Bacterial peptidoglycan muropeptides benefit mitochondrial homeostasis and animal physiology by acting as ATP synthase agonists

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Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin

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Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis

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A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo

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Structures of an active type III-A CRISPR effector complex

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ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis

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A conserved family of immune effectors cleaves cellular ATP upon viral infection

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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

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Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry

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Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters

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Nucleotide Binding,Evolutionary Insights,and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

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Structures of the human Wilson disease copper transporter ATP7B

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Localized glucose import,glycolytic processing,and mitochondria generate a focused ATP burst to power basement-membrane invasion

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Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions

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Pulmonary neuroendocrine cells sense succinate to stimulate myoepithelial cell contraction

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Serine metabolism antagonizes antiviral innate immunity by preventing ATP6V0d2-mediated YAP lysosomal degradation

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Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance

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Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2

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Fundamental behaviors emerge from simulations of a living minimal cell

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Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord

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