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1.
The aim of this study was to investigate the effect of previous warming on high-intensity intermittent running using nonmotorized treadmill ergometry. Ten male soccer players completed a repeated sprint test (10 x 6-second sprints with 34-second recovery) on a nonmotorized treadmill preceded by an active warm-up (10 minutes of running: 70% VO2max; mean core temperature (Tc) 37.8 +/- 0.2 degrees C), a passive warm-up (hot water submersion: 40.1 +/- 0.2 degrees C until Tc reached that of the active warm-up; 10 minutes +/- 23 seconds), or no warm-up (control). All warm-up conditions were followed by a 10-minute static recovery period with no stretching permitted. After the 10-minute rest period, Tc was higher before exercise in the passive trial (38.0 +/- 0.2 degrees C) compared to the active (37.7 +/- 0.4 degrees C) and control trials (37.2 +/- 0.2 degrees C; p < 0.05). There were no differences in pre-exercise oxygen consumption and blood lactate concentration; however, heart rate was greater in the active trial (p < 0.05). The peak mean 1-second maximum speed (MxSP) and group mean MxSP were not different in the active and passive trials (7.28 +/- 0.12 and 7.16 +/- 0.10 m x s(-1), respectively, and 7.07 +/- 0.33 and 7.02 +/- 0.24 m x s(-1), respectively; p > 0.05), although both were greater than the control. The percentage of decrement in performance fatigue was similar between all conditions (active, 3.4 +/- 1.3%; passive, 4.0 +/- 2.0%; and control, 3.7 +/- 2.4%). We conclude that there is no difference in high-intensity intermittent running performance when preceded by an active or passive warm-up when matched for post-warm-up Tc. However, repeated sprinting ability is significantly improved after both active and passive warm-ups compared to no warm-up.  相似文献   

2.
The purpose of this study was to compare a 5-minute treadmill activity at 70% maximum heart rate (MHR) and 5 to 6 minutes of ballistic stretching to a 5-minute treadmill activity at 60% of MHR and 5 to 6 minutes of static stretching. Thirty healthy college students, 7 men and 23 women, volunteered. Most volunteers were moderately active. All participants signed an informed consent. Participants received the aforementioned warm-ups in random order with 48 to 72 hours between warm-ups. The stretching exercises were a back stretch, a quadriceps stretch, and a hamstring stretch. Three trials for 30 seconds each were given. After each warm-up the participants performed the modified-modified Schober test for low back flexibility, active knee extension test for hamstring flexibility, and plantar flexion for ankle flexibility. There were no significant differences on any of the 3 range of motion (ROM) tests although the ankle ROM test was almost significantly greater (68.8 degrees ) after the warm-up with static stretching compared with 65.9 degrees after the warm-up with ballistic stretching. A more intense cardiovascular activity and ballistic stretching were similar to a less intense cardiovascular activity and static stretching on flexibility. If athletes perform a warm-up and static or ballistic stretching before their workouts, then they should continue to perform the warm-up and the stretching routine with which they are most familiar and comfortable.  相似文献   

3.
Muscle force production and power output in active males, regardless of the site of measurement (hand, leg, or back), are higher in the evening than in the morning. This diurnal variation is attributed to motivational, peripheral and central factors, and higher core and, possibly, muscle temperatures in the evening. This study investigated whether increasing morning rectal temperatures to evening resting values, by active or passive warm-ups, leads to muscle force production and power output becoming equal to evening values in motivated subjects. Ten healthy active males (mean ± SD: age, 21.2 ± 1.9 yrs; body mass, 75.4 ± 8 kg; height, 1.76 ± .06 m) completed the study, which was approved by the University Ethics Committee. The subjects were familiarized with the techniques and protocol and then completed four sessions (separated by at least 48 h): control morning (07:30 h) and evening (17:30 h) sessions (with an active 5-min warm-up) and then two further sessions at 07:30 h but proceeded by an extended active or passive warm-up to raise rectal temperature to evening values. These last two sessions were counterbalanced in order of administration. During each trial, three measures of handgrip strength, isokinetic leg strength measurements (of knee flexion and extension at 1.05 and 4.19 rad.s?1 through a 90° range of motion), and four measures of maximal voluntary contraction (MVC) on an isometric ergometer (utilizing the twitch-interpolation technique) were performed. Rectal and intra-aural temperatures, ratings of perceived exertion (RPE) and thermal comfort (TC) were measured. Measurements were made after the subjects had reclined for 30 min and after the warm-ups and prior to the measurement of handgrip and isokinetic and isometric ergometry. Muscle temperature was taken after the warm-up and immediately before the isokinetic and MVC measurements. Warm-ups were either active (cycle ergometer at 150 W) or passive (resting in a room at 35°C, relative humidity 45%). Data were analyzed using analysis of variance models with repeated measures. Rectal and intra-aural temperatures were higher at rest in the evening (.56°C and .74°C; p < .05) than in the morning, but there were no differences after the active or passive warm-ups, the subjects' ratings of thermal comfort reflecting this. Muscle temperatures also displayed significant diurnal variation, with higher values in the evening (~.31°C; p < .05). Grip strength, isokinetic knee flexion for peak torque and peak power at 1.05 rad.s?1, and knee extension for peak torque at 4.19 rad.s?1 all showed higher values in the evening. All other measures of strength or power showed a trend to be higher in the evening ( .10 > p > .05). There was no significant effect of active or passive warm-ups on any strength or power variable, and subjects reported maximal values for effort for each strength measure. In summary, effects of time of day were seen in some measures of muscle performance but, in this population of motivated subjects, there was no evidence that increasing morning rectal temperature to evening values by active or passive warm-up increased muscle strength to evening values. (Author correspondence: )  相似文献   

4.
The purpose of the study was to evaluate the effects of regular warm-up, and upper-body vibration (UBV), or UBV+ short warm-up on swimming performance in Masters Swimmers. Six women and 4 men, mean age 35 ± 9 years, active master swimmers volunteered to participate in the study. Participants were assigned to complete 1 of 3 warm-up types: regular, UBV-only, or UBV + short, rest for 3 minutes, and then completed a 50-yd (45.7 m) freestyle maximal performance time trial. The UBV treatment consisted of 5 minutes of upper-body vibration with a frequency of 22 Hz. Rating of perceived exertion (RPE) and heart rate (HR) were measured post warm-up and post 50-yd time trial. No significant mean differences (p = 0.56) were found among regular, UBV-only, or UBV + short warm-ups for 50-yd freestyle time (29.1 ± 3.36, 28.9 ± 3.39, and 29.1 ± 3.55 seconds, respectively). Individual data indicated that 40% (4/10) of the swimmers swam their fastest with UBV-only and 20% (2/10) with UBV + short warm-up compared to 40% (4/10) with regular warm-up. The RPE pre and post warm-ups did not differ significantly (p = 0.059 and p = 0.216, respectively). A significantly higher (p = 0.023) HR was observed after regular warm-up compared to UBV + short warm-up. Furthermore, HR post 50-yd after regular warm-up was significantly higher compared to UBV-only (p = 0.005) and UBV + short warm-up (p = 0.013). The findings of the present study indicate that UBV and UBV + short warm-up may be considered as addition or an alternative warm-up strategy to regular swimming warm-up, producing reduced cardio stress and perceived effort.  相似文献   

5.
The purpose of this study was to examine the effects of different modes of stretching within a pre-exercise warm-up on high-speed motor capacities important to soccer performance. Eighteen professional soccer players were tested for countermovement vertical jump, stationary 10-m sprint, flying 20-m sprint, and agility performance after different warm-ups consisting of static stretching, dynamic stretching, or no stretching. There was no significant difference among warm-ups for the vertical jump: mean +/- SD data were 40.4 +/- 4.9 cm (no stretch), 39.4 +/- 4.5 cm (static), and 40.2 +/- 4.5 cm (dynamic). The dynamic-stretch protocol produced significantly faster 10-m sprint times than did the no-stretch protocol: 1.83 +/- 0.08 seconds (no stretch), 1.85 +/- 0.08 seconds (static), and 1.87 +/- 0.09 seconds (dynamic). The dynamic- and static-stretch protocols produced significantly faster flying 20-m sprint times than did the no-stretch protocol: 2.41 +/- 0.13 seconds (no stretch), 2.37 +/- 0.12 seconds (static), and 2.37 +/- 0.13 seconds (dynamic). The dynamic-stretch protocol produced significantly faster agility performance than did both the no-stretch protocol and the static-stretch protocol: 5.20 +/- 0.16 seconds (no stretch), 5.22 +/- 0.18 seconds (static), and 5.14 +/- 0.17 seconds (dynamic). Static stretching does not appear to be detrimental to high-speed performance when included in a warm-up for professional soccer players. However, dynamic stretching during the warm-up was most effective as preparation for subsequent high-speed performance.  相似文献   

6.
BACKGROUND: In this research inactivity was simulated by immobilizing the forearm region in a plaster cast. Changes in skeletal muscle oxidative function were measured using near-infrared spectroscopy (NIRS), and the preventative effect of the training protocol on deterioration of skeletal muscle and the clinical utility of NIRS were examined. METHODS: Fourteen healthy adult men underwent immobilization of the forearm of the non-dominant arm by plaster cast for 21 days. Eight healthy adult subjects were designated as the immobilization group (IMM) and six were designated as the immobilization + training group (IMM+TRN). Grip strength, forearm circumference and dynamic handgrip exercise endurance were measured before and after the 21-day immobilization period. Using NIRS, changes in oxidative function of skeletal muscles were also evaluated. Muscle oxygen consumption recovery was recorded after the completion of 60 seconds of 40% maximum voluntary contraction (MVC) dynamic handgrip exercise 1 repetition per 4 seconds and the recovery time constant (TcVO2mus) was calculated. RESULTS: TcVO2mus for the IMM was 59.7 +/- 5.5 seconds (average +/- standard error) before immobilization and lengthened significantly to 70.4 +/- 5.4 seconds after immobilization (p < 0.05). For the IMM+TRN, TcVO2mus was 78.3 +/- 6.2 seconds before immobilization and training and shortened significantly to 63.1 +/- 5.6 seconds after immobilization and training (p < 0.05). CONCLUSIONS: The training program used in this experiment was effective in preventing declines in muscle oxidative function and endurance due to immobilization. The experimental results suggest that non-invasive monitoring of skeletal muscle function by NIRS would be possible in a clinical setting.  相似文献   

7.

Purpose

The purpose of this study was to determine whether endurance and strength hand grip exercises during 3-week upper limb immobilization preserve muscle oxidative capacity, endurance performance and strength.

Methods

Ten healthy adult men underwent non-dominant forearm immobilization by plaster cast for 21 days. Five healthy adult subjects were designated as the immobilization (IMM) group and five were designated as the immobilization + training (IMM+TRN) group. Grip strength, forearm circumference, dynamic handgrip endurance and muscle oxygenation response were measured before and after the 21 day immobilization period. Using near-infrared spectroscopy (NIRS), muscle oxygen consumption recovery (VO2mus) was recorded after a submaximal exercise and the recovery time constant (TcVO2mus) was calculated. Reactive hyperemic oxygenation recovery was evaluated after 5 minutes ischemia. Two training programs were performed by the IMM+TRN group twice a week. One exercise involved a handgrip exercise at 30% maximum voluntary contraction (MVC) at a rate of 1 repetition per 1 second until exhaustion (about 60 seconds). The other involved a handgrip exercise at 70% MVC for 2 seconds with a 2 second rest interval, repeated 10 times (40 seconds).

Results

There was a significant group-by-time interaction between the IMM and IMM+TRN groups in the TcVO2mus (p = 0.032, F = 6.711). A significant group-by-time interaction was observed between the IMM and IMM+TRN groups in the MVC (p = 0.001, F = 30.415) and in grip endurance (p = 0.014, F = 9.791). No significant group-by-time interaction was seen in forearm circumference and reactive hyperemic oxygenation response either in IMM or IMM+TRN group.

Conclusion

The training programs during immobilization period used in this experiment were effective in preventing a decline in muscle oxidative function, endurance and strength.
  相似文献   

8.
Bleiss W  Smith H 《Plant physiology》1985,77(3):552-555
Continuous recordings were made using a linear displacement transducer to investigate short-term growth responses of intact dark-grown wheat (Triticum aestivum L. cv Maris Huntsman) seedlings to red light. To eliminate any effect of light prior to the experimental treatments, the seedlings were grown and mounted on the transducer apparatus in total darkness. The growth kinetics after irradiation were complex and appeared to consist of three successive phases of growth deceleration. When the tip of the intact coleoptile was irradiated with red light from two opposite fiber bundles (fluence rate: 2 × 64 micromoles per square meter per second) for varying periods of time (10 seconds, 1 minute, 5 minutes, continuous), a decrease in extension rate was detectable after a latent period of 8 to 10 minutes. Up to 30 minutes after the start of the irradiation treatment, there was no difference in the kinetics of inhibition (about 20 to 25% inhibition) between the different lengths of irradiation. Extension rate reached a minimum (65% inhibition) at about 85 minutes, after which growth acceleration toward the dark control rate was observed. Far-red reversibility of the rapid effect of red light on growth was not observed, even when far-red light was given only 4 seconds after the end of 10 seconds red light. Short (15 seconds) far-red light did not induce a response.  相似文献   

9.
Recently, athletes have transitioned from traditional static stretching during warm-ups to incorporating dynamic stretching routines. However, the optimal volume of dynamic drills is yet to be identified. The aim of this repeated-measures study was to examine varying volumes (1, 2, and 3 sets) of active dynamic stretching (ADS) in a warm-up on 10- and 20-m sprint performance. With a within-subject design, 16 highly trained male participants (age: 20.9 ± 1.3 years; height: 179.7 ± 5.7 cm; body mass: 72.7 ± 7.9 kg; % body fat: 10.9 ± 2.4) completed a 5-minute general running warm-up before performing 3 preintervention measures of 10- to 20-m sprint. The interventions included 1, 2, and 3 sets of active dynamic stretches of the lower-body musculature (gastrocnemius, gluteals, hamstrings, quadriceps, and hip flexors) performed approximately 14 times for each exercise while walking (ADS1, ADS2, and ADS3). The active dynamic warm-ups were randomly allocated before performing a sprint-specific warm-up. Five minutes separated the end of the warm-up and the 3 postintervention measures of 10- to 20-m sprints. There were no significant time, condition, and interaction effects over the 10-m sprint time. For the 0- to 20-m sprint time, a significant main effect for the pre-post measurement (F = 10.81; p < 0.002), the dynamic stretching condition (F = 6.23; p = 0.004) and an interaction effect (F = 41.19; p = 0.0001) were observed. A significant decrease in sprint time (improvement in sprint performance) post-ADS1 (2.56%, p = 0.001) and post-ADS2 (2.61%, p = 0.001) was observed. Conversely, the results indicated a significant increase in sprint time (sprint performance impairment) post-ADS3 condition (2.58%, p = 0.001). Data indicate that performing 1-2 sets of 20 m of active dynamic stretches in a warm-up can enhance 20-m sprint performance. The results delineated that 3 sets of ADS repetitions could induce acute fatigue and impair sprint performance within 5 minutes of the warm-up.  相似文献   

10.
The purpose of this study was to determine if an active warm-up affects peak torque (PT), rate of torque development (RTD), and the electromyographic (EMG) and mechanomyographic (MMG) signals. Twenty-one men (mean age ± SD: 24.0 ± 2.7 years) visited the exercise physiology laboratory on 2 occasions. During the first visit, they either performed an active warm-up (10 minutes of stationary cycling at 70% of predicted maximum heart rate) or sat quietly (no warm-up). Participants were then tested for isometric and isokinetic (60°, 180°, and 300°·s) PT, and RTD (measured as S-gradient) on an isokinetic dynamometer. Electromyographic and MMG sensors were placed over the vastus lateralis muscle to monitor the electrical and mechanical aspects of muscle contractions, respectively. The testing protocol used for the first visit was repeated for the second visit, but the preexercise treatment (warm-up, no warm-up) not given during the first visit was administered. The results indicated that an active warm-up did not affect PT, RTD, or measures of muscle activation as reflected by EMG amplitude, EMG frequency, or MMG frequency (p > 0.05). However, MMG amplitude at 180°·s was significantly greater in the warm-up condition compared with the no warm-up condition. The isolated increase in MMG amplitude suggested that warm-up may have affected the mechanical properties of muscle by reducing muscular stiffness or decreasing intramuscular fluid pressure, but that it was not sufficient to influence performance.  相似文献   

11.
The purpose of this study was to determine the effectiveness of specific and nonspecific warm-ups on the vertical jump test performed by athletic men. Twenty-nine men (18-23 years) in athletics (speed positions in football) performed vertical jump tests on 4 separate days after completing 4 different warm-up protocols. The 4 warm-up protocols were (a) submaximal jump warm-up, (b) weighted jump warm-up, (c) stretching warm-up, and (d) no warm-up. The weighted jump warm-up protocol required 5 countermovement jumps onto a box, with the athletes holding dumbbells equaling 10% of their body weight. The submaximal jump warm-up protocol required the athletes to perform 5 countermovement jumps at 75% intensity of their past maximum vertical jump score. The stretching warm-up protocol required the athletes to perform 14 different stretches, each held for 20 seconds. The no warm-up protocol required the athletes to perform no activity prior to being tested. Three vertical jumps were measured following each warm-up; the score for analysis was the best jump. The data were analyzed with a repeated measures analysis of variance and Bonferroni post hoc tests. The Bonferroni post hoc tests showed a significant difference (p < 0.001) between the weighted jump warm-up and all other warm-ups. The effect size was 0.380 and the power was 1.00 for the statistical analyses. We concluded that utilizing a weighted resistance warm-up would produce the greatest benefit when performing the vertical jump test.  相似文献   

12.
13.
We sought to determine the relative contributions of cessation of skeletal muscle pumping and withdrawal of central command to the rapid decrease in arterial pressure during recovery from exercise. Twelve healthy volunteers underwent three exercise sessions, each consisting of a warm-up, 3 min of cycling at 60% of maximal heart rate, and 5 min of one of the following recovery modes: seated (inactive), loadless pedaling (active), and passive cycling. Mean arterial pressure (MAP), cardiac output, thoracic impedance, and heart rate were measured. When measured 15 s after exercise, MAP decreased less (P < 0.05) during the active (-3 +/- 1 mmHg) and passive (-6 +/- 1 mmHg) recovery modes than during inactive (-18 +/- 2 mmHg) recovery. These differences in MAP persisted for the first 4 min of recovery from exercise. Significant maintenance of central blood volume (thoracic impedance), stroke volume, and cardiac output paralleled the maintenance of MAP during active and passive conditions during 5 min of recovery. These data indicate that engaging the skeletal muscle pump by loadless or passive pedaling helps maintain MAP during recovery from submaximal exercise. The lack of differences between loadless and passive pedaling suggests that cessation of central command is not as important.  相似文献   

14.
The purpose of this study was to investigate the effects of 3 different warm-ups on vertical jump performance. The warm-ups included a 600-m jog, a 600-m jog followed by a dynamic stretching routine, and a 600-m jog followed by a proprioceptive neuromuscular facilitation (PNF) routine. A second purpose was to determine whether the effects of the warm-ups on vertical jump performance varied by gender. Sixty-eight men and women NCAA Division I athletes from North Dakota State University performed 3 vertical jumps on a Just Jump pad after each of the 3 warm-up routines. The subjects were split into 6 groups and rotated between 3 warm-up routines, completing 1 routine each day in a random order. The results of the 1-way repeated measures analysis of variance showed no significant differences in the combined (p = 0.927), men's (p = 0.798), or women's (p = 0.978) results. The results of this study showed that 3 different warm-ups did not have a significant affect on vertical jumping. The results also showed there were no gender differences between the 3 different warm-ups.  相似文献   

15.
Six endurance-trained young men were subjected to a 4 min maximal aerobic treadmill run (100% of VO2 max), after active or passive warm-up or rest on separate days. The increase in body temperature during the active and passive warm-up was controlled, so that the temperature reached the same level, before the subject was exposed to the maximal exercise. On average the rectal temperature rose to 38.3 degrees C (range 38.1-38.6 degrees C). The standard work resulted in a significant higher oxygen uptake, lower lactate concentration and higher blood pH when the work was preceded by active warm-up as compared with passive or no warm-up. The difference in total oxygen uptake during the run between the active and passive warm-up procedure was 0.8 1. No significant difference in minute volume of expired air or respiratory quotient was found. It is concluded that the physiological effects of a thorough active warm-up may be of substantial benefit to athletic performance.  相似文献   

16.
Recent evidence indicates that muscle ischemia and activation of the muscle chemoreflex are the principal stimuli to sympathetic nerve activity (SNA) during isometric exercise. We postulated that physical training would decrease muscle chemoreflex stimulation during isometric exercise and thereby attenuate the SNA response to exercise. We investigated the effects of 6 wk of unilateral handgrip endurance training on the responses to isometric handgrip (IHG: 33% of maximal voluntary contraction maintained for 2 min). In eight normal subjects the right arm underwent exercise training and the left arm sham training. We measured muscle SNA (peroneal nerve), heart rate, and blood pressure during IHG before vs. after endurance training (right arm) and sham training (left arm). Maximum work to fatigue (an index of training efficacy) was increased by 1,146% in the endurance-trained arm and by only 40% in the sham-trained arm. During isometric exercise of the right arm, SNA increased by 111 +/- 27% (SE) before training and by only 38 +/- 9% after training (P less than 0.05). Endurance training did not significantly affect the heart rate and blood pressure responses to IHG. We also measured the SNA response to 2 min of forearm ischemia after IHG in five subjects. Endurance training also attenuated the SNA response to postexercise forearm ischemia (P = 0.057). Sham training did not significantly affect the SNA responses to IHG or forearm ischemia. We conclude that endurance training decreases muscle chemoreflex stimulation during isometric exercise and thereby attenuates the sympathetic nerve response to IHG.  相似文献   

17.
Dietary supplement companies claim that arginine supplements acutely enhance skeletal muscular endurance. The purpose of this study was to determine whether acute arginine α-ketoglutarate supplementation (AAKG) will affect local muscle endurance of the arm and shoulder girdle or the blood pressure (BP) response to anaerobic exercise. Twelve trained college-aged men (22.6 ± 3.8 years) performed 2 trials of exercise separated by at least 1 week. At 4 hours before, and 30 minutes before exercise, a serving of an AAKG supplement (3,700 mg arginine alpha-ketoglutarate per serving) or placebo was administered. Resting BP was assessed pre-exercise after 16 minutes of seated rest, and 5 and 10 minutes postexercise. Three sets each of chin-ups, reverse chin-ups, and push-ups were performed to exhaustion with 3 minutes of rest between each set. Data were analyzed using repeated-measures analysis of variance and paired t-tests. The AAKG supplementation did not improve muscle endurance or significantly affect the BP response to anaerobic work. Subjects performed fewer total chin-ups (23.75 ± 6.38 vs. 25.58 ± 7.18) and total trial repetitions (137.92 ± 28.18 vs. 141.08 ± 28.57) in the supplement trial (p ≤ 0.05). Subjects executed fewer reverse chin-ups (5.83 ± 1.85 vs. 6.75 ± 2.09) during set 2 after receiving the supplement as compared to the placebo (p < 0.05). Because AAKG supplementation may hinder muscular endurance, the use of these supplements before resistance training should be questioned.  相似文献   

18.
The purpose of this study was to investigate the acute effect of 3 warm-up protocols on peak power production during countermovement jump (CMJ) testing. The intention was to devise and compare practical protocols that could be applied as a warm-up immediately before competition matches or weight training sessions. A group of 22 elite Australian Rules Football players performed 3 different warm-up protocols over 3 testing sessions in a randomized order. The protocols included a series of low load exercises targeting the gluteal muscle group (GM-P), a whole-body vibration (WBV) protocol (WBV-P) wherein the subjects stood on a platform vibrating at 30 Hz for 45 seconds, and a no-warm-up condition (CON). The CMJ testing was performed within 5 minutes of each warm-up protocol on an unloaded Smith machine using a linear encoder to measure peak power output. Peak power production was significantly greater after the GM-P than after both the CON (p < 0.05) and WBV-P (p < 0.01). No significant differences in peak power production were detected between the WBV-P and CON. These results have demonstrated that a low load exercise protocol targeting the gluteal muscle group is effective at acutely enhancing peak power output in elite athletes. The mechanisms for the observed improvements are unclear and warrant further investigation. Coaches may consider incorporating low load exercises targeting the gluteal muscle group into the warm-up of athletes competing in sports requiring explosive power output of the lower limbs.  相似文献   

19.
Intense exercise and insulin each increases total limb blood flow and recruits muscle capillaries, presumably to facilitate nutrient exchange. Whether mixed meals or light exercise likewise recruits capillaries is unknown. We fed 18 (9 M, 9 F) healthy volunteers a 480-kcal liquid mixed meal. Plasma glucose, insulin, brachial artery flow, and forearm muscle microvascular blood volume were measured before and after the meal. Brachial artery flow and microvascular volume were also examined with light (25% max), moderate (50%), and heavy (80%) forearm contraction every 20 s in 5 (4 M, 1 F) healthy adults. After the meal, glucose and insulin rose modestly (to approximately 7 mM and approximately 270 pM) and peaked by 30 min, whereas brachial artery blood flow (P < 0.05) and the microvascular volume (P < 0.01) each increased significantly by 60 min, and microvascular flow velocity did not change. For exercise, both 50 and 80%, but not 25% maximal handgrip, increased average forearm and brachial artery blood flow (P < 0.01). Flow increased immediately after each contraction and declined toward basal over 15 s. Exercise at 25% max increased microvascular volume threefold (P < 0.01) without affecting microvascular flow velocity or total forearm blood flow. Forearm exercise at 80% maximal grip increased both microvascular volume and microvascular flow velocity (P < 0.05 each). We conclude that light exercise and simple meals each markedly increases muscle microvascular volume, thereby expanding the endothelial surface for nutrient exchange, and that capillary recruitment is an important physiological response to facilitate nutrient/hormone delivery in healthy humans.  相似文献   

20.
Sympathetic alpha-adrenergic vasoconstrictor responses are blunted in the vascular beds of contracting muscle (functional sympatholysis). We tested the hypothesis that combined inhibition of nitric oxide (NO) and prostaglandins (PGs) restores sympathetic vasoconstriction in contracting human muscle. We measured forearm blood flow via Doppler ultrasound and calculated the reduction in forearm vascular conductance in response to alpha-adrenergic receptor stimulation during rhythmic handgrip exercise (6.4 kg) and during a control nonexercise vasodilator condition (using intra-arterial adenosine) before and after combined local inhibition of NO synthase (NOS; via N(G)-nitro-L-arginine methyl ester) and cyclooxygenase (via ketorolac) in healthy men. Before combined inhibition of NO and PGs, the forearm vasoconstrictor responses to intra-arterial tyramine (which evoked endogenous noradrenaline release), phenylephrine (a selective alpha1-agonist), and clonidine (an alpha2-agonist) were significantly blunted during exercise compared with adenosine treatment. After combined inhibition of NO and PGs, the vasoconstrictor responses to all alpha-adrenergic receptor stimuli were augmented by approximately 10% in contracting muscle (P <0.05), whereas the responses to phenylephrine and clonidine were also augmented by approximately 10% during passive vasodilation in resting muscle (P <0.05). In six additional subjects, PG inhibition alone did not alter the vasoconstrictor responses in resting or contracting muscles. Thus in light of our previous findings, it appears that inhibition of either NO or PGs alone does not affect functional sympatholysis in healthy humans. However, the results from the present study indicate that combined inhibition of NO and PGs augments alpha-adrenergic vasoconstriction in contracting muscle but does not completely restore the vasoconstrictor responses compared with those observed during passive vasodilation in resting muscle.  相似文献   

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