共查询到20条相似文献,搜索用时 46 毫秒
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Humberto H Lara Nilda V Ayala-Nu?ez Liliana Ixtepan-Turrent Cristina Rodriguez-Padilla 《Journal of nanobiotechnology》2010,8(1):1
Background
Silver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays. 相似文献2.
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Background
The orthologs of eukaryotic initiation factor 5C (eIF5C) are essential to the initiation of protein translation, and their regulation during development is not well known. 相似文献4.
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Background
Cell-free protein synthesis is not only a rapid and high throughput technology to obtain proteins from their genes, but also provides an in vitro platform to study protein translation and folding. A detailed comparison of in vitro protein synthesis in different cell-free systems may provide insights to their biological differences and guidelines for their applications. 相似文献6.
Arunachalam Vinayagam Coral del Val Falk Schubert Roland Eils Karl-Heinz Glatting Sándor Suhai Rainer König 《BMC bioinformatics》2006,7(1):161-7
Background
Vast progress in sequencing projects has called for annotation on a large scale. A Number of methods have been developed to address this challenging task. These methods, however, either apply to specific subsets, or their predictions are not formalised, or they do not provide precise confidence values for their predictions. 相似文献7.
Background
The current versions of the COG and arCOG databases, both excellent frameworks for studies in comparative and functional genomics, do not contain the nucleotide sequences corresponding to their protein or protein domain entries. 相似文献8.
Federico E Turkheimer Federico Roncaroli Benoit Hennuy Christian Herens Minh Nguyen Didier Martin Annick Evrard Vincent Bours Jacques Boniver Manuel Deprez 《BMC bioinformatics》2006,7(1):526
Background
Expression microarrays represent a powerful technique for the simultaneous investigation of thousands of genes. The evidence that genes are not randomly distributed in the genome and that their coordinated expression depends on their position on chromosomes has highlighted the need for mathematical approaches to exploit this dependency for the analysis of expression data-sets. 相似文献9.
Dawn Doré Jonathon de Hoog Graham Giles Changhai Ding Flavia Cicuttini Graeme Jones 《Arthritis research & therapy》2012,14(1):R13-10
Introduction
Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. 相似文献10.
Hong-Juan He Qian Wang Wei-Wei Zheng Jin-Xing Wang Qi-Sheng Song Xiao-Fan Zhao 《BMC cell biology》2010,11(1):1
Background
Nuclear transport factor 2 and small GTPase Ran participate in the nucleo-cytoplasm transport of macromolecules, but their function in the 20-hydroxyecdysone (20E) signal transduction pathway are not well known. 相似文献11.
Xavier Bailly Stefano Vanin Christine Chabasse Kenji Mizuguchi Serge N Vinogradov 《BMC evolutionary biology》2008,8(1):244
Background
Hemerythrins, are the non-heme, diiron binding respiratory proteins of brachiopods, priapulids and sipunculans; they are also found in annelids and bacteria, where their functions have not been fully elucidated. 相似文献12.
Introduction
Validity of biomarkers may be affected if studies do not include certain features in their design. We evaluated whether translational research studies of potential biomarkers incorporated design features important for valid clinical associations. 相似文献13.
Roderick F Felsheim Michael J Herron Curtis M Nelson Nicole Y Burkhardt Anthony F Barbet Timothy J Kurtti Ulrike G Munderloh 《BMC biotechnology》2006,6(1):42-9
Background
Tick-borne pathogens cause emerging zoonoses, and include fastidious organisms such as Anaplasma phagocytophilum. Because of their obligate intracellular nature, methods for mutagenesis and transformation have not been available. 相似文献14.
Qian Xiang Xianhua Dai Yangyang Deng Caisheng He Jiang Wang Jihua Feng Zhiming Dai 《BMC bioinformatics》2008,9(1):252
Background
It is an important pre-processing step to accurately estimate missing values in microarray data, because complete datasets are required in numerous expression profile analysis in bioinformatics. Although several methods have been suggested, their performances are not satisfactory for datasets with high missing percentages. 相似文献15.
Background
Identifying essential genes in bacteria supports to identify potential drug targets and an understanding of minimal requirements for a synthetic cell. However, experimentally assaying the essentiality of their coding genes is resource intensive and not feasible for all bacterial organisms, in particular if they are infective. 相似文献16.
Introduction
Many people with rheumatoid arthritis (RA) do not receive care from a rheumatologist. We surveyed primary care physicians (PCPs) to better understand their attitudes, knowledge, and practices regarding the optimal treatment of RA. 相似文献17.
Background
The correct folding and dimerization of tubulins, before their addition to the microtubular structure, needs a group of conserved proteins called cofactors A to E. The biochemical analysis of cofactors gave an insight to their general functions, however not much is known about the domain structure and detailed, molecular function of these proteins. 相似文献18.
Ingmar Janse Raditijo A Hamidjaja Jasper M Bok Bart J van Rotterdam 《BMC microbiology》2010,10(1):314
Background
Several pathogens could seriously affect public health if not recognized timely. To reduce the impact of such highly pathogenic micro-organisms, rapid and accurate diagnostic tools are needed for their detection in various samples, including environmental samples. 相似文献19.
Weiwu Jin Jason R Grant Paul Stothard Stephen S Moore Le Luo Guan 《BMC molecular biology》2009,10(1):90
Background
MicroRNAs (miRNAs) are a family of ~22 nucleotide small RNA molecules which regulate gene expression by fully or partially binding to their complementary sequences in mRNAs or promoters. A large number of miRNAs and their expression patterns have been reported in human, mouse and rat. However, miRNAs and their expression patterns in live stock species such as beef cattle are not well studied. 相似文献20.
Genome mapping and expression analyses of human intronic noncoding RNAs reveal tissue-specific patterns and enrichment in genes related to regulation of transcription
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Nakaya HI Amaral PP Louro R Lopes A Fachel AA Moreira YB El-Jundi TA da Silva AM Reis EM Verjovski-Almeida S 《Genome biology》2007,8(3):R43