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1.
E. A. Lutsik 《Neurophysiology》1990,22(2):193-198
The effects of water deprivation were investigated in the pattern of response produced by subiculum stimulation in antidromically identified hypothalamic supraoptic neurosecretory cells of lactating rats. In dehydrated animals as compared with the controls, the percentage of neurons responding to subiculum stimulation with an inhibitory action (blockade of antidromic action potential) remained unchanged, although the proportion of differing inhibitory response did alter: numbers of cells with gradually developing inhibitory response increased significantly and fewer cells showed transitory development of inhibition. Inhibitory response emerging as depression of background spike activity showed a quantitative increase, moreover. Plasticity was found to be one distinguishing feature of afferent input from the subiculum to supraoptic nucleus neurosecretory cells and, in particular, a capacity for reorganization under water deprivation.A. A. Ukhtomskii Institute of Physiology, State University, Leningrad. Translated from Neirofiziologiya, Vol. 22, No. 2, pp. 243–249, March–April, 1990. 相似文献
2.
The effects of subiculum stimulation were investigated in 80 antidromically identified hypothalamic supraoptic neurons in lactating rats. Inhibition manifesting as suppression of antidromic action potentials (or of their somatodendritic component) was revealed in 26% of cells, induced by applying conditioned and test stimuli to the subiculum and neurohypophysial stalk. In some instances inhibition arose following a latency of 5–25 msec after each subicular stimulus and lasted only briefly; it set in gradually in other cases, leading to stable long-term changes in the excitability of neurosecretory cells. No activation was produced by this stimulation. It is deduced that subicular inhibitory inputs follow different patterns, thus reflecting morphological organizational aspects of synaptic inhibitory inputs to neurosecretory cells.A. A. Ukhtomskii, Institute of Physiology, A. A. Zhdanov State University, Leningrad. Translated from Neirofiziologiya, Vol. 20, No. 4, pp. 431–437, July–August, 1988. 相似文献
3.
N. V. Popovichenko L. L. Chebotareva G. M. Pivnenko Yu. M. Pelevin 《Neurophysiology》1977,9(2):118-125
Bilateral electrolytic destruction of the paramedian zones of the caudal part of the tegmentum mesencephali caused an increase in the number of neurosecretory cells with low functional activity and the appearance of degenerating forms in the supraoptic nucleus of the hypothalamus (mainly in the medial part of the nucleus, adjacent to the optic chiasma); destruction of individual Herring's bodies was observed in the posterior lobe of the pituitary. The subnormal content of neurosecretory substance in all parts of the supraoptico-hypophyseal neurosecretory system was matched by a low plasma level of vasopressin-antidiuretic hormone. In animals with destructive lesions in the tegmentum mesencephali exposure to nociceptive stimulation activated mainly the neurosecretory cells in the lateral part of the supraoptic nucleus; the loss of neurosecretion from the posterior pituitary was partial; the plasma neurohormone level was much lower than in the control animals after nociceptive stimulation. It is postulated that changes in the response of the supraoptico-hypophyseal system to stress were probably the result of interruption of afferent pathways to the hypothalamus from the tegmentum mesencephali. The result of these experiments suggest that the paramedian zones of the tectum mesencephali exert a modulating influence on the function of this system during stress.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 9, No. 2, pp. 157–164, March–April, 1977. 相似文献
4.
Characteristics of antidromic action potentials of neurons of the paraventricular and supraoptic nuclei of the rat hypothalamus were studied during stimulation of the hypothalamo-hypophyseal tract by stimuli of varied amplitude and frequency. Step-like changes were found in spike latency in response to an increase in strength (up to 1.5–2.5 thresholds) or frequency (over 100 Hz) of stimulation, as well as cases with variation of the degree of division of the peak into A and B components. Injection of leu-enkephalin analog into the third ventricle or intravenous injection of NaCl solution (1 M) caused reversible changes in the level of excitability of antidromically activated neurons: leu-enkephalin mainly increased the latent period and threshold of action potential generation and reduced the reproducible frequency of stimulation to 10 Hz, whereas NaCl had the opposite effect. The results indicate that when the adopted criteria of antidromic identification of neurosecretory cells are used the level of their excitability must be taken into account.A. A. Ukhtomskii Physiological Research Institute, A. A. Zhdanov Leningrad State University. Translated from Neirofiziologiya, Vol. 14, No. 6, pp. 585–591, November–December, 1982. 相似文献
5.
The response of neurons of different hypothalamic structures to stimulation of painful tooth pulp afferents and painless sciatic nerve Aß afferents was investigated during acute experiments on cats. It was found that 80.7%, 81.5%, and 71.4% of neurons of the posterior, tuberal, and anterior hypothalamus respectively, responded to stimulation of the tooth pulp. Shortest latency of response was recorded in the posterolateral hypothalamus. Latency of response was shorter in the lateral than in the medial structures throughout the hypothalamus. A distinct prevalence of excitatory response was found in neurons of the posterior area and an almost equal proportion of excitatory and inhibitory response in neurons of the tuberal and anterior hypothalamus. A high degree of convergence between noxious and nonnoxious somatic afferents were discovered in hypothalamic neurons: 85.8% of those studied responded to stimulation of the sciatic nerve Aß afferents. The comparable unidirectional response pattern of hypothalamic neurons to stimulation of tooth pump painful afferents and painless sciatic nerve Aß fibers point to the nonspecific nature of the response observed in the mainstream population of multisensory hypothalamic neurons. A small population of unimodal nociceptive neurons (14.2%) was found in the hypothalamus. Nociceptive responses of anterior hypothalamic neurons were distinguished by their long refractory phase, lasting 200–500 msec, and their low rate of reproduction during rhythmic stimulation of tooth pulp (1.5–2 Hz). Neuronal organization of the nociceptive hypothalamic afferent system is discussed together with the role of convergent and specific "nociceptive" neurons in the shaping of thalamic regulatory functions.L. A. Orbeli Institute of Physiology, Academy of Sciences of the Armenian SSR, Erevan. Translated from Neirofiziologiya, Vol. 18, No. 2, pp. 171–180, March–April, 1986. 相似文献
6.
Summary The distribution pattern of CPP-containing neurons and fibers in the human pituitary and hypothalamus was studied with a specific antiserum to human CPP and the unlabeled antibody technique. Immunoreactive CPP was found in the magnocellular neurons of the supraoptic nucleus (SON), the paraventricular nucleus (PVN) and in neurons scattered in the supraoptic hypophyseal tract. CPP-containing parvocellular neurons were found in the suprachiasmatic nucleus (SCN). The CPP-containing fibers from the magnocellular neurons formed a tract coursing through the median eminence and the pituitary stalk to the posterior lobe of the hypophysis. In contrast, no such fibers from the SCN projected to SON, PVN and the median eminence. This pattern is identical to that of vasopressin and its associated neurophysin-containing neurons and fibers and strongly supports the concept that CPP is a part of the common precursor for vasopressin and neurophysin II. The biological importance of human CPP other than being a precursor fragment remains to be elucidated.To whom requests for reprints should be addressed 相似文献
7.
Neuronal response in the cat association cortex (area 5) to conditioned and non-conditioned acoustic stimulation was investigated. Numbers of neurons responding to a conditioned acoustic stimulus according to the traditional reflex pattern were twice as high. Numbers of inhibitory neuronal responses to the stimulus increased when instrumental reflex occurred. Neurons were found which only reacted to a conditioned acoustic stimulus in the absence of conditioned reflex movement occurring with instrumental food reflex. Although findings do not exclude the possibility of this cortical area contributing to the analysis of sensory signals and evaluation of their biological significance, it might be supposed that its main functional property lies in its involvement in the process of initiating behavioral response to a conditioned response.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 20, No. 5, pp. 637–645, September–October, 1988. 相似文献
8.
During acute experiments on awake cats the response of 98 neurons belonging to the head and tail of the caudate nucleus to direct electrical stimulation of the optic tract and presentation of photic stimuli was investigated using extracellular recording techniques. Of the test neurons 34.6% responded to stimulation of the optic tract and 36.2% to optic stimulation. Long latency (over 40 msec for the optic tract and over 80 msec for visual stimulation) excitatory responses prevailed in both cases. A small number of cells responded to optic tract stimulation with short latencies of 5–14 msec. Both types of stimulation were presented during investigations of 58 units of which eight were found to respond to both stimuli. The latter varied in their reaction to different stimuli and their response pattern. Findings are discussed in relation to the possible pathways by which visual information reaches the cortical structure under study.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 18, No. 4, pp. 476–485, July–August, 1986. 相似文献
9.
E. A. Vashchenko 《Neurophysiology》1971,3(4):294-299
The functional activity of the neurosecretory cells in the supraoptic and paraventricular nuclei was studied in male Wistar albino rats at various intervals after electric stimulation of the midbrain reticular formation. These studies showed that such stimulation elicits higher functional activity of the neurosecretory cells in the anterior hypothalamic nuclei, characterized by increased secretory synthesis by these cells and rapid transport of the neurosecretion. These changes were most pronounced 1 h after stimulation of the reticular formation. The changes observed were unidirectional in both neurosecretory centers, but their manifestation was different: in the supraoptic nucleus the reaction was more intense but short lived, in the paraventricular it was less intense but lasted longer.A. A. Bogomolets Institute of Physiology, Academy of Sciences, Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 3, No. 4, pp. 394–400, July–August, 1971. 相似文献
10.
Spike response to unconditioned electrocutaneous stimulation was investigated in cortical neurons of areas 3 and 4 in untrained hungry cats during heightened excitation motivated by food presentation and when at rest. This reinforcement led to changed background activity level, reduced intensity of the initial stages of spike response, and disappearance of late neuronal response. Neuronal response of the same cortical area to a conditioned stimulus (a clicking sound) during reduced food motivation (the animals being sated during the course of the experiment) was also studied under the effects of instrumental feeding reflex. Coordination between the timing of neuronal response and their corresponding movements was discovered from comparing response pattern accompanying the execution of paw-placing (conditioned reflex and intersignal) movements and those recorded at different levels of food-induced excitation, as well as a similarity between these reactions. It was found that the initial stages of neuronal response to a conditioned signal only occurred during contraction of the brachial biceps muscle, while coordination between their timing and that of EMG changes was dependent on the animal's degree of satiation. Findings indicate the possibility of food-induced excitation substantially influencing spike response pattern in somatic cortex neurons.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 19, No. 6, pp. 725–735, November–December, 1987. 相似文献
11.
Evoked potential (EPs) and responses of the medial (MPO) and lateral (LPO) preoptic region (RPO) and adjacent structures of the hypothalamus to stimulation of the prefrontal (area 8) and cingulate (area 24) cortex, piriform lobe (periamygdaloid cortex), and hippocampus (area CA3) were investigated in acute experiments on cats under ketamine anesthesia. The most pronounced EPs were observed in the RPO after stimulating the piriform and cingulate cortex. A close relation was found between neuronal responses and EP components. The majority of neurons responding to stimulation of various cortical structures were localized in the LPO, where primarily excitatory responses dominate. The MPO contained somewhat fewer neurons responding to cortical stimulation, and the dominant response here was primarily inhibitory. The ratio of inhibitory and excitatory responses in the LPO was 0.6:1 and in the MPO 5.8:1. Primarily in-inhibitory responses dominated also in the LPO zone adjacent to the bed nucleus stria terminalis (BST) and primarily excitatory in the region surrounding the supraoptic nucleus (SO) (respective ratios 4.9:1 and 0.7:1). The RPO is a broad convergence zone, where 3/4 of the neurons responded to stimuli of two and more cortical regions.A. M. Gorky Medical Institute, Ukrainian Minstry of Health, Donetsk. Translated from Neirofiziologiya, Vol. 23, No. 6, pp. 709–719, November–December, 1991. 相似文献
12.
13.
The response pattern of reticulo-spinal (RS) neurons in two reticulo-spinal structures (n. reticularus pontis caudalis and n. reticularis gigantocellularis) to both electrical (somatic) nerve stimulation and natural mechanical innocuous (tapping with varying force) and noxious (pinch and prick) stimulation were investigated in chloralose-anesthetized cats. Bulbar and pontine neurons were found to vary considerably in their sensory characteristics: of the former 43% were activated only by high-threshold electrical nerve stimulation and noxious stimuli, while the remainder responded to innocuous stimuli as well. In the case of pontine neurons 81% produced a response to stimulation of low-threshold nerve fibers, and to innocuous as well as noxious stimuli. A relationship was found between the sensory characteristics of reticulo-spinal neurons and their axon conductance velocities. Various aspects and the likely functional significance of specialization in brainstem neurons of the pontine and bulbar reticular formation come under discussion.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 18, No. 4, pp. 461–469, July–August, 1986. 相似文献
14.
Maghnie M 《Hormone research》2003,59(Z1):42-54
Diabetes insipidus is a heterogeneous condition characterized by polyuria and polydipsia caused by a lack of secretion of vasopressin, its physiological suppression following excessive water intake, or kidney resistance to its action. In many patients, it is caused by the destruction or degeneration of the neurons that originate in the supraoptic and paraventricular nuclei of the hypothalamus. Known causes of these lesions include: germinoma or craniopharyngioma; Langerhans cell histiocytosis and sarcoidosis of the central nervous system; local inflammatory, autoimmune or vascular diseases; trauma following surgery or accident; and, rarely, genetic defects in vasopressin biosynthesis inherited as autosomal dominant or X-linked recessive traits. Thirty to fifty percent of cases are considered idiopathic. Magnetic resonance imaging (MRI) allows identification of the posterior pituitary hyperintensity and of hypothalamic-pituitary abnormalities. Thickening of the pituitary stalk is the second most common finding on MRI scans in several local inflammatory pathologies and autoimmune diseases or germinoma, but it is not specific to any single subtype. A progressive increase in the size of the anterior pituitary gland should alert physicians to the possibility that a germinoma is present, whereas a decrease can suggest the presence of an inflammatory or autoimmune process. Most children with acquired central diabetes insipidus and a thickened pituitary stalk have anterior pituitary hormone deficiencies during follow-up. Biopsy of enlarged pituitary stalk should be reserved for patients with a hypothalamic-pituitary mass and progressive thickening of the pituitary stalk, since spontaneous recovery may occur. 相似文献
15.
M. Ya. Voloshin 《Neurophysiology》1970,2(1):57-61
In acute experiments in rabbits immobilized by d-tubocurarine, stimulation of the entorhinal area with rectangular electric impulses led to the appearance of evoked potentials (EP) with a latent period of 6–12 msec in the occipital, temporal, parietal, and cingular areas of the neocortex. The amplitude of the positive response component was 500 µV, and its duration 25–50 msec. The negative component was not always discernible. When rhythmic stimulation was used, these EPs followed stimulation frequencies not exceeding 20 per sec. Stimulation of the medial parts of the entorhinal area with a frequency of one to three per sec was accompanied by recruitment of the EP in the occipital and temporal neocortex areas. Nembutal depressed the amplitude of the neocortex EP appearing in response to stimulation of the entorhinal cortex. With the aid of double stimulation it could be established that, after conditioning stimulation of the entorhinal area, the positive component of the primary response (PR) evoked by stimulation of the contralateral sciatic nerve in the projection zone of the somatosensory cortex is strengthened during the first 50 msec, and subsequently after 80–120 msec. In these cases, the negative component was depressed. These findings are discussed with a view to the influence of limbic structures on the neocortex.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 2, No. 1, pp. 73–78, January–February, 1970. 相似文献
16.
Xiao-Chen Huang 《International journal of biometeorology》1993,37(4):222-228
The febrile response and sympathetic nervous response to hypothalamic microinjections of prostaglandin E2 (PGE2) were investigated in anesthetized rabbits. Microninjection of PGE2 (500–1000 ng) caused an increase in rectal temperature of more than 0.3°C in 13 of 50 loci in the preoptic and anterior hypothalamic area (PO/AH). At 8 of these 13 loci, PGE2 elicited response patterns in the sympathetic nervous system, such as an increase in cutaneous sympathetic nervous activity and decrease in renal sympathetic nervous activity. This pattern of sympathetic nervous responses was induced with a simultaneous increase in rectal temperature of more than 0.5°C. The 8 loci were distributed in the preoptic area, especially in the vicinity of the supraoptic nucleus. Electrolytic lesions of this region were made bilaterally, and intracerebroventricular injection of PGE2 (8 µg/kg) was found to inhibit fever and sympathetic activity. The results demonstrate that the action of PGE2 is responsible for the response patterns of sympathetic twigs during fever. The preoptic area, especially in the vicinity of the supraoptic nucleus, is most sensitive to PGE2 for the patternized response of sympathetic neurons and fever. 相似文献
17.
Mona Castel 《Cell and tissue research》1972,131(4):545-557
Summary The ultrastructure of the pars intermedia of Rana catesbeiana tadpoles was studied following isolation from the hypothalamus, in vivo after sectioning of the pituitary stalk, and in vitro after implantation of the pituitary into a piece of tail fin. Both experimental procedures were followed by rapid and sustained skin darkening. Pituitaries from normal light and dark adapted tadpoles served as controls.In 4-hour disinhibited glands, melanotrophs revealed hyperactive Golgi bodies, colloid vesicles (1–2 microns) in close proximity to axon terminals, and no apparent loss of secretory granules. At 24 hours extracellular colloid adjacent to axon terminals was found, and extensive arrays of RER appeared in the melanotrophs. Obvious granule loss from secretory cells occurred within a week, by which time the cytoplasm was occupied by large cisterns of SER and RER and abundant free ribosomes. Dense core vesicles (600–900 Å) in aminergic nerve terminals disappeared shortly after isolation of the pituitary from the hypothalamus, and only decreasing numbers of translucent vesicles (200–300 Å) were found.The functional significance of these changes is discussed, with particular emphasis on the mode of acute hormone release.This study was carried out in the Department of Anatomy, Albert Einstein College of Medicine, New York. I am greatly indebted to Professor Berta Scharrer and Professor William Etkin for their sponsorship, guidance and encouragement. Warm thanks are due to Mrs. Sarah Wurzelmann and Mr. Stanley Brown for their technical assistance. Support from U.S.P.H.S. grants NIH-NB 00840, NIH R01 Am 3984 and NSF Grant 12353 is gratefully acknowledged. 相似文献
18.
V. M. Shaban 《Neurophysiology》1975,7(6):455-460
Unit responses in area 17 of the visual cortex to stimulation of the lateral geniculate body and optic tract were studied in experiments on unanesthetized cats immobilized with D-tubocurarine. Of the neurons tested, 53.6% responded to stimulation of the lateral geniculate body. In 92% of these cells the responses were orthodromic with latent periods of between 2 and 12.5 msec. Most cells responded with latent periods of 2.0–2.5, 3.0–3.5, and 4.0–4.5 msec, corresponding to latent periods of the components of the electropositive wave of the primary response. Antidromic responses to stimulation of the lateral geniculate body were given by 8% of neurons. The difference between the latent periods of responses of the same visual cortical neurons to stimulation of the optic tract and lateral geniculate body was 0.1–1.8 msec, but for most neurons (55.8%) it was 0.5–1 msec. The histograms of response latencies of visual cortical neurons to stimulation of the above-mentioned formations were found to be similar. It is concluded that the optic radiation contains three principal groups of fibers with conduction velocities of 28.5–16.6, 11.7–8.9, and 7.4–6.0 m/sec, respectively.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 7, No. 6, pp. 589–596, November–December, 1975. 相似文献
19.
B. P. Kolomiets 《Neurophysiology》1985,17(5):444-450
During chronic experiments on unanesthetized cats neuronal response in the caudate nucleus to the presentation of local photic stimuli and electrical stimulation of the specific (field 17) and the association (Clare-Bishop) areas were compared. Stimulation of the Clare-Bishop area proved more effective than stimulating field 17 for neurons of the caudate nucleus; a response was produced in 47% of test neurons in comparison with 8% of units only in the specific area. Lower average values were observed for latency of neuronal response to stimulation of the Clare-Bishop area. An insignificant number of caudate nucleus neurons were activated as a result of stimulation of both cortical areas. A comparison between the response of one set of neurons to electrical cortical and visual stimulation showed that cells responding to visual stimulation were more highly activated by stimulating the Clare-Bishop area than by stimulation of field 17. This type of neuron predominated in the caudate nucleus. A discussion follows of the possible involvement of the Clare-Bishop area in shaping neuronal response to visual stimulation.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 17, No. 5, pp. 619–627, September–October, 1985. 相似文献
20.
R. Alvarez-Buylla B. G. Livett L. O. Uttenthal D. B. Hope S. H. Milton 《Cell and tissue research》1973,137(4):435-450
Summary 1. An immunohistochemical study has been made of the hypothalamo-neurohypophyseal system of the dog, 20h after crushing the pituitary stalk.2. By use of a cross-species-reactive neurophysin antiserum it was shown that neurophysin is a component of the axons which originate in the supraoptic and paraventricular nuclei and terminate around blood vessels in the posterior pituitary.3. Neurophysin specific fluorescence accumulated in axons proximal to the constriction but was absent from the axons immediately distal to the site of injury.4. In dogs left for six days it was shown by radioimmunoassay that the amount of neurophysin in the hypothalamus and stalk proximal to the constriction increased twofold while that remaining in the posterior pituitary and stalk distal to the constriction decreased five-fold over the same period.5. The results are interpreted as evidence for a rapid axonal transport of neurophysin from its site of synthesis in the cell bodies of the hypothalamus to the posterior pituitary.
Acknowledgements: This work was supported by a research grant to D. B. Hope from the Medical Research Council. L. O. Uttenthal was supported by a Medical Research Training Award and B. G. Livett by a Nuffield Dominions Trust Demonstratorship (Australia). We thank Mrs. Marion Martin for radioimmunoassay of neurophysin, Miss Wendy Jones for technical assistance and the U.C.L.A. Brain Information Service for help with the bibliography. 相似文献