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Summary In streptomycin (SM)-producing organisms, the lower affinity of ribosomes for SM gives rise to a lower susceptibility of protein synthesis to SM. But, even in a strain with considerably low affinity of ribosomes for SM, phosphorylation of SM in the cells by SM 6-kinase is necessary for the protein synthesis to be fully tolerant to SM. 相似文献
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The nucleotide sequence of a streptomycin streptomycin phosphotransferase (streptomycin kinase) [corrected] gene from a streptomycin producer 总被引:1,自引:0,他引:1
The nucleotide sequence of the DNA fragment containing the streptomycin phosphotransferase (streptomycin kinase) [corrected] gene from the streptomycin-producer Streptomyces griseus strain HUT 6037 was determined. Analysis of the sequence revealed an open reading frame which could encode 325 amino acid residues. A biased codon usage pattern, reflecting the high G + C composition (approximately 74%) of Streptomyces DNA, was observed in the gene. 相似文献
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M L Haigh 《BMJ (Clinical research ed.)》1973,3(5873):236-237
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