Gender context of personalism in bioethics

Personalism is one of the philosophical perspectives which hold that the reality in person and the human person has the highest intrinsic value. This paper makes reference to Louis Janssens' eight criteria in adequate consideration of the human person but further argues that there is need to consider people as situated agents especially within gender relational perspectives. The paper identifies gender as an important social construction that shapes the consideration of the human persons within socio-spatial spheres. The main crux of the paper is that there is a gender context of personalism and this has profound implications for bioethical agendas. Gender is part of the human condition, especially when we philosophically or sociologically engage the notion of equity and equality within the social system, because social realities in the relational perspective are not impartial, impersonal and equal. Gender does not determine morality but it plays a role in morality and expectations from moral agents. Women have been categorised as a sociological group because their integrity, freedom/autonomy and dignity (which are basic concerns of bioethics) are capable of being threatened. A gender perspective provides important incentives for moral theory which searches for possible conceptual imbalances or blind spots in ethical reflections. The paper refers to Sen's faces of gender inequality and expands on the notion that natality inequality is one of the fundamental levels of gender inequality, which in turn is the primary starting agenda in bioethics. The paper avers that the recognition of the fundamental importance of gender to the organization of social reality and the development of personal identities have important practical implications for bioethics.     

'Single molecule': theory and experiments,an introduction

At scales below micrometers, Brownian motion dictates most of the behaviors. The simple observation of a colloid is striking: a permanent and random motion is seen, whereas inertial forces play a negligible role. This Physics, where velocity is proportional to force, has opened new horizons in biology. The random feature is challenged in living systems where some proteins - molecular motors - have a directed motion whereas their passive behaviors of colloid should lead to a Brownian motion. Individual proteins, polymers of living matter such as DNA, RNA, actin or microtubules, molecular motors, all these objects can be viewed as chains of colloids. They are submitted to shocks from molecules of the solvent. Shapes taken by these biopolymers or dynamics imposed by motors can be measured and modeled from single molecules to their collective effects. Thanks to the development of experimental methods such as optical tweezers, Atomic Force Microscope (AFM), micropipettes, and quantitative fluorescence (such as Förster Resonance Energy Transfer, FRET), it is possible to manipulate these individual biomolecules in an unprecedented manner: experiments allow to probe the validity of models; and a new Physics has thereby emerged with original biological insights. Theories based on statistical mechanics are needed to explain behaviors of these systems. When force-extension curves of these molecules are extracted, the curves need to be fitted with models that predict the deformation of free objects or submitted to a force. When velocity of motors is altered, a quantitative analysis is required to explain the motions of individual molecules under external forces. This lecture will give some elements of introduction to the lectures of the session 'Nanophysics for Molecular Biology'.     

Glutamatergic mechanisms in different disease states: overview and therapeutical implications -- an introduction

Summary.  Glutamate is the most widely distributed excitatory transmitter in the central nervous system (CNS). It is acting via large – and still growing – families of receptors: NMDA-, AMPA-, kainate-, and metabotropic receptors. Glutamate has been implicated in a large number of CNS disorders, and it is hoped that novel glutamate receptor ligands offer new therapeutic possibilites in disease states such as chronic pain, stroke, epilepsy, depression, drug addiction and dependence or Parkinson's disease. While an extensive preclinical literature exists showing potential beneficial effects of NMDA-, AMPA-, kainate- and metabotropic receptor ligands, only NMDA receptor antagonists have been characterized clinically to any appreciable degree. In these trials it has been shown that while several compounds are therapeutically active, they also produce serious side effects at therapeutic doses. Current interest largely centers on the development of receptor subtype-selective compounds, namely compounds selective for receptors containing the NR2B subunit. Preclinical findings and the first clinical results are encouraging, and it may be that such subunit-selective compounds may have a sufficiently wide therapeutic window to be safe for human use. Received July 6, 2001 Accepted August 6, 2001 Published online August 9, 2002     

Gender and livestock in African production systems: An introduction

Since the 1970s, the study of gender relations and labor and resource use in different production systems has become an important subject of inquiry. While there has been recent interest in gender and livestock issues in pastoral societies, most of the work on gender and agriculture to date has focused primarily upon the role of women in crop production, to the virtual exclusion of the contributions women, children, and the elderly make to the livestock component of the farming system. The topic of gender (broadly defined to include age and sex criteria) and livestock management was addressed at a session at the 1992 Annual Meetings of the American Anthropological Association entitled, Gender and Livestock in African Production Systems, the contributions to which form the basis of the present volume. Topics presented in the papers include: a conceptual framework for investigation of gender and livestock production and disease control, responsibility for productive tasks, livestock ownership and rights to livestock products, and impacts of and responses to change. Nearly all papers in the volume argue explicitly or implicitly for the need to include gender considerations in the planning of livestock development programs, thereby rendering the collection of interest to both scientits and policymakers.     

An African theory of bioethics: reply to MacPherson and Macklin

In a prior issue of Developing World Bioethics, Cheryl Macpherson and Ruth Macklin critically engaged with an article of mine, where I articulated a moral theory grounded on indigenous values salient in the sub-Saharan region, and then applied it to four major issues in bioethics, comparing and contrasting its implications with those of the dominant Western moral theories, utilitarianism and Kantianism. In response to my essay, Macpherson and Macklin have posed questions about: whether philosophical justifications are something with which bioethicists ought to be concerned; why something counts as 'African'; how medicine is a moral enterprise; whether an individual right to informed consent is consistent with sub-Saharan values; and when thought experiments help to establish firm conclusions about moral status. These are important issues for the field, and I use this reply to take discussion of them a step or two farther, defending my initial article from Macpherson's and Macklin's critical questions and objections.     

Hypertrophic cardiomyopathy in daily practice: an introduction on diagnosis,prognosis and treatment

Hypertrophic cardiomyopathy (HCM) is a complex, inherited cardiac disease that has been subject to intense investigation since it was first described in 1957. Over the past 40 years, understanding has evolved regarding the diagnosis, prognosis and treatment of HCM. Analyses of HCM populations from nonreferral centres have refined the insights into the natural history and the occurrence of sudden cardiac death, which is the most devastating component of its natural history. Therapeutic strategies are diverse and may vary during the course of the disease. Optimal therapy depends on symptoms, haemodynamic findings and the presence of risk factors for sudden cardiac death. At present, invasive therapy for patients with obstructive HCM and drug-refractory symptoms includes surgery or percutaneous transluminal septal myocardial ablation.This report summarises the diagnostic criteria, clinical course and therapeutic management of HCM. Attention is also paid to certain issues of special interest in this disease.     

Framing Thai sexuality in the age of AIDS -- introduction

Four of the papers presented at a panel on acquired immunodeficiency syndrome (AIDS) at the 1994 conference of the Australian Anthropological Society focused on Thailand, which is widely regarded as the epicenter of the epidemic in Southeast Asia. In his introduction to these papers, Lyttleton notes that the discourse on AIDS in Thailand has been characterized by a medical, hierarchical approach. Unlike the situation in countries such as the US, where homosexuals have engaged in collective activism to prevent the further spread of AIDS, Thailand's high-risk groups (e.g., prostitutes and injecting drug users) lack the group identification essential for the development of a culture of safe sex practices. Any discussion of AIDS in the Thai context must include an examination of the role of social drinking in framing men's public sexuality and male identity. Moreover, the homophobic nature of Thai culture has led to a dismissal of the reality of homosexual transmission.     

Linking cardiovascular theory to practice in an undergraduate medical curriculum

Case-based teaching (CBT) tutorials were introduced by the Physiology Department at Adelaide University to bridge the gap between theory and practice in the early years of undergraduate medical education. With the use of a clinical case-based environment, CBT aimed to achieve integration of structure-function relationships and an increase in students' capacity to apply a physiological understanding to clinical observations/symptoms and data. With peer-peer interactions in small groups, students could trial history taking and examination skills, interpret common investigations, and relate their findings to an understanding of structure and function. Here, the cardiovascular tutorials highlight the centrality of an understanding of structure and function in the evaluation of a case of syncope. An independent evaluation of the students' learning experience demonstrated that CBT tutorials were successful in their aims. The "hands-on" experience was highly rated, with students reporting that the CBT approach gave relevance to structure and function. Whatever the curriculum learning style, underpinning practice with an understanding of theory remains a desirable feature of medical education.     

Individual transferable quotas: theory and practice

The paper examines the theory and practice of individual transferable quotas (ITQs) in fisheries. Using the experience of several countries, a number of ITQ programmes are examined with respect to fisher compliance and their effect upon economic efficiency, employment, the harvesting shares of fishers, cost recovery and rent capture.

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种子萌发对策:理论与实验

植物种子的萌发／休眠现象有复杂的原因和机制,综述了理论生态学家的研究结果。应用的理论基础是最优化理论和进化稳定对策(Ess)理论。当环境条件随机波动,种群受非密度依赖因素调节时,采用最优化理论的两头下注对策预测休眠一定会得到进化且萌发率与环境条件直接相关。环境条件稳定时采用进化稳定对策理论可得到在亲属竞争,种子扩散,基因冲突等等因素影响下的进化稳定休眠／萌发率,预测了休眠／萌发与它们之间的相互关系。以上各种环境条件影响种子萌发行为的方式可以表述为若种子立即萌发会遭遇到不良环境使适合度下降,那么就会推迟萌发,出现休眠,形成土壤种子库。萌发率应使种群适合度最优或具有进化稳定性。一些实验也部分验证了理论预测。