共查询到20条相似文献,搜索用时 15 毫秒
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Background
High-throughput genotyping technology has enabled cost effective typing of thousands of individuals in hundred of thousands of markers for use in genome wide studies. This vast improvement in data acquisition technology makes it an informatics challenge to efficiently store and manipulate the data. While spreadsheets and at text files were adequate solutions earlier, the increased data size mandates more efficient solutions. 相似文献2.
Geert Vandeweyer Edwin Reyniers Wim Wuyts Liesbeth Rooms R Frank Kooy 《BMC bioinformatics》2011,12(1):4
Background
Microarray technology allows the analysis of genomic aberrations at an ever increasing resolution, making functional interpretation of these vast amounts of data the main bottleneck in routine implementation of high resolution array platforms, and emphasising the need for a centralised and easy to use CNV data management and interpretation system. 相似文献3.
Background
As the use of microarray technology becomes more prevalent it is not unusual to find several laboratories employing the same microarray technology to identify genes related to the same condition in the same species. Although the experimental specifics are similar, typically a different list of statistically significant genes result from each data analysis. 相似文献4.
Ki-Yeol Kim Dong Hyuk Ki Ha Jin Jeong Hei-Cheul Jeung Hyun Cheol Chung Sun Young Rha 《BMC bioinformatics》2007,8(1):218
Background
With microarray technology, variability in experimental environments such as RNA sources, microarray production, or the use of different platforms, can cause bias. Such systematic differences present a substantial obstacle to the analysis of microarray data, resulting in inconsistent and unreliable information. Therefore, one of the most pressing challenges in the field of microarray technology is how to integrate results from different microarray experiments or combine data sets prior to the specific analysis. 相似文献5.
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Matthew E Ritchie Matthew S Forrest Antigone S Dimas Caroline Daelemans Emmanouil T Dermitzakis Panagiotis Deloukas Simon Tavaré 《BMC bioinformatics》2010,11(1):280
Background
High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use of Illumina's GoldenGate BeadArray technology to measure ASE. This platform exploits coding SNPs to obtain relative expression measurements for alleles at approximately 1500 positions in the genome. 相似文献7.
Background
Users of microarray technology typically strive to use universally acceptable data analysis strategies to determine significant expression changes in their experiments. One of the most frequently utilised methods for gene expression data analysis is SAM (significance analysis of microarrays). The impact of selection thresholds, on the output from SAM, may critically alter the conclusion of a study, yet this consideration has not been systematically evaluated in any publication. 相似文献8.
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Victoria Martin-Requena Antonio Mu?oz-Merida M Gonzalo Claros Oswaldo Trelles 《BMC bioinformatics》2009,10(1):16
Background
Nowadays, microarray gene expression analysis is a widely used technology that scientists handle but whose final interpretation usually requires the participation of a specialist. The need for this participation is due to the requirement of some background in statistics that most users lack or have a very vague notion of. Moreover, programming skills could also be essential to analyse these data. An interactive, easy to use application seems therefore necessary to help researchers to extract full information from data and analyse them in a simple, powerful and confident way. 相似文献12.
Wei Tan Ravi Madduri Alexandra Nenadic Stian Soiland-Reyes Dinanath Sulakhe Ian Foster Carole A Goble 《BMC bioinformatics》2010,11(1):542
Background
In biological and medical domain, the use of web services made the data and computation functionality accessible in a unified manner, which helped automate the data pipeline that was previously performed manually. Workflow technology is widely used in the orchestration of multiple services to facilitate in-silico research. Cancer Biomedical Informatics Grid (caBIG) is an information network enabling the sharing of cancer research related resources and caGrid is its underlying service-based computation infrastructure. CaBIG requires that services are composed and orchestrated in a given sequence to realize data pipelines, which are often called scientific workflows. 相似文献13.
Background
Current genomic research methods provide researchers with enormous amounts of data. Combining data from different high-throughput research technologies commonly available in biological databases can lead to novel findings and increase research efficiency. However, combining data from different heterogeneous sources is often a very arduous task. These sources can be different microarray technology platforms, genomic databases, or experiments performed on various species. Our aim was to develop a software program that could facilitate the combining of data from heterogeneous sources, and thus allow researchers to perform genomic cross-platform/cross-species studies and to use existing experimental data for compendium studies. 相似文献14.
Background
Improvements in technology have been accompanied by the generation of large amounts of complex data. This same technology must be harnessed effectively if the knowledge stored within the data is to be retrieved. Storing data in ontologies aids its management; ontologies serve as controlled vocabularies that promote data exchange and re-use, improving analysis. 相似文献15.
A compact phage display human scFv library for selection of antibodies to a wide variety of antigens 总被引:1,自引:0,他引:1
Potjamas Pansri Nanthnit Jaruseranee Kuntalee Rangnoi Peter Kristensen Montarop Yamabhai 《BMC biotechnology》2009,9(1):6-16
Background
Phage display technology is a powerful new tool for making antibodies outside the immune system, thus avoiding the use of experimental animals. In the early days, it was postulated that this technique would eventually replace hybridoma technology and animal immunisations. However, since this technology emerged more than 20 years ago, there have only been a handful reports on the construction and application of phage display antibody libraries world-wide. 相似文献16.
J Thomas Welcker Frank Nawroth Wilma Bilger 《Reproductive biology and endocrinology : RB&E》2010,8(1):111
Background
Self-administration of recombinant human follicle-stimulating hormone (r-hFSH) can be performed using injection pen devices by women undergoing assisted reproductive technology procedures. The objective of this study was to explore the use of the prefilled follitropin alfa pen in routine assisted reproductive technology procedures in Germany. 相似文献17.
Jesper Hedal Kløverpris Kenneth Baltzer Per H. Nielsen 《The International Journal of Life Cycle Assessment》2010,15(1):90-103
Background, aims and scope
Most life cycle inventory data for crops do not include the ultimate (marginal) land use induced by crop consumption. The aims of this study were to present, document and discuss a method which can solve this problem and, furthermore, to present concrete examples for wheat consumption in Brazil, China, Denmark and the USA. A global scope is applied and the simulated adaptation to increased wheat demand corresponds to a long-term temporal scope under present market conditions with present technology. 相似文献18.
Background
With current technology, vast amounts of data can be cheaply and efficiently produced in association studies, and to prevent data analysis to become the bottleneck of studies, fast and efficient analysis methods that scale to such data set sizes must be developed. 相似文献19.
Daniel Glez-Pe?a Rodrigo álvarez Fernando Díaz Florentino Fdez-Riverola 《BMC bioinformatics》2009,10(1):37
Background
Expression profiling assays done by using DNA microarray technology generate enormous data sets that are not amenable to simple analysis. The greatest challenge in maximizing the use of this huge amount of data is to develop algorithms to interpret and interconnect results from different genes under different conditions. In this context, fuzzy logic can provide a systematic and unbiased way to both (i) find biologically significant insights relating to meaningful genes, thereby removing the need for expert knowledge in preliminary steps of microarray data analyses and (ii) reduce the cost and complexity of later applied machine learning techniques being able to achieve interpretable models. 相似文献20.
Yao Yu Kang Tu Siyuan Zheng Yun Li Guohui Ding Jie Ping Pei Hao Yixue Li 《BMC bioinformatics》2009,10(1):264-7