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《Biophysical journal》2021,120(19):4252-4263
An interplay between algorithmic and mechanistic viewpoints is necessary to quantify the rates of transition between different states in developmental pathways. An ab initio method that uses only information theory and geometry to model the conformational entropy of linkages is discussed. This approach also reveals some ties between biological questions and the foundations of mathematics.  相似文献   

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Cartesian mind body dualism and modern versions of this viewpoint posit a mind thermodynamically unrelated to the body but informationally interactive. The relation between information and entropy developed by Leon Brillouin demonstrates that any information about the state of a system has entropic consequences. It is therefore impossible to dissociate the mind's information from the body's entropy. Knowledge of that state of the system without an energetically significant measurement would lead to a violation of the second law of thermodynamics.  相似文献   

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Since laws of physics exists in nature, their possible relationship to terrestrial growth is introduced. By considering the human body as a dynamic system of variable mass (and volume), growing under a gravity field, it is shown how natural laws may influence the vertical growth of humans. This approach makes sense because the non-linear percentile curves of different aspects of human physical growth from childhood to adolescence can be described in relation to physics laws independently of gender and nationality. Analytical relations for the dependence of stature, measured mass (weight), growth velocity (and their mix as the body mass index) on age are deduced with a set of common statistical parameters which could relate environmental, genetics and metabolism and different aspects of physical growth on earth. A relationship to the monotone smoothing using functional data analysis to estimate growth curves and its derivatives is established. A preliminary discussion is also presented on horizontal growth in an essentially weightless environment (i.e., aquatic) with a connection to the Laird-Gompertz formula for growth.  相似文献   

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Distinguishing things from beings, or matters from lives, is a fundamental question. Extending E. Schr?dinger's neg-entropy and I. Prigogine's dissipative structure, we propose a chemical kinetic view that the earliest "live" process is embedded essentially in a special interaction between a pair of specific components under a particular, corresponding environmental conditions. The interaction exists as an inter-molecular-force-bond complex(IMFBC) that couples two separate chemical processes: one is the spontaneous formation of the IMFBC driven by a decrease of Gibbs free energy as a dissipative process; while the other is the disassembly of the IMFBC driven thermodynamically by free energy input from the environment. The two chemical processes coupled by the IMFBC originated independently and were considered non-living on Earth, but the IMFBC coupling of the two can be considered as the earliest form of metabolism: the first landmark on the path from things to a being. The dynamic formation and disassembly of the IMFBC, as a composite individual, follows a principle designated as "… structure for energy for structure for energy…", the cycle continues; and for short it will be referred to as "structure for energy cycle". With additional features derived from this starting point, the IMFBC-centered "live" process spontaneously evolved into more complex living organisms with the characteristics currently known.  相似文献   

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This article examines a Christian tradition defined by descent, but a descent that extends beyond family lineages to include relatedness with saints and sacred land. This tradition emerges from the Orthodox Patriarchate of Jerusalem, one of the oldest churches in the world, composed of a Palestinian laity and a Greek monastic hierarchy. Through an ethnography of the Orthodox feast of St George and the ritual use of olive oil from Palestinian villages, the article frames discussion of indigeneity, land, and rootedness around the concept of descent. Putting Palestinian Orthodoxy in conversation with kinship theory and the critique of social structure, it argues against sequestering divine and human forms of relatedness in separate social domains. It suggests the concept of descent can be a powerful tool for integrating them when expanded to include all ‘forces that bring forth life’.  相似文献   

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Much research has focused on how the amygdala processes individual affects, yet little is known about how multiple types of positive and negative affects are encoded relative to one another at the single-cell level. In particular, it is unclear whether different negative affects, such as fear and disgust, are encoded more similarly than negative and positive affects, such as fear and pleasure. Here we test the hypothesis that the basolateral nucleus of the amygdala (BLA), a region known to be important for learned fear and other affects, encodes affective valence by comparing neuronal activity in the BLA during a conditioned fear stimulus (fear CS) with activity during intraoral delivery of an aversive fluid that induces a disgust response and a rewarding fluid that induces a hedonic response. Consistent with the hypothesis, neuronal activity during the fear CS and aversive fluid infusion, but not during the fear CS and rewarding fluid infusion, was more similar than expected by chance. We also found that the greater similarity in activity during the fear- and disgust-eliciting stimuli was specific to a subpopulation of cells and a limited window of time. Our results suggest that a subpopulation of BLA neurons encodes affective valence during learned fear, and furthermore, within this subpopulation, different negative affects are encoded more similarly than negative and positive affects in a time-specific manner.  相似文献   

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套袋对翠冠梨果实货架寿命及生理生化变化的影响   总被引:8,自引:0,他引:8  
以翠冠梨为试材,研究了套袋对其果实货架寿命及生理生化变化的影响,试验结果表明,套袋能提高果实硬度、Vc含量及SOD活性,抑制细胞膜透性、MDA含量、呼吸速率及乙烯释放的迅速增加,从而有利于延缓果实衰老软化,且双层袋效果更好。  相似文献   

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