共查询到20条相似文献,搜索用时 31 毫秒
1.
Relevance of nonlinear lumped-parameter models in the analysis of depth-EEG epileptic signals 总被引:5,自引:0,他引:5
In the field of epilepsy, the analysis of stereoelectroencephalographic (SEEG, intra-cerebral recording) signals with signal
processing methods can help to better identify the epileptogenic zone, the area of the brain responsible for triggering seizures,
and to better understand its organization. In order to evaluate these methods and to physiologically interpret the results
they provide, we developed a model able to produce EEG signals from “organized” networks of neural populations. Starting from
a neurophysiologically relevant model initially proposed by Lopes Da Silva et al. [Lopes da Silva FH, Hoek A, Smith H, Zetterberg
LH (1974) Kybernetic 15: 27–37] and recently re-designed by Jansen et al. [Jansen BH, Zouridakis G, Brandt ME (1993) Biol
Cybern 68: 275–283] the present study demonstrates that this model can be extended to generate spontaneous EEG signals from
multiple coupled neural populations. Model parameters related to excitation, inhibition and coupling are then altered to produce
epileptiform EEG signals. Results show that the qualitative behavior of the model is realistic; simulated signals resemble
those recorded from different brain structures for both interictal and ictal activities. Possible exploitation of simulations
in signal processing is illustrated through one example; statistical couplings between both simulated signals and real SEEG
signals are estimated using nonlinear regression. Results are compared and show that, through the model, real SEEG signals
can be interpreted with the aid of signal processing methods.
Received: 3 January 2000 / Accepted: 24 March 2000 相似文献
2.
So K Ganguly K Jimenez J Gastpar MC Carmena JM 《Journal of computational neuroscience》2012,32(3):555-561
Redundant encoding of information facilitates reliable distributed information processing. To explore this hypothesis in the
motor system, we applied concepts from information theory to quantify the redundancy of movement-related information encoded
in the macaque primary motor cortex (M1) during natural and neuroprosthetic control. Two macaque monkeys were trained to perform
a delay center-out reaching task controlling a computer cursor under natural arm movement (manual control, ‘MC’), and using
a brain-machine interface (BMI) via volitional control of neural ensemble activity (brain control, ‘BC’). During MC, we found
neurons in contralateral M1 to contain higher and more redundant information about target direction than ipsilateral M1 neurons,
consistent with the laterality of movement control. During BC, we found that the M1 neurons directly incorporated into the
BMI (‘direct’ neurons) contained the highest and most redundant target information compared to neurons that were not incorporated
into the BMI (‘indirect’ neurons). This effect was even more significant when comparing to M1 neurons of the opposite hemisphere.
Interestingly, when we retrained the BMI to use ipsilateral M1 activity, we found that these neurons were more redundant and
contained higher information than contralateral M1 neurons, even though ensembles from this hemisphere were previously less
redundant during natural arm movement. These results indicate that ensembles most associated to movement contain highest redundancy
and information encoding, which suggests a role for redundancy in proficient natural and prosthetic motor control. 相似文献
3.
A Vato M Semprini E Maggiolini FD Szymanski L Fadiga S Panzeri FA Mussa-Ivaldi 《PLoS computational biology》2012,8(7):e1002578
Progress in decoding neural signals has enabled the development of interfaces that translate cortical brain activities into commands for operating robotic arms and other devices. The electrical stimulation of sensory areas provides a means to create artificial sensory information about the state of a device. Taken together, neural activity recording and microstimulation techniques allow us to embed a portion of the central nervous system within a closed-loop system, whose behavior emerges from the combined dynamical properties of its neural and artificial components. In this study we asked if it is possible to concurrently regulate this bidirectional brain-machine interaction so as to shape a desired dynamical behavior of the combined system. To this end, we followed a well-known biological pathway. In vertebrates, the communications between brain and limb mechanics are mediated by the spinal cord, which combines brain instructions with sensory information and organizes coordinated patterns of muscle forces driving the limbs along dynamically stable trajectories. We report the creation and testing of the first neural interface that emulates this sensory-motor interaction. The interface organizes a bidirectional communication between sensory and motor areas of the brain of anaesthetized rats and an external dynamical object with programmable properties. The system includes (a) a motor interface decoding signals from a motor cortical area, and (b) a sensory interface encoding the state of the external object into electrical stimuli to a somatosensory area. The interactions between brain activities and the state of the external object generate a family of trajectories converging upon a selected equilibrium point from arbitrary starting locations. Thus, the bidirectional interface establishes the possibility to specify not only a particular movement trajectory but an entire family of motions, which includes the prescribed reactions to unexpected perturbations. 相似文献
4.
In this article, we study the neural encoding of acoustic information for FM-bats (such as Eptesicus fuscus) in simulation. In echolocation research, the frequency–time sound representation as expressed by the spectrogram is often
considered as input. The rationale behind this is that a similar representation is present in the cochlea, i.e. the receptor
potential of the inner hair cells (IHC) along the length of the cochlea, and hence similar acoustic information is relayed
to the brain. In this article, we study to what extent the latter assumption is true. The receptor potential is converted
into neural activity of the synapting auditory nerve cells (ANC), and information might be lost in this conversion process.
Especially for FM-bats, this information transmission is not trivial: in contrast to other mammals, they detect short transient
signals, and consequently neural activity can only be integrated over very limited time intervals. To quantify the amount
of information transmitted we design a neural network-based algorithm to reconstruct the IHC receptor potentials from the
spiking activity of the synapting auditory neurons. Both the receptor potential and the resulting neural activity are simulated
using Meddis’ peripheral model. Comparing the reconstruction to the IHC receptor potential, we quantify the information transmission
of the bat hearing system and investigate how this depends on the intensity of the incoming signal, the distribution of auditory
neurons, and previous masking stimulation (adaptation). In addition, we show how this approach allows to inspect which spectral
features survive neural encoding and hence can be relevant for echolocation. 相似文献
5.
We wondered whether random populations of dissociated cultured cortical neurons, despite of their lack of structure and/or
regional specialization, are capable of modulating their neural activity as the effect of a time-varying stimulation – a simulated
‘sensory’ afference. More specifically, we used localized low-frequency, non-periodic trains of stimuli to simulate sensory
afferences, and asked how much information about the original trains of stimuli could be extracted from the neural activity
recorded at the different sites. Furthermore, motivated by the results of studies performed both in vivo and in vitro on different
preparations, which suggested that isolated spikes and bursts may play different roles in coding time-varying signals, we
explored the amount of such ‘sensory’ information that could be associated to these different firing modes. Finally, we asked
whether and how such ‘sensory’ information is transferred from the sites of stimulation (i.e., the ‘sensory’ areas), to the
other regions of the neural populations.
To do this we applied stimulus reconstruction techniques and information theoretic concepts that are typically used to investigate
neural coding in sensory systems.
Our main results are that (1) slow variations of the rate of stimulation are coded into isolated spikes and in the time of
occurrence of bursts (but not in the bursts’ temporal structure); (2) increasing the rate of stimulation has the effect of
increasing the proportion of isolated spikes in the average evoked response and their importance in coding for the stimuli;
and, (3) the ability to recover the time course of the pattern of stimulation is strongly related to the degree of functional
connectivity between stimulation and recording sites.
These observations parallel similar findings in intact nervous systems regarding the complementary roles of bursts and tonic
spikes in encoding sensory information.
Our results also have interesting implications in the field of neuro-robotic interfaces. In fact, the ability of populations
of neurons to code information is a prerequisite for obtaining hybrid systems, in which neuronal populations are used to control
external devices. 相似文献
6.
In diagnosis of brain death for human organ transplant, EEG (electroencephalogram) must be flat to conclude the patient’s
brain death but it has been reported that the flat EEG test is sometimes difficult due to artifacts such as the contamination
from the power supply and ECG (electrocardiogram, the signal from the heartbeat). ICA (independent component analysis) is
an effective signal processing method that can separate such artifacts from the EEG signals. Applying ICA to EEG channels,
we obtain several separated components among which some correspond to the brain activities while others contain artifacts.
This paper aims at automatic selection of the separated components based on time series analysis. In the flat EEG test in
brain death diagnosis, such automatic component selection is helpful. 相似文献
7.
Background
The field of neural prosthetics aims to develop prosthetic limbs with a brain-computer interface (BCI) through which neural activity is decoded into movements. A natural extension of current research is the incorporation of neural activity from multiple modalities to more accurately estimate the user''s intent. The challenge remains how to appropriately combine this information in real-time for a neural prosthetic device.Methodology/Principal Findings
Here we propose a framework based on decision fusion, i.e., fusing predictions from several single-modality decoders to produce a more accurate device state estimate. We examine two algorithms for continuous variable decision fusion: the Kalman filter and artificial neural networks (ANNs). Using simulated cortical neural spike signals, we implemented several successful individual neural decoding algorithms, and tested the capabilities of each fusion method in the context of decoding 2-dimensional endpoint trajectories of a neural prosthetic arm. Extensively testing these methods on random trajectories, we find that on average both the Kalman filter and ANNs successfully fuse the individual decoder estimates to produce more accurate predictions.Conclusions
Our results reveal that a fusion-based approach has the potential to improve prediction accuracy over individual decoders of varying quality, and we hope that this work will encourage multimodal neural prosthetics experiments in the future. 相似文献8.
H. Meissl C. Martin M. Tabata 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1990,167(5):641-648
Summary Hormonal and neural signals transmitted from the pineal organ to the brain in cold-blooded vertebrates presumably convert information about the ambient illumination into signals which may be used to mediate photoperiodic and circadian responses. The possible intrapineal function of melatonin was investigated by recording intra- and extracellularly from photoreceptors and second-order neurons in the isolated superfused pineal organ of the trout (Salmo gairdneri). Melatonin added through the perfusion bath to the explanted pineal organ caused a dose-related and reversible inhibition of ganglion cells of the luminance type whereas the hormone did not significantly affect the membrane potential of photoreceptors and their light-evoked response. The observed effects seem to be independent from photoperiod and adaptation conditions. These results suggest that melatonin provides a feedforward signal to intrapineal neurons regulating the neural output of the organ.Laboratory of Fish Biology, School of Agriculture, Nagoya University, Chikusa, Nagoya 464 Japan 相似文献
9.
Thomas Trappenberg 《Cognitive neurodynamics》2008,2(3):171-177
We discuss the ability of dynamic neural fields to track noisy population codes in an online fashion when signals are constantly
applied to the recurrent network. To report on the quantitative performance of such networks we perform population decoding
of the ‘orientation’ embedded in the noisy signal and determine which inhibition strength in the network provides the best
decoding performance. We also study the performance of decoding on time-varying signals. Simulations of the system show good
performance even in the very noisy case and also show that noise is beneficial to decoding time-varying signals. 相似文献
10.
Hans Mohr 《Journal of plant research》1988,101(1):79-101
The powerful technology for transferring functional foreign genes into plants can only express its potential to the extent
that our knowledge about signals and signal transmission in plants improves. In higher plants gene expression is regulated
by ‘signals from within’ and ‘signals from without’ (e.g., light). Since light-mediated changes provide the basis for much
of plant development, photocontrol of gene expression will mainly be considered. The recently discovered ‘plastidic factor’
will serve as the prototype of an intracellular ‘signal from within’. Particular emphasis will be laid on rapid interorgan
signal transmission since these novel observations suggest a revision of the presently held concepts about the means of communication
within a plant. It will be concluded in the end that the prevailing views about the nature of plants underestimate the degree
of sophistication actually exhibited by higher plants. 相似文献
11.
Motor coordination in multi-tasking situations is relevant to everyday life, since numerous daily activities require the performance of more than one task simultaneously. Investigations into this topic often use dual-task experiments like bimanual tapping, with different instructions for the right and left hands, such as to tap repetitively with the right index finger at a given frequency and to concurrently execute a single tap in response to a go signal with the left index finger. A basic experimental set-up for tapping consists of only a pace signal generator and ground contact sensors such as micro switches for observation of motor action. Evaluation of the binary on-off signals provided by these switches is quite simple, but the amount of information obtained is also limited. This paper presents a novel experimental design for tapping experiments with high-resolution recording of the complete time course of continuous finger movements. The evaluation procedures required for biomechanical and EMG data are described. The latter are based on sophisticated maximum-likelihood techniques, which is an example of progress in research using advanced biosignal processing. 相似文献
12.
This paper argues that a discursive shift is taking place in Dutch water policy, from ‘a battle against water’ to ‘living
with water’ or ‘accommodating water’. Yet we ask ourselves whether this shift is just an adaptation strategy of the existing
elite group of water managers, who pay lip-service to new management approaches in order to maintain their vested interests,
as some authors claim, or whether it implies ‘deep’ institutional change, e.g. in terms of the emergence of new water institutions,
power relations and procedures. While investigating this question, we make use of the ‘policy arrangement approach’, which
pays attention to institutional and discursive aspects of policy making alike. Our conclusion is that we are currently observing
institutional changes beyond ‘policy talk’, particularly in terms of new legislation and procedures. However, it is too early
to speak of ‘deep’ institutional change in Dutch water management, because the former water institutions are still maintaining
their power positions, despite the availability of additional resources for policy and research as well as the emergence of
several new modes of governance. 相似文献
13.
Human motion studies have focused primarily on modeling straight point-to-point reaching movements. However, many goal-directed
reaching movements, such as movements directed towards oneself, are not straight but rather follow highly curved trajectories.
These movements are particularly interesting to study since they are essential in our everyday life, appear early in development
and are routinely used to assess movement deficits following brain lesions. We argue that curved and straight-line reaching
movements are generated by a unique neural controller and that the observed curvature of the movement is the result of an
active control strategy that follows the geometry of one’s body, for instance to avoid trajectories that would hit the body
or yield postures close to the joint limits. We present a mathematical model that accounts for such an active control strategy
and show that the model reproduces with high accuracy the kinematic features of human data during unconstrained reaching movements
directed toward the head. The model consists of a nonlinear dynamical system with a single stable attractor at the target.
Embodiment-related task constraints are expressed as a force field that acts on the dynamical system. Finally, we discuss
the biological plausibility and neural correlates of the model’s parameters and suggest that embodiment should be considered
as a main cause for movement trajectory curvature. 相似文献
14.
Electromyography (EMG) is a technique for recording biomedical electrical signals obtained from the neuromuscular activities. These signals are used to monitor medical abnormalities and activation levels, and also to analyze the biomechanics of any animal movements. In this article, we provide a short review of EMG signal acquisition and processing techniques. The average efficiency of capture of EMG signals with current technologies is around 70%. Once the signal is captured, signal processing algorithms then determine the recognition accuracy, with which signals are decoded for their corresponding purpose (e.g., moving robotic arm, speech recognition, gait analysis). The recognition accuracy can go as high as 99.8%. The accuracy with which the EMG signal is decoded has already crossed 99%, and with improvements in deep learning technology, there is a large scope for improvement in the design hardware that can efficiently capture EMG signals. 相似文献
15.
Brain-controlled interfaces are devices that capture brain transmissions involved in a subject's intention to act, with the potential to restore communication and movement to those who are immobilized. Current devices record electrical activity from the scalp, on the surface of the brain, and within the cerebral cortex. These signals are being translated to command signals driving prosthetic limbs and computer displays. Somatosensory feedback is being added to this control as generated behaviors become more complex. New technology to engineer the tissue-electrode interface, electrode design, and extraction algorithms to transform the recorded signal to movement will help translate exciting laboratory demonstrations to patient practice in the near future. 相似文献
16.
Ning Lan 《Biological cybernetics》1997,76(2):107-117
In this paper, we propose a model of biological motor control for generation of goal-directed multi-joint arm movements,
and study the formation of muscle control inputs and invariant kinematic features of movements. The model has a hierarchical
structure that can determine the control inputs for a set of redundant muscles without any inverse computation. Calculation
of motor commands is divided into two stages, each of which performs a transformation of motor commands from one coordinate
system to another. At the first level, a central controller in the brain accepts instructions from higher centers, which represent
the motor goal in the Cartesian space. The controller computes joint equilibrium trajectories and excitation signals according
to a minimum effort criterion. At the second level, a neural network in the spinal cord translates the excitation signals
and equilibrium trajectories into control commands to three pairs of antagonist muscles which are redundant for a two-joint
arm. No inverse computation is required in the determination of individual muscle commands. The minimum effort controller
can produce arm movements whose dynamic and kinematic features are similar to those of voluntary arm movements. For fast movements,
the hand approaches a target position along a near-straight path with a smooth bell-shaped velocity. The equilibrium trajectories
in X and Y show an ‘N’ shape, but the end-point equilibrium path zigzags around the hand path. Joint movements are not always smooth.
Joint reversal is found in movements in some directions. The excitation signals have a triphasic (or biphasic) pulse pattern,
which leads to stereotyped triphasic (or biphasic) bursts in muscle control inputs, and a dynamically modulated joint stiffness.
There is a fixed sequence of muscle activation from proximal muscles to distal muscles. The order is preserved in all movements.
For slow movements, it is shown that a constant joint stiffness is necessary to produce a smooth movement with a bell-shaped
velocity. Scaled movements can be reproduced by varying the constraints on the maximal level of excitation signals according
to the speed of movement.
When the inertial parameters of the arm are altered, movement trajectories can be kept invariant by adjusting the pulse height
values, showing the ability to adapt to load changes. These results agree with a wide range of experimental observations on
human voluntary movements.
Received: 4 December 1995 / Accepted in revised form: 17 September 1996 相似文献
17.
The neural basis of the blood-oxygen-level-dependent functional magnetic resonance imaging signal 总被引:20,自引:0,他引:20
Logothetis NK 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2002,357(1424):1003-1037
Magnetic resonance imaging (MRI) has rapidly become an important tool in clinical medicine and biological research. Its functional variant (functional magnetic resonance imaging; fMRI) is currently the most widely used method for brain mapping and studying the neural basis of human cognition. While the method is widespread, there is insufficient knowledge of the physiological basis of the fMRI signal to interpret the data confidently with respect to neural activity. This paper reviews the basic principles of MRI and fMRI, and subsequently discusses in some detail the relationship between the blood-oxygen-level-dependent (BOLD) fMRI signal and the neural activity elicited during sensory stimulation. To examine this relationship, we conducted the first simultaneous intracortical recordings of neural signals and BOLD responses. Depending on the temporal characteristics of the stimulus, a moderate to strong correlation was found between the neural activity measured with microelectrodes and the BOLD signal averaged over a small area around the microelectrode tips. However, the BOLD signal had significantly higher variability than the neural activity, indicating that human fMRI combined with traditional statistical methods underestimates the reliability of the neuronal activity. To understand the relative contribution of several types of neuronal signals to the haemodynamic response, we compared local field potentials (LFPs), single- and multi-unit activity (MUA) with high spatio-temporal fMRI responses recorded simultaneously in monkey visual cortex. At recording sites characterized by transient responses, only the LFP signal was significantly correlated with the haemodynamic response. Furthermore, the LFPs had the largest magnitude signal and linear systems analysis showed that the LFPs were better than the MUAs at predicting the fMRI responses. These findings, together with an analysis of the neural signals, indicate that the BOLD signal primarily measures the input and processing of neuronal information within a region and not the output signal transmitted to other brain regions. 相似文献
18.
Joshua I. Glaser Bradley M. Zamft Adam H. Marblestone Jeffrey R. Moffitt Keith Tyo Edward S. Boyden George Church Konrad P. Kording 《PLoS computational biology》2013,9(7)
A molecular device that records time-varying signals would enable new approaches in neuroscience. We have recently proposed such a device, termed a “molecular ticker tape”, in which an engineered DNA polymerase (DNAP) writes time-varying signals into DNA in the form of nucleotide misincorporation patterns. Here, we define a theoretical framework quantifying the expected capabilities of molecular ticker tapes as a function of experimental parameters. We present a decoding algorithm for estimating time-dependent input signals, and DNAP kinetic parameters, directly from misincorporation rates as determined by sequencing. We explore the requirements for accurate signal decoding, particularly the constraints on (1) the polymerase biochemical parameters, and (2) the amplitude, temporal resolution, and duration of the time-varying input signals. Our results suggest that molecular recording devices with kinetic properties similar to natural polymerases could be used to perform experiments in which neural activity is compared across several experimental conditions, and that devices engineered by combining favorable biochemical properties from multiple known polymerases could potentially measure faster phenomena such as slow synchronization of neuronal oscillations. Sophisticated engineering of DNAPs is likely required to achieve molecular recording of neuronal activity with single-spike temporal resolution over experimentally relevant timescales. 相似文献
19.
Aseev NA Nikitin ES Roshchin MV Ierusalimskiĭ VN Balaban PM 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2012,62(1):100-107
Fast voltage-sensitive dyes (VSD) are widely used in modern neuroscience for optical recording of electrical potentials at many levels, from single cell compartment to brain areas, containing populations of many neural cells. The more lipophilic a VSD, the better signal-to-noise ratio of the optical signal, but there are no effective ways to deliver a water-insoluble dye into the membrane of live cell. Here we report a new protocol based on rapid biolistic delivery of VSDs, which is optimal for further recordings of optical signals from live neurons of rat brain slices. This protocol allows us to stain locally (150 mkm) neural somata of brain structures with a Golgi-like pattern, and a VSD propagates even to distant neurites of stained cells very quickly. This technique also can be used for rapid local delivery of any lipophilic and water-insoluble substances into live cells, further optical recording of neural activity, and analysis of potential propagation in a nerve cell. 相似文献
20.
The focus of this paper is the study of stability and point-to-point movement of a one-link arm. The sagittal arm has two
musculotendon actuators, two neural oscillators that generate burst signals as motoneuron inputs, and spindles and Golgi tendon
organs for extrinsic reflex feedbacks. It is shown that coactivation leads to intrinsic position and velocity feedback, and
that the tendons introduce intrinsic force and rate of force feedback. In addition, the integrating effects of the tendons
are studied when the actuator is constructed from a large number of identical fibers that are excited by alpha signals whose
arrival times at the fiber are randomly distributed. Each of the musculotendon actuators receives two input signals – a burst
signal analogous to alpha inputs and a conventional analogue signal that represents fusimotor input to the spindles. The process
of combining burst signals and conventional analogue signals is studied. Simulation results show that the movement of the
system with burst signals as inputs has overshoot and speed similar to the system with analogue signals.
Received: 30 May 1994/Accepted in revised form: 13 January 1995 相似文献