血清尿酸水平与老年轻度高血压患者的内皮功能相关性分析

目的:探讨血清尿酸水平与老年轻度高血压患者的内皮功能相关性。方法:选取我院2020年1月到2020年12月共收治的200例老年轻度高血压患者作为研究对象,所有患者均为未使用过降压药物治疗,将其分为轻度高血压组。另选取同期收治的200例高血压常规药物治疗患者作为重度高血压组与200名健康者作为对照组,对比三组患者血清尿酸水平与血管内皮功能。对观察组所有患者依照血清尿酸水平进行分组,将血清尿酸水平208-360μmol/L的患者分为低尿酸组,共计136例,将血清尿酸水平≥360μmol/L的患者分为高尿酸组,共计64例。对比两组患者的一般临床指标、血管内皮功能与氧化应激指标,并分析血清尿酸水平与老年轻度高血压患者的内皮功能相关性。结果:重度、轻度高血压组与对照组患者NO、ET-1、SUA水平对比差异显著,具有统计学意义(P<0.05);高尿酸组与低尿酸组患者TG、TC、DBP、SBP水平对比无明显差异(P>0.05),高尿酸组患者Cr水平高于低尿酸组,组间对比,差异具有统计学意义(P<0.05);高尿酸组与低尿酸组患者T-AOC、GSH-Px、LHP、MDA、NO、ET-1水平对比差异显著,高尿酸组患者LHP、MDA和ET-1水平明显高于低尿酸组,高尿酸组患者T-AOC、GSH-Px、NO水平明显低于低尿酸组,组间对比,差异具有统计学意义(P>0.05);Spearman相关分析结果显示:TG、TC、Cr、DBP、SBP与血尿酸水平无明显相关性(P>0.05),T-AOC、GSH-Px、NO与血清尿酸水平呈负相关(P<0.05),LHP、MDA、ET-1与血清尿酸水平呈正相关(P<0.05)。结论:血清尿酸水平与老年轻度高血压患者的内皮功能具有明显相关性,而且证明血尿酸水平的升高可能由患者氧化应激导致,因此氧化应激水平也是引起血管内皮功能障碍的一种潜在机制,希望本研究结果能够为高血压患者的疾病控制提供参考意见。     

蝮蛇抗栓酶治疗腔隙性脑梗死血液流变学变化

我科用蝮蛇抗栓酶治疗 87例腔隙性脑梗死患者 ,疗效好。现将治疗前、后患者的血液流变学变化报告如下。1　资料与方法1 .1　一般资料　 87例患者均为我科住院病人 ,均符合第二次全国脑血管病学术会议制定的诊断标准 ,并经头颅 CT或 MRI证实 ,确诊为腔隙性脑梗死。其中男 59例 ,女 2 8例 ,年龄 42～ 83岁 ,平均 62 .5岁。1 .2　治疗方法　用蝮蛇抗栓酶 (沈阳药科大学生产 )做皮试 ,阴性者 ,将蝮蛇抗栓酶 0 .75u加入0 .9%生理盐水 2 0 0 ml中静脉滴注 ,每天 1次 ,1 5天为 1疗程。停药 3～ 5天 ,继续第 2疗程。治疗前后用 FL系列血液流变学…     

血清尿酸水平对急性脑梗死患者颈动脉粥样硬化斑块的影响

目的:探讨血清尿酸(UA)水平对急性脑梗死患者颈动脉粥样硬化斑块的影响。方法:回顾性分析2011年6月至2016年1月我院收治的251例急性脑梗死患者的临床资料,根据有无颈动脉粥样硬化斑块分为伴颈动脉粥样硬化斑块组(观察组)176例和无颈动脉粥样硬化斑块组(对照组)75例,观察组根据颈动脉粥样硬化程度分为斑块形成组(113例)、内中膜增厚组(63例),根据颈动脉斑块稳定程度分为不稳定组(106例)、稳定组(70例),比较各组血清UA水平,根据UA水平不同分为高UA组(134例)和正常UA组(117例),进行颈动脉斑块发生情况比较。结果:观察组的血清UA水平显著高于对照组,差异有统计学意义(P0.05)。(1)斑块形成组和内中膜增厚组血清UA水平显著高于对照组(P0.05),而斑块形成组和内中膜增厚组血清UA水平比较,差异无统计学意义(P0.05);(2)不稳定组血清UA水平显著高于对照组和稳定组(P0.05),而稳定组和对照组血清UA水平比较,差异无统计学意义(P0.05);(3)正常UA组和高UA组颈动脉斑块的发生情况比较,差异无统计学意义(P0.05)。结论:血清UA水平可以作为表征急性脑梗死患者伴随出现颈动脉粥样硬化斑块的生物学指标之一,此外,血清UA的水平在颈动脉粥样硬化斑块形成者和不稳定者表达更高,但血清UA水平与颈动脉斑块形成无明显联系。     

腔隙性和非腔隙脑梗塞患者的血压差异研究

目的:比较腔隙性(LI)与非腔隙性(NLI)脑梗塞患者血压变化,评价血压与腔隙性脑梗塞的相关性。方法:选取在我院住院治疗的249例急性脑梗塞患者,根据不同亚型将患者分为腔隙性脑梗塞组(LI组,n=187)与非腔隙性脑梗塞组(NLI组,n=62),比较两组患者血压差异,采用线性相关分析与cox相关分析评估血压与脑梗塞及其危险因素的相关性。结果:LI组患者入院3天收缩压、舒张压显著高于NLI患者组,差异有统计学意义(分别P=0.003,P=0.009);线性回归分析表明,入院时收缩压、入院第3天收缩压、入院第3天舒张压与LI显著相关(均P0.05);cox单因素与多因素分析表明,入院第3天收缩压与LI显著相关(分别P=0.009与P=0.006),与其他协变量不相关(均P0.05)。而患者出院时血压与m RS或NIHSS不相关(分别P=0.788和P=0.898)。结论:与相同严重程度NLI患者比较,LI患者高血压与LI独立相关。LI患者血压显著高于NLI患者,二者差异虽与临床疾病严重程度无关,但很可能是患者发生急性脑梗塞的根本原因。     

腔隙性脑梗死伴脑白质病变患者血清miR-146a和NSE水平与MoCA评分的关系研究

摘要 目的：研究腔隙性脑梗死（LI）伴脑白质病变（WML）患者血清miR-146a和神经元特异性烯纯化酶（NSE）水平与蒙特利尔认知评估量表（MoCA）评分的关系。方法：纳入我院从2017年3月～2019年3月收治的LI伴WML患者108例进行研究,记作LI伴WML组。另取同期收治的单纯WML患者与单纯LI患者各100例,分别记作WML组与LI组,再取同期于我院进行体检的健康人员100例作为对照组。比较四组人员的血清miR-146a和NSE水平、MoCA评分,并作相关性分析。结果：LI伴WML组、WML组、LI组血清miR-146a相对表达量均低于对照组,而LI伴WML组血清miR-146a相对表达量又显著低于WML组、LI组（均P＜0.05）;LI伴WML组、WML组、LI组血清NSE水平均显著高于对照组,且LI伴WML组血清NSE水平均显著高于WML组、LI组（均P＜0.05）。LI伴WML组MoCA总分显著低于WML组与LI组,且WML组与LI组MoCA总分显著低于对照组（均P＜0.05）。经Pearson相关性分析可得：LI伴WML组患者血清miR-146a相对表达量与MoCA总分呈正相关关系（P＜0.05）,而血清NSE水平与MoCA总分呈负相关关系（P＜0.05）。结论：LI伴WML患者的血清miR-146a水平存在明显低表达,而NSE水平存在明显高表达,并与MoCA评分相关,两者可能在认知功能损伤的发生、发展过程中起着至关重要的作用。     

2011~2014 年体检者血压水平与血清尿酸水平的关系

目的：分析2011~2014 年我院体检者血压水平与血清尿酸(UA)水平的关系。方法：选择我院2011~2014 年2150 例体检者为 研究对象,均完成血压（SBP、DBP),心率（HR）、身高、体重指数（BMI）、空腹血糖（FPG）、高密度脂蛋白胆固醇(HDL-C) 、低密度脂 蛋白胆固醇(LDL-C) 、血清总胆固醇(TC) 、甘油三酯(TG)及UA 指标检测,并对检测结果进行分析。结果：2150 例体检人群中,高 血压为860 人,占40.0%,高血压组BMI、FPG、LDL-C、TC、TG 及UA 均明显高于非高血压组,而HDL-C 明显低于非高血压组, 比较差异具有统计学意义（P＜0.05）;多因素Logistic 回归分析显示,上述指标均为高血压的独立危险因素（P＜0.05）。结论：血压 水平的升高与UA水平具有密切联系,早期控制UA水平对预防高血压的发生具有重要意义。     

脑小血管病患者血清尿酸水平和步态障碍之间的相关性

目的:探讨脑小血管病(Cerebral small vessel disease,CSVD)患者血清尿酸(Uric acid,UA)水平和步态障碍之间的相关性。方法:将我院自2018年1月至2019年1月收治的CSVD患者172例作为研究对象,根据患者血清尿酸水平分为研究组87例,对照组85例。收集和比较两组的临床资料,使用Logistic回归分析血清尿酸和CSVD患者脑室旁、深部白质高信号、步态障碍之间的相关性。结果:两组的年龄、性别、体质指数、血糖指标、血脂指标水平,合并高血压、糖尿病病史和吸烟情况比较差异无统计学意义(P0.05)。研究组血清尿酸水平、饮酒患者比例明显高于对照组(P0.05),脑室旁高信号和深部白质高信号中重度比例均明显高于对照组(P0.05);将步态障碍、脑室旁高信号与深部白质高信号作为影响因素带入相关分析,结果显示血清尿酸水平与步态障碍、脑室旁高信号与深部白质高信号比较存在正相关(P0.05)。结论:CSVD患者血清高尿酸水平与脑室旁、深部白质高信号病变程度呈明显的正相关性,也是患者步态障碍的影响因素。     

尿酸及NLRP3炎症小体与妊娠期高血压的相关性分析

目的:观察妊娠期高血压孕产妇尿酸与Nod样受体蛋白3(nucleotide-binding oligomerization domain-leucine-rich repeats containing pyrin domain 3,NLRP3)炎症小体表达,分析二者与疾病的相关性,为妊娠期高血压的诊断提供参考。方法:选择我院产科2016年3月至2019年3月常规产检并诊断为妊娠期高血压孕产妇200例为研究组,参照《妊娠期高血压诊治指南(2015)》中各妊娠期高血压分级标准将研究组200例孕产妇分为妊娠期高血压组(86例)、轻度子痫前期组(57例)、重度子痫前期组(57例),另选择同期在我院接受常规产检的200例健康孕产妇作为对照组。检测并比较4组孕产妇血清尿酸、NLRP3炎症小体m RNA及NLRP3蛋白表达,经双变量Spearman相关性分析检验各指标与疾病的相关性。结果:4组孕产妇年龄、孕周、孕次、产次等一般资料比较差异无统计学意义(P>0.05);重度子痫前期组血清尿酸水平、NLRP3 mRNA及NLRP3蛋白表达最高,后由高至低依次为轻度子痫前期组、妊娠期高血压组、对照组,组间两两比较差异均有统计学意义(P<0.05);经双变量Spearman相关性分析检验证实,血清尿酸、NLRP3 mRNA表达和蛋白表达与妊娠期高血压发生发展均呈正相关(r=0.709、0.833、0.693,P均<0.001)。结论:妊娠期高血压孕产妇血清尿酸与NLRP3炎症小体水平上调,且随着孕产妇病情的加重升高,可考虑将其作为妊娠期高血压疾病早期诊断及预后评估的血清学参考指标。     

老年高血压合并2 型糖尿病患者血清同型半胱氨酸、血尿酸水平 变化及临床意义

目的：探讨老年高血压合并2 型糖尿病患者血清同型半胱氨酸（Homocysteine, Hcy）、血尿酸（Serum uric acid, SUA）水平变 化及其临床意义。方法：2012 年9 月至2013 年9 月期间,我院诊治的40 例单纯高血压和40 例高血压合并2 型糖尿病患者,分别 作为对照组和研究组,检测两组血清Hcy、SUA水平。结果：两组患者收缩压、舒张压比较无统计学差异（P>0.05）。研究组空腹血 糖、餐后2h 血糖、血清Hcy、SUA 均显著高于对照组（P<0.05）。研究组中血管并发症患者血清Hcy、SUA为（25.0± 5.0）umol/L 和 （390.0± 65.0）mmol/L显著高于无血管并发症患者（17.0± 4.0）umol/L 和（330.0± 55.0）mmol/L,血管并发症患者FBG、餐后2h 血 糖与无血管并发症患者比较无统计学差异（P>0.05）。结论：高血压合并2 型糖尿病患者血清Hcy、SUA异常升高,且存在慢性血 管并发症患者两者水平更高,血清Hcy、SUA是老年高血压合并2 型糖尿病的危险因素。     

急性非ST 段抬高性心肌梗死患者血清尿酸水平与N末端B 型钠尿肽原的相关性分析

目的:探讨急性非ST段抬高性心肌梗死(NSTEMI)患者血清尿酸水平与N末端B型钠尿肽原(NT-pro BNP)的相关性分析。方法:将143例NSTEMI患者按照入院时血清尿酸四分位数分为四组:Ⅰ组(尿酸284.18μmol/L)、Ⅱ组(284.19~336.53μmol/L),Ⅲ组(336.54~390.78μmol/L),Ⅳ(尿酸390.79μmol/L);按照血清NT-pro BNP中位数分为2组:NT-pro BNP571.56 pg/m L组和NT-pro BNP≥571.56 pg/m L组;比较各组相关指标的差异。结果:Ⅰ组、Ⅱ组、Ⅲ组及Ⅳ组四组的NT-pro BNP、GRACE危险评分、CK-MB、LEVF、c Tn I比较统计学差异(P0.05),Ⅳ组NT-pro BNP、GRACE危险评分、c Tn I、CK-MB高于Ⅰ组、Ⅱ组、Ⅲ组,Ⅲ组高于Ⅰ组、Ⅱ组(P0.05);NT-pro BNP≥571.56 pg/m L组血清尿酸、GRACE危险评分、c Tn I、CK-MB高于NT-pro BNP571.56pg/m L组(P0.05)。血清尿酸分别与NT-pro BNP、GRACE危险评分呈现正相关(P0.05)。结论:血清尿酸水平与NSTEMI患者的NT-pro BNP密切相关,临床检测血清尿酸水平对于评估NSTEMI患者NT-pro BNP水平具有重要的意义。     

A relation of serum homocysteine and uric acid in Bosnian diabetic patients with acute myocardial infarction

Background: Coronary artery disease as a consequence of atherosclerosis is the most common cause of morbidity and mortality in type 2 Diabetes Mellitus (DM) patients. Homocysteine (HCY), as one of the risk factors, and uric acid (UA) as the most common antioxidant in serum have their roles in the processes of inflammation and atherogenesis, which underlie the pathogenesis of acute myocardial infarction (AMI). The effect of HCY in cardiovascular disease is thought to be manifested primarily through oxidative damage, implying a potential correlation between the HCY level and antioxidant status. Since the data related to the diagnostic significance of both HCY and UA in diabetic patients with AMI are conflicting, and so far not reported in Bosnian patients, this research aimed to examine the association of HCY and UA levels with glomerular filtration rate (eGFR) and explore the pathophysiological significance of these data in Bosnian diabetic patients with AMI. Methods: This prospective research included 52 DM type 2 patients diagnosed with AMI. Blood samples were taken on admission and used for biochemical analysis. Results of the biochemical analyses were statistically analysed. Results: Elevated HCY and UA levels were observed in diabetic patients. Females have higher HCY compared to males. A positive correlation was revealed between HCY and UA and was confirmed with different HCY levels in subgroups with different UA level. A negative correlation was observed between UA and HbA1c, as well as between both HCY and UA with eGFR. Conclusions: These results contribute to the clarification of the biochemical mechanisms characteristic in AMI patients with DM. According to these results, we believe that joint measurement of HCY and UA could enable a better assessment of the prognosis for this group of patients. This kind of assessment, as well as regression analysis, can identify high-risk patients at an earlier stage when appropriate interventions can influence a better outcome in such patients.     

血尿酸水平与急性脑梗死相关性分析

目的探讨血尿酸水平与急性脑梗死发病及预后的关系。方法检测129例急性脑梗死患者与120例健康组的血尿酸水平及相关指标进行比较,分析其相关性。结果急性脑梗死患者血尿酸水平及异常率明显增高,与对照组之间差异存在非常显著性(P0.01),在急性脑梗死患者中,血尿酸异常组高血压、高血糖、高血脂及高纤维蛋白原血症的发生率比正常组明显增高,血尿酸异常组较正常组入院第21天神经功能缺损的程度差异存在非常显著性(P0.01)。结论血尿酸水平与急性脑梗死的发病密切相关,是预后不良的预测因素。     

Effect of phytic acid on postprandial serum uric acid level in healthy volunteers: a randomized,double-blind,crossover study

Abstract

Phytic acid, a constituent of various plants, has been related to health benefits. Phytic acid has been shown to inhibit purine nucleotide metabolism in vitro and suppress elevation of plasma uric acid levels after purine administration in animal models. This study investigated the effect of phytic acid on postprandial serum uric acid (SUA) in humans. This randomized, double-blind, crossover design study included 48 healthy subjects with normal fasting SUA. Subjects consumed a control drink and a phytic acid drink with purine-rich food, and serum and urine uric acid levels were measured for 360?min after purine loading. Phytic acid lowered the incremental area under the curve (0–360?min) and incremental maximum concentration of SUA after purine loading (p?<?0.05); tended to lower cumulative urinary uric acid excretion (0–360?min) after purine loading (p?<?0.10); and suppressed postprandial SUA in this clinical study. Altogether, our findings suggest that phytic acid may play a beneficial role in controlling postprandial SUA.     

Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis

Multiterritorial atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than atherosclerotic disease with single‐artery affected. Serum uric acid (SUA) is an important predictor of stroke and atherosclerosis; however, which is supported by few direct evidence based on cohort studies. A prospective cohort study including 2644 North Chinese adults aged ≥40 years was performed in 2010‐2012 to investigate the association between SUA and multiterritorial vascular stenosis. Hyperuricaemia was defined as SUA levels >6 and >7 mg/dL for males and females, respectively. All participants underwent twice transcranial Doppler (TCD) and bilateral carotid duplex ultrasound to evaluate intracranial artery stenosis (ICAS) and extracranial arterial stenosis (ECAS) and peripheral arterial disease (PAD) was determined by ankle‐brachial index (ABI) on January 2010 and January 2012 based on regular health check‐ups. The cumulative incidence of vascular stenosis was significantly higher in subjects with hyperuricaemia than in those without hyperuricaemia (54.1% vs. 34.7%, P < 0.001). The adjusted odds ratios (ORs) with 95% confidence intervals (CIs) for new on‐set vascular stenosis due to hyperuricaemia and a 1‐mg/dL change in SUA level were 1.75 (1.32‐2.31) and 1.29 (1.21‐1.38), respectively. Furthermore, in the gender‐stratified analysis, the association between SUA levels and ICAS was statistically significant in males (OR: 2.02; 95% CI: 1.18‐3.46), but not females (OR: 0.85, 95% CI: 0.41‐1.76, P for interaction: 0.026).     

脑梗死患者同型半胧氨酸与血脂相关性的研究

目的：研究脑梗死患者空腹血浆总同型半胱氨酸（THCY）水平及其与血脂的关系。方法：观察组（54例）均为我院2002年1月．2006年5月住院脑梗死患者,测定空腹THCY水平及血脂各参数;另有同龄健康者为对照组（39例）,进行比较分析。结果：观察组与对照组比较,空腹THCY水平差异有统计学意义（P〈0．05）,血浆HCY含量与TC、TG、HDL-C、LDL-C含量的相关性均无统计学意义。结论：高HCY血症与血脂无关,是脑梗死的独立危险因素之一。     

A rapid and high‐throughput method for the determination of serum uric acid based on microarray technology and nanomaterial

Serum uric acid (SUA) is a new therapeutic target for non‐alcoholic fatty liver disease (NAFLD). In this study, we introduced a chemiluminescence (CL) method combined with microarray technology and a simple fabrication procedure to obtain a highly sensitive SUA probe based on a mesoporous metal oxide nanomaterial. The high‐throughput method was based on the generation of H₂O₂ from SUA by immobilized uricase and its measurement by a CL reaction catalyzed by mesoporous metal oxide nanomaterials. The CL probe was designed for SUA The linear range of the uric acid concentration was 0.6–9 μM and the detection limit was 0.1 μM. In comparison with the other SUA detection techniques, this method has the advantages of a low detection limit, high sensitivity and simplicity. A new sensitive high‐throughput approach was obtained for the determination of SUA.     

A high-performance liquid chromatographic method for the determination of pseudouridine and uric acid in native human urine and ultrafiltrated serum

A simple and reliable HPLC method for quantitative determination of pseudouridine and uric acid in human urine and serum using a cation-exchange resin is described. This method is straightforward (12 runs of urine samples per day since the sample is only diluted into buffer and then chromatographed), sensitive, and highly reproducible. The column is stable over long periods (3 months of uninterrupted use at a time; it is thereafter easily restored to the original state). Mean excretion values for pseudouridine (in μmol/mmol creatinine) are 26.4 ± 3.1 (17 female adults), 23.8 ± 2.5 (12 male adults), 164.7 ± 32.2 (37 male preterm infants); mean values for uric acid (μmol/mmol creatinine) are, respectively, 310.3 ± 90.5, 278.2 ± 56.1, and 1108 ± 314. Human serum is deproteinized by pressure ultrafiltration in microcollodion bags with a nominal exclusion molecular weight of 12,400 and then put directly onto the HPLC column. The complete procedure takes 4 h.     

老年冠心病患者血尿酸水平与肠道菌群的关系

目的探讨老年冠心病患者血尿酸(SUA)水平与肠道菌群的关系,为该类患者的治疗提供参考。方法选择2018年5月至2019年5月我院收治的83例冠心病患者为研究组,选择同期我院83例健康体检者的作为对照组。比较两组对象SUA水平及粪便标本中肠道菌群分布情况(乳杆菌、双歧杆菌、幽门螺杆菌、大肠埃希菌、链球菌);比较不同菌群紊乱程度冠心病患者SUA水平;比较不同SUA水平冠心病患者肠道菌群分布情况。采用Pearson相关分析冠心病患者SUA水平与肠道菌群相关性。结果研究组患者肠道乳杆菌、双歧杆菌数量明显低于对照组(均P<0.05),而肠道幽门螺杆菌、大肠埃希菌、链球菌数量明显高于对照组(均P<0.05)。研究组患者SUA水平明显高于对照组(P<0.05),不同菌群紊乱程度冠心病患者SUA水平有差异有统计学意义(均P<0.05)。不同SUA水平冠心病患者肠道乳杆菌、双歧杆菌、幽门螺杆菌、大肠埃希菌、链球菌数量差异有统计学意义(均P<0.05)。冠心病患者SUA水平与肠道乳杆菌、双歧杆菌数量呈负相关(r=-0.872、-0.912,均P<0.001),与肠道幽门螺杆菌、大肠埃希菌、链球菌数量呈正相关(r=0.915、0.896、0.889,均P<0.001)。结论冠心病患者存在肠道细菌紊乱及高尿酸现象。冠心病患者SUA水平与肠道菌群显著相关,检测冠心病患者SUA水平对监测肠道菌群状态及治疗方案制定具有重要意义。     

Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese

Serum uric acid levels are maintained by urate synthesis and excretion. URAT1 (coded by SLC22CA12) was recently proposed to be the major absorptive urate transporter protein in the kidney regulating blood urate levels. Because genetic background is known to affect serum urate levels, we hypothesized that genetic variations in SLC22A12 may predispose humans to hyperuricemia and gout. We investigated rs893006 polymorphism (GG, GT and TT) in SLC22A12 in a total of 326 Japanese subjects. Differences in clinical characteristics among the genotype groups were tested by the analysis of variance (ANOVA). In male subjects, mean serum uric acid levels were significantly different among the three genotypes. Levels in the GG genotype subjects were the highest, followed by those with the GT and TT genotypes. However, no differences between the groups were seen in the distributions of creatinine, Fasting plasma glucose (FPG), HbA(1c), total cholesterol, triglyceride, HDL cholesterol levels or BMI. A single nucleotide polymorphism (SNP) in the urate transporter gene SLC22CA12 was found to be associated with elevated serum uric acid levels among Japanese subjects. This SNP may be an independent genetic marker for predicting hyperuricemia.     

Association between serum calcium and periodontal disease progression in non-institutionalized elderly

Objective: To assess the effect of baseline serum calcium on the progression of periodontal disease in non‐institutionalized elderly. Background: Although a few studies have found some evidence of the role played by dietary calcium in periodontal disease process, there is a paucity of information pertinent to longitudinal assessment of serum calcium‐periodontal relationships. Material and methods: Clinical attachment levels of 266 Japanese subjects aged 70 years were recorded at baseline and annually for six consecutive years. Progression of periodontal disease (PPD) was defined as the number of teeth that showed additional attachment loss of ≥3 mm during the 6 years. The number of PPD was calculated for each subject and categorised into four levels, namely, PPD₀, PPD₁, PPD₂ and PPD₃ where the number of teeth with additional attachment loss ranged from 0, 1–10, 11–20 and >20 respectively. The levels of serum calcium, albumin, random blood sugar, immunoglobulin (IgG, IgA and IgM), gender, smoking habits, education, gingival bleeding and the number of teeth present were obtained at baseline. Results: Serum calcium, IgA, smoking, gingival bleeding and teeth present were associated with PPD at p ≤ 0.10 and were included in a multinomial logistic regression analysis. Serum calcium was the only variable that was significantly associated with PPD with relative risks of 100 at PPD₁ and PPD₂, respectively, and 1000 at PPD₃. Conclusion: Serum calcium may be considered a risk factor for periodontal disease progression in non‐institutionalized elderly.