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1.
《Electronic Notes in Theoretical Computer Science》1986,65(4):289-296
A syntactic pattern recognition procedure for classification of brain-stem auditory evoked potential (BSAEP) is presented. A pre-processing stage of zero-phase bandpass filtering enhances the peaks and suppresses the noise. A finite-state grammar was designed to identify the peaks. Attributes of the peaks (latencies and amplitudes) that are identified are checked for their acceptability. A training run in 70 subjects of known diagnosis was perfomed finr-tune the system and build up necessary acceptance criteria. Peak latency differences are used for the classification rather than absolute peak latencies. Acceptance criteria for peak latency differences were empirically optimized. A data base of normal BSAEPs, created during the training run, was updated and used during the test run. Test of the classifier using 60 subjects yielded a classification accuracy of 83%. The classifier has acceptable accuracy and can be modified for other evoked potentials such as visual and somatosensory by establishing relevant attribute tables. 相似文献
2.
《Electronic Notes in Theoretical Computer Science》1994,92(3):215-224
Recordings from the vicinity of the cochlear nucleus in 9 patients undergoing microvascular decompression operations to relieve hemifacial spasm, trigeminal neuralgia, tinnitus, and disabling positional vertigo were conducted by placing a monopolar electrode in the lateral recess of the fourth ventricle (through the foramen of Luschka), the floor of which is the dorsolateral surface of the dorsal cochlear nucleus. The click-evoked potentials recorded by such an electrode display a slow negative wave with a peak latency of about 6–7 msec on which several sharp peaks are superimposed. None of the peaks in the recordings from the vicinity of the cochlear nucleus coincided with any vertex-positive peaks of the brain-stem auditory evoked potentials. In recordings from the lateral aspect of the floor of the fourth ventricle near the cochlear nucleus 1 patient showed 2 positive peaks, the earliest of which had a latency close to that of peak II and the second of which had a latency close to the negative peak between peaks III and IV of the brain-stem auditory evoked potentials. There is a distinct negative peak in the responses recorded from the midline of the floor of the fourth ventricle, the latency of which is only slightly shorter than that of peak V of the brain-stem auditory evoked potentials, supporting earlier findings that the sharp tip of peak V of the brain-stem auditory evoked potentials is generated by the termination of the lateral lemniscus in the inferior colliculus. 相似文献
3.
《Electronic Notes in Theoretical Computer Science》1991,80(2):119-125
A very short latency trigeminal evoked potential (STEP) to electrical stimulation of the upper lip has been recorded from over the scalp. This potential consists of 5 distinct peaks within the 12 msec range.Normative data were obtained from 25 healthy volunteers. The impact of the stimulus rate and intensity on the response was studied in each subject.These results were compared to those of 19 patients suffering from lesions involving the trigeminal system in its peripheral aspect or the brain-stem. The STEP was consistently abnormal whenever the involved side was stimulated. Changes in peak latencies and in interpeak latency differences (IPLD) correlated well with clinical and radiological findings and improved with the removal of the offending lesion. The STEP proved to be a reliable method for evaluating the trigeminal system in its peripheral and central pathways; it may thus serve as an additional parameter for studying brain-stem functions. 相似文献
4.
《Electronic Notes in Theoretical Computer Science》1996,100(5):462-471
Fas habituation (FH) is defined as a general reduction in long-latency, vertex-recorded, averaged auditory evoked potential (AEP) amplitude that occurs in response to the second of a pair of acoustic stimuli. Our laboratory has been studying FH in a variety of human populations with different paradigms and has interpreted it to be a measure of neural attentional mechanism(s) and/or resource allocation related to the processing of cognitive information. We have also reported an analogous phenomenon in the rat. In the present investigation, we examined the relationship between FH (viz., averaged AEP component amplitude decrement) and the single-trial latency variability of the AEP peaks comprising that component. Specifically, AEPs were obtained to 60 paired-tone stimuli from unanesthetized and restrained albino rats previously implanted with chronic skull electrodes. Using a template-matching algorithm similar to that used by Michalewski et al. (Electroenceph. clin. Neurophysiol., 1986, 65:59–71), the latency variability for each animal was computed for the N1 and P2 peaks of the single-trial AEPs that were used to compose the averaged wave form. Findings indicated that (a) there was no difference in single-trial latency variability for these peaks either within or across tones, and (b) there was no relationship between single-trial latency variability for either the N1 or the P2 peaks and the overall peak-to-peak amplitude (N1-P2) of the averaged wave form in response to the second tone. Thus, FH of the N1-P2 (i.e. Peak 2) amplitude in the rat is not due to an increase in latency variability across tones. 相似文献
5.
《Electronic Notes in Theoretical Computer Science》1993,88(4):309-322
Spline generated surface Laplacian temporal wave forms are presented as a method to improve both spatial and temporal resolution of evoked EEG responses. Middle latency and the N1 components of the auditory evoked response were used to compare potential-based methods with surface Laplacian methods in the time domain. Results indicate that surface Laplacians provide better estimates of underlying cortical activity than do potential wave forms. Spatial discrimination among electrode sites was markedly better with surface Laplacian than with potential wave forms. Differences in the number and latencies of peaks, and their topographic distributions, were observed for surface Laplacian, particularly during the time period encompassing the middle latency responses. Focal activities were observed in surface Laplacian wave forms and topographic maps which were in agreement with previous findings from auditory evoked response studies. Methodological issues surrounding the application of spline methods to the time domain are also discussed. Surface Laplacian methods in the time domain appear to provide an improved way for studying evoked EEG responses by increasing temporal and spatial resolution of component characteristics. 相似文献
6.
《Electronic Notes in Theoretical Computer Science》1991,80(2):140-145
We have succeeded in recording short and middle latency vestibular evoked responses in human subjects. The head was held rigidly in a special, patented head holder, constructed individually for each subject, which gripped the teeth of the upper jaw. The stimulus consisted of 2/sec steps of angular acceleration impulses produced by a special motor with intensities of about 10,000°/sec2 and with a rise time of 1–2 msec. The electrical activity was recorded as the potential difference between special forehead and mastoid electrodes having a large, secure contact area with the skin. The activity was digitally filtered and averaged in 2 separate channels by means of a Microshev 2000 evoked response system. The short latency responses, with peaks at about 3.5 msec (forehead positive), 6.0 msec (forehead negative) and 8.4 msec (forehead positive; bandpass: 200–2000 Hz; average of 1024 trials), had amplitudes of about 0.5 μV. The middle latency responses had peaks at about 8.8 msec (forehead positive), 18.8 msec (forehead negative) and 26.8 msec (forehead positive; 30–300 Hz; N = 128 trials), with larger amplitudes (about 15 μV). These responses were consistently recorded in the same subject at different times and were similar in different normal subjects. Strenuous control experiments were conducted in order to ensure that these responses are not artefacts due to the movement of conducting media (head, electrodes and leads) in the electromagnetic field of the motor and are elicited by activation of normal labyrinths. Among other controls, they were not present in a cadaver, in patients with bilateral absence of nystagmus to caloric stimuli and in conducting volumes the size of the human head. They were also not masked by white noise. 相似文献
7.
《Electronic Notes in Theoretical Computer Science》1984,59(5):420-424
A growing body of research has focused on the P3 (P300) event-related potential as an electrophysiological correlate of selective attention. The present investigation examines the intrasubject test-retest reliability of the auditory evoked P3 latency measure for neurologically and audiologically normal young adults aged 22–34 years across test sessions separated by 2–4 weeks (N = 9) and across trials within one test session (N = 20). In a target-selection (‘oddball’) paradigm, subjects mentally counted infrequent 2 kHz tone bursts (targets) randomly interspersed within a sequence of 1 kHz tone bursts (non-targets). A strong positive correlation was demonstrated between latencies of test sessions I and II. An analysis of variance did not demonstrate statistically significant latency differences as a function of either tests of trials for the test-retest group (N = 9). Although analysis of variance demonstrated a statistically significant difference between trials within one test session for 20 subjects, the small mean latency difference between trials (4.7 msec) is interpreted as being clinically unimportant. The stability of P3 latency found in this study over a period of 2–4 weeks supports its application to the study of normal and disordered cognitive processes. 相似文献
8.
《Electronic Notes in Theoretical Computer Science》1987,68(2):157-160
The late auditory evoked potential (AEP) was studied in response to an alternatingly frequency-modulated complex tone. This ‘pattern-reversal’ AEP was found to be a heartier response than the conventional tone-burst evoked potential, albeit longer in latency. 相似文献
9.
《Electronic Notes in Theoretical Computer Science》1984,59(1):57-66
Somatosensory cerebral evoked potentials were recorded by intrathecal stimulation of the lumbo-sacral cord and roots in 16 normal subjects and patients having cauda/conus injury (group A, 15 cases), compressive lesions of cauda equina (group B, 13 cases) and lesions of both types covering the lumbar cord (group C, 24 cases). The shape of the intrathecally evoked cerebral potential (IECP) was basically the same as that obtained by posterior tibial nerve stimulation from 12 normal subjects except that the early components were 10–15 msec shorter in latency in the former potential, with an average of 12 msec.IECPs were easily recorded in groups A and B, but a significant delay was found in both groups, especially group A. It was difficult to obtain the IECP in group C, When it could be recorded the latency increase was apparent. These findings were explained on the basis of degeneration of the ascending spinal nerve fibers proximal to the lesion site. 相似文献
10.
《Electronic Notes in Theoretical Computer Science》1993,88(4):290-301
This study examined the relationships among 3 components of the somatosensory evoked potential (SEP) to painful stimuli. Painful stimuli were produced using intracutaneous electrical stimulation of a fingertip and two levels of non-painful stimuli were produced by superficial electrical stimulation of a neighboring fingertip. SEPs were recorded from Cz-A1 and Pz-A1, and difference waves were computed for 3 components: (1) a pain component (the difference between SEPs to painful vs. strong but non-painful stimuli); (2) an intensity component that is not related to pain (the difference between SEPs to strong non-painful vs. mild non-painful stimuli); and (3) a P300 component (the difference between SEPs to the same stimuli under Target instructions vs. Standard instructions).The positive peaks in the 3 types of difference waves differed in both latency and topography, although with latency and topography overlap. The intensity component had an earlier positive peak than the pain component, and the pain component had an earlier positive peak than the P300 component. The pain and intensity components were larger at Cz than Pz, whereas the P300 component was larger at Pz than Cz. Under certain conditions, the pain evoked SEP consists of a weighted combination of the 3 components, complicating interpretation of the positive peaks in the recorded wave forms. 相似文献
11.
《Electronic Notes in Theoretical Computer Science》1990,77(5):376-381
Cortical potentials evoked by unilateral stimulation of the major vibrissae were recorded in 12 rats subjected to unilateral crush of the infraorbital nerve. Immediately after nerve crushing, the latency of the initial positive potential evoked at contralateral scalp sites by stimulating the vibrissae of the nerve-crushed side was increased. In contrast, the latency of the ipsilaterally evoked potential was shortened. The relative amplitude of the negative component to the positive one of the evoked potentials tended, immediately after the nerve crush, to be smaller on the contralateral cortex (N/P-contra) and greater on the ipsilateral cortex (N/P-ipsi). These changes disappeared largely by the 2nd post-operative week. It is suggested that reduction of the tactile signals transmitted through the crossed pathway is responsible for the prolonged latency and the smaller N/P-contra. Shortening of the ipsilateral latency and the enhanced N/P-ipsi may be due to liberation of the ipsilateral sensory system from inhibition by the contralateral one. 相似文献
12.
《Electronic Notes in Theoretical Computer Science》1994,92(4):316-320
We measured the conduction velocity of the intracranial portion of the auditory nerve in 3 patients undergoing vestibular nerve section to treat Ménière's disease. The conduction velocity varied from patient to patient, with an average value of 15.1 m/sec. The latency of peak III of the brain-stem auditory evoked potentials (BAEPs) increased by an average of 0.5 msec as a result of exposure of the eighth nerve, and if that increase is assumed to affect the entire length of the auditory nerve (2.6 cm) evenly, then the corrected estimate of conduction velocity would be 22.0 m/sec. Estimates of conduction velocity based on the interpeak latencies of peaks I and II of the BAEP, assuming that peak II is generated by the mid-portion of the intracranial segment of the auditory nerve, yielded similar values of conduction velocities (about 20 m/sec). 相似文献
13.
《Electronic Notes in Theoretical Computer Science》1994,92(5):456-461
We developed a high-rate sequential recording technique that allowed simultaneous measurements of both auditory brain-stem response (ABR) and somatosensory evoked potential (SEP) every 10 sec. Using this method, a transient increase in amplitude of all the ABR and SEP components in response to hypoxia in dogs could be detected. The increase in amplitude preceded the prolongation of latency. Our study showed that there were succesive changes of evoked potentials in response to hypoxia. A transient increase in amplitude is the first to occur, followed by a latency prolongation and an amplitude decrease for both ABRs and SEPs. 相似文献
14.
隐神经C类纤维传入诱发小脑皮层电反应 总被引:1,自引:0,他引:1
当弱刺激只引起隐神经A类纤维传入时,小脑皮层出现A-CEP,由潜伏期为11.8±3.5ms的早成分和312.1±17.5ms的晚成分组成;当强刺激同时引起A类和C类纤维传入时,出现AC-CEP类似A-CEP;用极化电流选择性阻断A类纤维传导后,只让C类纤维传入时,出现潜伏期为134.2±18.4ms的C-CEP。在Ⅵ小叶蚓部原裂附近C-CEP以正波为主,幅值最大,并在深层位相倒转。C-CEP的潜伏期较长,频率响应较低,幅值较小,随C类纤维传入量而变化,且对镇痛剂较敏感。结果表明C-CEP是由单纯C类纤维传入引起的,在小脑皮层内产生,是小脑皮层对慢痛信息传入的反应。提示C类纤维传入可以到达小脑皮层,引起诱发电位。当A和C类纤维同时传入时,C-CEP不出现,可能是被A类纤维传入所抑制。 相似文献
15.
《Electronic Notes in Theoretical Computer Science》1986,65(5):383-392
Middle latency responses (MLRs) in the 10–100 msec latency range, evoked by click stimuli, were studied in 14 adult volunteer subjects during sleep-wakefulness to determine whether such changes in state were reflected by any MLR component. Evoked potentials were collected in 500 trial averages during continuos presentation of 1/sec clicks during initial awake recordings and thereafter during a 2 h afternoon nap or all-night sleep session. Continuously recorded EEG, EOG and EMG were scored for wakefulness, stages 2–4 of slow wave sleep (SWS), and rapid eye movement (REM) sleep during each evoked potential epoch. The major components included in this study and their latency ranges, as determined by peak latency measurements from the awake records, were: ABR V, 5–8 msec, Pa, 30–40 msec, Nb, 45–55 msec, and P1, 55–80 msec. In agreement with previous reports, ABR V and Pa showed no amplitude changes from wakefulness to either SWS or REM. Not previously reported, however, was the dramatic decrease and disappearance of P1 during SWS and its reappearance during REM to an amplitude similar to that during wakefulness. This unique linkage between a particular evoked potential component and sleep-wakefulness indicates that its generator system must be functionally related to states of arousal. Relevant data from the cat model suggest that the generator substrate for P1 may be within the ascending reticular activating system. 相似文献
16.
C J Cook P D Gluckman B M Johnston C Williams 《Journal of developmental physiology》1987,9(5):441-455
Somatosensory evoked potentials were recorded in utero from 13 chronically instrumented fetal lambs (97 to 148 days of gestation) following electrical stimulation of the upper lip or upper limb. Several clear and reproducible peaks were observed. Following upper lip stimulation, peaks were seen with mean peak latencies of 9, 13.2, 17.8, 21.3, 33.8 and 206 ms at a gestational age of 125 days. Similar peaks, but of slightly later mean latencies, were seen following limb stimulation. These peaks demonstrated significant gestational age related falls in peak latencies (P less than 0.05). Several of the mid to late latency peaks, notably those occurring at 21.3, 33.8 and 206 ms, demonstrated changes (P less than 0.05) in both latency (longer in low voltage) and amplitude (reduced in low voltage) dependent on electrocorticographic state. Rate of stimulus presentation also had a significant effect on both amplitude and latency of several peaks (P less than 0.05) with this effect lessening with advancing gestational age. Evoked potentials can thus be successfully obtained from chronically instrumented fetal lambs and provide a useful indice for studies of neural maturation. 相似文献
17.
J A Armour 《Canadian journal of physiology and pharmacology》1984,62(9):1244-1248
Stimulation of the cranial end of a decentralized canine cardiopulmonary nerve results in the generation of a compound action potential which can be recorded at the caudal end. A region has been identified which, on stimulation, produces a compound action potential with complex configuration which is different from simpler wave forms obtained by stimulating 1 mm or more in either the rostral or caudal direction. Histological examination reveals that clusters of neuronal cell bodies are localized to this region of the nerve, whereas none is found to either side. Characteristics of the different wave forms evoked by changing the site of stimulation and reversing the stimulation and recording electrodes provide evidence for the existence of both afferent and efferent synaptic pathways. The compound action potential evoked by the most rostral stimulations and presumed to contain synaptic components was not altered by intravenously administered cholinergic and adrenergic pharmacological blocking agents (hexamethonium, atropine, phentolamine, or propranolol). It was, however, depressed by local injections of chymotrypsin or manganese into the functionally identified transitional region. It is concluded that synapses, which can be activated at relatively high frequencies (1-10 Hz) and may be important for rapidly changing local neural regulation of the heart and lungs, appear to exist within the course of cardiopulmonary nerves. 相似文献
18.
《Electronic Notes in Theoretical Computer Science》1988,71(1):10-16
Visual evoked potentials (VEPs) were recorded from a 53-year-old man with prosopagnosia during presentation of slides of known and unknown faces and under two control conditions. ANOVA comparisons with a normal male group showed no differences in P100 amplitude, P300 amplitude or P300 latency. There were no significant evoked potential differences between the patient and controls specifically related to the face conditions.There was, however, a significant delay in the latency of P100 from both hemispheres during all types of stimuli. This prolonged latency was asymmetrical, showing a right sided emphasis with the control conditions: pattern reversal and slides of geometric designs. This finding, of a dissociation in the interhemispheric delay, provides physiological evidence of stimulus-specific organisation at an early, sensory level.The fact that the P100 component showed a marked delay, yet P300 fell within normal limits for amplitude and latency, suggests that this patient's problem lies at a perceptual level. 相似文献
19.
Tectal evoked potentials to stimulation of the facial nerve, containing afferent fibers of nonolfactory chemoreception, in the carp are positive evoked potentials with a latent period of 5 to 25 msec which show no phase shift as the microelectrode is advanced to a depth of 600 µ. Depending on the amplitude and latency of evoked potentials seven active zones differing in one or both parameters were distinguished in the ipsilateral tectum mesencephali. The role of impulses from the medulla in the mechanism of tectal evoked potentials to facial nerve stimulation is proved by differences in latent periods and disappearance of the tectal response (although it is preserved in the primary center) after severance of connections between the two parts of the brain. Descending influences from the tectum on the primary center were found: its extirpation disturbs evoked potential generation in several parts of the medullla, so that they either disappear completely or their parameters are modified.A. A. Zhdanov State University, Leningrad. Translated from Neirofiziologiya, Vol. 8, No. 1, pp. 39–46, January–February, 1976. 相似文献
20.
The electric field of evoked potentials developing in the rabbit superior colliculus in response to single electrical stimulation of the optic nerve was investigated. Regions of localization of sources and sinks of synaptic current creating the evoked potential were discovered by the current source density analysis method. Sinks with the shortest latency appeared in the depth of str. griseum superficiale, after which activity created by two dipoles appeared: The sink of one dipole was located in the upper part of str. griseum superficiale, the sink of the other in the lower part. The sinks thus found corresponded in their temporal characteristics and location to the principal components of the combined evoked potential. On the basis of these data the order of activation of the various systems of fibers and synapses responsible for evoked potential formation can be traced. 相似文献