Chromosome numbers of Costa Rican grasses

Chromosome counts are presented for 217 species of 103 genera of grasses from Costa Rica. Four of the genera and 90 of the species are reported for the first time. In addition, 26 counts differ from previous records for the same taxon. The generaGynerium, Lithachne, Luziola, andThrasya were heretofore unknown cytologically. First counts are also given for the following species:Agrostis bacillata, A. pittieri, A. sub patens, Andropogon angustatus, A. bicornis, A. virgatus, Aristida capillacea, A. jorullensis, Arundinella berteroniana, A. deppeana, Axonopus aureus, A. capillaris, A. chrysoblepharis, Bouteloua americana, B. disticha, Bromus exaltatus, Calamagrostis intermedia, C. nuda, C. pittieri, Chusquea lehmannii, C. tonduzii, Cinna poaeformis, Deschampsia pringlei, Digitaria panicea, Echinochloa polystachya, Echinolaena gracilis, Eragrostis simplicijlora, Eriochloa distachya, E. polystachya, Eriochrysis cayennensis, Festuca dolichophylla, Gymnopogon fastigiatus, Gynerium sagittatum, Hymenachne amplexicaulis, Imperata contracta, Isachne polygonoides, Ischaemum latijolium, Lithachne pauciflora, Luziola fragilis, Manisuris aurita, Panicum aquaticum, P. arundinariae, P. boliviense, P. cordovense, P. grande, P. haenkeanum, P. milleflorum, P. parviglume, P. pilosum, P. polygonatum, P. rudgei, P. stenodes, P. trichanthum, P. trichoides, P. viscidellum, Paspalum candidum, P. centrale, P. decumbens, P. fasciculatum, P. jimenezii, P. microstachyum, P. multicaule, P. nutans, P. parviflorum, P. pilosum, P. prostratum, P. pumilum, P. reclinatum, P. saccharoides, P. scabrum, P. serratum, P. squamulatum, P. standleyi, Pennisetum bambusiforme, P. distachyum, Pereilema beyrichianum, Pharus parvifolius, Sacciolepis myuros, Schizachyrium condensatum, Sorghastrum incompletum, Sporobolus ciliatus, S. purpurascens, Streptochaeta sodiroana, Thrasya gracilis, T. petrosa, T. robusta, Trisetum pringlei, T. tonduzii, Uniola pittieri, and Zeugites pittieri. In addition, the following counts are different from previous records for the same taxon:Aegopogon cenchroides, Axonopus poiophyllus, Bouteloua media, Brachiaria plantaginea, Chusquea subtessellata, Digitaria adscendens, Homolepis aturensis, Hymenachne donacifolia, Ichnanthus axillaris, I. pallens, I. tenuis, Ischaemum ciliare, Ixophorus unisetus, Oplismenus burmannii, O. hirtellus, Panicum geminatum, P. glutinosum, P. mertensii, P. parvifolium, P. sellowii, Paspalum convexum, Pennisetum nervosum, P. setosum, Polypogon elongalus, Raddia costaricensis, Schizachyrium hirtijlorum.     

Syllidae (Polychaeta) from Thalassia testudinum beds at Morrocoy National Park (Venezuela)

A total of 40 species of syllids (Polychaeta: Syllidae) inhabiting Thalassia testudinum beds in Morrocoy National Park, Venezuela, belonging to 13 genera, are reported; 36 species are new for Venezuela: Branchiosyllis exilis, B. oculata, Eusyllis lamelligera, Exogone arenosa, E. breviantennata, E. naidinoides, E. naidina, E. parahomoseta mediterranea, Grubeosyllis clavata, G. heterocirra, Odontosyllis detecta, O. enopla, O. gibba, Opisthosyllis brunnea, Plakosyllis brevipes, Sphaerosyllis bilobata, S. glandulata, S. magnidentata, S. piriferopsis, S. riseri, S. longilamina, S. taylori, Syllis alosae, Syllis riojai, n. comb., S. beneliahui, S. broomensis, S. cornuta, S. corallicola, S. garciai, S. hyalina, S. lutea, S. mexicana, S. prolifera, S. sardai and Xenosyllis scabra.     

Erhardorina n. g., Ascogregarina polynesiensis n. sp., Eimeria golemanskii n. sp., Isospora tamariscini n. sp., Gregarina kazumii n. nom., new combinations and emendations in the names of apicomplexan protozoa

On the basis of a review of the approximately 4300 species of apicomplexan protozoa, the following new species, new names, new combinations, and emendations are given: NEW GENUS, Erhardovina; NEW SPECIES, Ascogregarina polynesiensis, Eimeria golemanskii, Isospora tamariscini; NEW NAME, Gregarina kazumii; NEW COMBINATIONS, Ascogregarina brachyceri (Purrini, 1980), Erhardovina euzeti (Lipa, 1981), E. scutovertexi (Erhardová, 1955), Haemorhormidium batrachi (Chaudhuri & Choudhury, 1983); EMENDATIONS, Selenidium francianum (Arvy, 1952) Tuzet & Ormières, 1965, Pyxinioides bolitoides D. P. Henry, 1938, P. japonicus H. Hoshide, 1951, P. kamenote H. Hoshide, 1951, P. kurofuji H. Hoshide, 1951, P. oshoroensis H. Hoshide, 1951, P. pugetensis D. P. Henry, 1938, Gregarina levinei Haldar & Sarkar, 1980, Retractocephalus halticae Haldar, Chakraborty & Kundu, 1982, Cnemidospora schizophylli Tuzet & Guerin, 1947, Grebneckiella indica (Merton, 1911) Watson, 1916, Quadruspinospora atractomorphae Haldar & Chakraborty, 1978, Haemogregarina acipenseri Nawrotzky, 1914, H. lobianci Yakimov & Kohl-Yakimov, 1912, H. yakimovikohlae Wladimiroff, 1910, Hepatozoon luehi (Sambon, 1909) Pessoa, Cavalheiro & de Souza, 1970, Eimeria beyerae Ovezmukhammedov, 1977, E. (?) gigantea (Labbé, 1896) Reichenow, 1921, E. (?) labbei Hardcastle, 1943, E. rufi Prasad, 1960, E. (?) scylii (Drago, 1902) Levine & Becker, 1933, Isospora corvi Ray, Shivnani, Oommen & Bhaskaran, 1952, I. melopsittaci Bhatia, Chauhan, Arora & Agrawal, 1973, I. seicerci Ray, Shivnani, Oommen & Bhaskaran, 1952, I. stomatici Chakravarty & Kar, 1944, I. triffitae Nukerbaeva & Svanbaev, 1973, Wenyonella mackinnonae Misra, 1947, Octosporella sanguinolentae Ovezmukhammedov, 1975, Lankesterella millani Alvarez Calvo, 1975, Sarcocystis woodhousei Dogel', 1916, Haemoproteus lari Yakunin, 1972, Babesia ninakohlyakimovae (Yakimoff & Shokhor, 1916), Theileria ninakohlyakimovae (Yakimov, 1916) Krylov, 1974, Haemohormidium batrachi (Chaudhuri & Choudhury, 1983).     

广西田东雾云洞更新世脊椎动物群

发现于广西田东雾云洞之脊椎动物化石有9目24科44属种,根据动物群的组成分析并结合地貌特征判断,其时代为中更新世或晚更新世早期。根据动物习性分析,其生存的环境为热带-亚热带温暖湿润的环境。     

竹叶的化学成分研究

测定了角竹、高节竹、五月季竹、早竹、白哺鸡竹、毛金竹6个竹种的竹叶中的化学成份,都含有生物碱、氨基酸、有机酸、鞣质、皂甙、还原糖、蛋白质、甙类、蒽醌、香豆素,甾体等有机物质。其中角竹、五月季竹、早竹、白哺鸡竹和毛金竹的竹叶还含有黄酮体,而在高节竹叶中未检出黄酮体。角竹和早竹的竹叶含有Al、Ba、Zr、Ti、Pb、Sn、Ga、Sr、Fe、Zn、B、Mg、Ca、Mn、Si、Ni、Cu、Co和Ag等19种元素,而在高节竹、五月季竹、白哺鸡竹和毛金竹的竹叶中未检出Co元素,含有18种元素。     

Illustrated keys to the anopheline mosquitoes of Myanmar.

In the newly revised and illustrated keys to 4th instar larvae and adult female mosquitoes, the following 36 Anopheles species from Myanmar are included: Anopheles aconitus, An. aitkenii, An. annularis, An. argyropus, An. barbirostris, An. bengalensis, An. culicifacies, An. dirus, An. fluviatilis, An. gigas, An. insulaeflorum, An. jamesii, An. jeyporensis, An. karwari, An. kochi, An. kyondawensis, An. lindesayi, An. maculatus, An. majidi, An. minimus, An. nigerrimus, An. nitidus, An. pallidus, An. peditaeniatus, An. philippinensis, An. pseudojamesii, An. sinensis, An. splendidus, An. stephensi, An. subpictus, An. sundaicus, An. tessellatus, An. theobaldi, An. vagus, An. varuna, and An. willmori. The new keys presented in this paper will enable public health workers to rapidly identify mosquito vectors of malaria and to distinguish them from other species in the same genera.     

Comparison between two classes of selective EP(3) antagonists and their biological activities

Two different series of very potent and selective EP(3) antagonists have been reported: a novel series of ortho-substituted cinnamic acids [Belley, M., Gallant, M., Roy, B., Houde, K., Lachance, N., Labelle, M., Trimble, L., Chauret, N., Li, C., Sawyer, N., Tremblay, N., Lamontagne, S., Carrière, M.-C., Denis, D., Greig, G. M., Slipetz, D., Metters, K. M., Gordon, R., Chan, C. C., Zamboni, R. J. Bioorg. Med. Chem. Lett.2005, 15, 527] and the acylsulfonamides of ortho-(arylmethyl)cinnamates. [(a) Juteau, H., Gareau, Y., Labelle, M., Sturino, C. F., Sawyer, N., Tremblay, N., Lamontagne, S., Carrière, M.-C., Denis, D., Metters, K. M. Bioorg. Med. Chem. 2001, 9, 1977; (b) Juteau, H., Gareau, Y., Labelle, M., Lamontagne, S., Tremblay, N., Carrière, M.-C., Denis, D., Sawyer, N., Metters, K. M. Bioorg. Med. Chem. Lett.2001, 11, 747] The structural differences between the two series, along with their biological activity in vivo, in vitro, and metabolism, are analyzed. Some of those compounds, including hybrids containing the best structural features of both series, possess K(i) as low as 0.6 nM on the EP(3) receptor.     

Book reviews

Books reviewed in this article:
BICKEL, P. J. and DOKSUM, K. A. Mathematical Statistics: Basic Ideas and Selected Topics, Volume I, 2nd edition.
BALDI, P. and BRUNAK, S. Bioinformatics: The Machine Learning Approach, 2nd edition.
GATSONIS, C., KASS, R. E., CARLIN, B., CARRIQUIRY, A., GELMAN, A., VERDINELLI, I. and WEST, M. (editors). Case Studies in Bayesian Statistics: Volume V.
LAWSON, A. B. and WILLIAMS, F. L. R. An Introductory Guide to Disease Mapping.
MACLEOD, N. and FOREY, P. L. (editors). Morphology, Shape, and Phylogeny.
FINKELSTEIN, M. O. and LEVIN, B. Statistics for Lawyers, 2nd edition.
ZWILLINGER, D. and KOKOSKA, S. CRC Standard Probability and Statistics Tables and Formulae.
WILSON, R. and CROUCH, E. A. C. Risk-Benefit Analysis.
IBRAHIM, J. G., CHEN, M.-H. and SINHA, D. Bayesian Survival Analysis.     

Recent ornithological publications

Aspinwall , D.R. & Beel , C. A Field Guide to Zambian Birds not Found in Southern Africa. Beaman , M. & MADGE, S. The Handbook of Bird Identification for Europe and the Western Palearctic. Beletsky , L. The Ecotraveller's Guide to Belize and Northern Guatemala. Bellairs , R. & Osmond , M. The Atlas of Chick Development. 323 + xii pages, 63 figures, 8 tables, 2 appendices. London: Academic Press, 1998. Bibby , C, Jones , M. & Marsden , S. Expedition Field Techniques: Bird Surveys. Byrkjedal , I. & Thompson , D.B.A. Tundra Plovers: the Eurasian, Pacific and American Golden Plovers and Grey Plover. Devort , M. (ed.) The Snipe: Elements of an Action Plan. Erritzoe , J. & Erritzoe , H.B. Pittas of the World. A Monograph on the Pitta Family. Feare , C. & Craig , A. Starlings and Mynas. Frith , C.B. & Beehler , B.M. The Birds of Paradise. Knobil , E. & Neill , J.D. (eds) Encyclopedia of Reproduction. Mc Cullough , D.R. (ed.) Metapopulations and Wildlife Conservation. Meyburg , B.U., Chancellor , R.D. & Ferrero , J.J. (eds) Holarctic Birds of Prey: Proceedings of an International Conference. Mock , D.W. & Parker , G.A. The Evolution of Sibling Rivalry. Morris , P. & Hawkins , F. Birds of Madagascar: a Photographic Guide. Sinclair , I. & Langrand , O. Birds of the Indian Ocean Islands. Murrey , R.D., Holling , M., Dott , H.E.M. & Vandome , P. (eds) The Breeding Birds of South-east Scotland. A Tetrad Atlas 1988–1994. Oatley , T. & Arnott , G. Robins of Africa. Osborne , J. The Ruby-throated Hummingbird. DE LA Peña M.R. & Rumboll , R. Birds of Southern South America and Antarctica. Polhill , R. & Wiens , D. Mistletoes of Africa. Rothstein , S.I. & Robinson , S.K. (eds) Parasitic Birds and Their Hosts: Studies in Coevolution. Schmid , H., Luder , R., Naef -Daenzer , B., Graf , R. & Zbinden . N. Schweizer Brutvogelatlas: Verbreitung der Brutvögel in der Schweiz und im Fürstentum Liechtenstein 1993–1996. Atlas des Oiseaux Nicheurs de Suisse: Distribution des Oiseaux Nicheurs en Suisse et au Liechtenstein en 1993–1996. Strads , M. Latvian Countryside Birds. Tennekes , H. The Simple Science of Flight: from Insects to Jumbo Jets. Vaughan , R. Seabird City: a Guide to the Breeding Seabirds of the Flamborough Headlands. Woods , R.W. & Woods , A. Atlas of Breeding Birds of the Falkland Islands. Blokhin , YU.YU. & Mazin , L.N. (eds) Problems of Conservation of Poorly-studied Fauna of the North, Parts 1–2 (in Russian, with English summaries). Bocca , M. & Maffei , G. Gli Uccelli della Valle d'Aosta: Indagine Bibliografica e Dati Inediti. 307 pages, 75 color photos, few black-and-white illustrations and tables. Aosta: Regione Autonoma Valle d'Aosta, 1997 Girard , O. Echassiers, Canards et Limicoles de I'Ouest Africain. [Waterbirds of West Africa]. 136 pages, 22 colour plates, many illustrations, figures, maps. Le Château d'Olonne: Castel Editions, 1998 Ca. Low, R. Hancock House Encyclopedia of the Lories. 432 pages, 140 colour photographs. Surrey, BC: Stagg , A. & Hearl , G. A Birdwatching Guide to Cyprus. 85 pages, colour photographs, maps. Chelmsford: Arlequin, 1998 van Wetten , J.C.J. & Spierenburg , P. (eds) Waders and Waterfowl in the Floodplains of the Logone, Cameroun, January, 1993 . 76 pages, tables, maps. WIWO Report No. 67. Zeist: Working Group International Waterbird & Wetland Research,     

Glucocorticoid receptor-binding site in the human immunodeficiency virus long terminal repeat.

Previous reports (P. D. Katsanakis, C. E. Sekaris, and D. A. Spandidos, Anticancer Res. 11:381-383, 1991; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; R. Miksicek, A. Heber, W. Schmid, U. Danesch, G. Posseckert, M. Beato, and G. Schutz, Cell 46:283-290, 1986) have suggested the existence of a glucocorticoid response element in the long terminal repeat of human immunodeficiency virus (HIV) type 1. This study demonstrated a sequence-specific interaction of the glucocorticoid receptor DNA-binding domain with the previously predicted HIV glucocorticoid response element. This interaction may be relevant to the steroid responsiveness of HIV (P. A. Furth, H. Westphal, and L. Hennighausen, AIDS Res. Hum. Retroviruses 6:553-560, 1990; J. Laurence, M. B. Sellers, and S. K. Sikder, Blood 74:291-297, 1989; J. Laurence, H. Cooke, and S. K. Sikder, Blood 75:696-703, 1990; D. A. Spandidos, V. Zoounpovilis, A. Kotsinas, C. Tsiripotis, and C. E. Sekeris, Anticancer Res. 10:1241-1246, 1990).     

新疆独山子油田原油中的孢子花粉

本文研究了新疆准噶尔盆地独山子油田原油中分离出的孢子花粉35属51种。基于原油中孢子花粉的研究,追溯了该含油区的油源并讨论了油气运移问题。根据原油中找到的孢子花粉化石来判断,准噶尔盆地西南含油区有两套油源岩系,即下一中侏罗统八道湾一头屯河组和渐新统安集海河组。     

Taxonomy and preliminary phylogeny of the parasitic genus Apocephalus, subgenus Mesophora (Diptera: Phoridae)

Abstract. The species of Apocephalus , subgenus Mesophora , are revised and twenty-eight species are recognized, including the following twenty-two new to science: from the Nearctic Region A. brunnipes, A. gemursus, A. pristinus, A. setialvus and A. unitarsus , and from the Neotropical Region A. absentis, A. adustus, A. anfractus, A. angustistylus, A. bisetus, A. brevicercus, A. curtus, A. gracilis, A. hansoni, A. leptotarsus, A. longistylus, A. micrepelis, A. moraviensis, A. prolatus, A. trisetus, A. tritarsus and A. truncaticercus. Additionally, three species known only from female specimens are described but not formally named. A lectotype is designated for A. mortifer Borgmeier, and immature stages of A. borealis, A. antennatus and A. mortifer are described. Unlike larvae of other Apocephalus species, all of which are parasites of ants (Hymenoptera: Formicidae), those of Mesophora species are parasites of various other hosts.     

A revision of male ants of the Malagasy Amblyoponinae (Hymenoptera: Formicidae) with resurrections of the genera Stigmatomma and Xymmer

In a male-based revision of ants of the subfamily Amblyoponinae from the Southwest Indian Ocean islands (SWIO: Comoros, Madagascar, Mauritius, Mayotte, Reunion, and Seychelles), we explore and reconsider male morphological characters that distinguish genera within the group. Our investigation redefines Amblyopone Erichson sensu Brown (1960), here referred to as Amblyopone sensu lato, into three genera: Xymmer Santschi stat. rev.,Amblyopone sensu stricto, Stigmatomma Roger stat. rev. All species names under Amblyopone s. l. reassign into Xymmer and Amblyopone s. s., which are small, well-defined genera, and Stigmatomma, a large group with a generic delimitation that still needs further refinement. Based on a study of male mandible characters and our scenario for mandibular evolution of the worker caste within Amblyopone s. l, we conclude that Amblyopone s. s. nests outside of XMAS (Xymmer+Mystrium+Adetomyrma+Stigmatomma) clade. The following names are transferred from Amblyopone s. l. to Xymmer as comb. rev.: muticus. The following names are transferred from Amblyopone s. l. to Stigmatomma as comb. rev.: amblyops, armigerum, bellii, bierigi, bruni, celata, chilense, denticulatum, elongatum, emeryi, feae, impressifrons, luzonicum, minuta, normandi, oregonense, pallipes, quadratum, reclinatum, rothneyi, santschii, saundersi, silvestrii, zwaluwenburgi; as comb. nov.: agostii, annae, besucheti, boltoni, caliginosum, cleae, crenatum, degeneratum, egregium, electrinum, eminia, exiguum, falcatum, ferrugineum, fulvidum, gaetulicum, gingivalis, glauerti, gnoma, gracile, groehni, heraldoi, lucidum, lurilabes, monrosi, mystriops, noonadan, octodentatum, ophthalmicum, orizabanum, papuanum, pertinax, pluto, punctulatum, rubiginoum, sakaii, smithi, trigonignathum, trilobum, wilsoni, zaojun, and testaceum. A male-based key to the genera of Malagasy amblyoponine ants, their diagnoses, and a discussion of the evolution of the morphological character of males in the subfamily are given, and the distinguishing characters of each are illustrated. In addition, our results predict that Paraprionopelta belongs in the XMAS clade and that Concoctio should have males with two mandibular teeth.     

中国古蚤属分类研究(蚤目,栉眼蚤科)

通过对我国现有古蚤属标本和有关资料进行全面整理和系统分类研究,认为目前我国已知古蚤属共有27种,它们隶属于4个种团,分别为钝刺古蚤种团obtuspina group(1种)、鼩鼱古蚤种团soricis group(2种)、偏远古蚤种团remota group(16种)和短额古蚤种团brevifrontata group(8种),其数量已近该属世界已知种的一半.文中分别对我国已知各种古蚤的鉴别特征、生物学和地理分布状况作了介绍,并编制了各种团、种及亚种检索表.根据它们的分布特征认为我国西南部横断山区可能是古蚤属的分布中心.文中对偏远古蚤种团目前存在的问题进行了讨论.     

Book Reviews

Books reviewed in this article:
COLES, S. An Introduction to Statistical Modeling of Extreme Values.
DOWNES, B. J., BARMUTA, L. A., FAIRWEATHER, P.G., FAITH, D. P., KEOUGH, M. J., LAKE, P. S., MAPSTONE, B. D. and QUINN, G. P. Monitoring Ecological Impacts: Concepts and Practice in Flowing Waters.
BRUNNER, E., DOMHOF, S. and LANGER, F. Nonparametric Analysis of Longitudinal Data in Factorial Experiments.
LANGE, K. Mathematical and Statistical Methods for Genetic Analysis, 3rd edition.
MILLIKEN, G. A. and JOHNSON, D. E. Analysis of Messy Data, Volume III: Analysis of Covariance.
SMITH, P. J. Analysis of Failure and Survival Data.
JONES, P. W. and SMITH, P. Stochastic Processes: An Introduction.
PERCUS, J. K. Mathematics of Genome Analysis.
ROSENBAUM, P. Observational Studies, 2nd edition.
THODE, H. C., Jr. Testing for Normality.
GLAZ, J., NAUS, J. and WALLENSTEIN, S. Scan Statistics.
TOWNEND, J. Practical Statistics for Environmental and Biological Scientists.
REDDY, M. V. Statistics for Mental Health Care Research.     

Recent ornithological publications

UK Raptor Wording Group Armstrong , P. The English Country Parson: A companionship between Science and Religion. Berry , R. J. Orkney Nature. Bibby , C. J., Burgess , N.D., Hill , D.A. & Mustoe , S.H. Bird Census Techniques Böhm , C. Die Wasserpieper: Vom Meeresstrand zum Gletscherrand. Brewer , D., Diamond , A., Woodsworth , E.J., Collins , B.T. & Dunn , E.H. Canadian Atlas of Bird Banding. Volume 1: Doves, Cuckoos, and Hummingbirds through Passerines Chapman , A, The Hobby. Chiappe , L.M., Sh'uan , J., Qiang , J. & Norell , M.A. Anatomy and Systematics of the Confucius‐ornithidae (Theropoda: Aves) from the Late Mesozoic of Northeastern China. Coro Arizmendi , M. & Marquez Valdelamar , L. (eds) Areas de importancia para la Conservación de las Aves en MéAxico. Dean , W.R.J. The Birds of Angola. dolling , R.J., Fay , R.R. & Popper , A.N. (eds) Comparative Hearing: Birds and Reptiles. Elias , G. L., Reino , L. M., Silva , T., Tome , R. & Geraldes , P. Atlas das Aves Invernantes do Baixo Alentejo. Fry , C.H., Keith , S. & Urban , E.K. (eds) Birds of Africa Volume 6. Harris , T. & Franklin , K. Shrikes and Bush‐shrikes; including wood‐shrikes, helmet‐shrikes, flycatchershrikes, philentomas, batises and wattle‐eyes. Johnsgard , P.A. Trogons and Quetzals of the World. Lenz , N. Evolutionary Ecology of the Regent Bowerbird Sericulus chrysocephalus (Lewin, 1808). Olney , P.J.S., & Fisken , F.A. (eds) International Zoo Yearbook, Vol.37. Petersen , Islenskir Fuglar (Icelandic Birds) (in Icelandic). Robb, M.S. Introcuction to Vocalizations of Crossbills in North‐western Europe. Rodner , C., Lentino , M., & Restall , R. Checklist of the Birds of Nortehrn South America: an annotated checklist of the species and subspecies of Ecuador, Colombia, Venezuela, Aruba, Curaçao, Bonaire, Trinidad & Tobago, Guyana, Suriname and French Guiana. Sayre , R., Roca , E., Sedaghatkish , G., Young , B., Keel , S., Roca , R. & Shepparo , S. Nture n Focus: Rapid Ecological Assessment. Schulze ‐Hagen , K. & Geus , A. Joseph Wolf. Shawyer , C., Clarke , R. & Dixon , N. A Study into the Raptor Predation of Domestic Pigeons. Sibley , D. The North American Bird Guide. Siokhin , V.D. (ed.) Chislennost' i razmeshchenie gneziashchikhia okolovodnykh ptits v vodno‐bolotnykh ugodiakh Azovo‐Chernomorskogo poberezhia Ukrainy [Numbers and Distribution of Breeding Waterbirds in the Wetlands of the Azov‐Black Sea Region of Ukraine] (in Russian, with English summaries and captions). Skutch , A.F. Harmony and Conflict in the Living World. Snyder , N., Mc Gowan , P., Gilardi , J., & Grajal , A. (eds) Parrots. Status Survey and Conservation Action Plan 2000–2004. Storch , I. Status Survey and Conservation Action Plan 2000–2004: Grouse. Tamisier , A. & Dehorter , O. Camargue, Canards et Foulques. Tickell , W.L.N. Albatrosses. Vickery , P.D. & Herkert , R. (eds) Ecology and Conservation of Grassland Birds in the Western Hemisphere. Wilcove , D.S. The Condor's Shadow. The Loss and Recovery of Wildlife in America. Chamberlain , D.E., Fuller , R.J., Shrubb , M. Bunce , R.G.H., Duckworth , J.C, Garthwaite , D.G., Impey , A.J. & Hart , A.D.M. The Effects of Agricultural Management on Farmland Birds. Datskevich , V.A. Istoricheskii ocherk i nekotorye itogi ornitologicheskikh issledovanii v Belovezhskoi pushche (1945–1985 gg.) [Historical Survey and some Results of Ornithological Studies in the Belovezhskaya Pushcha (1945–1985)]. Fesenko , G.V. & Bokotey , A.A. Anotovanii spisok ukraînskikh naukovikh nazv ptakhiv fauni Ukraîni [The Annotated List of the Ukrainian Scientific Names of the Bird Species belonging to the Fauna of Ukraine] (in Ukrainian). Oddie , B. Bill Oddie's Birding Map of Britain & Ireland, 2nd edn. Pemberton , J.E. (ed.) The Birdwatcher's Yearbook and Diary 2001. Rusev , I.T. (ed.) Ptitsy Azovo‐Chernomorskogo regiona na rubezhe tysiacheletil: materialy iubileinoi mezhdunarodnoi nauchnoi konferentsii, posviashchennoi 20‐letiu Azovo Chernomorskoi ornitologicheskoi rabochei gruppy, Odessa 10–14 febralia 2000g [Birds of Black Sea Region on Border of Millenium] Serebryakov , V.V. & Alekseyenko , V.R. Vodno‐bolotnye ugod'ia Azovo‐Chernomorskogo poberezh'ia Ukrainy, bibliograficheskii ukazatel' 1970–1999 [Wetlands of the Azov‐Black Sea Region of Ukraine: Bibliography 1970–19991 (in Russian and English). Symanski , R. Blackhearts: Ecology in Outback Australia. World Conservation Monitoring Centre . Checklist of CITES Species: a Reference to the Appendices to the Convention on International Trade in Endangered Species of Wild Fauna and Flora. Chappuis , C. Oiseaux d'Afrique. African Bird Sounds.     

Book Reviews

Books reviewed in this article:
BERNARDO, J. M., BERGER, J. O., DAWID, A. P., and SMITH, A. F. M. (editors). Bayesian Statistics 6.
VAN DER VAART, A. W. Asymptotic Statistics.
NOLAN, D. and SPEED, T. StatLabs: Mathematical Statistics Through Applications.
BINNS, M. R., NYROP, J. P., and VAN DER WERF, W. Sampling and Monitoring in Crop Protection: The Theoretical Basis for Developing Practical Decision Guides.
DIECKMANN, U., LAW, R., and METZ, J. A. J. (editors). The Geometry of Ecological Interactions: Simplifying Spatial Complexity.
LAWSON, A., BIGGERI, A., BOHNING, D., LESAFFRE, E., VIEL, 3.-F., and BERTOLLINI, R. Disease Mapping and Risk Assessment for Public Health.
BLAND, M. and PEACOCK, J. Statistical Questions in Evidence Based Medicine. Oxford University Press, Oxford, 2000.
MANLY, B. F. J. Statistics for Environmental Science and Management.
RÍOS INSUA, D. and RUGGERI, F. (editors) Robust Bayesian Analysis.
BARNDORFF-NIELSEN, 0. E., COX, D. R., and KLUP-PELBERG, C. Complex Stochastic Systems.
PETRIE, A. and SABIN, C. Medical Statistics at a Glance.
THERNEAU, T. M. and GRAMBSCH, P. M. Modeling Survival Data: Extending the Cox Model.
TAN, W.-Y. Stochastic Modeling of AIDS Epidemiology and HIV Pathogenesis.
CHATFIELD, C. Time-Series Forecasting.
MATTHEWS, J. N. S. An Introduction to Randomized Controlled Clinical Trials.
CLARK, I. and HARPER, W. V. Practical Geostatistics 2000.
TANIGUCHI, M. and KAKIZAWA, Y. Asymptotic Theory of Statistical Inference for Time Series.
KARIAN, Z. A. and DUDEWICZ, E. J. Fitting Statistical Distributions: The Generalized Lambda Distribution and Generalized Bootstrap Methods.     

From genome to drug lead: identification of a small-molecule inhibitor of the SARS virus

Virtual screening, a fast, computational approach to identify drug leads [Perola, E.; Xu, K.; Kollmeyer, T. M.; Kaufmann, S. H.; Prendergast, F. G. J. Med. Chem.2000, 43, 401; Miller, M. A. Nat. Rev. Drug Disc.2002, 1 220], is limited by a known challenge in crystallographically determining flexible regions of proteins. This approach has not been able to identify active inhibitors of the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) using solely the crystal structures of a SARS-CoV cysteine proteinase with a flexible loop in the active site [Yang, H. T.; Yang, M. J.; Ding, Y.; Liu, Y. W.; Lou, Z. Y. Proc. Natl. Acad. Sci. U.S.A.2003, 100, 13190; Jenwitheesuk, E.; Samudrala, R. Bioorg. Med. Chem. Lett.2003, 13, 3989; Rajnarayanan, R. V.; Dakshanamurthy, S.; Pattabiraman, N. Biochem. Biophys. Res. Commun.2004, 321, 370; Du, Q.; Wang, S.; Wei, D.; Sirois, S.; Chou, K. Anal. Biochem.2005, 337, 262; Du, Q.; Wang, S.; Zhu, Y.; Wei, D.; Guo, H. Peptides2004, 25, 1857; Lee, V.; Wittayanarakul, K.; Remsungenen, T.; Parasuk, V.; Sompornpisut, P. Science (Asia)2003, 29, 181; Toney, J.; Navas-Martin, S.; Weiss, S.; Koeller, A. J. Med. Chem.2004, 47, 1079; Zhang, X. W.; Yap, Y. L. Bioorg. Med. Chem.2004, 12, 2517]. This article demonstrates a genome-to-drug-lead approach that uses terascale computing to model flexible regions of proteins, thus permitting the utilization of genetic information to identify drug leads expeditiously. A small-molecule inhibitor of SARS-CoV, exhibiting an effective concentration (EC50) of 23 microM in cell-based assays, was identified through virtual screening against a computer-predicted model of the cysteine proteinase. Screening against two crystal structures of the same proteinase failed to identify the 23-microM inhibitor. This study suggests that terascale computing can complement crystallography, broaden the scope of virtual screening, and accelerate the development of therapeutics to treat emerging infectious diseases such as SARS and Bird Flu.