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1.
A series of substituted 2-pyrazolines were synthesized, and the steric and electronic effects of substituents on the C3- and C5-positions of the heterocyclic ring on their fluorescent ability were investigated. Two different conjugative intramolecular charge transfer (ICT) and intramolecular charge transfer through space (spiro-conjugation) affect the fluorescence intensity of these compounds. The extent of the ICT process and spiro-conjugation depends on the electronic nature of the additional substitution and its position on the attached aryl rings. In addition, the effects of the concentration and the solvent polarity on the fluorescence emission were studied. Density functional theory (DFT) calculations were carried out to gain insight into the geometric, electronic, and spectroscopic properties of the pyrazoline derivatives. The results of both experimental and computational studies explain the effects of the geometrical orientation of the C3- and C5-aryl rings toward the heterocyclic ring and also the electronic nature of their additional substitutions on the fluorescence intensity. 相似文献
2.
The photophysical properties of some 3-hydroxychromones (3-HC) and 3-hydroxyquinolones (3-HQ) derivatives are investigated in polar and non-polar aprotic solvents using the TDDFT method and the PCM formalism. In acetonitrile and n-hexane, 2–(2-benzothienyl)-3-HC) (BTHC), 2-furyl-3-HQ (FHQ), and 1-methyl-2-furyl-3-HQ (MFHQ) have exhibited dual emission bands due to the excited state intramolecular proton transfer (ESIPT) reaction, leading to a single excited tautomer form. Our results indicate a very high BTHC light absorption efficiency and radiative rate constant. A charge transfer (CT) analysis suggests that the chromone moiety acts as an acceptor group while quinolone moiety acts as an electron donor. In addition, in non-polar n-hexane the furyl group may act as an acceptor, while in polar acetonitrile it may act as an electron donor. The energies of the upper and lower states of the normal form fluorescence have been decreased by the introduction of ortho-methyl group in FHQ. In all states, MFHQ exhibits large distortions of the dihedral angle between the chromone moiety and the furan group in para position. The ESIPT reaction is irreversible for the three derivatives in all cases studied in this work. Since experimental data with n-hexane are not available, results concerning this solvent are only predictions. 相似文献
3.
Ortho-substituted phenyl-N-butyl carbamates (1-9) are characterized as "pseudo-pseudo-substrate" inhibitors of acetylcholinesterase. Since the inhibitors protonate at pH 7.0 buffer solution, the virtual inhibition constants (K'is) of the protonated inhibitors are calculated from the equation, - logK'i = - logKi - logKb. The logarithms of the inhibition constant (Ki), the carbamylation constant (k(c)), and the bimolecular inhibition constant (k(i)) for the enzyme inhibitions by carbamates 1-9 are multiply linearly correlated with the Hammett para-substituent constant (sigma(p)), the Taft-Kutter-Hansch ortho steric constant (E(S)), and the Swan-Lupton ortho polar constant (F). Values of rho, delta, and f for the - logKi-, logk(c)-, and logk(i)-correlations are -0.6, -0.16, 0.7; 0.11, 0.03, -0.3; and - 0.5, - 0.12, 0.4, respectively. The Ki step further divides into two steps: 1) the pre-equilibrium protonation of the inhibitors, Kb step and 2) formation of a negatively charged enzyme-inhibitor Michaelis-Menten complex--virtual inhibition, K'i step. The Ki step has little ortho steric enhancement effect; moreover, the k(c)step is insensitive to the ortho steric effect. The f value of 0.7 for the Ki step indicates that ortho electron-withdrawing substituents of the inhibitors accelerate the inhibition reactions from the ortho polar effect; however, the f value of -0.3 for the k(c)step implies that ortho electron-withdrawing substituents of the inhibitors lessen the inhibition reactions from the ortho polar effect. 相似文献
4.
Bergen A Bohne C Fuentealba D Ihmels H Pace TC Waidelich M Yihwa C Willem Bats J 《Photochemical & photobiological sciences》2012,11(4):752-767
The influence of the substituent of the N-aroylurea functionality on the solvatochromic properties of this class of compounds was investigated with eight examples. The absorption spectra of these compounds exhibit the characteristic spectroscopic properties of the corresponding arene fragment and are only slightly dependent on the solvent. In contrast, all investigated aroylurea derivatives exhibit a strong solvatochromism with a good linear correlation between the emission energy and the acceptor numbers (AN) of the solvents; that is, the emission maximum shifts bathochromically (Δλ = 50-93 nm) with increasing AN. Furthermore, in media with increasing viscosity, as established in glycerol or ethanol solutions with decreasing temperature, the emission maxima are significantly shifted to shorter wavelengths and the full width at half maximum (FWHM) changes. All experimental data point to two emitting states, namely the locally excited (LE) state and the charge-transfer (CT) state. Thus, after initial photoexcitation to the LE state an internal charge transfer (ICT) takes place due to the donor-acceptor interplay between the arene unit and the N-acylureido functionality, mainly assisted by the intramolecular hydrogen bond between the terminal NH group and the aryl-substituted carbonyl functionality, hence interconverting the latter to a stronger acceptor. In the polarized CT state the acylurea unit develops a negative charge, which, after solvent relaxation, is stabilized by solvents with high acceptor number. Time-resolved emission spectroscopy revealed additional conformational changes in the excited state. Two emissive species were identified at room temperature, whose lifetimes depend strongly on the chemical environment. In addition, time-resolved emission spectra (TRES) showed red-shifted emission bands at longer delays after the excitation pulse in polar solvents. These findings are rationalized by the presence of two different emitting rotational conformers. 相似文献
5.
6.
Two novel donor-acceptor-substituted vinyltetrahydropyrene derivatives, 2-N,N-dimethylamino-7-(1-carbethoxyvinyl)-4,5,9,10-tetrahydropyrene, , and 2-N,N-dimethylamino-7-(1,1-dicyanovinyl)-4,5,9,10-tetrahydropyrene, , were synthesized and their photophysical properties investigated in solvents of different polarities. Our studies revealed the existence of intramolecular charge transfer excited states in these molecules. For both compounds the fluorescence maxima exhibited solvent polarity-dependent red shifts. These were quantitatively analysed by the Lippert-Mataga and Liptay equations to obtain the excited state dipole moments. Our results indicated that in the case of , emission takes place from a planar (1)CT state in all non-protic solvents. In the case of , the nature of the excited state depends on the solvent. A fast relaxation to a triplet state is proposed in cyclohexane. The emitting state in medium polar solvents is a planar (1)CT state. In highly polar solvents a twisted (1)CT state is invoked to explain the low fluorescence quantum yield. For both compounds CT nature of the emitting states were further confirmed by studies in acidic medium. The ground and excited state pK(a) values for and were determined using absorption and emission spectral changes observed in the presence of protic acids. 相似文献
7.
Ala PJ Gonneville L Hillman M Becker-Pasha M Yue EW Douty B Wayland B Polam P Crawley ML McLaughlin E Sparks RB Glass B Takvorian A Combs AP Burn TC Hollis GF Wynn R 《The Journal of biological chemistry》2006,281(49):38013-38021
Structural analyses of the protein-tyrosine phosphatase 1B (PTP1B) active site and inhibitor complexes have aided in optimization of a peptide inhibitor containing the novel (S)-isothiazolidinone (IZD) phosphonate mimetic. Potency and permeability were simultaneously improved by replacing the polar peptidic backbone of the inhibitor with nonpeptidic moieties. The C-terminal primary amide was replaced with a benzimidazole ring, which hydrogen bonds to the carboxylate of Asp(48), and the N terminus of the peptide was replaced with an aryl sulfonamide, which hydrogen bonds to Asp(48) and the backbone NH of Arg(47) via a water molecule. Although both substituents retain the favorable hydrogen bonding network of the peptide scaffold, their aryl rings interact weakly with the protein. The aryl ring of benzimidazole is partially solvent exposed and only participates in van der Waals interactions with Phe(182) of the flap. The aryl ring of aryl sulfonamide adopts an unexpected conformation and only participates in intramolecular pi-stacking interactions with the benzimidazole ring. These results explain the flat SAR for substitutions on both rings and the reason why unsubstituted moieties were selected as candidates. Finally, substituents ortho to the IZD heterocycle on the aryl ring of the IZD-phenyl moiety bind in a small narrow site adjacent to the primary phosphate binding pocket. The crystal structure of an o-chloro derivative reveals that chlorine interacts extensively with residues in the small site. The structural insights that have led to the discovery of potent benzimidazole aryl sulfonamide o-substituted derivatives are discussed in detail. 相似文献
8.
Ying Chen Ran Lu WenYan Wang Quan Wang Xiao‐Chun Chi Han‐Zhuang Zhang 《Luminescence》2020,35(4):572-579
Two new difluoroboron β‐carbonyl cyclic ketonate complexes C2B and DC2B were investigated using several spectroscopic methods. Relative to the absorption spectra, the fluorescence spectra were more affected by the polarity of the solvent. Also, compound C2B showed a more pronounced Stokes’ shift after solvent polarity increased. Transient absorption measurements then demonstrated the relaxation behaviour of the excited state compound molecule. The kinetic results showed that the excited state C2B in tetrahydrofuran (THF) can return from the intramolecular charge‐transfer (ICT) state and the initial excited state to the ground state. The kinetic relaxation pathway after THF was replaced by dimethyl sulfoxide became single. When the carbazole unit was introduced, DC2B also exhibited an ICT state but there was no significant difference in the excited state relaxation path after solvent polarity was changed. The results indicated that C2B is more susceptible to solvent polarity regulation. The global fit results revealed that an increase in the solvent polarity prolonged the lifetime of the ICT state of compound C2B and had the opposite effect on compound DC2B. These results provide guidance for understanding the relationship between solvent polarity and the designing and synthesizing advanced compound materials. 相似文献
9.
(-)-Epigallocatechin 3-O-gallate (EGCG) a molecule found in green tea and known for a plethora of bioactive properties is an inhibitor of heat shock protein 90 (HSP90), a protein of interest as a target for cancer and neuroprotection. Determination of the spectral properties of EGCG fluorescence in environments similar to those of binding sites found in proteins provides an important tool to directly study protein-EGCG interactions. The goal of this study is to examine the spectral properties of EGCG fluorescence in an aqueous buffer (AB) at pH=7.0, acetonitrile (AN) (a polar aprotic solvent), dimethylsulfoxide (DMSO) (a polar aprotic solvent), and ethanol (EtOH) (a polar protic solvent). We demonstrate that EGCG is a highly fluorescent molecule when excited at approximately 275 nm with emission maxima between 350 and 400 nm depending on solvent. Another smaller excitation peak was found when EGCG is excited at approximately 235 nm with maximum emission between 340 and 400 nm. We found that the fluorescence intensity (FI) of EGCG in AB at pH=7.0 is significantly quenched, and that it is about 85 times higher in an aprotic solvent DMSO. The Stokes shifts of EGCG fluorescence were determined by solvent polarity. In addition, while the emission maxima of EGCG fluorescence in AB, DMSO, and EtOH follow the Lippert-Mataga equation, its fluorescence in AN points to non-specific solvent effects on EGCG fluorescence. We conclude that significant solvent-dependent changes in both fluorescence intensity and fluorescence emission shifts can be effectively used to distinguish EGCG in aqueous solutions from EGCG in environments of different polarity, and, thus, can be used to study specific EGCG binding to protein binding sites where the environment is often different from aqueous in terms of polarity. 相似文献
10.
M E Kugler-Steigmeier U Friederich U Graf W K Lutz P Maier C Schlatter 《Mutation research》1989,211(2):279-289
Various substituted aniline derivatives were tested for genotoxicity in several short-term tests in order to examine the hypothesis that a substitution at both ortho positions (2,6-disubstitution) could prevent genotoxicity due to steric hindrance of an enzymatic activation to electrophilic intermediates. In the Salmonella/microsome assay, 2,6-dialkylsubstituted anilines and 2,4,6-trimethylaniline (2,4,6-TMA) were weakly mutagenic in strain TA100 when 20% S9 mix was used, although effects were small compared to those of 2,4-dimethylaniline and 2,4,5-trimethylaniline (2,4,5-TMA). In Drosophila melanogaster, however, 2,4,6-TMA and 2,4,6-trichloroaniline (TCA) were mutagenic in the wing spot test at 2-3 times lower doses than 2,4,5-TMA. In the 6-thioguanine resistance test in cultured fibroblasts, 2,4,6-TMA was again mutagenic at lower doses than 2,4,5-TMA. Two methylene-bis-aniline derivatives were also tested with the above methods: 4,4'-methylene-bis-(2-chloroaniline) (MOCA) was moderately genotoxic in all 3 test systems whereas 4,4'-methylene-bis-(2-ethyl-6-methylaniline) (MMEA) showed no genotoxicity at all. DNA binding studies in rats, however, revealed that both MOCA and MMEA produced DNA adducts in the liver at levels typically found for moderately strong genotoxic carcinogens. These results indicate that the predictive value of the in vitro test systems and particularly the Salmonella/microsome assay is inadequate to detect genotoxicity in aromatic amines. Genotoxicity seems to be a general property of aniline derivatives and does not seem to be greatly influenced by substitution at both ortho positions. 相似文献
11.
《Bioorganic chemistry》1986,14(2):119-133
Roseoflavin analogs with a morpholino group or a monoaza-15-crown-5 group at the 8-position [3-methyl-8-morpholino-10-ethylisoalloxazine or 3-methyl-8-(1′,4′,7′,10′-tetraoxa-13′-azacyclopentadec-13′-yl)-10-ethylisoalloxazine (NCrFl), respectively] were synthesized. We have found that the absorption spectra of these roseoflavin analogs are very sensitive to solvent effects: that is, they imparted a red color to polar solvents characteristic of the intramolecular charge transfer from the 8-amino group to the pteridine moiety while they imparted a yellow color to nonpolar solvents characteristic of the inhibition of the charge transfer. The fluorescence spectra were also sensitive to solvent effects: the emission maximum of NCrFl, for example, shifted from 564 nm (water) to 509 nm (benzene) and the fluorescence intensity increased with decreasing solvent polarity. The oxidizing ability, which was estimated by photooxidation of 1-benzyl-1,4-dihydronicotinamide, was well correlated with the absorption maxima: the shorter the maximum wavelength, the more reactive. In particular, the logarithm of the rate constants was linearly correlated with ET. These results strongly suggest that roseoflavin, inactive in polar media, is possibly activated when it is bound to hydrophobic pockets of enzymes and that the color change can be a quantitative measure of the reactivities. 相似文献
12.
Highly fluorescent N-methylanthranilyl (Mantyl) peptide derivatives were prepared by a one-step reaction with N-methylisatoic anhydride (MIA) for quantitative detection in HPLC. Reactions were carried out in an organic medium of acetonitrile-triethylamine, in aqueous alkaline sodium carbonate and sodium phosphate buffers. 4-Dimethylaminopyridine (DMAP) catalyzed specific mantylation of -NH2 groups of peptides in the organic reaction medium. The DMAP had no effect in the aqueous buffered reaction systems. Proline amino-terminal peptides reacted equally well with MIA. Mantyl-bradykinin had excitation and fluorescence maxima at 350 nm and 426 nm in water and water/acetonitrile (ACN)/trifluoroacetic acid (TFA) solvent mixtures, respectively. Fluorescence intensity increased with an increase in ACN concentration and decreased with an increase in acid content. Mantyl kinins were completely resolved on a C18 reversed phase HPLC column using an ACN-0.1% TFA gradient and their behavior on the column was similar to having an extra amino acid. Di-Mantyl derivatives obtained with Lys-BK and Met-Lys-BK did not exhibit fluorescence appreciably higher than Mantyl-BK. Fluorescence detection of Mantyl kinins was about 50-100 times more sensitive (lower limits of 0.1 to 0.5 picomole) than UV detection of the phenylisothiocyanate-derivatized kinins under typical HPLC conditions. 相似文献
13.
Bin Chen Ming-Li Peng Li-Zhu Wu Li-Ping Zhang Chen-Ho Tung 《Photochemical & photobiological sciences》2006,5(10):943-947
The absorption and fluorescence spectra of a Hantzsch 1,4-dihydropyridine derivative bearing a N,N-dimethylaminophenyl group at 4-position (H(2)Py-PhN(CH(3))(2)) in aprotic solvents have been examined and compared to model compounds 4-phenyl- and 4-methyl-substituted Hantzsch 1,4-dihydropyridines (H(2)Py-Ph and H(2)Py-Me). While H(2)Py-Ph and H(2)Py-Me show fluorescence around 420 nm from the local excited state of the dihydropyridine chromophore, H(2)Py-PhN(CH(3))(2) exhibits fluorescence around 520 nm from the intramolecular charge transfer (ICT) state involving the aniline and dihydropyridine groups as donor and acceptor, respectively. Upon addition of an acid to the solution of H(2)Py-PhN(CH(3))(2), the amino group in the aniline is protonated. Thus, the photoinduced intramolecular charge transfer is prevented, and only the fluorescence from the local excited state of the dihydropyridine chromophore can be detected. These changes in the fluorescence behavior are fully reversible: subsequent addition of a base to the acidic solution leads to the recovery of the ICT fluorescence and the quenching of the local fluorescence. Transition metal ions also can switch the fluorescence of H(2)Py-PhN(CH(3))(2). Evidence for the interaction between transition metal ions and the amino group in the dimethylaniline have been provided by absorption and emission spectrum as well as NMR studies. 相似文献
14.
P Dahiya M Kumbhakar D K Maity T Mukherjee J P Mittal A B R Tripathi N Chattopadhyay H Pal 《Photochemical & photobiological sciences》2005,4(1):100-105
The photophysical properties of 2-amino-9,10-anthraquinone (2AAQ) have been investigated in different solvents and solvent mixtures and correlated with the Lippert-Mataga solvent polarity parameter, Deltaf. In the low solvent polarity region with Deltaf < ca. 0.1, the dye shows unusually high fluorescence quantum yields (Phif) and lifetimes (tauf) in comparison to those in other solvents of medium to high polarities. Similarly, the radiative rate constants (kf) are relatively lower and the non-radiative rate constants (knr) are relatively higher in the low polarity solvents in comparison to those in the medium to high polarity solvents. The current results have been rationalized assuming that the dye adopts different structural forms below and above the Deltaf value of approximately 0.1. It is inferred that in the low solvent polarity region the dye exists in a non-planar structure, with its 2-NH2 plane away from that of the 9,10-anthraquinone moiety in the ground state. In solvents of medium to high polarities, the dye exists in a polar intramolecular charge transfer (ICT) structure, where the amino lone pair of the 2-NH2 group is in strong resonance with the anthraquinone pi-cloud in the ground state. In all the solvents, however the dye is inferred to exist in the ICT structure in its excited (S1) state. Supportive evidence for the above hypothesis has been obtained from the solvent polarity effect on the Stokes' shifts for the dye. Quantum chemical studies on the structures of 2AAQ dye in the gas phase also give qualitative support for the inferences drawn from the photophysical properties of the dye in different solvents. 相似文献
15.
Vandorpe J Schacht E Stolnik S Garnett MC Davies MC Illum L Davis SS 《Biotechnology and bioengineering》1996,52(1):89-95
The use of biodegradable derivatives of poly(organo phosphazenes) for the preparation of nanoparticles and their surface modification with the novel poly(ethylene oxide) derivative of poly(organo phosphazene) has been assessed using a range of in vitro characterization methods. The nanoparticles were produced by the precipitation solvent evaporation method from the derivative co-substituted with phenylalanine and glycine ethyl ester side groups. A reduction in particle size to less than 200 nm was achieved by an increase in pH of the preparation medium. The formation (and colloidal stability) of these nanoparticles seems to be controlled by two opposite effects: attractive hydrophobic interactions between phenylalanine ester groups and electrostatic repulsions arising from the carboxyl groups formed due to (partial) hydrolysis of the ester bond(s) at the high pH of the preparation medium. The poly[(glycine ethyl ester)phosphazene] derivative containing 5000-Da poly(ethylene oxide) as 5% of the side groups was used for the surface modification of nanoparticles. Adsorbed onto the particles, the polymer produced a thick coating layer of approximately 35 nm. The coated nanoparticles exhibited reduced surface negative potential and improved colloidal stability toward electrolyte-induced flocculation, relative to the uncoated system. However, the steric stabilization provided was less effective than that of a Poloxamine 908 coating. This difference in effectiveness of the steric stabilization might indicate that, although both the stabilizing polymers possess a 5000-Da poly(ethylene oxide) moiety, there is a difference in the arrangements of these poly(ethylene oxide) chains at the particle surface. (c) 1996 John Wiley & Sons, Inc. 相似文献
16.
Shuning Yu Shaoling Li Zhixin Xie Wei Liu Md. Monarul Islam Carl Redshaw Mei Juan Cao Qing Chen Xing Feng 《Luminescence》2024,39(2):e4594
Three new pyrrolo[3,2-b]pyrrole derivatives containing methoxyphenyl, pyrene or tetraphenylethylene (TPE) units (compounds 1 – 3) have been designed, synthesized and fully characterized. The aggregation-induced emission (AIE) properties of compounds 1 – 3 were tested in different water fraction (fw) of tetrahydrofuran (THF). The pyrrolo[3,2-b]pyrrole derivative 3 containing TPE units exhibited typical AIE features with an enhanced emission (∼32-fold) in the solid state versus in solution; compounds 1 and 2 exhibited an aggregation-caused quenching effect. In addition, the steric and electronic effects of the peripheral moieties on the emission behavior, both in solution and in the solid state, have been investigated. Moreover, pyrrolo[3,2-b]pyrrole 1 exhibits high sensitivity and selectivity for dichloromethane and chloroform solvents, with the system displaying a new emission peak and fast response time under ultraviolet irradiation. 相似文献
17.
Daisuke Kosumi Ritsuko Fujii Mitsuru Sugisaki Naohiro Oka Masahiko Iha Hideki Hashimoto 《Photosynthesis research》2014,121(1):61-68
Fucoxanthin, containing a carbonyl group in conjugation with its polyene backbone, is a naturally occurring pigment in marine organisms and is essential to the photosynthetic light-harvesting function in brown alga and diatom. Fucoxanthin exhibits optical characteristics attributed to an intramolecular charge transfer (ICT) state that arises in polar environments due to the presence of the carbonyl group. In this study, we report the spectroscopic properties of fucoxanthin in methanol (polar and protic solvent) observed by femtosecond pump–probe measurements in the near-infrared region, where transient absorption associated with the optically allowed S2 (11B u + ) state and stimulated emission from the strongly coupled S1/ICT state were observed following one-photon excitation to the S2 state. The results showed that the amplitude of the stimulated emission of the S1/ICT state increased with decreasing excitation energy, demonstrating that the fucoxanthin form associated with the lower energy of the steady-state absorption exhibits stronger ICT character. 相似文献
18.
Malcolm H. Chisholm 《Inorganica chimica acta》2004,357(13):3877-3882
The room temperature electronic absorption spectra of the oxalate bridged MM quadruply bonded complexes [(tBuCO2)3M2]2(μ-O2C2O2), where M = Mo or W have been recorded in H2O, THF:H2O mixtures, THF, CH2Cl2, toluene, DMSO, aniline, toluene saturated with N,N-dimethylaniline and ethanol. The strong absorptions in the visible region of the electronic absorption spectra assignable to the metal-to-ligand (bridge) charge transfer are shown to be highly solvent dependent. Those samples prepared in H2O, CH2Cl2 and toluene are shown to comprise of a suspension of microcrystalline particles ranging in size from 100 nm to 5 μm. Individual particles were found by scanning electron microscopy to have an aspect ratio of ∼10:1, all being needle shaped. The spectra in THF, EtOH, aniline, DMSO and toluene-N,N-dimethylaniline all show similar vibronic progressions and are attributed to discrete solvated molecular species. The spectra recorded in aniline are notably red-shifted which is proposed to arise from a combination of hydrogen bonding and Lewis base stabilization of the photoexcited state. 相似文献
19.
A series of new fluorescent-labeled gangliosides bearing the residues of acids labeled by 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) in the polar or/and apolar moiety were synthesized. These are ganglioside GM1 labeled with the residue of 4,4-difluoro-4-bora-3a,4a-diaza-5,7-dimethyl-s-indacenyl-3-propanoic BODIPY-FL-propanoic) and -indacenyl-5-pentanoic (BODIPY-FL-pentanoic) acid in the oligosaccharide moiety of the molecule, and ganglioside GD1a labeled with two residues of BODIPY-FL-pentanoic acid in the oligosaccharide moiety and also with the residue of BODIPY-FL-pentanoic acid and the residue of 4,4-difluoro-4-bora-3a,4a-diaza-5-octyl-s-indacenyl-5-pentanoic acid in the ceramide part of the molecule. Some spectral characteristics and the behavior in the model membrane systems of the synthesized probes were studied. In their emission spectra, the BODIPY-labeled gangliosides included into phosphatidylcholine liposomes at high concentrations (> 1 mol %) exhibit a long-wavelength maximum (at approximately 630 nm) in addition to the usual maximum (at 510-515 nm). 相似文献
20.
《Inorganica chimica acta》1986,125(3):151-158
Some picket fence porphyrinatocobalt(II) complexes which contain a replaced polar or non-polar group in their fences were newly prepared and characterized, and their oxygen affinities were measured spectrophotometrically. The O2 affinities of the complexes containing a replaced polar group other than amido linkages are appreciably reduced as compared with those of the complexes with a similar non-polar group, regardless of the charge sign of the polarity in the cavity. On the other hand, solvent polarity affects the O2 affinity of the complex with a polar group which is accessible to the coordinated dioxygen molecule, while solvation effects of the corresponding complex without such a group are little. On the basis of these results the relationships between O2 affinity and pocket polarity or solvent polarity are discussed. 相似文献