Predicting dynamic postural instability using center of mass time-to-contact information

Our purpose was to determine whether spatiotemporal measures of center of mass motion relative to the base of support boundary could predict stepping strategies after upper-body postural perturbations in humans. We expected that inclusion of center of mass acceleration in such time-to-contact (TtC) calculations would give better predictions and more advanced warning of perturbation severity. TtC measures were compared with traditional postural variables, which do not consider support boundaries, and with an inverted pendulum model of dynamic stability developed by Hof et al. [2005. The condition for dynamic stability. Journal of Biomechanics 38, 1-8]. A pendulum was used to deliver sequentially increasing perturbations to 10 young adults, who were strapped to a wooden backboard that constrained motion to sagittal-plane rotation about the ankle joint. Subjects were instructed to resist the perturbations, stepping only if necessary to prevent a fall. Peak center of mass and center of pressure velocity and acceleration demonstrated linear increases with postural challenge. In contrast, boundary-relevant minimum TtC values decreased nonlinearly with postural challenge, enabling prediction of stepping responses using quadratic equations. When TtC calculations incorporated center of mass acceleration, the quadratic fits were better and gave more accurate predictions of the TtC values that would trigger stepping responses. In addition, TtC minima occurred earlier with acceleration inclusion, giving more advanced warning of perturbation severity. Our results were in agreement with TtC predictions based on Hof's model, and suggest that TtC may function as a control parameter, influencing the postural control system's decision to transition from a stationary base of support to a stepping strategy.     

Dynamic postural stability during advancing pregnancy

Pregnant women are at an increased risk of experiencing a fall. Numerous anatomical, physiological, and hormonal alterations occur during pregnancy, but the influence of these factors on dynamic postural stability has not been explored. The purpose of this study was to examine dynamic postural stability in pregnant women during their second and third trimesters as well as in a group of non-pregnant control women.MethodsEighty-one women (41 pregnant, 40 controls) participated stood on a force plate that translated anteroposteriorly at small, medium, and large magnitudes. Reaction time and center of pressure (COP) movement during the translations were analyzed. Trimester, perturbation direction, and perturbation magnitude were the independent variables in a mixed-model analysis of variance on each of the following dependent variables: reaction time, initial sway, total sway, and sway velocity.ResultsReaction time to the perturbation was not significantly different between the groups. Initial sway, total sway, and sway velocity were significantly less during the third trimester than during the second trimester and when compared to the non-pregnant controls (P<0.05). No differences were found in any of the measures between the pregnant women in their second trimesters and the control group.ConclusionAlterations in sway responses to perturbations are seen in the third trimester in healthy women with uncomplicated pregnancies. Further study is needed to examine the biomechanical and physiological reasons behind this altered dynamic postural stability.     

Plantar hypoesthesia alters time-to-boundary measures of postural control

Our purpose was to identify the effect of diminished plantar cutaneous sensation on time-to-boundary (TTB) measures of postural control during double and single limb quiet standing. Thirty-two healthy young adults underwent 10 min of ice immersion of the plantar aspect of the feet prior to balance testing. On a different day, the subjects did not receive this intervention prior to testing. A 2 × 2 vision (eyes open, eyes closed) by sensation (control, hypoesthesia) repeated measures design was used to analyze the TTB measures. In double limb stance, there were significant interactions between sensation and vision for the absolute TTB minimum and the mean of TTB minima in the anteroposterior (AP) direction. There was a significant increase in both measures after sensation was diminished with eyes closed compared to the control, but not with eyes open. In single limb stance, the TTB absolute minimum, the mean of TTB minima in the AP direction, and the standard deviation of TTB minima significantly increased with hypoesthesia regardless of vision. No significant differences were found in the medial–lateral (ML) direction for any of the TTB measures in double or single limb stance. Sensory information from the plantar cutaneous receptors appears to be most important in the maintenance of AP postural control.     

Plantar hypoesthesia alters time-to-boundary measures of postural control

Our purpose was to identify the effect of diminished plantar cutaneous sensation on time-to-boundary (TTB) measures of postural control during double and single limb quiet standing. Thirty-two healthy young adults underwent 10 min of ice immersion of the plantar aspect of the feet prior to balance testing. On a different day, the subjects did not receive this intervention prior to testing. A 2 x 2 vision (eyes open, eyes closed) by sensation (control, hypoesthesia) repeated measures design was used to analyze the TTB measures. In double limb stance, there were significant interactions between sensation and vision for the absolute TTB minimum and the mean of TTB minima in the anteroposterior (AP) direction. There was a significant increase in both measures after sensation was diminished with eyes closed compared to the control, but not with eyes open. In single limb stance, the TTB absolute minimum, the mean of TTB minima in the AP direction, and the standard deviation of TTB minima significantly increased with hypoesthesia regardless of vision. No significant differences were found in the medial-lateral (ML) direction for any of the TTB measures in double or single limb stance. Sensory information from the plantar cutaneous receptors appears to be most important in the maintenance of AP postural control.     

Factors affecting postural stability of healthy young adults

The objective of this paper was to examine the relationship between body balancing functions and body characteristics, motor abilities and reaction time. Subjects were 33 university students and 11 professional basketball players sorted into four groups of athletic and non-athletic women and men. Each group consisted of eleven subjects. The body height, weight was measured and the body mass index (BMI) calculated. A bioelectrical device computed the body fat (%). Static and dynamic motor tests, as well as static and dynamic balance tests were used. The reaction time (RT) to sound and light stimuli was measured. The regression analysis of the data revealed significant linear relationship between the amplitude of body sways (BS) and BMI in all groups. Also high correlation was found between back muscle strength and BS in all groups except the non-athletic women. Negative correlation was found between endurance capacity and BS in basketball players, i.e. at higher endurance capacity smaller amplitude BS occurred (r = -0.620, p < 0.04). The RT values showed significant correlations with BS only in the basketball players (r = 0.620, p < 0.04). It is concluded that increase in BMI, back muscle strength and endurance capacity is associated with better postural stability. Some motor abilities (hip flexibility, vertical jumping) show no significant correlations with body balancing, while other motor performances (static hanging) and RT values correlate well with BS only in the well-trained elite basketball players.     

Time-to-boundary measures of postural control during single leg quiet standing

A novel approach to quantifying postural stability in single leg stance is assessment of time-to-boundary (TTB) of center of pressure (COP) excursions. TTB measures estimate the time required for the COP to reach the boundary of the base of support if it were to continue on its instantaneous trajectory and velocity, thus quantifying the spatiotemporal characteristics of postural control. Our purposes were to examine: (a) the intrasession reliability of TTB and traditional COP-based measures of postural control, and (b) the correlations between these measures. Twenty-four young women completed three 10-second trials of single-limb quiet standing on each limb. Traditional measures included mean velocity, standard deviation, and range of mediolateral (ML) and anterior-posterior (AP) COP excursions. TTB variables were the absolute minimum, mean of minimum samples, and standard deviation of minimum samples in the ML and AP directions. The intrasession reliability of TTB measures was comparable to traditional COP based measures. Correlations between TTB and traditional COP based measures were weaker than those within each category of measures, indicating that TTB measures capture different aspects of postural control than traditional measures. TTB measures provide a unique method of assessing spatiotemporal characteristics of postural control during single limb stance.     

Reduction of neuromuscular redundancy for postural force generation using an intrinsic stability criterion

Postural control requires the coordination of multiple muscles to achieve both endpoint force production and postural stability. Multiple muscle activation patterns can produce the required force for standing, but the mechanical stability associated with any given pattern may vary, and has implications for the degree of delayed neural feedback necessary for postural stability. We hypothesized that muscular redundancy is reduced when muscle activation patterns are chosen with respect to intrinsic musculoskeletal stability as well as endpoint force production. We used a three-dimensional musculoskeletal model of the cat hindlimb with 31 muscles to determine the possible contributions of intrinsic muscle properties to limb stability during isometric force generation. Using dynamic stability analysis we demonstrate that within the large set of activation patterns that satisfy the force requirement for posture, only a reduced subset produce a mechanically stable limb configuration. Greater stability in the frontal-plane suggests that neural control mechanisms are more highly active for sagittal-plane and for ankle joint control. Even when the limb was unstable, the time-constants of instability were sufficiently great to allow long-latency neural feedback mechanisms to intervene, which may be preferential for movements requiring maneuverability versus stability. Local joint stiffness of muscles was determined by the stabilizing or destabilizing effects of moment-arm versus joint angle relationships. By preferentially activating muscles with high local stiffness, muscle activation patterns with feedforward stabilizing properties could be selected. Such a strategy may increase intrinsic postural stability without co-contraction, and may be useful criteria in the force-sharing problem.     

A graph theoretical approach for assessing bio-macromolecular complex structural stability

Fast and proper assessment of bio macro-molecular complex structural rigidity as a measure of structural stability can be useful in systematic studies to predict molecular function, and can also enable the design of rapid scoring functions to rank automatically generated bio-molecular complexes. Based on the graph theoretical approach of Jacobs et al. [Jacobs DJ, Rader AJ, Kuhn LA, Thorpe MF (2001) Protein flexibility predictions using graph theory. Proteins: Struct Funct Genet 44:150–165] for expressing molecular flexibility, we propose a new scheme to analyze the structural stability of bio-molecular complexes. This analysis is performed in terms of the identification in interacting subunits of clusters of flappy amino acids (those constituting regions of potential internal motion) that undergo an increase in rigidity at complex formation. Gains in structural rigidity of the interacting subunits upon bio-molecular complex formation can be evaluated by expansion of the network of intra-molecular inter-atomic interactions to include inter-molecular inter-atomic interaction terms. We propose two indices for quantifying this change: one local, which can express localized (at the amino acid level) structural rigidity, the other global to express overall structural stability for the complex. The new system is validated with a series of protein complex structures reported in the protein data bank. Finally, the indices are used as scoring coefficients to rank automatically generated protein complex decoys.     

Statistical methods for assessing long-term analyte stability in biological matrices

The objective of a long-term stability experiment is to confirm analyte stability in a given biological matrix, encompassing the duration of time from sample collection to sample analysis for a clinical or preclinical study. While long-term analyte stability has been identified as a key component of bioanalytical method validation, current regulatory guidance provides no specific recommendations regarding the design and analysis of such experiments. This paper reviews and evaluates various experimental designs, data analysis methods, and acceptance criteria for the assessment of long-term analyte stability. Statistical equivalence tests based on linear regression techniques are advocated. Both a nested errors and bivariate mixed model regression approach are suitable for application to long-term stability assessment, and control the risk of falsely concluding stability.     

Reliability of assessing postural control during seated balancing using a physical human-robot interaction

This study evaluated the within- and between-visit reliability of a seated balance test for quantifying trunk motor control using input–output data. Thirty healthy subjects performed a seated balance test under three conditions: eyes open (EO), eyes closed (EC), and eyes closed with vibration to the lumbar muscles (VIB). Each subject performed three trials of each condition on three different visits. The seated balance test utilized a torque-controlled robotic seat, which together with a sitting subject resulted in a physical human-robot interaction (pHRI) (two degrees-of-freedom with upper and lower body rotations). Subjects balanced the pHRI by controlling trunk rotation in response to pseudorandom torque perturbations applied to the seat in the coronal plane. Performance error was expressed as the root mean square (RMSE) of deviations from the upright position in the time domain and as the mean bandpass signal energy (E_mb) in the frequency domain. Intra-class correlation coefficients (ICC) quantified the between-visit reliability of both RMSE and E_mb. The empirical transfer function estimates (ETFE) from the perturbation input to each of the two rotational outputs were calculated. Coefficients of multiple correlation (CMC) quantified the within- and between-visit reliability of the averaged ETFE. ICCs of RMSE and E_mb for all conditions were ≥0.84. The mean within- and between-visit CMCs were all ≥0.96 for the lower body rotation and ≥0.89 for the upper body rotation. Therefore, our seated balance test consisting of pHRI to assess coronal plane trunk motor control is reliable.     

Acute stretching increases postural stability in nonbalance trained individuals

ABSTRACT: Nelson, AG, Kokkonen, J, Arnall, DA, and Li, L. Acute stretching increases postural stability in nonbalance trained individuals. J Strength Cond Res 26(11): 3095-3100, 2012-Studies into the relationship between acute stretching and maintenance of postural balance have been inconclusive. It was hypothesized that familiarization with the task and subsequent learning might be involved in the conflicting results. Therefore, this study was to designed determine if a regimen of static stretching exercises after a familiarization period would improve a person's ability to maintain a stabilometer in a neutral position and whether stretching had the same effect on individuals with extensive involvement with balancing tasks. Forty-two college students (21 male, 21 female) and 10 surfers (all male) performed tests on a stabilometer on 2 separate days after 3 days of familiarization. Testing followed either 30 minutes of quiet sitting (nonstretched) or 30 minutes of stretching activities (stretched). Stretching exercises consisted of various assisted and unassisted static stretches of the muscles around the hip, knee, and ankle joints. Improved flexibility after the stretching exercises was demonstrated by significant (p < 0.05) 6.5 ± 2.7 cm (mean ± SD) increase in the sit and reach. Balance time for the students improved significantly by 11.4% (2.0-second increase), but the surfers had no significant change. Thus, stretching improved maintenance of balance perhaps by helping the subjects to eliminate the gross muscle contractions that caused large stabilometer displacements and to replace them with fine muscle contractions that caused little or no stabilometer displacements. However, it appears that experience doing balance tasks supplants any stretching benefit.     

Diabetic neuropathy and surface sway-referencing disrupt somatosensory information for postural stability in stance

In order to determine the type of somatosensory information for postural control that is most affected by neuropathy, we compared the relative effects of three methods of sway-referencing the surface in a group of subjects with profound loss of somatosensory function associated with sensory polyneuropathy from diabetes with age-matched control subjects. Sway-referencing disrupted somatosensory feedback for postural control by servo-controlling the dorsi- and plantar-flexion rotation of the support surface in proportion to anterior-posterior excursion of (1) ankle angle, (2) center of body mass (CoM) angle or (3) filtered center of pressure (CoP). Postural sway in subjects with somatosensory loss was significantly larger than normal on a firm surface but not on the sway-referenced surfaces, suggesting that sway-referencing disrupts somatosensory information for postural control already disrupted by neuropathy. Control subjects standing on any sway-referenced surface swayed significantly more than neuropathy subjects who stood on a firm surface, suggesting that sway-referencing disrupts more somatosensory information than disrupted by severe neuropathy. CoP sway-referencing was less sensitive than ankle or CoM sway-referencing for distinguishing postural sway in subjects with somatosensory loss from age-matched control subjects. Given that filtered CoP sway-referencing disrupts the ability to utilize somatosensory information related to surface reactive force to a greater extent than the other two methods of sway-referencing, then these results support the hypothesis that subjects with diabetic peripheral neuropathy have lost more CoP information, than ankle or CoM angle information, for controlling postural sway in stance.     

Diabetic neuropathy and surface sway-referencing disrupt somatosensory information for postural stability in stance

In order to determine the type of somatosensory information for postural control that is most affected by neuropathy, we compared the relative effects of three methods of sway-referencing the surface in a group of subjects with profound loss of somatosensory function associated with sensory polyneuropathy from diabetes with age-matched control subjects. Sway-referencing disrupted somatosensory feedback for postural control by servo-controlling the dorsi- and plantar-flexion rotation of the support surface in proportion to anterior-posterior excursion of (1) ankle angle, (2) center of body mass (CoM) angle or (3) filtered center of pressure (CoP). Postural sway in subjects with somatosensory loss was significantly larger than normal on a firm surface but not on the sway-referenced surfaces, suggesting that sway-referencing disrupts somatosensory information for postural control already disrupted by neuropathy. Control subjects standing on any sway-referenced surface swayed significantly more than neuropathy subjects who stood on a firm surface, suggesting that sway-referencing disrupts more somatosensory information than disrupted by severe neuropathy. CoP sway-referencing was less sensitive than ankle or CoM sway-referencing for distinguishing postural sway in subjects with somatosensory loss from age-matched control subjects. Given that filtered CoP sway-referencing disrupts the ability to utilize somatosensory information related to surface reactive force to a greater extent than the other two methods of sway-referencing, then these results support the hypothesis that subjects with diabetic peripheral neuropathy have lost more CoP information, than ankle or CoM angle information, for controlling postural sway in stance.     

Evaluation of the lambda model for human postural control during ankle strategy

An accurate modeling of human stance might be helpful in assessing postural deficit. The objective of this article is to validate a mathematical postural control model for quiet standing posture. The postural dynamics is modeled in the sagittal plane as an inverted pendulum with torque applied at the ankle joint. The torque control system is represented by the physiological lambda model. Two neurophysiological command variables of the central nervous system, designated and , establish the dynamic threshold muscle at which motoneuron recruitment begins. Kinematic data and electromyographic signals were collected on four young males in order to measure small voluntary sway and quiet standing posture. Validation of the mathematical model was achieved through comparison of the experimental and simulated results. The mathematical model allows computation of the unmeasurable neurophysiological commands and that control the equilibrium position and stability. Furthermore, with the model it is possible to conclude that low-amplitude body sway during quiet stance is commanded by the central nervous system.     

A comparison of results obtained with two methods for assessing yield stability

Summary A major objective of the CIMMYT Maize Program is to develop open-pollinated varieties of maize (Zea mays L.) that are well adapted to a wide range of environments. To achieve this breeding goal, it is essential that the program use a stability technique that will identify high-yielding, stable genotypes accurately in international trials conducted under different environmental conditions. The objective of this study was to compare a spatial method with a modified conventional regression analysis method to determine the yield stability of 27 CIMMYT maize varieties evaluated at 37 locations. The methods also were compared on the basis of their consistency in assessing the stability of varieties when certain locations were omitted, and when subsets of varieties were analyzed. The varieties found to be stable by the spatial method with all sites included in the analysis were also stable (1) when the lowest and highest yielding sites were excluded from the analyses, and (2) when the varieties were considered, along with others, as a subset of the original group of materials. Stability parameters determined by regression analysis, however, varied for some varieties when (1) extreme sites were excluded, and (2) a subset of entries was considered in isolation. Because the spatial method was more consistent in identifying high-yielding stable varieties, it was considered the more useful of the two methods.     

Network measures for dyadic interactions: stability and reliability

Social network analysis (SNA) is a general heading for a collection of statistical tools that aim to describe social interactions and social structure by representing individuals and their interactions as graph objects. It was originally developed for the social sciences, but more recently it was also adopted by behavioral ecologists. However, although SNA offers a full range of exciting possibilities for the study of animal societies, some authors have raised concerns about the correct application and interpretation of network measures. In this article, we investigate how reliable and how stable network measures are (i.e. how much variation they show under re-sampling and how much they are influenced by erroneous observations). For this purpose, we took a data set of 44 nonhuman primate grooming networks and studied the effects of re-sampling at lower re-sampling rates than the originally observed ones and the inclusion of two types of errors, "mis-identification" and "mis-classification," on six different network metrics, i.e. density, degree variance, vertex strength variance, edge weight disparity, clustering coefficient, and closeness centrality. Although some measures were tolerant toward reduced sample sizes, others were sensitive and even slightly reduced samples could yield drastically different results. How strongly a metric is affected seems to depend on both the sample size and the structure of the specific network. The same general effects were found for the inclusion of sampling errors. We, therefore, emphasize the importance of calculating valid confidence intervals for network measures and, finally, we suggest a rough research plan for network studies.     

The effect of leg preference on postural stability in healthy athletes

In research regarding postural stability, leg preference is often tested and controlled for. However, leg preference may vary between tasks. As athletes are a group of interest for postural stability testing, we evaluated the effect of five leg preference tasks categorization (step up, hop, ball kick, balance, pick up) on single-leg postural stability of 16 field hockey athletes. The ‘center of pressure speed’ was calculated as the primary outcome variable of single-leg postural stability. Secondary variables were ‘mean length of the GRF vector in the horizontal plane’, ‘mean length of the ankle angular velocity vector’, and ‘mean length of the hip angular velocity vector’, as well as the separate outcomes per degree of freedom. Results showed that leg preference was inconsistent between leg preference tasks. Moreover, the primary and secondary variables yielded no significant difference between the preferred and non-preferred legs, regardless of the applied leg preference task categorization (p>0.05). The present findings do not support the usability of leg preference tasks in controlling for bias of postural stability. In conclusion, none of the applied leg preference tasks revealed a significant effect on postural stability in healthy field hockey athletes.