Rescuing stalled replication forks: MMS22L-TONSL,a novel complex for DNA replication fork repair in human cells

Comment on: Piwko W, et al. EMBO J 2010; 29:4210-22, Duro E, et al. Mol Cell 2010; 40:632–44, O’Connell BC, et al. Mol Cell 2010; 40:645–57 and O’Donnell L, et al. Mol Cell 2010; 40:619–31.     

A new role for microRNA-9 in human neural progenitor cells

Comment on: Delaloy C, et al. Cell Stem Cell 2010; 6:323–35     

Code breaking: The RNAPII modification code in pluripotency

Comment on: Brookes E, et al. Cell Stem Cell 2012; 10:157-70.     

Human pluripotency: A difficult state to make smart choices

Comment on: Hong SH, et al. Cell Stem Cell 2011; 9:24-36.     

Through the looking-glass: Observing HSCs through the lens of infection reveals unexpected insights into HSC function

Comment on: Hall CJ, et al. Cell Stem Cell 2012; 10:198-209.     

Rejuvenating regeneration: Metformin activates endogenous adult stem cells

Comment on: Wang J, et al. Cell Stem Cell 2012; 11:23-35.     

The “X factor” in cellular reprogramming and proliferation

Comment on: Pomp O, et al. Cell Stem Cell 2011; 9:156-65.     

Hedgehog and hematopoietic stem cell differentiation: Don't believe the hype!

Comment on: Gao J, et al. Cell Stem Cell 2009; 4:548-58.     

Genetic instability in human induced pluripotent stem cells: Classification of causes and possible safeguards

Comment on: Mayshar Y, et al. Cell Stem Cell 2010; 7:521-31.     

MiRegulators in cancer stem cells of solid tumors

Comment on: Ma S, et al. Cell Stem Cell 2010; 7:694-707.     

Chemical inactivation of Pat1

Comment on: Guerra-Moreno A, et al. Cell Cycle 2012; 11:1621-5 and Cipak L, et al. Cell Cycle 2012; 11:1626-33     

CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis

Comment on: Capparelli C, et al. Cell Cycle 2012; 11:2272-84 and Capparelli C, et al. Cell Cycle 2012; 11:2285-302.     

Cancers co-opt cohabitants’ catabolism

Comment on: Capparelli C, et al. Cell Cycle 2012; 11:2272-84 and Capparelli C, et al. Cell Cycle 2012; 11:2285-302.     

Dissecting the role of mTOR complexes in cellular senescence

Comment on: Kolesnichenko M, et al. Cell Cycle 2012; 11:2391-401. and Pospelova TV, et al. Cell Cycle 2012; 11:2402-407.     

A critical role for TORC1 in cellular senescence

Comment on: Kolesnichenko M, et al. Cell Cycle 2012; 11:2391-401 and Pospelova TV, et al. Cell Cycle 2012; 11:2402-407.     

Clp1p and Mid1p form links between cell cycle progression and gene expression at cytokinesis in fission yeast

Comment on: Papadopoulou K, et al. J Cell Sci 2010; 123:4374–81 and Agarwal M, et al. J Cell Sci 2010; 123:4366–73     

Dissecting the role of mTOR complexes in cellular senescence

Comment on: Kolesnichenko M, et al. Cell Cycle 2012; 11:2391-401. and Pospelova TV, et al. Cell Cycle 2012; 11:2402-407.     

Features that determine telomere homolog oligonucleotide‐induced therapeutic DNA damage‐like responses in cancer cells

The article to which this erratum refers was published in J Cell Physiol (2007) 210:582–595. J. Cell. Physiol. 215: 285, 2008. © 2007 Wiley‐Liss, Inc.     

Eukaryotic cells and their cell bodies: Cell Theory revised

BACKGROUND: Cell Theory, also known as cell doctrine, states that all eukaryotic organisms are composed of cells, and that cells are the smallest independent units of life. This Cell Theory has been influential in shaping the biological sciences ever since, in 1838/1839, the botanist Matthias Schleiden and the zoologist Theodore Schwann stated the principle that cells represent the elements from which all plant and animal tissues are constructed. Some 20 years later, in a famous aphorism Omnis cellula e cellula, Rudolf Virchow annunciated that all cells arise only from pre-existing cells. General acceptance of Cell Theory was finally possible only when the cellular nature of brain tissues was confirmed at the end of the 20th century. Cell Theory then rapidly turned into a more dogmatic cell doctrine, and in this form survives up to the present day. In its current version, however, the generalized Cell Theory developed for both animals and plants is unable to accommodate the supracellular nature of higher plants, which is founded upon a super-symplasm of interconnected cells into which is woven apoplasm, symplasm and super-apoplasm. Furthermore, there are numerous examples of multinucleate coenocytes and syncytia found throughout the eukaryote superkingdom posing serious problems for the current version of Cell Theory. SCOPE: To cope with these problems, we here review data which conform to the original proposal of Daniel Mazia that the eukaryotic cell is composed of an elemental Cell Body whose structure is smaller than the cell and which is endowed with all the basic attributes of a living entity. A complement to the Cell Body is the Cell Periphery Apparatus, which consists of the plasma membrane associated with other periphery structures. Importantly, boundary structures of the Cell Periphery Apparatus, although capable of some self-assembly, are largely produced and maintained by Cell Body activities and can be produced from it de novo. These boundary structures serve not only as mechanical support for the Cell Bodies but they also protect them from the hostile external environment and from inappropriate interactions with adjacent Cell Bodies within the organism. CONCLUSIONS: From the evolutionary perspective, Cell Bodies of eukaryotes are proposed to represent vestiges of hypothetical, tubulin-based 'guest' proto-cells. After penetrating the equally hypothetical actin-based 'host' proto-cells, tubulin-based 'guests' became specialized for transcribing, storing and partitioning DNA molecules via the organization of microtubules. The Cell Periphery Apparatus, on the other hand, represents vestiges of the actin-based 'host' proto-cells which have become specialized for Cell Body protection, shape control, motility and for actin-mediated signalling across the plasma membrane.     

The role of androgen in determining differentiation and regulation of androgen receptor expression in the human prostatic epithelium transient amplifying population

The original article to which this erratum refers was published in J Cell Phys (2007) 212:572–578. J. Cell. Physiol. 215: 283–284, 2008. © 2007 Wiley‐Liss, Inc.