共查询到14条相似文献,搜索用时 15 毫秒
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HPLC‐UV and LC–MS Analyses of Acylquinic Acids in Geigeria alata (DC) Oliv. & Hiern. and their Contribution to Antioxidant and Antimicrobial Capacity 下载免费PDF全文
Dimitrina Zheleva‐Dimitrova Reneta Gevrenova Maya M. Zaharieva Hristo Najdenski Silviya Ruseva Valentin Lozanov Vessela Balabanova Sakina Yagi Georgi Momekov Vanio Mitev 《Phytochemical analysis : PCA》2017,28(3):176-184
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ESI‐MS2 and Anti‐inflammatory Studies of Cyclopropanic Triterpenes. UPLC‐ESI‐MS and MS2 Search of Related Metabolites from Donella ubanguiensis 下载免费PDF全文
Louis P. Sandjo Marcus V.P. dos Santos Nascimento Layzon A.L. da Silva Antonio C.M. Munhoz Luiz A.E. Pollo Maique W. Biavatti Bonaventure T. Ngadjui Till Opatz Tania S. Fröde 《Phytochemical analysis : PCA》2017,28(1):27-41
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Yogini Jaiswal Zhitao Liang Alan Ho Hubiao Chen Zhongzhen Zhao 《Phytochemical analysis : PCA》2014,25(6):514-528
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《Chirality》2017,29(6):282-293
Enantiomeric thalidomide undergoes various kinds of biotransformations including chiral inversion, hydrolysis, and enzymatic oxidation, which results in several metabolites, thereby adding to the complexity in the understanding of the nature of thalidomide. To decipher this complexity, we analyzed the multidimensional metabolic reaction networks of thalidomide and related molecules in vitro . Characteristic patterns in the amount of various metabolites of thalidomide and related molecules generated during a combination of chiral inversion, hydrolysis, and hydroxylation were observed using liquid chromatography–tandem mass spectrometry and chiroptical spectroscopy. We found that monosubstituted thalidomide derivatives exhibited different time‐dependent metabolic patterns compared with thalidomide. We also revealed that monohydrolyzed and monohydroxylated metabolites of thalidomide were likely to generate mainly by a C‐5 oxidation of thalidomide and subsequent ring opening of the hydroxylated metabolite. Since chirality was conserved in most of these metabolites during metabolism, they had the same chirality as that of nonmetabolized thalidomide. Our findings will contribute toward understanding the significant pharmacological effects of the multiple metabolites of thalidomide and its derivatives. 相似文献
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Comparison of Soxhlet,Accelerated Solvent and Supercritical Fluid Extraction Techniques for Volatile (GC–MS and GC/FID) and Phenolic Compounds (HPLC–ESI/MS/MS) from Lamiaceae Species 下载免费PDF全文
Raquel Rodríguez‐Solana José Manuel Salgado José Manuel Domínguez Sandra Cortés‐Diéguez 《Phytochemical analysis : PCA》2015,26(1):61-71
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Simultaneous UHPLC/DAD/(+/−)HESI–MS/MS Analysis of Phenolic Acids and Nepetalactones in Methanol Extracts of Nepeta Species: A Possible Application in Chemotaxonomic Studies 下载免费PDF全文
Danijela Mišić Branislav Šiler Uroš Gašić Stevan Avramov Suzana Živković Jasmina Nestorović Živković Milica Milutinović Živoslav Tešić 《Phytochemical analysis : PCA》2015,26(1):72-85