共查询到20条相似文献,搜索用时 109 毫秒
1.
目的:探讨BRMS1的表达与乳腺癌腋窝淋巴结微转移的关系.方法:采用连续切片和CK-19联合检测86例腋窝淋巴结转移阴性的所有淋巴结微转移灶的情况,术后随访其复发情况,免疫组化检测乳腺癌组织中BRMS1的表达并分析其与淋巴结微转移及术后复发率的关系.结果:86例乳腺癌腋窝淋巴结转移阴性的689淋巴结中有48粒(6.97%)检测到微转移,其中阳性病例22例(25.58%),BRMS1的表达阴性的乳腺癌患者腋窝淋巴结微转移病例率(43.24%)和术后复发率(54.05%)远高于BRMS1表达阳性的乳腺癌患者(12.24%,8.16%),差异具有显著性,且呈明显的负相关.结论:BRMS1与腋窝淋巴结微转移密切相关,可以成为乳腺癌腋窝淋巴结微转移分子指标,并对乳腺癌的分期、预后、治疗具有重要的指导意义. 相似文献
2.
3.
4.
肺癌是发病率和死亡率增长最快、对人类健康威胁最大的恶性肿瘤之一。侵袭转移是肺癌患者死亡的首要原因。研究表明,在肺癌中发挥转移抑制作用的相关基因主要有nm23、KAI1、TIMP、Cadherin以及MRP-1等。本文对近年来这些基因的研究进展及其对肺癌侵袭转移的抑制作用作一综述 相似文献
5.
KAI-1──前列腺癌转移抑制基因邓欣珠,罗贤懋(第四军医大学军队卫生学教研室,西安710032)(中国医学科学院肿瘤研究所营养与肿瘤室,北京100021)关键词前列腺癌,肿瘤转移抑制基因前列腺癌是男性常见肿瘤。美国癌症协会预测,1995年美国将有2... 相似文献
6.
癌症抑制因子──肿瘤抑制基因杨杰(安徽教育学院生物系,230061)张为民(焦作教育学院生物系)1、肿瘤抑制基因与癌症的关系1.l肿瘤抑制基因的缺失引发多种癌症。肿瘤抑制基因的研究大约始于1969年。HerryHam's等发现当高度恶化的鼠埃利希腹水... 相似文献
7.
肿瘤转移抑制基因nm23研究的新进展 总被引:6,自引:0,他引:6
肿瘤转移抑制基因nm23在不同转移潜能的癌细胞中多为低表达,在nm23的两种亚型中,nm23-H1可能在转移抑制中起着更重要的作用。nm23蛋白可能 是通过与NDPK一致或相似的途径调节肿瘤的转移抑制,对nm23的研究是近年肿瘤转移换制研究的热点,本文就其新近进展作一综述。 相似文献
8.
hTid1(human tumorous imaginal disc 1)是果蝇肿瘤抑制因子Tid56的人类同源蛋白。hTid1属于DnaJ蛋白家族成员,主要定位于线粒体基质中,作为Hsp70蛋白的辅助分子伴侣发挥作用。然而,越来越多的文献报道,hTid1可以与线粒体外的许多蛋白相互作用,进而调控细胞内许多的信号通路。该文综述了近年来hTid1蛋白的最新研究进展,并主要从hTid1蛋白的结构和功能、与肿瘤的相关性、与神经系统的联系及在细胞信号通路中的作用等方面进行系统的阐述。 相似文献
9.
10.
LASP-1(LIM and SH3 protein 1)最初是由乳腺癌转移性淋巴结cDNA文库中筛选克隆得到,含有LIM和SH3两个结构域.LASP-1在乳腺癌和卵巢癌等多种恶性肿瘤中高表达,并和肿瘤发生、侵袭和转移密切相关.近年来研究还证实LASP-1是抑癌基因p53的靶蛋白.目前的研究均表明LASP-1是一种新的肿瘤转移蛋白. 相似文献
11.
Kim B Nam HJ Pyo KE Jang MJ Kim IS Kim D Boo K Lee SH Yoon JB Baek SH Kim JH 《Biochemical and biophysical research communications》2011,(4):720-726
Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis without affecting primary tumorigenesis. The regulatory mechanism of BRMS1 at the protein level has not been revealed until recently. Here, we found that cullin 3 (Cul3), a component of E3 ubiquitin ligase, is a new binding partner of BRMS1 and the interaction between BRMS1 and Cul3 is mediated by the SPOP adaptor protein. Intriguingly, BRMS1 turns out to be a potent substrate that is ubiquitinated by the Cul3–SPOP complex. Knockdown of SPOP increases the level of BRMS1 protein and represses the expression of BRMS1 repressive target genes such as OPN and uPA in breast cancer cells. These results suggest that the novel regulatory mechanism of BRMS1 by Cul3–SPOP complex is important for breast cancer progression. 相似文献
12.
13.
14.
15.
Muhammad Muzammal Adeel Muhammad Qasim Usman Ali Ashfaq Muhammad Shareef Masoud Mahmood ur Rehman Muhammad Tahir ul Qamar Muhammad Rizwan Javed 《Bioinformation》2014,10(7):454-459
Computational tools occupy the prime position in the analysis of large volume of post-genomic data. These tools have advantage
over the wet lab experiments in terms of high coverage, cost and time. Breast cancer is the most common cancer in females
worldwide. It is a genetically heterogeneous disorder and many genes are involved in the pathway of the disease. Mutations in
metastasis suppressor gene are the major cause of the disease. In this study, the effects of mutations in breast cancer metastasis
suppressor 1gene upon protein structure and function were examined by means of computational tools and information from
databases.This study can be useful to predict the potential effect of every allelic variant, devise new biological experiments and to
interpret and predict the patho-physiological impact of new mutations or non-synonymous polymorphisms. 相似文献
16.
17.
The breast cancer metastasis suppressor 1 (BRMS1) is a member of a family of proteins that actively suppress tumour metastasis. Understanding BRMS1 mediated metastasis suppression is critical to the development of new therapies designed to prevent and treat patients with late stage breast cancer. To aid research into the functional aspects that underpin BRMS1 mediated metastasis suppression we have expressed and purified recombinant BRMS1 and produced BRMS1 polyclonal antibodies. Using these antibodies to immunoprecipitate endogenous BRMS1 containing complexes from MCF7 breast cancer cell lines we have identified, by mass spectrometry, the small heat shock protein Hsp27 in complex with BRMS1. We also show that the expression of both BRMS1 and Hsp27 are inversely correlated with metastatic potential. 相似文献
18.
Y Wu W Jiang Y Wang J Wu H Saiyin X Qiao X Mei B Guo X Fang L Zhang H Lou C Wu S Qiao 《PloS one》2012,7(8):e42976
Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active metastasis suppressor in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and BRMS1 suppresses several steps required for tumor metastasis. However, the role of BRMS1 in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that the expression level of BRMS1 was significantly down-regulated in HCC tissues. Expression of BRMS1 in SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized cells to apoptosis induced by serum deprivation or anoikis. Consistently, knockdown of endogenous BRMS1 expression in Hep3B cells suppressed cell apoptosis. We identified that BRMS1 suppresses osteopontin (OPN) expression in HCC cells and that there is a negative correlation between BRMS1 and OPN mRNA expression in HCC tissues. Moreover, knockdown of endogenous OPN expression reversed the anti-apoptosis effect achieved by knockdown of BRMS1. Taken together, our results show that BRMS1 sensitizes HCC cells to apoptosis through suppressing OPN expression, suggesting a potential role of BRMS1 in regulating HCC apoptosis and metastasis. 相似文献
19.
Jennifer F. Knight Vanessa Y.C. Sung Elena Kuzmin Amber L. Couzens Danielle A. de Verteuil Colin D.H. Ratcliffe Paula P. Coelho Radia M. Johnson Payman Samavarchi-Tehrani Tina Gruosso Harvey W. Smith Wontae Lee Sadiq M. Saleh Dongmei Zuo Hong Zhao Marie-Christine Guiot Ryan R. Davis Jeffrey P. Gregg Morag Park 《Cell reports》2018,22(12):3191-3205
20.
Yi Zhang Jie Guan Yanlai Sun Jie Chai Tao Zou Weipeng Gong Zhenyu Zhu Xin Liu Qingsheng Hou Xilin Song 《Cell biochemistry and biophysics》2014,70(1):505-509
Breast cancer metastasis suppressor gene-1 (BRMS1) is newly discovered tumor metastasis gene, which has been reported to play an important role in the progression of human tumor. However, its role in rectal cancer has never been investigated. In this present study, we evaluated the associated of BRMS1 with colorectal cancer, its value in prognosis, and its role in metastasis of rectal cancer. BRMS1 expression examined in 80 patients and the role of BRMS1 in metastasis was studied using mice model. Our results showed that BRMS1 expression was significantly associated with clinicopathological parameters in rectal cancer patients and overexpression of BRMS1 in rectal cancer xenograft led to decreased growth, invasiveness and metastasis. Our findings indicate that high expression of BRSM1 in rectal cancer plays an essential role in tumor progression. 相似文献