共查询到20条相似文献,搜索用时 15 毫秒
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Tingzhe Sun Chun Chen Yuanyuan Wu Shuai Zhang Jun Cui Pingping Shen 《BMC bioinformatics》2009,10(1):190
Background
The tumor suppressor p53 plays pivotal roles in tumorigenesis suppression. Although oscillations of p53 have been extensively studied, the mechanism of p53 pulses and their physiological roles in DNA damage response remain unclear. 相似文献3.
Background
The actin cytoskeleton plays critical roles in early development in Caenorhabditis elegans. To further understand the complex roles of actin in early embryogenesis we use RNAi and in vivo imaging of filamentous actin (F-actin) dynamics. 相似文献4.
Zhu W Meng L Jiang C He X Hou W Xu P Du H Holmdahl R Lu S 《Arthritis research & therapy》2011,13(3):R103-15
Introduction
Toll-like receptors (TLRs) are likely to play crucial roles in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to determine the key TLRs in synovium and explore their roles in the activation of fibroblast-like synoviocytes (FLSs) mediated by T cells in arthritis. 相似文献5.
Allisan Aquilina-Beck Kristine Ilagan Qin Liu Jennifer O Liang 《BMC developmental biology》2007,7(1):126
Background
Nodals are secreted signaling proteins with many roles in vertebrate development. Here, we identify a new role for Nodal signaling in regulating closure of the rostral neural tube of zebrafish. 相似文献6.
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Identification, cloning and functional characterization of novel beta-defensins in the rat (Rattus norvegicus) 总被引:1,自引:0,他引:1
Suresh Yenugu Vishnu Chintalgattu Christopher J Wingard Yashwanth Radhakrishnan Frank S French Susan H Hall 《Reproductive biology and endocrinology : RB&E》2006,4(1):7-9
Background
beta-defensins are small cationic peptides that exhibit broad spectrum antimicrobial properties. The majority of beta-defensins identified in humans are predominantly expressed in the male reproductive tract and have roles in non-immunological processes such as sperm maturation and capacitation. Characterization of novel defensins in the male reproductive tract can lead to increased understanding of their dual roles in immunity and sperm maturation. 相似文献8.
Mi-Nyeu Kim Moon Nyeo Park Hoi Kyung Jung Chunghee Cho Kelly E Mayo Byung-Nam Cho 《Reproductive biology and endocrinology : RB&E》2008,6(1):63
Background
The TGF-beta family protein activin has numerous reported activities with some uncertainty in the reproductive axis and development. The precise roles of activin in in vivo system were investigated using a transient gain of function model. 相似文献9.
Wanda M Waterworth Jaroslav Kozak Claire M Provost Clifford M Bray Karel J Angelis Christopher E West 《BMC plant biology》2009,9(1):79
Background
DNA ligase enzymes catalyse the joining of adjacent polynucleotides and as such play important roles in DNA replication and repair pathways. Eukaryotes possess multiple DNA ligases with distinct roles in DNA metabolism, with clear differences in the functions of DNA ligase orthologues between animals, yeast and plants. DNA ligase 1, present in all eukaryotes, plays critical roles in both DNA repair and replication and is indispensable for cell viability. 相似文献10.
Background
The periplasmic High Temperature Requirement protein A (HtrA) plays important roles in bacterial protein folding and stress responses. However, the role of chlamydial HtrA (cHtrA) in chlamydial pathogenesis is not clear. 相似文献11.
Alexander Goonesinghe Xing-Ming Luan Adam Hurlstone David Garrod 《BMC developmental biology》2012,12(1):1
Background
The desmosomal cadherins (DCs), desmocollin (Dsc) and desmoglein (Dsg), are the adhesion molecules of desmosomes, intercellular adhesive junctions of epithelia and cardiac muscle. Both the DCs and desmosomes have demonstrably essential roles in mammalian development. In order to initiate their study in a more tractable developmental system we have characterised zebrafish DCs and examined their roles in early zebrafish development. 相似文献12.
Background
Stromal derived factor (SDF-1), an alpha chemokine, is a widely known chemoattractant in the immune system. A growing body of evidence now suggests multiple regulatory roles for SDF-1 in the developing nervous system. 相似文献13.
Jie Lian Xiansheng Zhang Hui Tian Ning Liang Yong Wang Chaozhao Liang Xin Li Fei Sun 《Reproductive biology and endocrinology : RB&E》2009,7(1):13-10
Background
MicroRNAs (miRNAs), a class of small non-coding RNA molecules, are indicated to play essential roles in spermatogenesis. However, little is known about the expression patterns or function of miRNAs in human testes involved in infertility. 相似文献14.
Tomomi Aono Yoichi Sakamoto Masahiro Miura Fusako Takeuchi Hiroshi Hori Motonari Tsubaki 《Journal of biomedical science》2010,17(1):90
Background
Cytochrome b 5 performs central roles in various biological electron transfer reactions, where difference in the redox potential of two reactant proteins provides the driving force. Redox potentials of cytochromes b 5 span a very wide range of ~400 mV, in which surface charge and hydrophobicity around the heme moiety are proposed to have crucial roles based on previous site-directed mutagenesis analyses. 相似文献15.
Background
Brassinosteroids (BRs) play crucial roles in plant development and also promote tolerance to a range of abiotic stresses. Although much has been learned about their roles in plant development, the mechanisms by which BRs control plant stress responses and regulate stress-responsive gene expression are not fully known. Since BR interacts with other plant hormones, it is likely that the stress tolerance conferring ability of BR lies in part in its interactions with other stress hormones. 相似文献16.
Gunay Mammadova Tetsushi Iwasaki Alexander A Tokmakov Yasuo Fukami Ken-ichi Sato 《BMC developmental biology》2009,9(1):68-12
Background
Studies have examined the function of PI 3-kinase in the early developmental processes that operate in oocytes or early embryos of various species. However, the roles of egg-associated PI 3-kinase and Akt, especially in signal transduction at fertilization, are not well understood. 相似文献17.
Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer
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Xueyan Zang Lei Pan Wei Liang Jingyan Chen Hui Qian Wenrong Xu Pengcheng Jiang Xu Zhang 《Cell proliferation》2018,51(1)
Objectives
Long noncoding RNAs (lncRNAs) play important roles in cancer development and progression. The deregulated expression of LINC00978 has been reported in human cancers. However, the expression pattern and biological roles of LINC00978 in gastric cancer (GC) remain unclear. In this study, we investigated the potential roles and clinical value of LINC00978 in gastric cancer.Materials and methods
QRT‐PCR was performed to investigate the expression of LINC00978 in gastric cancer cell lines, tissues and serum samples. Cell counting, colony formation, transwell migration and matrigel invasion assays were performed to determine the effects of shRNA‐mediated knockdown of LINC00978 on gastric cancer cell functions. In vivo tumour growth assay was also conducted. Flow cytometry, immunohistochemistry, western blot and qRT‐PCR were used for potential mechanism study.Results
LINC00978 expression level was elevated in GC tumour tissues, serum samples and cell lines. The expression level of LINC00978 was significantly correlated with tumour size (P = 0.02), lymphatic metastasis (P = 0.009) and TNM stage (P = 0.009). LINC00978 knockdown inhibited the proliferation of GC cells by suppressing cell cycle progression and inducing apoptosis. LINC00978 knockdown also inhibited the migration and invasion of GC cells. In addition, LINC00978 knockdown inhibited the activation of TGF‐β/SMAD signalling pathway and the process of epithelial‐mesenchymal transition (EMT) in GC cells. Moreover, the in vivo tumorigenicity of LINC00978 knockdown GC cells in mice was significantly decreased.Conclusions
LINC00978 promotes gastric cancer progression and may serve as a potential biomarker for GC. 相似文献18.
Qiangwei Xia Tiansong Wang Erik L Hendrickson Thomas J Lie Murray Hackett John A Leigh 《BMC microbiology》2009,9(1):149
Background
Methanogenic Archaea play key metabolic roles in anaerobic ecosystems, where they use H2 and other substrates to produce methane. Methanococcus maripaludis is a model for studies of the global response to nutrient limitations. 相似文献19.
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