共查询到20条相似文献,搜索用时 31 毫秒
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《Cell cycle (Georgetown, Tex.)》2013,12(7):904-908
Hedgehog proteins signal for differentiation, survival and proliferation of the earliest thymocyte progenitors, but their functions at later stages of thymocyte development and in peripheral T-cell function are controversial. Here we show that repression of Hedgehog (Hh) pathway activation in T-lineage cells, by expression of a transgenic repressor form of Gli2 (Gli2δC2), increased T-cell differentiation and activation in response to TCR signalling. Expression of the Gli2δC2 transgene increased differentiation from CD4+CD8+ to single positive thymocyte, and increased peripheral T cell populations. Gli2δC2 T-cells were hyper-responsive to activation by ligation of CD3 and CD28: they expressed cell surface activation markers CD69 and CD25 more quickly, and proliferated more than wild-type T-cells. These data show that Hedgehog pathway activation in thymocytes and T-cells negatively regulates TCR-dependent differentiation and proliferation. Thus, as negative regulators of TCR-dependent events, Hh proteins provide an environmental influence on T-cell fate. 相似文献
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Suppressing Wnt signaling by the hedgehog pathway through sFRP-1 总被引:1,自引:0,他引:1
He J Sheng T Stelter AA Li C Zhang X Sinha M Luxon BA Xie J 《The Journal of biological chemistry》2006,281(47):35598-35602
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Tyler Schwend Zhigang Jin Kai Jiang Brian J. Mitchell Jianhang Jia Jing Yang 《The Journal of biological chemistry》2013,288(45):32809-32820
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