Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

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Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation

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DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation

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PRC1 Catalytic Activity Is Central to Polycomb System Function

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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

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Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells

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The Polycomb group protein MEDEA controls cell proliferation and embryonic patterning in Arabidopsis

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EED is required for mouse primordial germ cell differentiation in the embryonic gonad

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Loss of Ezh2 function remodels the DNA replication initiation landscape

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Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells

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Dnmt3bas coordinates transcriptional induction and alternative exon inclusion to promote catalytically active Dnmt3b expression

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TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways

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Machine-learning-optimized Cas12a barcoding enables the recovery of single-cell lineages and transcriptional profiles

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Microtubule-sliding modules based on kinesins EG5 and PRC1-dependent KIF4A drive human spindle elongation

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Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells

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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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