共查询到20条相似文献,搜索用时 15 毫秒
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Gutfeeling, a Drosophila Gene Encoding an Antizyme-like Protein, Is Required for Late Differentiation of Neurons and Muscles
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The gutfeeling (guf) gene was uncovered in a genetic screen for genes that are required for proper development of the embryonic peripheral nervous system. Mutations in guf cause defects in growth cone guidance and fasciculation and loss of expression of several neuronal markers in the embryonic peripheral and central nervous systems. guf is required for terminal differentiation of neuronal cells. Mutations in guf also affect the development of muscles in the embryo. In the absence of guf activity, myoblasts are formed properly, but myoblast fusion and further differentiation of muscle fibers is severely impaired. The guf gene was cloned and found to encode a 21-kD protein with a significant sequence similarity to the mammalian ornithine decarboxylase antizyme (OAZ). In mammals, OAZ plays a key regulatory role in the polyamine biosynthetic pathway through its binding to, and inhibition of, ornithine decarboxylase (ODC), the first enzyme in the pathway. The elaborate regulation of ODC activity in mammals still lacks a defined developmental role and little is known about the involvement of polyamines in cellular differentiation. GUF is the first antizyme-like protein identified in invertebrates. We discuss its possible developmental roles in light of this homology. 相似文献
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Kimura T Chowdhury S Tanaka T Shimizu A Iwase K Oyadomari S Gotoh T Matsuzaki H Mori M Akira S Takiguchi M 《FEBS letters》2001,494(1-2):105-111
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CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation 总被引:4,自引:0,他引:4
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Shirakawa K Maeda S Gotoh T Hayashi M Shinomiya K Ehata S Nishimura R Mori M Onozaki K Hayashi H Uematsu S Akira S Ogata E Miyazono K Imamura T 《Molecular and cellular biology》2006,26(16):6105-6116
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Chen C Dudenhausen EE Pan YX Zhong C Kilberg MS 《The Journal of biological chemistry》2004,279(27):27948-27956
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CCAAT/enhancer binding protein beta (C/EBPbeta) is known to play an important role in the expression of several genes necessary for bone development and homeostasis including osteocalcin, IGF-1, and IL-6. In this study, we show that C/EBPbeta protein levels and, consequently, DNA-binding activity are temporally regulated, dramatically decreasing upon differentiation of MC3T3-E1 mouse osteoblasts. Corresponding with these results, the constitutive expression of C/EBPbeta LAP in MC3T3-E1 osteoblasts increased proliferation and suppressed osteogenic differentiation. Thus, C/EBPbeta LAP not only appears to participate in the regulation of genes associated with mature bone physiology, but is also a critical regulator of osteoblast growth and differentiation. 相似文献
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