第四届国际神经科学大会在京都召开

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美国激光医学学会第21届年会简介

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美国实验动物学会第60届年会参感选编

2009年11月5日～11月16日,中国实验动物学会组团参加了美国实验动物学会第60届年会,并参观访问了相关高校和企业。归国后,访问团成员积极向学会提交了此次访问的观感、体会和总结,内容涉及美国实验动物学会和年会的介绍、美国实验动物从业人员的管理和分工情况、美国实验动物福利的情况、相关企业的生产情况以及中关在实验动物工作方面的差距等众多内容。本刊精选了其中一些内容,以供各位科研工作者学习和交流。     

从美国生物物理学会第46届年会看国际生物物理发展趋势

由美国生物物理学会举办的第４６届年会于２００２年２月２３ -２７日在加州旧金山Ｍｏｓｃｏｎｅ会议中心举行 ,来自美国各地和其他国家的６０００余名代表出席了为期３天半的会议 ,与２００１年在波士顿的会议相比 ,参会代表人数增加了约５ %。来自亚洲国家的会议代表也占了相当的比例 ,其中日本代表无论在人数上和论文质量上都远远高于亚洲其他国家。笔者从２１日至２７日全程参加了此次会议 ,深切体会到美国生物物理大会对国际生物物理发展的影响 ,它虽然是一年一度的美国国内会议 ,但其规模远大于三年一届的国际生物物理大会(ＩＵＰＡ…     

了解和恢复生态系统——第87届美国生态学学会年会暨第14届国际恢复生态学大会

第87届美国生态学学会年会暨第14届国际恢复生态学大会于2002年8月4日至9日在美国图森（Tucson）市会议中心召开。这是首次由美国生态学会和国际生态学会两个非常重要的学会共同举办的大型学术会议,盛况空前,有来自26个国家的超过3200人参加了大会。大会共举办了36个专题讨论会,2000多人提供论文并发言;5个墙报专题展,包含900多个墙报展板;另有18个研讨会和晚间19个学术交流会。整个会议的内容涵盖了生态学和恢复生态学研究领域的方方面面。大会还组织了16个主题的野外     

北美古脊椎动物学会第73届年会在美国洛杉矶举行

正北美古脊椎动物学会(Society of Vertebrate Paleontology,SVP)第73届年会于2013年10月30~11月2日在美国加利福尼亚州洛杉矶市顺利召开,来自世界各地的1000余名古脊椎动物学者参加了此次盛会。北美古脊椎动物年会由北美古脊椎动物学会主办,是全球最大的古脊椎动物专题会议,旨在交流与推动全球古脊椎动物学的研究进展。     

北美古脊椎动物学会第71届年会在美国拉斯维加斯举行

<正>北美古脊椎动物学会(Society of Vertebrate Paleontology,SVP)第71届年会于2011年11月2～5日在美国内华达州拉斯维加斯举行,来自世界各地的1300余人参加了此次盛会。     

北美古脊椎动物学会第67届年会在美国德克萨斯州奥斯汀举行

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美国家科学院研究报告建议美军——以神经科学打造“未来士兵”

最近,美国国家科学院下属的一个委员会提出的一份建议美军用神经科学提高战斗力的研究报告引起人们关注。根据这份名为《神经科学在未来军事应用中的机遇》报告,未来作战部队的战斗力不仅取决于其装备和信息化程度,而且与每个士兵的心理承受力、连续作战的抗疲劳能力和排除外界干扰的专注度等密不可分,而这些大都受制于人的神经系统,而借用目前神经科学的研究成果,有可能改善士兵的这些能力。     

Brief history of the Society for Melanoma Research: A community of clinicians,researchers, and friends

To commemorate the 20th Anniversary of the Society of Melanoma Research and the first International Melanoma Research Congress held in June of 2003, we have described in brief, how the Society for Melanoma Research (SMR) began, the purpose, goals, and governance of the SMR, and how the society has evolved to support new melanoma researchers. In celebration of the immense progress in treating melanoma patients over the last 20 years and the impact of the SMR on these advances, we have highlighted memories and insight from early SMR members and founders.     

中国微生物学会微生物资源专业委员会发展历程北大核心

中国微生物学会微生物资源专业委员会成立于2009年,致力于推动微生物资源科研工作的开展,为微生物资源的保护与可持续利用提供技术支撑和战略指导。积极开展各种形式的学术交流、人才培养和国际合作,促进微生物资源领域的创新与发展,推动我国微生物学科的不断进步。随着科技的不断进步和经济的快速发展,微生物资源的研究和利用已成为国际科技领域的重要热点之一。因此,微生物资源专业委员会的建设与发展具有重要意义,将进一步推动我国微生物学科的发展,提高我国在该领域的学术地位和国际竞争力。     

Gray zones around diffuse large B cell lymphoma. Conclusions based on the workshop of the XIV meeting of the European Association for Hematopathology and the Society of Hematopathology in Bordeaux, France

The term “gray-zone” lymphoma has been used to denote a group of lymphomas with overlapping histological, biological, and clinical features between various types of lymphomas. It has been used in the context of Hodgkin lymphomas (HL) and non-Hodgkin lymphomas (NHL), including classical HL (CHL), and primary mediastinal large B cell lymphoma, cases with overlapping features between nodular lymphocyte predominant Hodgkin lymphoma and T-cell/histiocyte-rich large B cell lymphoma, CHL, and Epstein–Barr-virus-positive lymphoproliferative disorders, and peripheral T cell lymphomas simulating CHL. A second group of gray-zone lymphomas includes B cell NHL with intermediate features between diffuse large B cell lymphoma and classical Burkitt lymphoma. In order to review controversial issues in gray-zone lymphomas, a joint Workshop of the European Association for Hematopathology and the Society for Hematopathology was held in Bordeaux, France, in September 2008. The panel members reviewed and discussed 145 submitted cases and reached consensus diagnoses. This Workshop summary is focused on the most controversial aspects of gray-zone lymphomas and describes the panel’s proposals regarding diagnostic criteria, terminology, and new prognostic and diagnostic parameters.     

N-Acetyl-D-glucosamine binding lectins. A model system for the study of binding specificity

Synthetic glycoconjugates prepared by the direct reductive amination of di-N-acetylchitobiose and tetra-N-acetyl-chitotetraose to poly-l-lysine with sodium cyanoborohydride have been used to explore the binding specificities of the lectins wheat germ agglutinin and Bandeiraea simplicifolia II. These conjugates are effective precipitating antigens for these lectins, and hapten inhibition experiments, employing the per-N-acetylated oligomers of chitin as inhibitors, demonstrate that wheat germ agglutinin and Bandeiraea simplicifolia II lectin have binding sites complementary to three and two contiguous β 1,4-linked N-acetyl-d-glucosamine residues, respectively, in agreement with conclusions reached using other methods. Conjugates prepared by this technique should be useful for examining the binding specificities of other lectins, and the results of a study of the effect of chain length of the hapten on the affinity of the lectin for these conjugates should provide guidance in selection of the hapten most appropriate for these studies.     

Inhibition of parathormone-stimulated bone resorption by type I interferon

The effect of Type I interferon on bone resorption was studied by measuring its effect on parathormone-stimulated calcium release from neonatal murine calvaria in vitro. A pure human recombinant leukocyte interferon hybrid of the A and D subtypes was used, which has high antiviral activity on mouse cells. Calcium release was inhibited in a dose dependent fashion with 50% inhibition at about 10(-10) M or 600 U/ml, and the inhibition was reversible. The presence of interferon was required before or during the activation phase of the resorptive response, when the formation of osteoclasts from precursor cells would occur. When added to actively resorbing bone it had no effect. The data suggest that Type I interferon can inhibit the parathormone-regulated development of active osteoclasts, possibly by inhibiting osteoclast precursor differentiation.     

何氏益气养血补肾方治疗气血亏虚型类风湿关节炎并血液系统受累患者的效果分析

摘要 目的：探讨何氏益气养血补肾方治疗气血亏虚型类风湿关节炎并血液系统受累患者的治疗效果。方法：选取我院2020年10月到2022年10月收治的60例气血亏虚型类风湿关节炎并血液系统受累患者作为研究对象,分为观察组与对照组,每组30例。对照组采取常规本病治疗与对症治疗,观察组采取何氏益气养血补肾方与本病治疗,对比两组患者临床疗效,治疗前后中医证候积分变化,血红蛋白（Hb）、白细胞计数（WBC）、超敏C反应蛋白（hsCRP）及血沉（ESR）相关血液指标水平变化,CD4⁺、CD3⁺、CD4⁺/ CD8⁺相关T淋巴细胞亚群水平变化,并应用谷丙转氨酶（ALT）表达水平、谷草转氨酶（AST）评价患者治疗前后肝功能,应用血肌酐（Scr）、尿素氮(BUN)来评价患者肾功能变化。结果：观察组总有效率为93.33%明显高于对照组总有效率86.66%（P<0.05）;治疗后,两组患者神疲乏力、心悸气短、自汗、头晕眼花、怕冷、睡眠障碍相关中医证候积分均降低,且观察组低于对照组（P＜0.05）;治疗后两组患者Hb、WBC升高,观察组较对照组高,ESR、hsCRP降低,且观察组低于对照组（P＜0.05）;治疗后两组患者CD4⁺、CD3⁺和CD4⁺/ CD8⁺数值均升高,且观察组高于对照组（P＜0.05）;治疗后两组患者ALT、AST水平无明显变化,但两组患者SCr、BUN水平降低,观察组低于对照组（P＜0.05）。结论：何氏益气养血补肾方治疗气血亏虚型类风湿关节炎并血液系统受累疗效显著,可改善患者相关中医症状,提升血红蛋白和白细胞计数,提高患者免疫功能,且不对肝肾功能造成损伤,能够轻度提升患者肾功能水平,值得临床应用推广。     

Prognostic impact of definitive local therapy of the primary tumor in men with metastatic prostate cancer at diagnosis: A population-based,propensity score analysis

BackgroundThis study investigated whether definitive local therapy [radical prostatectomy (RP) or brachytherapy (BT)] of the primary tumor improves survival in men with metastatic prostate cancer (PrCA) at diagnosis.MethodsData on newly diagnosed metastatic PrCA cases (stage IV, N = 7858) were obtained from the Surveillance Epidemiology and End Results (SEER) program. Conventional multivariable survival analysis and propensity score analysis were used to estimate hazard ratios (HRs) and corresponding 95% confidence intervals (95% CI) comparing men who underwent definitive local therapy of the primary tumor to those who did not.ResultsAfter adjusting for sociodemographic and tumor attributes, having RP after diagnosis with metastatic PrCA was associated with 73% (HR = 0.27, 95% CI: 0.20–0.38) lower risk of all-cause mortality and 72% (HR = 0.28, 95% CI: 0.20–0.39) reduced risk of death from PrCA. Having BT also was associated with 57% (HR = 0.43, 95% CI: 0.31–0.59) and 54% (HR = 0.46, 95% CI: 0.33–0.64) lower risk of all-cause and PrCA-specific mortality. Similar results were observed in propensity score-adjusted analysis as well as when stratified by age and extent of tumor metastasis.ConclusionsThese findings suggest that definitive local therapy improves survival in men with metastatic PrCA at diagnosis. Future work should consider comorbidities, diet, physical activity and smoking status.