共查询到20条相似文献,搜索用时 15 毫秒
1.
Claire Monod Cassidy 《Culture, medicine and psychiatry》1982,6(4):325-345
A new definition of the concept of culture-bound syndrome demonstrates that culture-boundedness is common and applies as well to Western biomedical disease categories as to nonWestern categories. Culture-boundedness is important when a common disorder with a large sociopsychological component is frequently treated, but unsuccessfully. To improve intervention success, therapists must recognize and accept that clients and interventionists may employ widely dissimilar culture-bound explanatory models. Therapists must learn to synthesize among models, neither rejecting nor discounting those of clients. The fact that Western notions of cause are culture-bound has gone largely unrecognized because of the tendency among biomedical scientists to treat science as if it were culture-free and universally comprehensible. This is of course a naive and invalid understanding. These points are illustrated for the case of protein-energy malnutrition. If those who design and facilitate intervention to alleviate hunger can come to understand that the scientific explanatory model of protein-energy malnutrition is only one among several cogent models, they will be in a strong position to understand intervention failure and possibly to overcome it. 相似文献
2.
Arthur Kleinman 《Culture, medicine and psychiatry》1982,6(2):117-190
The author reviews conceptual and empirical issues regarding the interaction of neurasthenia, somatization and depression in Chinese culture and in the West. The historical background of neurasthenia and its current status are discussed, along with the epidemiology and phenomenology of somatization and depression. Findings are presented from a combined clinical and anthropological field study of 100 patients with neurasthenia in the Psychiatry Outpatient Clinic at the Hunan Medical College. Eighty-seven of these patients made the DSM-III criteria of Major Depressive Disorder; diagnoses of anxiety disorders were also frequent. Forty-four patients were suffering from chronic pain syndromes previously undiagnosed, and cases of culture-bound syndromes also were detected. For three-quarters of patients the social significances and uses of their illness behavior chiefly related to work. Although from the researchers' perspective 70% of patients with Major Depressive Disorder experienced substantial improvement and 87% some improvement in symptoms when treated with antidepressant medication, fewer experienced decreased help seeking, and a much smaller number perceived less social impairment and improvement in illnes problems (the psychosocial accompaniment of disease including maladaptive coping and work, family and school problems). These findings are drawn on to advance medical anthropology and cultural psychiatry theory and research regarding somatization in Chinese culture, the United States and cross culturally. The author concludes that though neurasthenia can be understood in several distinctive ways, it is most clinically useful to regard it as bioculturally patterned illness experience (a special form of somatization) related to either depression and other diseases or to culturally sanctioned idioms of distress and psychosocial coping. 相似文献
3.
This study investigated behavioral syndromes, which are defined as correlations between behaviors. Behavioral syndromes can
lead to the unintentional alteration of a wide range of behavioral traits of hatchery fish if unintentional selection on one
behavior leads to selection on a correlated behavior. Specifically, this study used brown rockfish, Sebastes auriculatus, to test the hypothesis that a fish that feeds at high rates in the absence of a predator also takes more risks when a predator
is present, and that through such a correlation, unintentional hatchery selection for high feeding rates may also lead to
changes in risk taking behavior (here defined as behavior that increases predation risk). Behavioral syndromes were found—feeding
behavior in the absence of a predator tended to correlate positively with both feeding behavior in the presence of a predator
model and time near the model. These syndromes were stable through time—that is, the same correlations appeared 10 days later
when the behavioral assays were repeated. However individual behavior was inconsistent (plastic). A fish could both feed and
take risks at high rates on Day 1, but then both feed and take risks at low rates on Day 10. Thus, while behavioral syndromes
were stable (i.e. present in both rounds 1 and 2), individuals were plastic in their behavior (i.e. inconsistent between rounds
1 and 2). After 16 weeks of hatchery rearing, neither growth nor survival were predicted by behavior. It is suggested that
the behavioral plasticity within individuals through time makes consistent selection for strong feeders less likely, and that
species with more plastic behavior may be less susceptible to unintentional selection on behavioral syndromes than species
with behavior that is more fixed. 相似文献
4.
Yoeli-Tlalim R 《Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences》2010,41(4):318-324
This article discusses the Tibetan notion of rlung, usually translated as: 'wind', but perhaps better understood as a close equivalent of pneuma in the Greek tradition, or qi in the Chinese tradition. The article focuses on the way rlung provides a useful prism through which concepts of health, illness and disease may be observed in a cross-cultural perspective. An analysis of syndromes linked with rlung in a Tibetan cultural context illuminates some of the ways in which culture determines particular syndromes. The article raises a number of questions which are relevant for a more general multicultural approach to concepts of health, illness and disease. The article argues that notions of rlung/pneuma/wind/ qi constitute a particularly interesting area for an exploration of culture-bound syndromes, as they reside in the meeting point between material and non-material, physical and mental, as well as the psychological, spiritual and religious. They are hence fundamental for a more cross-cultural approach to the mind-body problem. The article also deals with the significance of history of medicine, particularly histories of medicine, which attempt to widen the scope of the traditional Eurocentric narrative of the history of medicine, in dealing with questions such as concepts of health and illness. Allowing alternative narratives-whether narratives of patients, other cultures or historical ones-can enhance our understanding of what health, illness and disease are. Discussing perceptions of the body as culturally defined is not only important from a philosophical or historical point of view, but also has important practical ramifications, which are particularly crucial in our global age. 相似文献
5.
Obesity as a culture-bound syndrome 总被引:4,自引:0,他引:4
Cheryl Ritenbaugh 《Culture, medicine and psychiatry》1982,6(4):347-361
Although the term culture-bound syndrome has been used for many years, a concise definition has not been available. The less precise synonym folk illness has implied that such syndromes exist only in other cultures. This paper provides a four-part definition to permit examination and comparison of disease categories in any system, including biomedicine.Anthropologists have tended to view biomedicine as the standard for comparison, and have not examined it in the same critical light as other systems. This may be due in part to a confusion of the biomedical classificatory system (biomedicine per se, emic level) with the biological data on which in is based (etic level). One can in fact retain use of the biological data while analyzing biomedicine, which is understood to include cultural componentsMild-to-moderate obesity in the U.S. today fits the proposed definition of a culture-bound syndrome. This paper offers a brief overview of the evidence that culture has shaped both the definition of the disease over time and its treatment. 相似文献
6.
Raymond L. M. Lee 《Culture, medicine and psychiatry》1981,5(3):233-248
Turner's concepts of structure and anti-structure are applied to the culture-bound syndromes to demonstrate that they are dialectical aspects of cultural reality. The Malay cases of amok, latah and possession hysteria are discussed as instances of anti-structural behaviors that dramatize role-reversals and role-enhancement. The performers of these behaviors are not subjected to the Malay code of moral conduct. The supernatural ethos in Malay culture plays an important role in shaping tolerance towards them. Although this tolerance has been gradually eroded as a result of the introduction of Western psychiatry, the anti-structural status of these syndromes has not faded away but has assumed new meanings in terms of psychopathology. 相似文献
7.
Phenotypic Plasticity and the Ecotypic Differentiation of Aggressive Behavior in Threespine Stickleback 总被引:1,自引:0,他引:1
Melissa-Ann L. Scotti & Susan A. Foster 《Ethology : formerly Zeitschrift fur Tierpsychologie》2007,113(2):190-198
The threespine stickleback fish, Gasterosteus aculeatus, has undergone a remarkable postglacial adaptive radiation in which an ancient oceanic ancestor has given rise to uncountable freshwater populations. The radiation is characterized by repeated, independent evolution of similar derived phenotypes under similar environmental conditions. A common pattern of divergence is caused by differences in habitat that favor morphological and behavioral features that enhance efficiency of feeding on plankton (limnetic ecotypes) vs. those that enhance efficiency of feeding on benthic invertebrates (benthic ecotypes). These two ecotypes exhibit consistently different patterns of courtship and of foraging and cannibalistic behavior (divergent behavioral syndromes). Here, we demonstrate that there also exist differences in aggression toward conspecifics that are likely to be characteristic of the ecotypes. We report differences in patterns of aggression toward rivals between the ecotypes and offer evidence of differences in the patterns of phenotypic plasticity (norms of reaction) for these traits across population types, and of differences in the incorporation of aggressive elements of behavior in courtship. These data support an earlier suggestion that differences in aggressive tendencies could have facilitated assortative mating between the four benthic–limnetic species pairs found in British Columbia lakes, and they demonstrate the need to evaluate divergent behavioral phenotypes in this radiation as phenotypic norms of reaction rather than as fixed traits. 相似文献
8.
COMT Val158Met genotype is associated with reward learning: a replication study and meta‐analysis
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N. S. Corral‐Frías D. A. Pizzagalli J. M. Carré L. J. Michalski Y. S. Nikolova R. H. Perlis J. Fagerness M. R. Lee E. Drabant Conley T. M. Lancaster S. Haddad A. Wolf J. W. Smoller A. R. Hariri R. Bogdan 《Genes, Brain & Behavior》2016,15(5):503-513
Identifying mechanisms through which individual differences in reward learning emerge offers an opportunity to understand both a fundamental form of adaptive responding as well as etiological pathways through which aberrant reward learning may contribute to maladaptive behaviors and psychopathology. One candidate mechanism through which individual differences in reward learning may emerge is variability in dopaminergic reinforcement signaling. A common functional polymorphism within the catechol‐O‐methyl transferase gene (COMT; rs4680, Val158Met) has been linked to reward learning, where homozygosity for the Met allele (linked to heightened prefrontal dopamine function and decreased dopamine synthesis in the midbrain) has been associated with relatively increased reward learning. Here, we used a probabilistic reward learning task to asses response bias, a behavioral form of reward learning, across three separate samples that were combined for analyses (age: 21.80 ± 3.95; n = 392; 268 female; European‐American: n = 208). We replicate prior reports that COMT rs4680 Met allele homozygosity is associated with increased reward learning in European‐American participants (β = 0.20, t = 2.75, P < 0.01; ΔR2 = 0.04). Moreover, a meta‐analysis of 4 studies, including the current one, confirmed the association between COMT rs4680 genotype and reward learning (95% CI ?0.11 to ?0.03; z = 3.2; P < 0.01). These results suggest that variability in dopamine signaling associated with COMT rs4680 influences individual differences in reward which may potentially contribute to psychopathology characterized by reward dysfunction. 相似文献
9.
Sensing external stimulation is crucial for central processing in the brain and subsequent behavioral expression. Although sensory alteration or deprivation may result in behavioral changes, most studies related to the control of behavior have focused on central mechanisms. Here we created a sensory deficit model of mice lacking acid‐sensing ion channel 3 (Asic3?/?) to probe behavioral alterations. ASIC3 is predominately distributed in the peripheral nervous system. RT‐PCR and immunohistochemistry used to examine the expression of Asic3 in the mouse brain showed near‐background mRNA and protein levels of ASIC3 throughout the whole brain, except for the sensory mesencephalic trigeminal nucleus. Consistent with the expression results, Asic3 knockout had no effect on synaptic plasticity of the hippocampus and the behavioral tasks of motor function, learning and memory. In anxiety behavior tasks, Asic3?/? mice spent more time in the open arms of an elevated plus maze than did their wild‐type littermates. Asic3?/? mice also displayed less aggressiveness toward intruders but more stereotypic repetitive behaviors during resident–intruder testing than did wild‐type littermates. Therefore, loss of ASIC3 produced behavioral changes in anxiety and aggression in mice, which suggests that ASIC3‐dependent sensory activities might relate to the central process of emotion modulation. 相似文献
10.
Life‐history strategy and behavioral type: risk‐tolerance reflects growth rate and energy allocation in ant colonies
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Despite the recent interest in animal personality and behavioral syndromes, there is a paucity of explanations for why distinct behavioral traits should evolve to correlate. We investigate whether such correlations across apparently distinct behavioral traits may be explained by variation in life history strategy among individual ant colonies. Life history theory predicts that the way in which individuals allocate energy towards somatic maintenance or reproduction drives several distinct traits in physiology, morphology, and energy use; it also predicts that an individual's willingness to engage in risky behaviors should depend on reproductive strategy. We use Temnothorax ants, which have been shown to exhibit ‘personalities’ and a syndrome that may reflect risk tolerance at the colony level. We measure colonies' relative investment in growth rate (new workers produced) compared to reproductive effort (males and queens produced). Comparing sterile worker production to reproductive alate production provides a direct measure of how colonies are investing their energy, analogous to investment in growth versus reproduction in a unitary organism. Consistently with this idea, we found that behavioral type of ant colonies was associated with their life history strategy: risk‐tolerant colonies grew faster and invested more in reproduction, whereas risk‐averse colonies had lower growth rate but invested relatively more in workers. This provides evidence that behavioral syndromes can be a consequence of life‐history strategy variation, linking the two fields and supporting the use of an integrative approach. 相似文献
11.
Raphaël Royauté Christopher M. Buddle Charles Vincent 《Ethology : formerly Zeitschrift fur Tierpsychologie》2014,120(2):127-139
Variations in environmental conditions can influence behavioral syndromes (correlated tendencies in behaviors), and understanding the factors that shape trait covariation is particularly relevant when species are challenged by environmental changes. We investigated how behavioral syndromes varied at extremes of a gradient of anthropogenic disturbance, using apple orchards with different histories of insecticidal applications as a model system. Eris militaris (Araneae: Salticidae) jumping spiders were sampled from an insecticide‐free orchard and an insecticide‐treated orchard from Southern Québec. Spiders were tested for activity, aggression, boldness, and voracity under standardized conditions. Behavioral syndrome structure was compared between the two populations using Bayesian multiresponse models and structural equation modeling. Syndrome structure differed significantly between the two populations. The insecticide‐free population showed evidence of a syndrome involving all measured traits, while only aggression, boldness and voracity were correlated in the insecticide‐treated population. The insecticide‐free population showed negative correlations between active and voracious behavioral types vs. aggressive and bold types while the insecticide‐treated population showed a negative correlation between aggression‐boldness and voracity. This research is a first step in investigating the impact of anthropogenic disturbances on behavioral syndromes and demonstrates that behavioral syndromes may vary with respect to insecticidal applications. 相似文献
12.
Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder
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P.A. Kabitzke D. Brunner D. He P.A. Fazio K. Cox J. Sutphen L. Thiede E. Sabath T. Hanania V. Alexandrov R. Rasmusson W. Spooren A. Ghosh P. Feliciano B. Biemans M. Benedetti A.L. Clayton 《Genes, Brain & Behavior》2018,17(1):4-22
To expand, analyze and extend published behavioral phenotypes relevant to autism spectrum disorder (ASD), we present a study of three ASD genetic mouse models: Feng's Shank3tm2Gfng model, hereafter Shank3/F, Jiang's Shank3tm1Yhj model, hereafter Shank3/J and the Cacna1c deletion model. The Shank3 models mimick gene mutations associated with Phelan–McDermid Syndrome and the Cacna1c model recapitulates the deletion underlying Timothy syndrome. This study utilizes both standard and novel behavioral tests with the same methodology used in our previously published companion report on the Cntnap2 null and 16p11.2 deletion models. We found that some but not all behaviors replicated published findings and those that did replicate, such as social behavior and overgrooming in Shank3 models, tended to be milder than reported elsewhere. The Shank3/F model, and to a much lesser extent, the Shank3/J and Cacna1c models, showed hypoactivity and a general anxiety‐like behavior triggered by external stimuli which pervaded social interactions. We did not detect deficits in a cognitive procedural learning test nor did we observe perseverative behavior in these models. We did, however, find differences in exploratory patterns of Cacna1c mutant mice suggestive of a behavioral effect in a social setting. In addition, only Shank3/F showed differences in sensory‐gating. Both positive and negative results from this study will be useful in identifying the most robust and replicable behavioral signatures within and across mouse models of autism. Understanding these phenotypes may shed light of which features to study when screening compounds for potential therapeutic interventions. 相似文献
13.
Patricia Kabitzke Diana Morales Dansha He Kimberly Cox Jane Sutphen Lucinda Thiede Emily Sabath Taleen Hanania Barbara Biemans Daniela Brunner 《Genes, Brain & Behavior》2020,19(7)
Phenotyping mouse model systems of human disease has proven to be a difficult task, with frequent poor inter‐ and intra‐laboratory replicability, particularly in behavioral domains such as social and cognitive function. However, establishing robust animal model systems with strong construct validity is of fundamental importance as they are central tools for understanding disease pathophysiology and developing therapeutics. To complete our studies of mouse model systems relevant to autism spectrum disorder (ASD), we present a replication of the main findings from our two published studies of five genetic mouse model systems of ASD. To assess the intra‐laboratory robustness of previous results, we chose the two model systems that showed the greatest phenotypic differences, the Shank3/F and Cntnap2, and repeated assessments of general health, activity and social behavior. We additionally explored all five model systems in the same framework, comparing all results obtained in this three‐yearlong effort using informatics techniques to assess commonalities and differences. Our results showed high intra‐laboratory replicability of results, even for those with effect sizes that were not particularly large, suggesting that discrepancies in the literature may be dependent on subtle but pivotal differences in testing conditions, housing enrichment, or background strains and less so on the variability of the behavioral phenotypes. The overall informatics analysis suggests that in our behavioral assays we can separate the set of tested mouse model system into two main classes that in some aspects lie on opposite ends of the behavioral spectrum, supporting the view that autism is not a unitary concept. 相似文献
14.
Zuoshi Huang Richard A. Satterlie 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1990,166(6):875-887
Summary In the pteropod mollusc Clione limacina, wing retraction takes precedence over spontaneous and continuous swimming, a phenomenon here defined as behavioral switching. The wing retraction system is organized as a simple reflex in which wing mechanoreceptors activate a pair of retraction interneurons which in turn excite at least two pairs of retraction motoneurons.Activation of individual mechanoreceptors does not inhibit swimming or trigger wing retraction. A pair of retraction interneurons can fully suppress swimming when induced to fire at physiological frequencies, and may be both sufficient and necessary for swim inhibition.Retraction interneurons monosynaptically inhibit both swim interneurons and swim motoneurons. Retraction motoneurons inhibit swim motoneurons through a polysynaptic pathway.A model summarizing the neural circuitry underlying behavioral switching in Clione is presented. A comparison of this model with the behavioral choice model in Pleurobranchaea reveals that the overall neural mechanisms for behavioral choice and behavioral switching are similar as both involve dual function interneurons that not only activate their own motor pathway, but also inhibit the competing motor system. While inhibition is biased toward the afferent side of the competing circuit in behavioral choice, it is biased to the efferent side in behavioral switching. 相似文献
15.
Emma L. Berdan Rebecca C. Fuller 《Evolution; international journal of organic evolution》2012,66(10):3224-3237
Behavioral isolation is a common and potent mechanism of reproductive isolation. Determining the extent to which behavioral isolation varies with environmental conditions is critical to understanding speciation and the maintenance of species boundaries. Here, we tested the effect of salinity on behavioral isolation (female species recognition, male–male competition, and male species recognition) between two closely related killifish (Lucania goodei and L. parva) that differ in salinity tolerance. We performed no‐choice assays and behavioral trials where males could compete and court females in fresh water (0 ppt) and brackish water (15 ppt). We found high levels of behavioral isolation that did not vary as a function of salinity. In behavioral trials, male species recognition of females was strong and asymmetric between the two species. Lucania goodei males preferred conspecifics and rarely courted or mated with L. parva females. Lucania parva males preferred conspecifics but readily courted and mated with L. goodei females. This asymmetry matches previously documented asymmetries in hybrid offspring fitness. Crosses between L. parva males and L. goodei females produce fully viable/fertile hybrids, but crosses between L. goodei males and L. parva females produce males with reduced fertility. Hence, behavioral isolation may have evolved in part due to reinforcement. 相似文献
16.
Richard E. Miller Norma L. Fowler 《Evolution; international journal of organic evolution》1993,47(5):1446-1455
Recent research has emphasized the importance of investigating the reaction norms of quantitative traits to understand evolution in natural environments. In this study, genetic differences in reaction norms among eight populations of the grass Bouteloua rigidiseta were examined using clonal replicates of genotypes planted in a common garden with two levels of competition (single B. rigidiseta without competition and single B. rigidiseta surrounded by four Erioneuron pilosum). The populations were found to be genetically differentiated for a variety of traits. Differences in reaction norms of size-specific fecundity (spikelet clusters per tiller number) were detected among the populations: some showed little response to competition; in others size-specific fecundity was much greater in the absence of competition. This divergence in reaction norms among these populations may be the result of past selection (including the cost of plasticity), or genetic drift. 相似文献
17.
A variable-response model for parasitoid foraging behavior 总被引:5,自引:0,他引:5
L. E. M. Vet W. J. Lewis D. R. Papaj J. C. van Lenteren 《Journal of Insect Behavior》1990,3(4):471-490
An important factor inducing variability in foraging behavior in parasitic wasps is experience gained by the insect. Together with the insect's genetic constitution and physiological state, experience ultimately defines the behavioral repertoire under specified environmental circumstances. We present a conceptual variable-response model based on several major observations of a foraging parasitoid's responses to stimuli involved in the hostfinding process. These major observations are that (1) different stimuli evoke different responses or levels of response, (2) strong responses are less variable than weak ones, (3) learning can change response levels, (4) learning increases originally low responses more than originally high responses, and (5) hostderived stimuli serve as rewards in associative learning of other stimuli. The model specifies how the intrinsic variability of a response will depend on the magnitude of the response and predicts when and how learning will modify the insect's behavior. Additional hypotheses related to the model concern how experience with a stimulus modifies behavioral responses to other stimuli, how animals respond in multistimulus situations, which stimuli act to reinforce behavioral responses to other stimuli in the learning process, and finally, how generalist and specialist species differ in their behavioral plasticity. We postulate that insight into behavioral variability in the foraging behavior of natural enemies may be a help, if not a prerequisite, for the efficient application of parasitoids in pest management. 相似文献
18.
Jennifer Scales Jeremy Hyman Melissa Hughes 《Ethology : formerly Zeitschrift fur Tierpsychologie》2011,117(10):887-895
Animals in urban habitats face a number of unique stresses, including the necessity of dealing with high levels of human activity. Growing research suggests that: (1) inherent traits, as opposed to learned behavior, influence which species invade urban habitats, and (2) individuals exhibit behavioral syndromes that limit behavioral flexibility. As a result, perhaps only animals with inherently bold personalities successfully settle in areas of high human activity, and such animals may also exhibit correlated variation in other behavioral traits, such as territorial aggression. In this study, we examine boldness and aggression in several urban and rural populations of song sparrows (Melospiza melodia). We found that urban birds were both bolder toward humans and also showed higher levels of aggression. We found a correlation between boldness and aggression in all populations combined, but no correlation within urban populations. Our results agree with other recent studies of song sparrow behavior, suggesting that greater boldness and aggression are general features of urban song sparrow populations, and a lack of a correlation between boldness and aggression in urban habitats is a general phenomenon as well. Urban habitats may select for bold and aggressive birds, and yet the traits can vary independently. These results add to a small number of studies which find that behavioral syndromes break down in potentially high quality habitats. 相似文献
19.
Drosophila melanogaster is increasingly being used to model human conditions that are associated with cognitive deficits including fragile‐X syndrome, Alzheimer’s disease, Parkinson’s disease, sleep loss, etc. With few exceptions, cognitive abilities that are known to be modified in these conditions in humans have not been evaluated in fly models. One reason is the absence of a simple, inexpensive and reliable behavioral assay that can be used by laboratories that are not expert in learning and memory. Aversive phototaxic suppression (APS) is a simple assay in which flies learn to avoid light that is paired with an aversive stimulus (quinine/humidity). However, questions remain about whether the change in the fly’s behavior reflects learning an association between light and quinine/humidity or whether the change in behavior is because of nonassociative effects of habituation and/or sensitization. We evaluated potential effects of sensitization and habituation on behavior in the T‐maze and conducted a series of yoked control experiments to further exclude nonassociative effects and determine whether this task evaluates operant learning. Together these experiments indicate that a fly must associate the light with quinine/humidity to successfully complete the task. Next, we show that five classic memory mutants are deficient in this assay. Finally, we evaluate performance in a fly model of neurodegenerative disorders associated with the accumulation of Tau. These data indicate that APS is a simple and effective assay that can be used to evaluate fly models of human conditions associated with cognitive deficits. 相似文献
20.
以果蝇模型研究人类神经退行性疾病 总被引:3,自引:0,他引:3
人类神经退行性疾病是一类以神经元退行性病变导致个体行为异常乃至死亡为主要特征的疾病.果蝇以其独特的分子遗传学优势成为研究人类神经退行性疾病的理想模型.通过对果蝇模型的研究不仅可以揭示神经退行性疾病发生的细胞分子通路,还可以研究对疾病有调控作用的基因及其表达产物,寻找可能的药物作用靶点并进行药物筛选,为防治人类神经退行性疾病提供新的方法和有效的药物. 相似文献