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Use of chromatin immunoprecipitation to clone novel E2F target promoters 总被引:20,自引:0,他引:20 下载免费PDF全文
Weinmann AS Bartley SM Zhang T Zhang MQ Farnham PJ 《Molecular and cellular biology》2001,21(20):6820-6832
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Jeffrey V Wong Peng Dong Joseph R Nevins Bernard Mathey-Prevot Lingchong You 《Cell cycle (Georgetown, Tex.)》2011,10(18):3086-3094
Stimulation of quiescent mammalian cells with mitogens induces an abrupt increase in E2F1–3 expression just prior to the onset of DNA synthesis, followed by a rapid decline as replication ceases. This temporal adaptation in E2F facilitates a transient pattern of gene expression that reflects the ordered nature of DNA replication. The challenge to understand how E2F dynamics coordinate molecular events required for high-fidelity DNA replication has great biological implications. Indeed, precocious, prolonged, elevated or reduced accumulation of E2F can generate replication stress that culminates in either arrest or death. Accordingly, temporal characteristics of E2F are regulated by several network modules that include feedforward and autoregulatory loops. In this review, we discuss how these network modules contribute to “shaping” E2F dynamics in the context of mammalian cell cycle entry.Key words: E2F, dynamics, feedback, feedforward, network, DNA replication 相似文献
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Xu Hongli Liang Shengnan Hu Junjie Liu Wentong Dong Zhiqiang Wei Shaozhong 《Molecular biology reports》2022,49(3):1661-1668
Molecular Biology Reports - The mortality rate of colorectal cancer (CRC) remains high in developing countries. Interventions that can inhibit the proliferation of tumor cells represent promising... 相似文献
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Cell cycle molecules and vertebrate neuron death: E2F at the hub 总被引:10,自引:0,他引:10