共查询到20条相似文献,搜索用时 15 毫秒
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Yan Li Jasmina Kurepa Jan Smalle 《The Plant journal : for cell and molecular biology》2013,74(1):13-24
The plant hormone cytokinin plays essential roles in many aspects of growth and development. The cytokinin signal is transmitted by a multi‐step phosphorelay to the members of two functionally antagonistic classes of Arabidopsis response regulators (ARRs): type B ARRs (response activators) and type A ARRs (negative‐feedback regulators). Previous studies have shown that mutations in AXR1, encoding a subunit of the E1 enzyme in the RUB (related to ubiquitin) modification pathway, lead to decreased cytokinin sensitivity. Here we show that the cytokinin resistance of axr1 seedlings is suppressed by loss of function of the type A ARR family member ARR5. Based on the established role of the RUB pathway in ubiquitin‐dependent proteolysis, these data suggest that AXR1 promotes the cytokinin response by facilitating type A ARR degradation. Indeed, both genetic (axr1 mutants) and chemical (MLN4924) suppression of RUB E1 increased ARR5 stability, suggesting that the ubiquitin ligase that promotes ARR5 proteolysis requires RUB modification for optimal activity. 相似文献
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Type-A Arabidopsis response regulators are partially redundant negative regulators of cytokinin signaling
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To JP Haberer G Ferreira FJ Deruère J Mason MG Schaller GE Alonso JM Ecker JR Kieber JJ 《The Plant cell》2004,16(3):658-671
Type-A Arabidopsis (Arabidopsis thaliana) response regulators (ARRs) are a family of 10 genes that are rapidly induced by cytokinin and are highly similar to bacterial two-component response regulators. We have isolated T-DNA insertions in six of the type-A ARRs and constructed multiple insertional mutants, including the arr3,4,5,6,8,9 hextuple mutant. Single arr mutants were indistinguishable from the wild type in various cytokinin assays; double and higher order arr mutants showed progressively increasing sensitivity to cytokinin, indicating functional overlap among type-A ARRs and that these genes act as negative regulators of cytokinin responses. The induction of cytokinin primary response genes was amplified in arr mutants, indicating that the primary response to cytokinin is affected. Spatial patterns of ARR gene expression were consistent with partially redundant function of these genes in cytokinin signaling. The arr mutants show altered red light sensitivity, suggesting a general involvement of type-A ARRs in light signal transduction. Further, morphological phenotypes of some arr mutants suggest complex regulatory interactions and gene-specific functions among family members. 相似文献
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Multiple type-B response regulators mediate cytokinin signal transduction in Arabidopsis 总被引:1,自引:0,他引:1
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Mason MG Mathews DE Argyros DA Maxwell BB Kieber JJ Alonso JM Ecker JR Schaller GE 《The Plant cell》2005,17(11):3007-3018
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Expression profiling of cytokinin action in Arabidopsis 总被引:1,自引:0,他引:1
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