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1.
《Molecular & cellular proteomics : MCP》2020,19(1):167-180
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- •Novel two-dimensional separation system for identification of citrullinated peptides.
- •Dedicated software developed for confident validation of citrullination.
- •P. gingivalis citrullinome: 78 proteins with a total of 161 citrullinated peptides.
- •Confident discrimination of P. gingivalis OMVs from wild-type and PPAD mutants.
2.
Anatte Margalit James C. Carolan David Sheehan Kevin Kavanagh 《Molecular & cellular proteomics : MCP》2020,19(8):1346-1359
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- •Pseudomonas aeruginosa growth increases in Aspergillus fumigatus culture filtrates.
- •A. fumigatus culture filtrates are characterized by a range of peptidases and proteases.
- •LFQ proteomics characterizes the response of P. aeruginosa to A. fumigatus culture filtrates.
- •A. fumigatus creates an environment for P. aeruginosa to proliferate.
3.
《Molecular & cellular proteomics : MCP》2020,19(4):589-607
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- •P. aeruginosa grown with exosiderophores and analyzed by proteomic and RT-qPCR.
- •Catechol-type exosiderophores strongly induce the expression of their transporters.
- •Repression of the endogenous iron uptake pathways.
- •Complex phenotypic plasticity in the expression of the various iron-uptake pathways.
4.
《Molecular & cellular proteomics : MCP》2020,19(5):900-912
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- •Affinity-based proteomics of infected macrophage cells.
- •Salmonella-modified membranes exhibit host-specific composition.
- •Proteome differences explain some host-dependent pathophysiological differences.
5.
Factors promoting (orange) and suppressing (blue) the frequency of sexual commitment rate in Plasmodium falciparum. 相似文献
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6.
Felicia Grasso Stefania Mochi Federica Fratini Anna Olivieri Chiara Curr Inga Siden Kiamos Elena Deligianni Cecilia Birago Leonardo Picci Elisabetta Pizzi Tomasino Pace Marta Ponzi 《Molecular & cellular proteomics : MCP》2020,19(12):1986-1997
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- •Quantitative analysis of Plasmodium sexual stage egress secretome.
- •Activated gametocytes release gender-related proteins.
- •Gametocyte egress process involves different types of vesicles.
7.
《Molecular & cellular proteomics : MCP》2020,19(1):155-166
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- •Characterization of 12 proteins from across the P. falciparum sexual-stages as possible TBV targets.
- •Heterologously expressed recombinant proteins recapitulate native parasite epitopes.
- •Some recombinant proteins exhibit immunoreactivity when tested against sera from individuals from malaria-endemic Burkina Faso and Mali.
- •Purified IgG against the antigen enolase moderately inhibits parasite development in the mosquito midgut.
8.
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9.
Steven T. Bruckbauer Benjamin B. Minkoff Deyang Yu Vincent L. Cryns Michael M. Cox Michael R. Sussman 《Molecular & cellular proteomics : MCP》2020,19(8):1375-1395
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- •Quantifying ionizing radiation-induced oxidation in E. coli and D. radiodurans.
- •Amelioration of protein damage dependent upon cellular components.
- •GAPDH active site is highly modified and also IR-modified in H. sapiens.
10.
《Molecular & cellular proteomics : MCP》2020,19(3):518-528
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- •Discovery of peptide biomarker candidates of respiratory tract pathogens S. pneumoniae, H. influenzae, M. catarrhalis and S. aureus as target pathogens.
- •Peptide biomarker candidates were experimentally verified in clinical samples.
- •Targeted MS using promising peptide biomarker candidates shown as proof-of-concept.
11.
《Molecular & cellular proteomics : MCP》2020,19(6):994-1004
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- •HLA-B*27:05 and ERAP2 are risk factors for ankylosing spondylitis.
- •The effects of ERAP2 on the B*27:05 ligandome are defined.
- •P1, P2, P3, P7, and PΩ peptide positions are influenced by ERAP2.
- •These effects provide a basis for the association of ERAP2 with the autoimmune disease.
12.
《Molecular & cellular proteomics : MCP》2020,19(1):198-208
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- •An automated de novo sequencing program is evaluated with respect to different types of data.
- •The number of unique high scoring de novo sequences that can be assigned to a data set provides a metric of overall data quality.
- •A database suitability metric is presented for situations when the database choice is not obvious, or when the database quality is uncertain.
13.
《Molecular & cellular proteomics : MCP》2020,19(4):690-700
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- •Two molecular groups in anal squamous carcinoma according proteomic profile.
- •Differences in possible targeted processes such as metabolism or immune response.
- •Different percentage of tumor lymphocyte infiltration.
- •Difference in the frequency of ATM variants, related to PPAR inhibitors.
14.
《Molecular & cellular proteomics : MCP》2020,19(1):101-113
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- •A predictive modelling framework has been established to analyze IgG antibody responses against a large panel of P. falciparum-specific antigens to identify a specific antigen signature of NAI.
- •An individual's immune status can be accurately predicted by measuring IgG responses against a small set of 15 defined parasite antigens.
- •Proteins identified in the 15-antigen signature represent potential candidates for next-generation malaria vaccines or biomarkers for monitoring the impact of malaria interventions.
- •The developed predictive framework can be adapted for developing novel surveillance and intervention tools for other infectious diseases.
15.
Jana Zecha Chien-Yun Lee Florian P. Bayer Chen Meng Vincent Grass Johannes Zerweck Karsten Schnatbaum Thomas Michler Andreas Pichlmair Christina Ludwig Bernhard Kuster 《Molecular & cellular proteomics : MCP》2020,19(9):1503-1522
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- •In-depth proteomes of 4 SARS-CoV-2 cell line models (Vero E6, Calu-3, Caco-2, A549).
- •Proteomic evidence for thousands of Chlorocebus sabaeus proteins.
- •Proteomic response of Vero E6 cells to SARS-CoV-2 infection.
- •Synthetic peptides, spectral libraries, and targeted assays for SARS-CoV-2 proteins.
16.
Deborah Chang William E. Hackett Lei Zhong Xiu-Feng Wan Joseph Zaia 《Molecular & cellular proteomics : MCP》2020,19(9):1533-1545
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- •Changes in N-linked glycosylation in influenza A virus affect antigenicity of the virus.
- •Glycosylation similarity can be quantified, even in heterogeneously glycosylated proteins.
- •Glycosylation is measurably and site-specifically distinct in influenza from related strains.
17.
《Molecular & cellular proteomics : MCP》2020,19(3):529-539
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- •N-glycosylation site analysis of the hemipteran pest insect Nilaparvata lugens.
- •Differential N-glycosylation of proteins is observed between male and female adults.
- •Sex-specific glycoproteins are involved in insect reproduction.
18.
《Molecular & cellular proteomics : MCP》2020,19(3):501-517
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- •Urinary peptide profiling of youths with type 1 diabetes before clinical injury.
- •Internal validation of uromodulin peptides by parallel reaction monitoring.
- •Discovery of novel bioactivity of uromodulin peptides in vitro.
- •In silico prediction of proteases involved in uromodulin processing.
19.
Prashali Bansal Johannes Madlung Kristina Schaaf Boris Macek Fulvia Bono 《Molecular & cellular proteomics : MCP》2020,19(9):1485-1502
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- •Label-free and dimethyl labeling MS analysis of 6 RBPs from Drosophila ovaries.
- •Functionally related RBPs show overlapping proteomes.
- •Selective co-purification of splicing factors and translational regulators.
- •Validation of 26 novel interactions by co-immunoprecipitation.
20.
Barbara Steigenberger Henk W.P. van den Toorn Emiel Bijl Jean-Franois Greisch Oliver Rther Markus Lubeck Roland J. Pieters Albert J.R. Heck Richard A. Scheltema 《Molecular & cellular proteomics : MCP》2020,19(10):1677-1687
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- •Cross-linked peptides are physically separated from mono-linked peptides in the gas-phase by TIMS ion mobility.
- •Development of a novel data acquisition routine that a-priori distinguishes cross-linked from mono-linked peptides called caps-PASEF.
- •First application of PhoX-driven cross-linking mass spectrometry on the timsTOF Pro.
- •Application of cross-linking mass spectrometry to medium to high complexity samples.