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Prediction and preliminary validation of oncogene regulation by miRNAs   总被引:1,自引:0,他引:1  

Background  

MicroRNAs (miRNAs) are one of the most abundant groups of regulatory genes in multicellular organisms, playing important roles in many fundamental cellular processes. More than four hundred miRNAs have been identified in humans and the deregulation of miRNA expression has been also shown in many cancers. Despite the postulated involvement of miRNAs in tumourigenesis, there are only a few examples where an oncogene or a tumour suppressor has been identified as a miRNA target.  相似文献   

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Background  

Plant microRNAs (miRNAs) are a class of small, non-coding RNAs that play an important role in development and environmental responses. Hundreds of plant miRNAs have been identified to date, mainly from the model species for which there are available genome sequences. The current challenge is to characterise miRNAs from plant species with agricultural and horticultural importance, to aid our understanding of important regulatory mechanisms in crop species and enable improvement of crops and rootstocks.  相似文献   

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Yu X  Zhou Q  Li SC  Luo Q  Cai Y  Lin WC  Chen H  Yang Y  Hu S  Yu J 《PloS one》2008,3(8):e2997
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