Development of health biotechnology in developing countries: Can private-sector players be the prime movers?

Health biotechnology has rapidly become vital in helping healthcare systems meet the needs of the poor in developing countries. This key industry also generates revenue and creates employment opportunities in these countries. To successfully develop biotechnology industries in developing nations, it is critical to understand and improve the system of health innovation, as well as the role of each innovative sector and the linkages between the sectors. Countries' science and technology capacities can be strengthened only if there are non-linear linkages and strong interrelations among players throughout the innovation process; these relationships generate and transfer knowledge related to commercialization of the innovative health products. The private sector is one of the main actors in healthcare innovation, contributing significantly to the development of health biotechnology via knowledge, expertise, resources and relationships to translate basic research and development into new commercial products and innovative processes. The role of the private sector has been increasingly recognized and emphasized by governments, agencies and international organizations. Many partnerships between the public and private sector have been established to leverage the potential of the private sector to produce more affordable healthcare products. Several developing countries that have been actively involved in health biotechnology are becoming the main players in this industry. The aim of this paper is to discuss the role of the private sector in health biotechnology development and to study its impact on health and economic growth through case studies in South Korea, India and Brazil. The paper also discussed the approaches by which the private sector can improve the health and economic status of the poor.     

Ecosystem Approaches to Health for a Global Sustainability Agenda

International research agendas are placing greater emphasis on the need for more sustainable development to achieve gains in global health. Research using ecosystem approaches to health, and the wider field of ecohealth, contribute to this goal, by addressing health in the context of inter-linked social and ecological systems. We review recent contributions to conceptual development of ecosystem approaches to health, with insights from their application in international development research. Various similar frameworks have emerged to apply the approach. Most predicate integration across disciplines and sectors, stakeholder participation, and an articulation of sustainability and equity to achieve relevant actions for change. Drawing on several frameworks and on case studies, a model process for application of ecosystem approaches is proposed, consisting of an iterative cycles of participatory study design, knowledge generation, intervention, and systematization of knowledge. The benefits of the research approach include innovations that improve health, evidence-based policies that reduce health risks; empowerment of marginalized groups through knowledge gained, and more effective engagement of decision makers. With improved tools to describe environmental and economic dimensions, and explicit strategies for scaling-up the use and application of research results, the field of ecohealth will help integrate both improved health and sustainability into the development agenda.     

物质代谢及其资源环境效应研究进展

从物质代谢的视角研究物质在社会经济系统中的流通过程,不仅能深入理解人类活动与自然环境之间的关系,更有助于实现资源的合理利用和可持续发展.本文在对国内外有关物质代谢的研究方法、在不同空间尺度的应用、资源和环境效应的研究进展进行综述的基础上,较全面的对上述研究中已取得的成果以及尚待完善之处进行总结.物质代谢研究应从过去的单一理论和方法向多学科和方法交叉融合的方向发展,以解决复杂的代谢问题.随着城市在全球生态环境中的重要性日益凸显,应加强传统的代谢研究与地理空间分析的结合,并将人类福祉等评价指标纳入物质代谢的研究范畴,进而从物质代谢的视角提出节约资源、降低环境负荷、提高环境-经济-社会协调发展的可持续管理对策.     

Dealing with different conceptions of pollution in the Gene Regulation Knowledge Commons

Current research of gene regulatory mechanisms is increasingly dependent on the availability of high-quality information from manually curated databases. Biocurators undertake the task of extracting knowledge claims from scholarly publications, organizing these claims in a meaningful format and making them computable. In doing so, they enhance the value of existing scientific knowledge by making it accessible to the users of their databases.In this capacity, biocurators are well positioned to identify and weed out information that is of insufficient quality. The criteria that define information quality are typically outlined in curation guidelines developed by biocurators. These guidelines have been prudently developed to reflect the needs of the user community the database caters to. The guidelines depict the standard evidence that this community recognizes as sufficient justification for trustworthy data. Additionally, these guidelines determine the process by which data should be organized and maintained to be valuable to users. Following these guidelines, biocurators assess the quality, reliability, and validity of the information they encounter.In this article we explore to what extent different use cases agree with the inclusion criteria that define positive and negative data, implemented by the database. What are the drawbacks to users who have queries that would be well served by results that fall just short of the criteria used by a database? Finally, how can databases (and biocurators) accommodate the needs of such more explorative use cases?     

IMPROVING GLOBAL HEALTH: COUNTING REASONS WHY

This paper examines cumulative ethical and self-interested reasons why wealthy developed nations should be motivated to do more to improve health care in developing countries. Egalitarian and human rights reasons why wealthy nations should do more to improve global health are that doing so would (1) promote equality of opportunity, (2) improve the situation of the worst-off, (3) promote respect of the human right to have one's most basic needs met, and (4) reduce undeserved inequalities in well-being. Utilitarian reasons for improving global health are that this would (5) promote the greater good of humankind, and (6) achieve enormous benefits while requiring only small sacrifices. Libertarian reasons are that this would (7) amend historical injustices and (8) meet the obligation to amend injustices that developed world countries have contributed to. Self-interested reasons why wealthy nations should do more to improve global health are that doing so would (9) reduce the threat of infectious diseases to developed countries, (10) promote developed countries' economic interests, and (11) promote global security. All of these reasons count, and together they add up to make an overwhelmingly powerful case for change. Those opposed to wealthy government funding of developing world health improvement would most likely appeal, implicitly or explicitly, to the idea that coercive taxation for redistributive purposes would violate the right of an individual to keep his hard-earned income. The idea that this reason not to improve global health should outweigh the combination of rights and values embodied in the eleven reasons enumerated above, however, is implausibly extreme, morally repugnant and perhaps imprudent.     

The big ecological questions inhibiting effective environmental management in Australia

The need to improve environmental management in Australia is urgent because human health, well‐being and social stability all depend ultimately on maintenance of life‐supporting ecological processes. Ecological science can inform this effort, but when issues are socially and economically complex the inclination is to wait for science to provide answers before acting. Increasingly, managers and policy‐makers will be called on to use the present state of scientific knowledge to supply reasonable inferences for action based on imperfect knowledge. Hence, one challenge is to use existing ecological knowledge more effectively; a second is to tackle the critical unanswered ecological questions. This paper identifies areas of environmental management that are profoundly hindered by an inability of science to answer basic questions, in contrast to those areas where knowledge is not the major barrier to policy development and management. Of the 22 big questions identified herein, more than half are directly related to climate change. Several of the questions concern our limited understanding of the dynamics of marine systems. There is enough information already available to develop effective policy and management to address several significant ecological issues. We urge ecologists to make better use of existing knowledge in dialogue with policy‐makers and land managers. Because the challenges are enormous, ecologists will increasingly be engaging a wide range of other disciplines to help identify pathways towards a sustainable future.     

A total approach in ergonomics is a must to attain humane, competitive and sustainable work systems and products

Globalization brings along complexity, competition and change as anticipated by working in teams, quality enhancement of human resources and a change of mind-set to be more holistic in approaches. Enhancement of expertise, widening of the horizon, developing added values as well as preparedness to carry out management of the future have to be built and developed. Conditioning and customizing programs through formal and informal education and training should also be carried out in bridging existing gaps, filling needs and solving key problems. New proper and appropriate curricula must be developed together with encouraging the change of mind-set. It is essential to attain the highest capabilities to work in a team and to think and act holistically, as well as to enhance human relations capabilities in communicating the research results. By so doing, the gaps between research and implementation and between theory and practice need to be bridged; the felt real needs of the target groups could thus be filled; and the root causes of the problems faced in any activity could be solved in a sustainable manner. In implementation, a SHIP (Systemic, Holistic, Interdisciplinary and Participatory) approach must be conducted for identifying, analyzing and solving the problems so as to attain sustainable results. In defining the technology being used, it must be comprehensively assessed through six criteria so that it can be technically, economically, ergonomically and socio-culturally sound, save energy and preserve the environment. Through this total approach, work organization and work systems and their products are expected to be more humane (healthier, safer, comfortable, efficient), competitive and sustainable, as prerequisites for survival and continual development.     

Recent Advances in Behavioral Research in Geriatric Dentistry1

This paper examines recent studies in behavioral science and health services aspects of geriatric dentistry. With the increased focus on special needs of older patients, researchers have become concerned with psychological and sociocultural factors that influence older people's oral health status, behavior, and attitudes. Studies of dental service utilization patterns among subgroups of the elderly, including those in long-term care settings, will be reviewed. Research on methods to improve oral health care behaviors will be discussed, with their implications for developing oral health promotion and service delivery programs. The special oral health needs of cognitively impaired and frail elderly will be reviewed. Studies of clinical decision-making in geriatric dentistry have been conducted. These studies have revealed significant gaps in dental professionals' knowledge and attention to the special needs of older patients. This and other aspects of behavioral research suggest the need for better methods to disseminate research findings in geriatric dentistry to clinical practice in this field. The presentation will discuss ways of improving dissemination and transfer of research findings to the clinical management of aged patients.     

Phytotechnologies – Preventing Exposures,Improving Public Health

Phytotechnologies have potential to reduce the amount or toxicity of deleterious chemicals and agents, and thereby, can reduce human exposures to hazardous substances. As such, phytotechnologies are tools for primary prevention in public health. Recent research demonstrates phytotechnologies can be uniquely tailored for effective exposure prevention in a variety of applications. In addition to exposure prevention, plants can be used as sensors to identify environmental contamination and potential exposures. In this paper, we have presented applications and research developments in a framework to illustrate how phytotechnologies can meet basic public health needs for access to clean water, air, and food. Because communities can often integrate plant-based technologies at minimal cost and with low infrastructure needs, the use of these technologies can be applied broadly to minimize potential contaminant exposure and improve environmental quality. These natural treatment systems also provide valuable ecosystem services to communities and society. In the future, integrating and coordinating phytotechnology activities with public health research will allow technology development focused on prevention of environmental exposures to toxic compounds. Hence, phytotechnologies may provide sustainable solutions to environmental exposure challenges, improving public health and potentially reducing the burden of disease.     

Connecting to the oceans: supporting ocean literacy and public engagement

Improved public understanding of the ocean and the importance of sustainable ocean use, or ocean literacy, is essential for achieving global commitments to sustainable development by 2030 and beyond. However, growing human populations (particularly in mega-cities), urbanisation and socio-economic disparity threaten opportunities for people to engage and connect directly with ocean environments. Thus, a major challenge in engaging the whole of society in achieving ocean sustainability by 2030 is to develop strategies to improve societal connections to the ocean. The concept of ocean literacy reflects public understanding of the ocean, but is also an indication of connections to, and attitudes and behaviours towards, the ocean. Improving and progressing global ocean literacy has potential to catalyse the behaviour changes necessary for achieving a sustainable future. As part of the Future Seas project (https://futureseas2030.org/), this paper aims to synthesise knowledge and perspectives on ocean literacy from a range of disciplines, including but not exclusive to marine biology, socio-ecology, philosophy, technology, psychology, oceanography and human health. Using examples from the literature, we outline the potential for positive change towards a sustainable future based on knowledge that already exists. We focus on four drivers that can influence and improve ocean literacy and societal connections to the ocean: (1) education, (2) cultural connections, (3) technological developments, and (4) knowledge exchange and science-policy interconnections. We explore how each driver plays a role in improving perceptions of the ocean to engender more widespread societal support for effective ocean management and conservation. In doing so, we develop an ocean literacy toolkit, a practical resource for enhancing ocean connections across a broad range of contexts worldwide.

     

The More the Better? A Comparison of the Information Sources Used by the Public during Two Infectious Disease Outbreaks

Recent infectious disease outbreaks have resulted in renewed recognition of the importance of risk communication planning and execution to public health control strategies. Key to these efforts is public access to information that is understandable, reliable and meets their needs for informed decision-making on protective health behaviours. Learning from the trends in sources used in previous outbreaks will enable improvements in information access in future outbreaks. Two separate random-digit dialled telephone surveys were conducted in Alberta, Canada, to explore information sources used by the public, together with their perceived usefulness and credibility, during the 2003 Severe Acute Respiratory Syndrome (SARS) epidemic (n = 1209) and 2009–2010 H1N1 pandemic (n = 1206). Traditional mass media were the most used information sources in both surveys. Although use of the Internet increased from 25% during SARS to 56% during H1N1, overall use of social media was not as high as anticipated. Friends and relatives were commonly used as an information source, but were not deemed very useful or credible. Conversely, doctors and health professionals were considered credible, but not consulted as frequently. The use of five or more information sources increased by almost 60% between the SARS and H1N1 surveys. There was a shift to older, more educated and more affluent respondents between the surveys, most likely caused by a decrease in the use of landlines amongst younger Canadians. It was concluded that people are increasingly using multiple sources of health risk information, presumably in a complementary manner. Subsequently, although using online media is important, this should be used to augment rather than replace more traditional information channels. Efforts should be made to improve knowledge transfer to health care professionals and doctors and provide them with opportunities to be more accessible as information sources. Finally, the future use of telephone surveys needs to account for the changing demographics of the respondents accessed through such surveys.     

生态系统健康研究进展

健康的生态系统一般被视为环境管理的终极目标,进行生态系统健康研究对探索区域与生态系统可持续发展具有重要意义。随着国际生态与健康学会(International Association for Ecology and Health)的解体,生态系统健康研究视角出现转型。系统梳理了近年来国际上有关生态系统健康概念及其评估方法、指标的新进展,通过文献统计和重要文献引用揭示了国际生态系统健康研究的发展历程,提出了从生态系统健康到生态健康再到生态文化健康的三大核心框架发展阶段,生态系统健康的研究对象和范围正在不断扩充。资源环境研究领域是国内研究者应用生态系统健康概念与方法的优势领域,在区域尺度上评价生态系统的健康更贴近资源环境和社会文化交互作用的复合表征理念。因此,我国生态系统健康研究的趋向不仅应包括在生态系统尺度上研究的继续深化,也应包含对生态文化健康概念的完善与应用,并发挥地理-生态视角的区域集成研究优势,从而有效指导区域生态与环境政策制定与实施。     

细胞培养肉的生物伦理学思考

近年来,为了解决人类社会发展和环境资源的矛盾日益突出的问题,人造肉越来越多的进入人们的视野。通常所说的人造肉,可以分为植物蛋白肉和细胞培养肉。其中植物蛋白肉已经逐步开始商业化,细胞培养肉采用动物细胞进行培养,与真实肉制品更为接近。文中在分析细胞培养肉本质基础上,探讨细胞培养肉对肉类生产行业、消费者群体以及人类未来可持续发展的积极意义。在生物伦理学的视角下,研发和生产细胞培养肉有助于保障人类社会的可持续发展、提升动物福利、减少资源需求、改善肉制品营养功能,并为其他行业的发展提供新的增长点。此外,对于细胞培养肉生产涉及的食品安全、技术滥用、技术监管层面上的伦理风险提出进行了深入思考,希望能从生物伦理学的层面为人造肉行业的可持续发展提供参考。     

城市绿地土壤健康质量问题与对策

城市绿地土壤质量是保障绿化植物健康生长的基础,也是保障绿地为城市及其居民提供健康生态系统服务和城市可持续发展的重要基础.目前在提升城市绿地土壤质量方面,主要关注了肥力质量和环境质量方面的问题,对健康质量方面的问题还较少关注.本文综述了土壤健康质量的概念、内涵及其评价指标,总结了城市绿地土壤健康质量所面临的主要问题和挑战...     

Ethnicity as a variable in epidemiological research.

Ethnicity is used increasingly as a key variable to describe health data, and ethnic monitoring in the NHS will further stimulate this trend. We identify four fundamental problems with ethnicity in this type of research: the difficulties of measurement, the heterogeneity of the populations being studied, lack of clarity about the research purpose of the research, and ethnocentricity affecting the interpretation and use of data. Ethnicity needs to be used carefully to be a useful tool for health research. We make nine recommendations for future practice, one of which is that ethnicity and race should be recognised and treated as distinct concepts.     

生物多样性相关传统知识研究热点与前沿的可视化分析

传统知识研究目前已经成为生物多样性保护研究的热点领域, 并对生态系统服务管理、社区可持续发展等领域产生了重要影响。本文以Web of Science (WoS)数据库为数据源, 应用WoS自带的统计分析功能和可视化分析软件CiteSpace III, 采用关键词共现分析、突现词分析、文献共被引分析等方法对传统知识的研究态势、研究热点以及知识演进进行系统分析。研究发现, 传统知识研究的文献数量呈逐年上升趋势; 中国科学院、墨西哥国立自治大学、印度农业研究理事会、加州大学系统等研究机构在该领域表现出较强的科研实力; 非洲、南美洲的巴西、玻利维亚以及亚洲的印度等地区为传统知识研究的热点区域; Albuquerque UP、Singh R、薛达元在该领域发表的学术论文最多; Berkes F、Drew JA、Gómez-Baggethun E等学者发表的论文为该领域知识基础的构建及相关研究的推进奠定了坚实的基础。与生物资源管理、生物多样性保护、生态系统服务和人类福祉、政策管理等相关的传统知识研究是未来该领域的重要方向。     

景感生态学在城市生态系统服务中的应用研究——以城市公园景观设计为例

城市生态系统服务和可持续发展是当前城市生态学研究的热点问题。景感生态学作为联系生态系统服务和可持续发展的桥梁,可作为研究城市生态系服务和可持续发展的一种有效途径。随着社会发展所伴随的人们经济生活的生活压力增大,城市居民的亚健康状态日益突出。城市公园作为城市生态系统的重要构成,其设计目的应考虑应对城市居民健康问题和促进人类精神文明建设方面的作用。以城市公园景观设计为例,从园路、建筑、植物、水体景观和小品等方面探讨景感生态学在城市公园景观设计中的应用价值。景感生态学作为探索城市公园景观设计的新思路,以实现生态效益和居民福祉的提升,丰富和提升城市公园的生态系统服务功能,从而有利于促进为人类当代和后代提供可持续的福祉,以期驱使人类行为和言行规律朝着对生态系统有益的方向演化,自觉维护和改善生态系统服务,从而可持续地保障城市生态系统服务。     

基于无线物联网的远程脑卒中诊疗服务模式研究

远程医学在推动优质医疗资源纵向流动方面发挥出越来越重要的作用,远程脑卒中项目在发达国家的开展也日益规范。从我国脑卒中诊疗服务的实际需求出发,结合目前计算机网络、通讯技术的发展状况,提出基于无线物联网的远程脑卒中诊疗服务模式,充分利用现代信息技术优势,提高脑卒中诊疗水平,促进远程医学的发展。     

Managing marine mollusc diseases in the context of regional and international commerce: policy issues and emerging concerns

Marine mollusc production contributes to food and economic security worldwide and provides valuable ecological services, yet diseases threaten these industries and wild populations. Although the infrastructure for mollusc aquaculture health management is well characterized, its foundations are not without flaws. Use of notifiable pathogen lists can leave blind spots with regard to detection of unlisted and emerging pathogens. Increased reliance on molecular tools has come without similar attention to diagnostic validation, raising questions about assay performance, and has been accompanied by a reduced emphasis on microscopic diagnostic expertise that could weaken pathogen detection capabilities. Persistent questions concerning pathogen biology and ecology promote regulatory paralysis that impedes trade and which could weaken biosecurity by driving commerce to surreptitious channels. Solutions that might be pursued to improve shellfish aquaculture health management include the establishment of more broad-based surveillance programmes, wider training and use of general methods like histopathology to ensure alertness to emerging diseases, an increased focus on assay assessment and validation as fundamental to assay development, investment in basic research, and application of risk analyses to improve regulation. A continual sharpening of diagnostic tools and approaches and deepening of scientific knowledge is necessary to manage diseases and promote sustainable molluscan shellfish industries.