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瘦蛋白(leptin)通过结合瘦蛋白受体,启动信号转导,发挥控制摄食和调节能量代谢等重要神经内分泌调节功能。肥胖症患者血浆瘦蛋白水平普遍升高,存在瘦蛋白抵抗,瘦蛋白抵抗是导致肥胖症的关键因素。本文综述了瘦蛋白信号转导作用及瘦蛋白抵抗可能的机制。 相似文献
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近年来发现一些G蛋白偶联受体(GPCR)能在细胞膜上形成同源或异源双聚体,并证实受体的双聚化为一些有重要生理功能的GPCR在细胞膜上的表达和信号转导的启动所必需,进一步研究表明,一些GPCR的双聚化不仅可以改变受体与配体结合的特异性和亲和力,而且影响GPCR介导的信号转导的调控,这些结果提示,GPCR之间以及GPCR与其它蛋白在细胞膜上的相互作用是调控GPCR转导信号的一个新途径。 相似文献
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生长激素受体(growth hormone receptor,GHR)是细胞因子/造血因子受体超级家族的一员。它通过二聚体的形式和生长激素(growth hormone,GH)相结合,然后诱发Janus激酶2(Janus kinase 2,JAK2)等细胞因子酪氨酸磷酸化并通过4条不同的途径将信号传入细胞内从而产生一系列的生理效应。现在了解GHR的结构特征、组织分布的基础上,对其介导的信号转导途径作进一步的阐明。 相似文献
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细胞因子受体及其介导的信号转导 总被引:1,自引:0,他引:1
细胞因子受体及其介导的信号转导朱锦芳,郑仲承,刘新垣(中国科学院上海生物化学研究所,上海200031)关键词细胞因子,受体,信号转导,Ras-MAPK途径,JAK-STAT途径免疫或造血细胞之间的相互通讯依靠一种可溶性的细胞因子介导。细胞因子包括白细... 相似文献
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干细胞因子及其受体介导的细胞内信号转导 总被引:2,自引:0,他引:2
干细胞因子 (stemcellfactor,SCF)是一种重要的造血因子 ,对正常造血细胞、肥大细胞、黑色素细胞、生殖细胞的增殖和分化以及肿瘤细胞的增殖和恶性演进等起着重要的调节作用。其受体是由原癌基因c kit编码的一种具有酪氨酸激酶活性的跨膜蛋白c Kit,分子量为 1 1 7~ 1 45kD[1] 。c Kit受体由胞外结构域、单一的短跨膜区和胞内结构域三部分组成。SCF与c Kit之间的特异性结合可触发c Kit的同源二聚体化和其细胞膜内酪氨酸残基的磷酸化 ,产生停泊位点 ,捕获含有SH2结构域的信号分子 ,还能直接激活… 相似文献
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细胞因子受体超家族与信号转导 总被引:1,自引:0,他引:1
细胞因子受体超家族及其介导信号转导的新途径已引起人们的广泛注意.主要包括受体结构特征, Janus激酶(JAKs)的作用,信号转导及转录激活因子(STAT)和Ras蛋白的激活,以及细胞因子信号转导的异常与临床疾病的关系等.有助于人们正确认识细胞因子的生物学效应. 相似文献
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G蛋白βγ亚单位介导的信号转导途径 总被引:3,自引:0,他引:3
跨膜信息传递有关的G蛋白由α、β和γ亚单位所组成,受体激动后,引起GTP与α亚单位结合,导致Gα与Gβγ分离。近年来发现Gα、受体本射和许多效应分子如K^+通道、Ga^2+通道、磷脂酶C-β、腺苷酸环化酶、酷氨酸、MAPK和受体激酶等都受Gβγ的调节,Gβγ同Gα一样均可引起效应蛋白的激活,在细胞信号转导中起同样重要作用,共同介导一系列的生物学效应。 相似文献
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Signal transduction by allosteric receptor oligomerization 总被引:41,自引:0,他引:41
J Schlessinger 《Trends in biochemical sciences》1988,13(11):443-447
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To generate an adaptive response from the mammalian immune system requires that antigen bind to cognate receptors on T and B cells, a process which activates intracellular signaling pathways. Crosslinking the B cell antigen receptor (BCR) ultimately activates cell proliferation in both higher and lower vertebrates. Recent studies suggest that many functional components of these intracellular pathways were evolutionarily conserved among the vertebrates. Antibody-mediated crosslinking of surface immunoglobulin leads to tyrosine phosphorylation on presumptive accessory molecules of the teleost BCR as well as several intracellular proteins. Crosslinking the teleost BCR also triggers calcium influx and activation of protein kinase C (PKC) which are hallmark components of the phosphatidyl inositol signal transduction pathway in mammalian lymphocytes. The activation of teleost PKC ultimately generates dually-phosphorylated forms of mitogen activated protein kinase. The latter enzyme is viewed as a key cytoplasmic control point for integrating signals arriving from several kinase/phosphatase pathways in mammalian cells. Preliminary evidence suggests that intracellular signaling mediated through antigen receptor complexes may be very sensitive to external factors, including heavy metals such as mercuric chloride which can alter calcium flux and tyrosine phosphorylation patterns in teleost leukocytes. As the process of lymphocyte activation in teleost fish is better understood, it may be possible to provide aquaculturists, environmental regulators and fisheries managers with better information on those natural and man-made conditions which interfere with the development of protective immune responses in natural and captive finfish populations. 相似文献
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Friedrich Titgemeyer 《Journal of cellular biochemistry》1993,51(1):69-74
Gram-negative bacteria are able to respond chemotactically to carbohydrates which are substrates of the bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS). The mechanism of signal transduction in PTS-mediated chemotaxis is different from the well-studied mechanism involving methyl-accepting chemotaxis proteins (MCPs). In PTS-mediated chemotaxis, carbohydrate transport is required, and phosphorylation seems to be involved in both excitation and adaptation. In this review the roles of the components of the PTS in chemotactic signal transduction are discussed. © 1993 Wiley-Liss, Inc. 相似文献
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Signal transduction by tumor necrosis factor and its relatives 总被引:30,自引:0,他引:30