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p45 NF-E2 regulates expression of thromboxane synthase in megakaryocytes. 总被引:12,自引:2,他引:10
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S Deveaux S Cohen-Kaminsky R A Shivdasani N C Andrews A Filipe I Kuzniak S H Orkin P H Roméo V Mignotte 《The EMBO journal》1997,16(18):5654-5661
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Cheng S Afif H Martel-Pelletier J Pelletier JP Li X Farrajota K Lavigne M Fahmi H 《The Journal of biological chemistry》2004,279(21):22057-22065
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IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages 总被引:5,自引:0,他引:5
Kim YM Im JY Han SH Kang HS Choi I 《Journal of immunology (Baltimore, Md. : 1950)》2000,165(6):3198-3205
Constitutive IL-18 expression is detected from many different cells, including macrophages, keratinocytes, and osteoblasts. It has been known that IL-18 gene expression is regulated by two different promoters (p1 promoter and p2 promoter). When RAW 264.7 macrophages were treated with IFN-gamma, IL-18 gene expression was increased in a dose- and time-dependent manner. IFN-gamma activated the inducible promoter 1, but not the constitutive promoter 2. Mutagenesis studies indicated that an IFN consensus sequence-binding protein (ICSBP) binding site between -39 and -22 was critical for the IFN-gamma inducibility. EMSA using an ICSBP oligonucleotide probe showed that IFN-gamma treatment increased the formation of DNA-binding complex, which was supershifted with anti-IFN regulatory factor-1 Ab and anti-ICSBP Ab. Another element, an AP-1 site between -1120 and -1083, was important. EMSA using an AP-1-specific oligonucleotide demonstrated that IFN-gamma or LPS treatment increased the AP-1-binding activity. The addition of anti-c-Jun Ab or anti-c-Fos Ab to IFN-gamma- or LPS-treated nuclear extracts resulted in the reduction of AP-1 complex or the formation of a supershifted complex. Taken together, these results indicate that IFN-gamma increased IL-18 gene expression via ICSBP and AP-1 elements. 相似文献
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NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis 总被引:1,自引:0,他引:1
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Shin S Wakabayashi N Misra V Biswal S Lee GH Agoston ES Yamamoto M Kensler TW 《Molecular and cellular biology》2007,27(20):7188-7197
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Armoni M Harel C Karni S Chen H Bar-Yoseph F Ver MR Quon MJ Karnieli E 《The Journal of biological chemistry》2006,281(29):19881-19891