Francis Galton

Ohne Zusammenfassung     

Gentlemanly Men of Science: Sir Francis Galton and the Professionalization of the British Life-Sciences

Because Francis Galton (1822–1911) was a well-connected gentleman scientist with substantial private means, the importance of the role he played in the professionalization of the Victorian life-sciences has been considered anomalous. In contrast to the X-clubbers, he did not seem to have any personal need for there forms his Darwinist colleagues were advocating. Nor for making common cause with individuals haling from social strata clearly inferior to his own. However, in this paper I argue that Galton quite realistically discerned in the reforming endeavors of the1860s, and beyond, the potential for considerably enhancing his own reputation and standing within both the scientific community and the broader Victorian culture. In addition, his professionalizing aspirations, and those of his reformist allies, were fully concordant with the interests, ambitions and perceived opportunities of his elite social group during the Victorian period. Professionalization appealed to gentlemen of Galton's status and financial security as much as it did to the likes of Thomas Huxley and John Tyndall, primarily because it promised to confer on the whole scientific enterprise an unprecedented level of social prestige. This revised version was published online in July 2006 with corrections to the Cover Date.     

Sir Francis Knowles

Cell and Tissue Research -     

Quality control in cytopathology. A system for simultaneous monitoring of accuracy and education and for proficiency testing

Because of its very nature, cytopathology has not lent itself well to quality control. At the University of North Carolina, we practice an internal quality control system based on peer review, interprofessional dialogue and utilization of follow-up information. Recently reported cytology specimens are rescreened and correlated with related surgical specimens. This review is summarized in a weekly conference, at which retrospective accuracy judgments are made for each case under the supervision of the medical director and head cytotechnologist. Diagnostic accuracy is thus monitored. Accuracy is also improved since education is simultaneously monitored. A practical proficiency-testing program built into this system is described.     

Training in molecular cytopathology testing

Training in molecular cytopathology testing is essential in developing and maintaining skills in modern molecular technologies as they are introduced to a universal health care system such as extant in the UK and elsewhere. We review the system in place in Northern Ireland (NI) for molecular testing of solid tumours, as an example to train staff of all grades, including pathologists, clinical scientists, biomedical scientists and equivalent technical grades. We describe training of pathologists as part of the NI Deanery medical curriculum, the NI training programme for scientists and laboratory rotation for Biomedical Scientists. Collectively, the aims of our training are two‐fold: to provide a means by which individuals may extend their experience and skills; and to provide and maintain a skilled workforce for service delivery. Through training and competency, we introduce new technologies and tests in response to personalised medicine therapies with a competent workforce. We advocate modifying programmes to suit individual needs for skill development, with formalised courses in pre‐analytical, analytical and postanalytical demands of modern molecular pathology. This is of particular relevance for cytopathology in small samples such those from formalin‐fixed paraffin‐embedded cell blocks. We finally introduce how university courses can augment training and develop a skilled workforce to benefit the delivery of services to our patients.     

Francis Galton’s theory of inheritance and the problem of unconceived alternatives

Elsewhere I have argued that the most significant threat to scientific realism arises from what I call the problem of unconceived alternatives: the repeated failure of past scientists and scientific communities to even conceive of alternatives to extant scientific theories, even when such alternatives were both (1) well-confirmed by the evidence available at the time and (2) sufficiently scientifically serious as to be actually embraced in the course of further investigation. In this paper I explore Francis Galton’s development and defense of his “stirp” theory of inheritance and conclude that this particular historical example offers impressive support for the challenge posed by the problem of unconceived alternatives while simultaneously showing how we can make that challenge deeper and sharper.     

Canadian experience in cytology proficiency testing

The mandatory Laboratory Proficiency Testing Program (LPTP) of the province of Ontario as applied to cytology laboratories is briefly described. LPTP evaluates reporting of test slides to identify laboratories that have deficiencies. Such laboratories receive an on-site visit, followed by recommendations on means of improvement (especially educational) and subsequent monitoring. Most of the 18 cytology laboratories visited to date have shown an improved level of performance on later tests.     

Clinical relevance of human papillomavirus testing in cytopathology

Cancer of the uterine cervix is the second most common cancer in women worldwide. Currently, cervical screening is based on cytology alone. Because infection with high-risk human papillomavirus types (hrHPVs) is a necessary cause of cervical cancer, it has been postulated that screening might become more efficient when it is based on combined cytology and hrHPV testing. In this review we will discuss the advantages of added HPV tests in cervical cancer screening, as a quality control for false-negative smears, in triage of women with equivocal smears, in follow-up of women treated for CIN3 or cervical cancer and for the detection of cervical adenocarcinoma.