共查询到20条相似文献,搜索用时 31 毫秒
1.
Characterization of a novel non-specific nuclease from thermophilic bacteriophage GBSV1 总被引:1,自引:0,他引:1
Background
Thermostable enzymes from thermophiles have attracted extensive studies. In this investigation, a nuclease-encoding gene (designated as GBSV1-NSN) was obtained from a thermophilic bacteriophage GBSV1 for the first time. 相似文献2.
Fabien Scalzo Shadnaz Asgari Sunghan Kim Marvin Bergsneider Xiao Hu 《Biomedical engineering online》2010,9(1):61
Background
The waveform morphology of intracranial pressure pulses (ICP) is an essential indicator for monitoring, and forecasting critical intracranial and cerebrovascular pathophysiological variations. While current ICP pulse analysis frameworks offer satisfying results on most of the pulses, we observed that the performance of several of them deteriorates significantly on abnormal, or simply more challenging pulses. 相似文献3.
Knut R Steffensen Mariam Bouzga Frode Skjeldal Cecilie Kasi Almira Karahasan Vilborg Matre Oddmund Bakke Sylvain Guérin Winnie Eskild 《BMC molecular biology》2007,8(1):106
Background
Novel, uncharacterised proteins represent a challenge in biochemistry and molecular biology. In this report we present an initial functional characterization of human kidney predominant protein, NCU-G1. 相似文献4.
Background
The emergence of the 2009 H1N1 Influenza pandemic followed a multiple reassortment event from viruses originally circulating in swines and humans, but the adaptive nature of this emergence is poorly understood. 相似文献5.
Susan Fanayan Mona Shehata Annelies P Agterof Michael A McGuckin Miguel A Alonso Jennifer A Byrne 《BMC cell biology》2009,10(1):7-13
Background
The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners. 相似文献6.
Goang-Won Cho Seung Min Shin Hyun Kee Kim Seon-Ah Ha Sanghee Kim Joo-Hee Yoon Soo Young Hur Tae Eung Kim Jin Woo Kim 《BMC cell biology》2007,8(1):50
Background
The Human cervical cancer oncogene (HCCR-1) has been isolated as a human oncoprotein, and has shown strong tumorigenic features. Its potential role in tumorigenesis may result from a negative regulation of the p53 tumor suppressor gene. 相似文献7.
Iraldo Bello-Rivero Yeny Torrez-Ruiz Elizabeth Blanco-Garcés Giselle Pentón-Rol Osmani Fernández-Batista Luís Javier-González Haydee Gerónimo-Perez Pedro López-Saura 《BMC biotechnology》2006,6(1):25-13
Background
TH1 immune response antagonism is a desirable approach to mitigate some autoimmune and inflammatory reactions during the course of several diseases where IL-2 and IFN-γ are two central players. Therefore, the neutralization of both cytokines could provide beneficial effects in patients suffering from autoimmune or inflammatory illnesses. 相似文献8.
Alessandro Pintar Corrado Guarnaccia Somdutta Dhir Sándor Pongor 《BMC structural biology》2009,9(1):43-8
Background
Notch signaling drives developmental processes in all metazoans. The receptor binding region of the human Notch ligand Jagged-1 is made of a DSL (Delta/Serrate/Lag-2) domain and two atypical epidermal growth factor (EGF) repeats encoded by two exons, exon 5 and 6, which are out of phase with respect to the EGF domain boundaries. 相似文献9.
Aonghus?J?O'Loughlin Crochan?J?O'Sullivan Nandini?Ravikumar Anne?M?Friel John?T?Elliott John?J?Morrison
Background
The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs), and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP), and a PAR-1 antagonist on human umbilical artery tone in vitro. 相似文献10.
Xiaomin Hou Minghuang Chen Liqing Chen Edward J Meehan Jieming Xie Mingdong Huang 《BMC structural biology》2007,7(1):29
Background
Protein sequence can be obtained through Edman degradation, mass spectrometry, or cDNA sequencing. High resolution X-ray crystallography can also be used to derive protein sequence information, but faces the difficulty in distinguishing the Asp/Asn, Glu/Gln, and Val/Thr pairs. Luffaculin 1 is a new type 1 ribosome-inactivating protein (RIP) isolated from the seeds of Luffa acutangula. Besides rRNA N-glycosidase activity, luffaculin 1 also demonstrates activities including inhibiting tumor cells' proliferation and inducing tumor cells' differentiation. 相似文献11.
Maria Carla Re Paola Monari Isabella Bon Davide Gibellini Francesca Vitone Marco Borderi Michele La Placa 《BMC microbiology》2001,1(1):1-6
Background
Recent studies of viral entry proteins from influenza, measles, human immunodeficiency virus, type 1 (HIV-1), and Ebola virus have shown, first with molecular modeling, and then X-ray crystallographic or other biophysical studies, that these disparate viruses share a coiled-coil type of entry protein. 相似文献12.
Background
Bladder transitional cell carcinoma (BTCC) is the fourth most frequent neoplasia in men, clinically characterized by high recurrent rates and poor prognosis. Availability of urinary tumor biomarkers represents a convenient alternative for early detection and disease surveillance because of its direct contact with the tumor and sample accessibility. 相似文献13.
Background
Antibacterial activity is a novel function of high-mobility group box 1 (HMGB1). However, the functional site for this new effect is presently unknown. 相似文献14.
Emmanuel G Reynaud Miguel A Andrade Fabien Bonneau Thi Bach Nga Ly Michael Knop Klaus Scheffzek Rainer Pepperkok 《BMC biology》2005,3(1):21
Background
Compartmentalization is a key feature of eukaryotic cells, but its evolution remains poorly understood. GTPases are the oldest enzymes that use nucleotides as substrates and they participate in a wide range of cellular processes. Therefore, they are ideal tools for comparative genomic studies aimed at understanding how aspects of biological complexity such as cellular compartmentalization evolved. 相似文献15.
Background
Solenoid repeat proteins of the Tetratrico Peptide Repeat (TPR) family are involved as scaffolds in a broad range of protein-protein interactions. Several resources are available for the prediction of TPRs, however, they often fail to detect divergent repeat units. 相似文献16.
Babu?A?Manjasetty Frank?H?Niesen Christoph?Scheich Yvette?Roske Frank?Goetz Joachim?Behlke Volker?Sievert Udo?Heinemann
Background
Human Aortic Preferentially Expressed Protein-1 (APEG-1) is a novel specific smooth muscle differentiation marker thought to play a role in the growth and differentiation of arterial smooth muscle cells (SMCs). 相似文献17.
Nitar Nwe Qigai He Sudarat Damrongwatanapokin Qingyun Du Ivanus Manopo Yukol Limlamthong Beau James Fenner Lynn Spencer Jimmy Kwang 《BMC microbiology》2006,6(1):16-7
Background
Prevention of a possible avian influenza pandemic necessitates the development of rapid diagnostic tests and the eventual production of a vaccine. 相似文献18.
19.
Bin He Jian Xiao An-Jing Ren Yu-Feng Zhang Hao Zhang Min Chen Bing Xie Xiao-Gang Gao Ying-Wei Wang 《Journal of biomedical science》2011,18(1):22
Background
Ischemic postconditioning (IPost) has aroused much attention since 2003 when it was firstly reported. The role of microRNAs (miRNAs or miRs) in IPost has rarely been reported. The present study was undertaken to investigate whether miRNAs were involved in the protective effect of IPost against myocardial ischemia-reperfusion (IR) injury and the probable mechanisms involved. 相似文献20.
Hong Zhao Joy Innes David C Brooks Scott Reierstad Mehmet B Yilmaz Zhihong Lin Serdar E Bulun 《Reproductive biology and endocrinology : RB&E》2009,7(1):37