Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation

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The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response

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Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores

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Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA

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SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal

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Transcript-specific determinants of pre-mRNA splicing revealed through in vivo kinetic analyses of the 1st and 2nd chemical steps

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Mechanism of exon ligation by human spliceosome

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Alternative RNA structures formed during transcription depend on elongation rate and modify RNA processing

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High-resolution quantitative profiling of tRNA abundance and modification status in eukaryotes by mim-tRNAseq

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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

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METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

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Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation

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Efficient RNA polymerase II pause release requires U2 snRNP function

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Translational adaptation of human viruses to the tissues they infect

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DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing

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FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism

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Gene architecture directs splicing outcome in separate nuclear spatial regions

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Structural basis for conformational equilibrium of the catalytic spliceosome

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Alternative splicing is a developmental switch for hTERT expression

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Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification

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