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1.
Dr. S. J. Potolicchio Jr. A. S. Zukerman N. V. Chernigovskaya 《Applied psychophysiology and biofeedback》1979,4(3):211-219
Twenty subjects, aged 17 to 25, were given from 5 to 10 sessions of training in controlling alpha. They were divided into three groups, respectively reinforced for increasing alpha from the central area, reinforced for decreasing alpha from the central area, and given noncontingent reinforcement. Compared with the initial baseline, the alpha of the noncontingent subjects did not change, while those reinforced for increases were reliably higher and those reinforced for decreases reliably lower than the noncontingent group. A slight trend toward improvement during successive sessions was not reliable. Since the experiment was conducted in the Soviet Union, the subjects had no expectations of an “alpha experience.” Although tests showed a slight elevation in mood at the end of the sessions, there were no differences among the groups. There was an increase in reports of fatigue after the training sessions. There were no reports of using visual or somatomotor maneuvers as a means of controlling alpha. Furthermore, alpha rhythm control was not found to be consistently correlated with changes in heart rate, respiration, or mood, as determined by cross-correlation analysis. 相似文献
2.
Is the alpha rhythm a control parameter for brain responses? 总被引:4,自引:0,他引:4
Erol Bas¸ar Juliana Yordanova Vasil Kolev Canan Bas¸ar-Eroglu 《Biological cybernetics》1997,76(6):471-480
The main goal of the present study is to develop a conceptual analysis of alpha response in the brain based on single sweep
evaluation. A new method was employed to estimate a set of single-sweep parameters and quantify the oscillatory behaviour
of single, electroencephalograph (EEG) sweeps. It was aimed to demonstrate that brain alpha responses are governed by spontaneous
alpha activity and to validate the principle of brain response excitability. Because the spontaneous alpha activity depends
on both the topology of recording and the subject’s age, topology and age models were used. Spontaneous and evoked alpha activity
were recorded at frontal and occipital sites in three groups of subjects: 3-year-old children, young adults and middle-aged
subjects. Amplitude, enhancement and phase-locking of single alpha responses to visual stimuli were analysed. Major results
showed that: (1) visual alpha responses could be recorded only if the alpha rhythm was developed in the spontaneous EEG independent
of electrode location; (2) middle-aged adults showed more expressed frontal spontaneous alpha activity in comparison with
young adults; (3) accordingly, alpha responses with higher amplitude and stronger phase-locking were produced over the frontal
brain area in middleaged than young adults. These results validate the principle of brain response excitability and demonstrate
that a shift towards frontal brain areas for both the spontaneous and evoked alpha activity occurs with increasing age in
adults. The results are discussed in the context of the diffuse and distributed alpha system of the brain. Age-dependent changes
in frontal alpha activity are suggested to be related to frontal brain functioning during aging.
Received: 6 November 1995 / Accepted in revised form: 13 March 1997 相似文献
3.
Bark ED Shevelev IA Kulikov MA Kamenkovich VM Pokazan'eva LN 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2005,55(3):336-346
Dynamic study of 3D localization of the equivalent current dipoles (ECD)--sources of the EEG alpha rhythm in the human brain was performed in seven subjects with closed eyes using a one-dipole model. An exact localization of ECDs was obtained by combination of EEG and MRI mapping that allowed tracing of ECD shifts over the cortex with 4 ms step. Our data confirmed localization of these ECDs mainly in the occipital cortex and revealed their successive shift over this area during generation of each alpha-wave. Typical trajectories of these shifts were revealed and quantitatively compared by the hierarchical cluster analysis. The data obtained directly proved periodical rhythmic alpha-wave spreading process in the human visual cortex and an external control of this process. The data are discussed in terms of the "scanning hypothesis" (Pitts W., McCulloch W.H. Bull. Math. Biophys. 1947. V. 9. P. 127) which predicted a certain functional meaning of the alpha activity for cortical processing of sensory information in the human brain. 相似文献
4.
Some characteristics of electroencephalographic reaction (alpha frequency, whole alpha range power spectrum and alpha index) have been studied. In the first series the indifferent single, rhythmic and complex stimuli were presented to the test subjects, in another series a conditioned motor reflex was elaborated, in the third series the test subjects rhythmically reproduced fixed temporal interval. It has been shown that the functional loads lead to higher alpha frequency. The alpha rhythm frequency was higher in subjects verbally underestimating and reproducing intervals with some delay than in ones overestimating intervals and reproducing them in advance. It has been suggested that alpha rhythm instability is due to reorganization processes in neuronal complexes of different lability. 相似文献
5.
Equilibrium maintenance during standing in humans was investigated with a 3-joint (ankle, knee and hip) sagittal model of
body movement. The experimental paradigm consisted of sudden perturbations of humans in quiet stance by backward displacements
of the support platform. Data analysis was performed using eigenvectors of motion equation. The results supported three conclusions.
First, independent feedback control of movements along eigenvectors (eigenmovements) can adequately describe human postural
responses to stance perturbations. This conclusion is consistent with previous observations (Alexandrov et al., 2001b) that
these same eigenmovements are also independently controlled in a feed-forward manner during voluntary upper-trunk bending.
Second, independent feedback control of each eigenmovement is sufficient to provide its stability. Third, the feedback loop
in each eigenmovement can be modeled as a linear visco-elastic spring with delay. Visco-elastic parameters and time-delay
values result from the combined contribution of passive visco-elastic mechanisms and sensory systems of different modalities 相似文献
6.
Dr. Thomas Mulholland Thomas McLaughlin Frank Benson 《Applied psychophysiology and biofeedback》1976,1(4):411-422
The response of the posterior EEG alpha rhythms to visual stimulation is so variable that it is difficult to obtain reliable on-line measurement of it. Feedback between the EEG alpha and the visual stimulus (1) reduces random variation in the response and (2) facilitates on-line quantification. With feedback EEG, the response to visual stimulation is measured as a series of time durations of alpha and of no-alpha intervals in the EEG. This time series occurs in two stages: an initial disturbance followed by a recovery. The quantification of the series of time durations is achieved by fitting curves to the series of alpha time intervals and of no-alpha time intervals. These functions, computed in each trial of 30 stimulations, are an objective, quantitative definition of EEG response. The utility of the method was demonstrated by testing it with reference to well-known effects. Habituation to a repeated stimulus, dishabituation, habituation to a class of stimuli, dishabituation by changing the class of stimuli, and differences among brain-lesioned, psychiatric patients and normals were shown with a detailed quantification. It was concluded that biofeedback is the method of choice for quantitative research on the EEG component of the human orienting response. 相似文献
7.
Erik Peper 《Biological cybernetics》1970,7(3):107-112
Summary Experiments with feedback stimulation triggered from the subject's electroencephalogram result in changing the sequential time series of intervals of occipital alpha and intervals of little or no alpha EEG activity. The rate of recurrence of alpha and no-alpha EEG can be changed by regulating the external feedback stimuli or by asking the subject to change his internal state. Four different paradigms were investigated and the results interpreted in terms of the hypothesis that oculomotor functions regulate the occurrence and nonoccurrence of alpha.This work was supported by NIGMS Grants 5 PO1 GM 14940-04 and GM 15006-03.Most of this research was conducted at the Perception Laboratory, Veterans' Administration Hospital, Bedford, Massachusetts, with the cooperation of Dr. Thomas B. Mulholland. 相似文献
8.
Mobile phones (MP) emit low-level electromagnetic fields that have been reported to affect neural function in humans; however, demonstrations of such effects have not been conclusive. The purpose of the present study was to test one of the strongest findings in the literature; that of increased "alpha" power in response to MP-type radiation. Healthy participants (N = 120) were tested using a double-blind counterbalanced crossover design, with each receiving a 30-min Active and a 30-min Sham Exposure 1 week apart, while electroencephalogram (EEG) data were recorded. Resting alpha power (8-12 Hz) was then derived as a function of time, for periods both during and following exposure. Non-parametric analyses were employed as data could not be normalized. Previous reports of an overall alpha power enhancement during the MP exposure were confirmed (relative to Sham), with this effect larger at ipsilateral than contralateral sites over posterior regions. No overall change to alpha power was observed following exposure cessation; however, there was less alpha power contralateral to the exposure source during this period (relative to ipsilateral). Employing a strong methodology, the current findings support previous research that has reported an effect of MP exposure on EEG alpha power. 相似文献
9.
V M Verkhliutov 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1990,40(5):944-950
Using one-channel SQUID biomagnetometer alpha rhythm was recorded in five healthy men and eight healthy women. Maps of distribution of maximum values of mean MEG amplitudes were analyzed. Most frequently MEG maxima predominated in the parietal parts of the head. Less frequently they were found in the occipital parts. In single instances they could be found in the posterocentral sections and on the midline. In most cases an amplitude interhemispheric asymmetry of extrema was revealed. In men the mean amplitude of the alpha-rhythm predominated more frequently on the left side and in women--on the right one. The map of distribution of mean amplitudes was stable at least during two weeks. Narrow-band filtration allowed to reveal up to three discrete amplitude modes. At definite frequencies the MEG amplitude was continuously stable during several seconds. 相似文献
10.
MARTIN J. R. HALL 《Physiological Entomology》1980,5(3):223-233
ABSTRACT. The proboscis extension response of the blowfly, Protophormia terraenovae (R.-D.), elicited by stimulation of the tarsi with sucrose, was studied behaviourally under LD 12:12. A diel rhythm in responsiveness was found that occurred at successively higher daily mean levels as the test flies became increasingly starved. This rhythm persisted for at least one cycle in constant light, demonstrating it to be truly endogenous and circadian. The tarsal chemo-receptors concerned in initiating the response were examined electrophysiologically in whole fly preparations. No daily change occurred in the response of these receptors to sucrose. Hence central control of the behavioural rhythm of response to sucrose is inferred, and a model is proposed which incorporates a circadian oscillator into the currently accepted model for the control of proboscis extension thresholds. 相似文献
11.
12.
The role of peatlands in the global carbon cycle is confounded by two inconsistencies. First, peatlands have been a large reservoir for carbon sequestered in the past, but may be either net sources or net sinks at present. Second, long-term rates of peat accumulation (and hence carbon sequestration) are surprisingly steady, despite great variability in the short-term rates of peat formation. Here, we present a feedback mechanism that can explain how fine-scale and short-term variability in peat-forming processes is constrained to give steady rates of peat accumulation over longer time-scales. The feedback mechanism depends on a humpbacked relationship between the rate of peat formation and the thickness of the aerobic surface layer (the acrotelm), such that individual microforms (hummocks, lawns, hollows and pools) expand or contract vertically in response to fluctuations in the position of the water table. Hummocks (but not hollows) 'evolve' to a steady state where changes in acrotelm thickness compensate for climate-mediated variations in surface wetness. With long-term growth of a topographically confined peat deposit, the steady state gradually shifts to a thicker acrotelm (i.e. taller hummocks) and lower rates of peat formation and carbon sequestration. 相似文献
13.
Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha 总被引:1,自引:0,他引:1
TAB1, a subunit of the kinase TAK1, was phosphorylated by SAPK2a/p38alpha at Ser423, Thr431 and Ser438 in vitro. TAB1 became phosphorylated at all three sites when cells were exposed to cellular stresses, or stimulated with tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or lipopolysaccharide (LPS). The phosphorylation of Ser423 and Thr431 was prevented if cells were pre-incubated with SB 203580, while the phosphorylation of Ser438 was partially inhibited by PD 184352. Ser423 is the first residue phosphorylated by SAPK2a/p38alpha that is not followed by proline. The activation of TAK1 was enhanced by SB 203580 in LPS-stimulated macrophages, and by proinflammatory cytokines or osmotic shock in epithelial KB cells or embryonic fibroblasts. The activation of TAK1 by TNF-alpha, IL-1 or osmotic shock was also enhanced in embryonic fibroblasts from SAPK2a/p38alpha-deficient mice, while incubation of these cells with SB 203580 had no effect. Our results suggest that TAB1 participates in a SAPK2a/p38alpha-mediated feedback control of TAK1, which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other signalling pathways that lie downstream of TAK1 (JNK and IKK). 相似文献
14.
15.
A. van Rotterdam F. H. Lopes da Silva J. van den Ende M. A. Viergever A. J. Hermans 《Bulletin of mathematical biology》1982,44(2):283-305
A linear spatially distributed model of a chain of neurons and interneurons was investigated in relation to the generation
of propagated alpha rhythmic activity. It was assumed that the elements of the chain were interconnected by means of recurrent
collaterals and inhibitory fibres in such a way that the connectivity functions were assumed to be homogeneous and their strength
was an exponentially decreasing function of distance. It was found that such a neuronal chain shows propagation properties
for frequencies in the alpha band. The results obtained with the model are in agreement with the phase velocities encountered
experimentally. In this way, it was possible to estimate the length of the neural fibres responsible for the phenomenon of
propagated activity. The estimates obtained are in good agreement with recent quantitative neuroanatomical data on the circuitry
of the neocortex. 相似文献
16.
O M Grindel' O B Sazonova S B Zhirov 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1992,42(3):491-499
EEG study was conducted in the state of relative rest in 15 healthy subjects with predominance of the alpha rhythm. Data processing was performed on neuromapper ("Neuroscience", Great Britain). Principal attention was paid to the dynamics of spatial-temporal relations of the alpha rhythm. Cyclic changes were shown of the alpha-rhythm amplitude, proceeding with change of high and low amplitudes during seconds, varying in time in various individuals. Three types of spatial distribution of the alpha rhythm over the cortex at the relative rest were obtained: 1) generalized distribution over the cortex with the wavy shift of the frequency fields; 2) formation of delimited local zones of the alpha rhythm, differing by the frequency from the rhythm in other cortical areas; 3) local zone of the low-frequency alpha rhythm in the visual projection zone (18 and 19 fields). Change of the distribution types of the alpha rhythm in the state of rest takes place in the seconds of time intervals, corresponding, according to the literature data, to the proceeding of elementary mental processes. 相似文献
17.
18.
Feedback control of mitosis in budding yeast. 总被引:158,自引:0,他引:158
We have investigated the feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. We isolated budding yeast mutants sensitive to the anti-microtubule drug benomyl. Mitotic arrest-deficient (mad) mutants are the subclass of benomyl-sensitive mutants in which the completion of mitosis is not delayed in the presence of benomyl and that die as a consequence of their premature exit from mitosis. A number of properties of the mad mutants indicate that they are defective in the feedback control over the exit from mitosis: their killing by benomyl requires passage through mitosis; their benomyl sensitivity can be suppressed by an independent method for delaying the exit from mitosis; they have normal microtubules; and they have increased frequencies of chromosome loss. We cloned MAD2, which encodes a putative calcium-binding protein whose disruption is lethal. We discuss the role of feedback controls in coordinating events in the cell cycle. 相似文献
19.
A novel approach is presented which suggests the use of human metabolic work rate to define and regulate exercise intensity during robotics-assisted treadmill training. The work describes the design and technical validation of the new method.A feedback structure is proposed which provides automatic regulation of metabolic work rate, in conjunction with an embedded feedback loop for volitional control of mechanical work rate. Human metabolic work rate was derived in real time from breath-by-breath measurements of oxygen uptake and carbon dioxide output.The results show that the feedback method provides close to nominal performance for square-wave and ramp reference tracking tasks and that good disturbance rejection properties are obtained. A collateral finding of this work is an estimate of 14.5% of the metabolic efficiency of robotics-assisted treadmill exercise.The use of feedback control of human metabolic work rate provides a direct measure of exercise intensity as perceived by the exercising human as it directly reflects the energy requirements of the working muscles. This complements previous approaches to guiding robotics-assisted treadmill training based on mechanical work rate, heart rate or oxygen uptake. The new approach based on metabolic work rate may have advantages in populations with compromised and widely varying exercise responses. This provides a new approach for driving and controlling active patient participation during robotics-assisted treadmill exercise. 相似文献
20.
A Sarnesto T K?hlin O Hindsgaul K Vogele M Blaszczyk-Thurin J Thurin 《The Journal of biological chemistry》1992,267(4):2745-2752
A beta-N-Acetylglucosaminide alpha 1----3-fucosyltransferase was purified from human serum by ammonium sulfate precipitation, hydrophobic chromatography on phenyl-Sepharose, ion-exchange chromatography on sulfopropyl-Sepharose, affinity chromatography on GDP-hexanolamine-Sepharose, and finally high pressure liquid chromatography gel filtration. Gel filtration chromatography of the native enzyme revealed a Mr of 45,000. Upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis, the purified protein also appeared as a single molecular species of Mr 45,000. In contrast to the multisubunit beta-galactoside alpha 1----2-fucosyltransferases with an apparent Mr of 150,000, present in human serum, the native beta-N-acetylglucosaminide alpha 1----3-fucosyltransferase is a monomer with a Mr of 45,000. The enzyme is glycosylated, as revealed by wheat germ agglutinin binding properties. The alpha 1----3 linkage formed by the enzyme between alpha-L-fucose and the penultimate beta-N-acetylglucosamine by the purified enzyme was confirmed by 1H NMR homonuclear cross-irradiation analysis of the oligosaccharide product. The specificity of the purified enzyme is restricted to type 2 structures, as revealed by its reactivity with different substrates and from the Km values calculated from the initial rate data using various oligosaccharide acceptors. The enzyme has the ability to utilize the N-acetyl-beta-lactosamine determinant (Gal beta 1----4GlcNAc) and the sialylated (NeuAc alpha 2----3Gal beta 1----4GlcNAc) and fucosylated (Fuc alpha 1----2Gal beta 1----4GlcNAc) derivatives of N-acetyl-beta-lactosamine and thus is distinct from both the human Lewis gene-encoded enzyme and the alpha 1----3-fucosyltransferase of the myeloid cell type. 相似文献