Relation of the mental foramen to teeth on the mandibles belonging to the Byzantium period

Fifty mandibles belonging to the Byzantium period were studied in order to determine to racial differences about of the localization of the mental foramen according to the mandibular teeth. Mandibles of adult males without missing teeth, proximal decay and proximal attrition were used. On the right side, the most common position of the mental foramen was between the first and second lower teeth (50%), whereas on the left side, the most common position was in line with the longitudinal axis of the lower second premolar tooth (46%). Because of materials including mostly Alpine's and a few of Mediterranean subraces, two different positions of the mental foramen were determined in high similar ratios.     

Effect of adaptation to hypoxia on the resistance of rats to the epileptogenic action of penicillin

The influence of adaptation to moderate hypoxia on anticonvulsive resistance of low tolerant rats has been investigated. Focal epilepsy was induced by penicillin application to sensorimotor cortex of the rat brain. Adaptation to hypoxia has been shown to increase the resistance of rats to epileptogenic penicillin effect which is manifested in the prolongation of the latent period of epileptiform discharges and less frequent epileptic fits. The mechanisms of the resistance increase remains to be investigated.     

MYC on the path to cancer

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities. MYC's activation by bromodomain proteins could be inhibited by drug-like molecules, resulting in tumor inhibition in?vivo. Tumor growth can also be curbed by pharmacologically uncoupling bioenergetic pathways involving glucose or glutamine metabolism from Myc-induced cellular biomass accumulation. Other approaches to halt Myc on the path to cancer involve targeting Myc-Max dimerization or Myc-induced microRNA expression. Here the richness of our understanding of MYC is reviewed, highlighting new biological insights and opportunities for cancer therapies.     

RNA on the road to myelin

In oligodendrocytes some mRNAs are transported from the perikaryon to the distal processes and localized in the myelin compartment where they are translated. This review describes the cis-acting signals and trans-acting factors that mediate intracellular trafficking of myelin basic protein (MBP) RNA, the prototype for such mRNAs in myelinating glia.