共查询到20条相似文献,搜索用时 109 毫秒
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HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor. 总被引:14,自引:0,他引:14 下载免费PDF全文
Audrey H. Wang Nicholas R. Bertos Marko Vezmar Nadine Pelletier Milena Crosato Henry H. Heng John Thng Jiahuai Han Xiang-Jiao Yang 《Molecular and cellular biology》1999,19(11):7816-7827
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HDAC4 deacetylase associates with and represses the MEF2 transcription factor. 总被引:28,自引:0,他引:28 下载免费PDF全文
E A Miska C Karlsson E Langley S J Nielsen J Pines T Kouzarides 《The EMBO journal》1999,18(18):5099-5107
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Direct interaction of Ca2+/calmodulin inhibits histone deacetylase 5 repressor core binding to myocyte enhancer factor 2 总被引:1,自引:0,他引:1
Berger I Bieniossek C Schaffitzel C Hassler M Santelli E Richmond TJ 《The Journal of biological chemistry》2003,278(20):17625-17635
Myocyte enhancer factor 2 (MEF2) proteins play a pivotal role in the differentiation of cardiac and skeletal muscle cells. MEF2 factors are regulated by histone deacetylase enzymes such as histone deacetylase 5 (HDAC5). HDAC5 in turn is responsive to Ca(2+) signaling mediated by the intracellular calcium sensor calmodulin. Here a combination of proteolytic fragmentation, matrix-assisted laser desorption ionization mass spectrometry, Edman degradation, circular dichroism, gel filtration, and surface plasmon resonance studies is utilized to define and characterize a stable core domain of HDAC5 and to examine its interactions with MEF2a and calmodulin. Results from real time binding experiments provide evidence for direct interaction of Ca(2+)/calmodulin with HDAC5 inhibiting MEF2a association with this enzyme. 相似文献
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Grégoire S Xiao L Nie J Zhang X Xu M Li J Wong J Seto E Yang XJ 《Molecular and cellular biology》2007,27(4):1280-1295
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A dynamic role for HDAC7 in MEF2-mediated muscle differentiation 总被引:14,自引:0,他引:14
Dressel U Bailey PJ Wang SC Downes M Evans RM Muscat GE 《The Journal of biological chemistry》2001,276(20):17007-17013
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