细锥香茶菜化学成分的研究

从细锥香茶菜（Ｒａｂｄｏｓｉａｃｏｅｔｓａ（Ｂｕｃｈ．Ｈａｍ．ｅｘＤ．Ｄｏｎ）Ｈａｒａ）的叶中分离到９个化合物,通过波谱分析阐明其结构,其中１个为新的二萜酸———７α,１２α,１４β三羟基１５酮对映贝壳杉１８羧酸,命名为细锥香茶菜酸（ｃｏｅｔｓａｎｏｉｃａｃｉｄ）。另外８个化合物分别为二氢昆明香茶菜丙素、昆明香茶菜丙素、白柔毛香茶菜甲素、大萼香茶菜丙素、４羟基Δ８,９（Ｚ）鞘氨醇２′羟基正二十（二十一二十六）碳酸酰胺、乌苏酸、２α,３β二羟基乌苏酸和胡萝卜甙。神经酰胺类化合物系首次从该属植物中分离得到。     

瘿花香茶菜的微量成分

从唇形科瘿花茶菜（Ｒａｂｄｏｓｉａ ｒｏｓｔｈｏｒｎｉｉ）叶的乙醚抽出物中分出２个新的微量成分,瘿花丙素和丁素。基于详细的光谱分析,包括应用二维核磁共振数据,瘿花丙素和化学结合分别确定为对映－１１α－乙酰氧基－７β,１３β,１９－三羟基贝壳杉－１６烯－１５－酮（１）和对映－１１α－乙酰氧基－７β,１２β,１４α－三羟基贝壳杉－１６烯－１５－酮（２）。     

Chemical compounds and pharmacological effects of Rabdosia excisa

Many kinds of diterpenoids have been isolated from Rabdosia spp.Some of them have anti-microbial effects,counteract inflammation,and inhibit tumor progression activities.We conducted the present study in order to look for bioactive compounds in the medicinal plant Rabdosia excisa.In this study,five compounds were isolated from R.excisa;they were oridonin,isokamebakaurin,oleanolie acid,ursolic acid,and β-sitosterol.In order to identify the function of the extracts,the activity of antibiotics,antioxidation,and immunity test were carried out against these functions.Prospective results were observed in all of the tested items.     

Three angiotensin-converting enzyme inhibitors from Rabdosia coetsa

The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate (1), rosmarinic acid (2) and methyl rosmarinate (3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10 μg/ml.     

细锥香茶菜的化学成分研究

从云南丽江产细锥香茶菜(Rabdosia coetsa)叶中分离得到11个单体成分,根据光谱方法分别鉴定为:gesneroidin c 1、胡萝卜甙(daucosterol 2)、熊果酸(ursolic acid 3)、乌发醇(uvaol 4)、齐墩果酸(oleanolic acid 5)、2α,3β-二羟基齐墩果酸(2α,3β-dihydroxy-oleano-lic acid 6)、白桦脂酸(Betulinic acid 7)、植物醇(phytol 8)、肉豆蔻酸植物醇酯(phytyl myris-tate 9)、9Z,12Z-二烯肉豆蔻酸乙酯(ethyl 9Z,12Z-dien-palmitate 10),12Z,15Z-二烯花生酸甘油酯(glyceryl 12Z,15Z-dien-arachidate 11)。     

Chemical Structure of Macrocalyxin D

A new diterpenoid which exhibits cytotoxic activity, macrocalyxin D has been isolated from the e-thereal extract of the leaves of Rabdosia macrocalyx (Dunn) Hara. On the basis of chemical and spectroscopic data, the chemical structure of macrocalyxin D was established as (3).     

大接骨丹的化学成分

ＴｏｒｉｃｅｌｌｉａａｎｇｕｌａｔａＯｌｉｖ .ｖａｒ.ｉｎｔｅｒｍｅｄｉａ (Ｈａｒｍｓ .)Ｈｕ ,ｂｅｌｏｎｇｉｎｇｔｏＴｏｒｉｃｅｌｌｉａｃｅａｅ ,ｉｓａｓｉｎｇｌｅｆａｍｉｌｙａｎｄｓｉｎｇｌｅｇｅｎｕｓｐｌａｎｔ.ＩｔｉｓｄｉｓｔｒｉｂｕｔｅｄｉｎＹｕｎｎａｎ ,Ｇｕｉｚｈｏｕ ,ａｎｄＳｉｃｈｕａｎｐｒｏｖｉｎｃｅｓｉｎＣｈｉｎａａｓｗｅｌｌａｓｔｈｅＨｉｍａｌａｙａｓ.ＩｎＣｈｉｎｅｓｅｆｏｌｋｍｅｄｉｃｉｎｅ ,Ｔ .ａｎｇｕｌａｔａｉｓｕｓｅｄｔｏｔｒｅａｔｂｏｎｅｆｒａｃｔｕｒｅ ,ｔｏｎ ｓｉ…     

Chemical Structure of Macrocalyxin E

Macrocalyxin E, a new diterpenoid has been isolated from the leaves of Rabdosia macrocalyx (Dunn) Hara. Its structure was established by spectroscopic and chemical data.     

The Variation and Ecochemistry of Rabdosia eriocalyx

In this paper, authors deal with the change Laws of phytomorphology and active component content of Rabdosia eriocalyx (Dunn) Hara showing antitumor activity in various time, locality and habitat, From these authors illustrate the relation between species and variety, and the best harvest stage.     

冬凌草中一个苯丙醇酯新化合物

通过多种色谱手段,从冬凌草95％乙醇提取物中分离得到一个新化合物。运用多种波谱技术（1D、2D—NMR和MS）,该新化合物鉴定为2-氨基-3-苯丙基2-苯甲酰氨基-3-利胆醇酯（苯丙醇酯）。     

细锥香茶菜甲素的结构订正和丙素的化学结构

前已报道［１］从唇形科香茶菜属植物细锥香茶菜（Ｒａｂｄｏｓｉａｃｏｅｔｓａ（Ｂｕｃｈ．Ｈａｎ．ｅｘＤ．Ｄｏｎ）Ｈａｒａ）中分离到３个结晶单体,并测定了其中两个单体——细锥香茶菜甲素（１）和乙素的结构。本文通过１Ｈ－１ＨＣＯＳＹ、１３Ｃ－１ＨＣＯＳＹ和ＮＯＥＳＹ,修订细锥香茶菜甲素（１）的结构为（２）,并经理化常数测定和光谱分析,确定了另一结晶单体——微量新成分细锥香茶菜丙素（３）的结构。（２）Ｒ１＝Ｒ２＝Ｒ４＝Ｈ,Ｒ３＝ＯＡｃ,Ｒ５＝ＯＣＨ３（３）Ｒ１＝Ｒ３＝Ｒ４＝Ｈ,Ｒ２＝ＯＡｃ,Ｒ５＝ＯＣＨ…     

细锥香茶菜二萜的研究

从四川省峨眉山产细锥香茶菜[Rabdosia coetsa(Buch-Ham,ex,D.Don)Hara]乙醚抽提物中分得了一个新二萜化合物,命名为细锥香茶菜丁素(rabdocoetsin D),其结构经各项波谱数据和化学证据确定为1α,7β-二羟基-11β-乙酰氧基-对映-7β,20-环氧-贝壳杉-16-烯-15-酮(1)。另外还分离到3个已知二萜,细锥香茶菜乙素(rabdocoetsin B)、细锥香茶菜丙素(rabdocoetsin C)、瘿花香茶菜甲素(rosthorin A)。     

冬凌草二萜类成分的化学指纹图谱研究及评价

为了建立冬凌草(Rabdosia rubescens)二萜类成分的HPLC指纹图谱,并通过指纹图谱对来自不同产地和不同类型的冬凌草进行评价,本研究以10批太行山产冬凌草HPLC色谱图为参照,建立了冬凌草二萜类成分的指纹图谱,色谱条件为,色谱柱:phenomsil C18(250 ×4.6 mm,5 μm)柱;流动相:甲醇:0.5％磷酸水溶液梯度洗脱;柱温:30℃;检测波长:238 nm;流速:0.8 mL/min.通过化学成分指纹图谱相似度分析以及主成分分析方法,综合评价不同产地冬凌草样品质量的差异.结果表明冬凌草种质资源出现多种分化,不同地区冬凌草二萜类成分差异明显;不同变异类型冬凌草二萜类成分也发生了变化,但没有明显规律性.     

陆地革菌的化学成分研究

从陆地革菌(Thelephora terrestris)子实体中分离得到9个已知化合物,经波谱学分析鉴定为:(22E,24R)-麦角甾-7,22-二烯-3β -醇 (1),(22E, 24R)-麦角甾-7, 22-二烯-3β ,5α,6β -三醇 (2),(22E,24R)-麦角甾-4,6,8(14),22-四烯-3-酮 (3),24-亚甲基羊毛甾-8-烯-3β -醇 (4),熊果酸 (5),木栓酮 (6),cerebroside B (7),(2S,3S,4R,2'R)-2-(2'-羟基二十二碳酰氨基)-十八碳烷-1,3,4-三醇 (8),(2S,3S,4R,2'R)-2-(2'-羟基二十三碳酰氨基)-十八碳烷-1,3,4-三醇 (9)。     

Ent-Kaurene Diterpenoids from Rabdosia eriocalyx

Two new named maoecrystal F(1) and G(2) and seven known ent-kaurene diterpenoids were isolated from the leaves of Rabdosia eriocalyx (Dunn) Hara collected at Xundian County, Yunnan Province, and their structures were determined by spectroscopic analysis. Maoecrystal F and G are elucidated as ent-7α, 15α-dihydrooxyl- lβ,6α-diacetoxyl-7β, 20-epoxy-16-kaurene (1) and ent-7α,15α-dihydroxyl-6α-ace-toxyl-7β, 20-epoxy-16-kaurene(2), respectively.     

Studies on the Diterpenoids of Rabdosia ternifolia

From the whole plant of Rabdosia ternifolia (Labiatae) two diterpeno-ids were isolated. One of them is a new tetracyclic diterpenoids named ternifolin. Bymeans of spectral methods combined wish chemical conversion ternifolin is assigned as6-acetylsodoponin (Ⅲ). The other one is identified as sodoponin (Ⅰ).     

叶穗香茶菜的二萜成分

从云南省中甸县产叶穗香茶菜[Rabdosia phyllostachys(Diels)Hara]叶中分得1个新二萜化合物,命名为叶穗香茶菜乙素(phyllostachysin B),经各项波谱数据确定,叶穗香茶菜乙素为6β,11β,14β—三羟基-15α-乙酰氧基-对映-贝壳杉-16-烯-20 醛-7-酮。另一个为已知化合物叶穗香茶菜甲素(phyllostachysin A)。     

The Chemical Constituents in Dacrydium pierrei

Nine compounds are isolated from the leaves and branches of Dacrydiurn pierrei Hickle for the first time. Comparison of physico-chemical data were assayed by means of spectrometry chemical analysis. They are identified as sotetsuflavone (1), amentoflavone-4', 4'", 7, 7"-tetramethyl-ether (2), trans-communic acid (3), 19- hydroxy-totarol (4), 12-methoxy-dehydro-abietic acid (5), (+) phyllocladene (6), daucosterol(7), β-sitosterol (8), and n-tetratriacontanol (9).