共查询到20条相似文献,搜索用时 62 毫秒
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Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells
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Tapan Kumar Mistri Arun George Devasia Lee Thean Chu Wei Ping Ng Florian Halbritter Douglas Colby Ben Martynoga Simon R Tomlinson Ian Chambers Paul Robson Thorsten Wohland 《EMBO reports》2015,16(9):1177-1191
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Key regulators control distinct transcriptional programmes in blood progenitor and mast cells
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Fernando J Calero‐Nieto Felicia S Ng Nicola K Wilson Rebecca Hannah Victoria Moignard Ana I Leal‐Cervantes Isabel Jimenez‐Madrid Evangelia Diamanti Lorenz Wernisch Berthold Göttgens 《The EMBO journal》2014,33(11):1212-1226
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转录因子对顺势调控元件的选择性结合,在哺乳动物细胞类型特异的基因表达中扮演重要的角色.这个过程受到染色质表观遗传状态的潜在调控.近期,染色质免疫共沉淀结合测序的研究提供了大量泛基因组水平的数据,阐述转录因子结合以及组蛋白修饰的位点,这为系统地研究转录因子和表观遗传标记之间的空间及调控关系提供了基础.该研究对公共数据库中的染色质免疫共沉淀结合测序数据进行整合分析,涉及5个细胞系中的85种转录因子、9种组蛋白修饰,目的是研究转录因子结合位点与组蛋白修饰模式以及基因表达在泛基因组水平上的关联.作者发现,不同转录因子与组蛋白修饰的共定位模式高度一致,并且组蛋白修饰在距离转录因子结合位点约500碱基对的位置富集.作者还发现,转录因子结合位点的占有率与活性组蛋白修饰的水平和双峰模式正相关,并且启动子区域组蛋白修饰的双峰和共定位模式和基因的高转录水平相一致.组蛋白修饰模式、转录因子结合位点的占有率与基因转录之间的关联暗示了细胞可能利用的基因表达调控机制. 相似文献
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Mariano Oppikofer Tianyi Bai Yutian Gan Benjamin Haley Peter Liu Wendy Sandoval Claudio Ciferri Andrea G Cochran 《EMBO reports》2017,18(10):1697-1706
ISWI chromatin remodelers mobilize nucleosomes to control DNA accessibility. Complexes isolated to date pair one of six regulatory subunits with one of two highly similar ATPases. However, we find that each endogenously expressed ATPase co‐purifies with every regulatory subunit, substantially increasing the diversity of ISWI complexes, and we additionally identify BAZ2B as a novel, seventh regulatory subunit. Through reconstitution of catalytically active human ISWI complexes, we demonstrate that the new interactions described here are stable and direct. Finally, we profile the nucleosome remodeling functions of the now expanded family of ISWI chromatin remodelers. By revealing the combinatorial nature of ISWI complexes, we provide a basis for better understanding ISWI function in normal settings and disease. 相似文献
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Map‐based cloning of the pear gene MYB114 identifies an interaction with other transcription factors to coordinately regulate fruit anthocyanin biosynthesis
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Gaifang Yao Meiling Ming Andrew C. Allan Chao Gu Leiting Li Xiao Wu Runze Wang Yaojun Chang Kaijie Qi Shaoling Zhang Jun Wu 《The Plant journal : for cell and molecular biology》2017,92(3):437-451
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Brett Burdo John Gray Mary P. Goetting‐Minesky Bettina Wittler Matthew Hunt Tai Li David Velliquette Julie Thomas Irene Gentzel Michael dos Santos Brito Maria Katherine Mejía‐Guerra Layne N. Connolly Dalya Qaisi Wei Li Maria I. Casas Andrea I. Doseff Erich Grotewold 《The Plant journal : for cell and molecular biology》2014,80(2):356-366