for 18 crops around the year 2000. These datasets depict the regions of the world that meet their climatic potential, and highlight places where yields might potentially be raised. Most often, low yield gaps are concentrated in developed countries or in regions with relatively high‐input agriculture. Main conclusions While biophysical factors like climate are key drivers of global crop yield patterns, controlling for them demonstrates that there are still considerable ranges in yields attributable to other factors, like land management practices. With conventional practices, bringing crop yields up to their climatic potential would probably require more chemical, nutrient and water inputs. These intensive land management practices can adversely affect ecosystem goods and services, and in turn human welfare. Until society develops more sustainable high‐yielding cropping practices, the trade‐offs between increased crop productivity and social and ecological factors need to be made explicit when future food scenarios are formulated.     

Mind the Gap: Molecular Architecture of the Axon Initial Segment – From Fold Prediction to a Mechanistic Model of Function?

The axon initial segment (AIS) is a distinct neuronal domain, which is responsible for initiating action potentials, and therefore of key importance to neuronal signaling. To determine how it functions, it is necessary to establish which proteins reside there, how they are organized, and what the dynamic features are. Great strides have been made in recent years, and it is now clear that several AIS cytoskeletal and membrane proteins interact to form a higher-order periodic structure. Here we briefly describe AIS function, protein composition and molecular architecture, and discuss perspectives for future structural characterization, and if structure predictions will be able to model complex higher-order assemblies.     

‘The Mind of Christ’: Financial Success,Born-again Personhood,and the Anthropology of Christianity

In this article, I contribute to the emerging project of the anthropology of Christianity by exploring the subject of born-again personhood. As a nascent field of inquiry, the anthropology of Christianity must delimit what theoretical opportunities exist for comparative research. I argue that a focus on personhood offers a promising series of questions toward this end. To illustrate this claim, I use the case study of one Evangelical Sunday school teacher – Rick Betcher – and his life as a ‘Christian businessman.’ Anthropologists and other scholars have shown great interest in how matters of money figure in the culture of Protestantism. Using Rick's self-designed Sunday school class, The Mind of Christ, I argue that conceptions of personal financial success among born-again Christians are structured by the prevailing model of born-again personhood – the New Mind.