共查询到20条相似文献,搜索用时 15 毫秒
1.
Background
Microarray and other high-throughput technologies are producing large sets of interesting genes that are difficult to analyze directly. Bioinformatics tools are needed to interpret the functional information in the gene sets. 相似文献2.
Jürgen Hartler Gerhard G Thallinger Gernot Stocker Alexander Sturn Thomas R Burkard Erik Körner Robert Rader Andreas Schmidt Karl Mechtler Zlatko Trajanoski 《BMC bioinformatics》2007,8(1):197
Background
The advancements of proteomics technologies have led to a rapid increase in the number, size and rate at which datasets are generated. Managing and extracting valuable information from such datasets requires the use of data management platforms and computational approaches. 相似文献3.
Background
The development of high-throughput technologies such as yeast two-hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction (PPI) datasets. Mining these datasets for underlying biological knowledge has, however, remained a challenge. 相似文献4.
Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma 下载免费PDF全文
Bin Yan Xinping Yang Tin-Lap Lee Jay Friedman Jun Tang Carter Van Waes Zhong Chen 《Genome biology》2007,8(5):R78
5.
Michael A Gieseg Theresa Cody Michael Z Man Steven J Madore Mark A Rubin Eric P Kaldjian 《BMC bioinformatics》2002,3(1):26-13
Background
Molecular characterization has contributed to the understanding of the inception, progression, treatment and prognosis of cancer. Nucleic acid array-based technologies extend molecular characterization of tumors to thousands of gene products. To effectively discriminate between tumor sub-types, reliable laboratory techniques and analytic methods are required. 相似文献6.
Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
Background
Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells. As the size of the interaction dataset increases, powerful computational methods are required in order to effectively distil network models from large-scale interactome data. 相似文献7.
8.
Background
Gene synthesis technologies are an important tool for structural biology projects, allowing increased protein expression through codon optimization and facilitating sequence alterations. Existing methods, however, can be complex and not always reproducible, prompting researchers to use commercial suppliers rather than synthesize genes themselves. 相似文献9.
Background
As high-throughput technologies rapidly generate genome-scale data, it becomes increasingly important to visually integrate these data so that specific hypotheses can be formulated and tested. 相似文献10.
Daniel Rios William M McLaren Yuan Chen Ewan Birney Arne Stabenau Paul Flicek Fiona Cunningham 《BMC bioinformatics》2010,11(1):238
Background
Advances in sequencing and genotyping technologies are leading to the widespread availability of multi-species variation data, dense genotype data and large-scale resequencing projects. The 1000 Genomes Project and similar efforts in other species are challenging the methods previously used for storage and manipulation of such data necessitating the redesign of existing genome-wide bioinformatics resources. 相似文献11.
Background
Ultra-high throughput sequencing technologies provide opportunities both for discovery of novel molecular species and for detailed comparisons of gene expression patterns. Small RNA populations are particularly well suited to this analysis, as many different small RNAs can be completely sequenced in a single instrument run. 相似文献12.
Background
Recent advances in proteomics technologies such as SELDI-TOF mass spectrometry has shown promise in the detection of early stage cancers. However, dimensionality reduction and classification are considerable challenges in statistical machine learning. We therefore propose a novel approach for dimensionality reduction and tested it using published high-resolution SELDI-TOF data for ovarian cancer. 相似文献13.
Background
Advances in high-throughput technologies available to modern biology have created an increasing flood of experimentally determined facts. Ordering, managing and describing these raw results is the first step which allows facts to become knowledge. Currently there are limited ways to automatically annotate such data, especially utilizing information deposited in published literature. 相似文献14.
Robert Kofler Tatiana Teixeira Torres Tamas Lelley Christian Schl?tterer 《BMC bioinformatics》2009,10(1):143
Background
Next generation sequencing technologies hold great potential for many biological questions. While mainly used for genomic sequencing, they are also very promising for gene expression profiling. Sequencing of cDNA does not only provide an estimate of the absolute expression level, it can also be used for the identification of allele specific gene expression. 相似文献15.
Background
Despite significant progress in imaging technologies, the efficient detection of edges and elongated features in images of intracellular and multicellular structures acquired using light or electron microscopy is a challenging and time consuming task in many laboratories. 相似文献16.
Laxman Yetukuri Mikko Katajamaa Gema Medina-Gomez Tuulikki Seppänen-Laakso Antonio Vidal-Puig Matej Orešič 《BMC systems biology》2007,1(1):12-15
Background
Lipids are an important and highly diverse class of molecules having structural, energy storage and signaling roles. Modern analytical technologies afford screening of many lipid molecular species in parallel. One of the biggest challenges of lipidomics is elucidation of important pathobiological phenomena from the integration of the large amounts of new data becoming available. 相似文献17.
Background
The recent availability of new, less expensive high-throughput DNA sequencing technologies has yielded a dramatic increase in the volume of sequence data that must be analyzed. These data are being generated for several purposes, including genotyping, genome resequencing, metagenomics, and de novo genome assembly projects. Sequence alignment programs such as MUMmer have proven essential for analysis of these data, but researchers will need ever faster, high-throughput alignment tools running on inexpensive hardware to keep up with new sequence technologies. 相似文献18.
Alfonso Baldi Raffaele Murace Emanuele Dragonetti Mario Manganaro Oscar Guerra Stefano Bizzi Luca Galli 《Biomedical engineering online》2009,8(1):18-10
Background
New generations of image-based diagnostic machines are based on digital technologies for data acquisition; consequently, the diffusion of digital archiving systems for diagnostic exams preservation and cataloguing is rapidly increasing. To overcome the limits of current state of art text-based access methods, we have developed a novel content-based search engine for dermoscopic images to support clinical decision making. 相似文献19.
Philippe Lehert Joan C Schertz Diego Ezcurra 《Reproductive biology and endocrinology : RB&E》2010,8(1):112
Background
Human menopausal gonadotrophins and recombinant human follicle stimulating hormone are the two main gonadotrophin products utilized for controlled ovarian stimulation in assisted reproductive technologies. In this meta-analysis, the number of oocytes was designated as the most relevant endpoint directly resulting from ovarian stimulation, and therefore where the drug effect may be estimated with the best sensitivity. 相似文献20.