共查询到20条相似文献,搜索用时 15 毫秒
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J L Millán 《Nucleic acids research》1987,15(24):10599
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Molecular cloning and structure of the human interleukin 2 receptor gene. 总被引:10,自引:2,他引:10 下载免费PDF全文
N Ishida H Kanamori T Noma T Nikaido H Sabe N Suzuki A Shimizu T Honjo 《Nucleic acids research》1985,13(21):7579-7589
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Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5. 总被引:11,自引:0,他引:11
S G Hymowitz H W Christinger G Fuh M Ultsch M O'Connell R F Kelley A Ashkenazi A M de Vos 《Molecular cell》1999,4(4):563-571
Formation of a complex between Apo2L (also called TRAIL) and its signaling receptors, DR4 and DR5, triggers apoptosis by inducing the oligomerization of intracellular death domains. We report the crystal structure of the complex between Apo2L and the ectodomain of DR5. The structure shows three elongated receptors snuggled into long crevices between pairs of monomers of the homotrimeric ligand. The interface is divided into two distinct patches, one near the bottom of the complex close to the receptor cell surface and one near the top. Both patches contain residues that are critical for high-affinity binding. A comparison to the structure of the lymphotoxin-receptor complex suggests general principles of binding and specificity for ligand recognition in the TNF receptor superfamily. 相似文献
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Promoter elements and factors required for hepatic transcription of the human ApoA-II gene 总被引:2,自引:0,他引:2
J Chambaz P Cardot D Pastier V I Zannis C Cladaras 《The Journal of biological chemistry》1991,266(18):11676-11685