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A novel family of mitochondrial plasmids associated with longevity mutants of Podospora anserina 总被引:4,自引:0,他引:4
We have identified a novel family of plasmids, each containing very short monomeric units, in Podospora anserina longevity mutants. These plasmids, termed small mitochondrial DNAs (sMt-DNAs), are derived from a highly ordered 368-base pair region of the mitochondrial genome. A total of five direct repeat sequences and seven significant regions of dyad symmetry (i.e. palindromes) were found within a 434-base pair mitochondrial sequence, which includes this 368-base pair region. Mitochondrial DNA rearrangements accompany the formation of these small plasmids indicating their derivation from a plastic region of the mitochondrial genome. A possible relationship between the direct repeat sequences, the palindromic regions, and the excision process is discussed. 相似文献
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James F. Hare 《Biochemical and biophysical research communications》1978,83(3):1206-1215
Mitochondrial inner membranes catalyzed the endoproteolytic release of radioactively labelled polypeptide fragments of 125I labelled insulin covalently attached to agarose beads. Demonstration of this proteolytic activity was dependent upon detergent and inhibited by a variety of proteinase and sulfhydryl group inhibitors. Unlike three previously described peripheral mitochondrial proteinases, the insulin hydrolyzing mitochondrial proteinase was resistent to extraction with high salt but solubilized with a non-ionic detergent, indicating its integral association with the membrane. 相似文献
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Distribution and evolutionary significance of mitochondrial plasmids in Neurospora spp. 总被引:7,自引:0,他引:7 下载免费PDF全文
The lethal and mutagenic effects of various mutagens on Neisseria gonorrhoeae were investigated. Lethality studies demonstrated that N. gonorrhoeae was relatively sensitive to ethyl methanesulfonate, UV light, and methyl methanesulfonate. Although N. gonorrhoeae was readily mutated by ethyl methanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine for the three genetic markers assayed, no increase in the mutation frequency was observed for any of the selective markers after UV irradiation or methyl methanesulfonate treatment. These results suggest that N. gonorrhoeae lacks an error-prone repair mechanism. 相似文献
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The nucleotide sequence of a specific region of the mitochondrial plasmid
from the Neurospora intermedia Varkud-lc strain was determined. Analysis of
the sequence revealed the presence of a long (up to 710 amino acids) ORF.
This ORF is almost identical to a previously characterized ORF in the
mitochondrial plasmid from the Neurospora crassa Mauriceville-lc strain.
When the ORFs from the two plasmids are compared over their entire length
of 2,133 bp, only 34 nucleotide substitutions are found (greater than 98%
identity). These substitutions result in only nine amino acid replacements
in the protein sequences predicted from the two ORFs. Though no function
can be assigned to the putative products of these ORFs, their high
conservation of nucleotide and deduced amino acid sequence suggest that
they are under selective pressure, presumably to preserve the function of
some protein.
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Pascal Nouvel 《Genetica》1994,93(1-3):191-201
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